{"id":"https://openalex.org/W2980475449","doi":"https://doi.org/10.7534/j.issn.1009-2137.2018.05.041","title":"[Role of Th17 Cells, Interleukin-17 and Matrix Metalloproteinase-13 in Pathogenesis of Henoch-Schonlein Purpura].","display_name":"[Role of Th17 Cells, Interleukin-17 and Matrix Metalloproteinase-13 in Pathogenesis of Henoch-Schonlein Purpura].","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2980475449","doi":"https://doi.org/10.7534/j.issn.1009-2137.2018.05.041","mag":"2980475449","pmid":"https://pubmed.ncbi.nlm.nih.gov/30295275"},"language":"en","primary_location":{"id":"pmid:30295275","doi":"https://doi.org/10.7534/j.issn.1009-2137.2018.05.041","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30295275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060683514","display_name":"Xiaofang Hou","orcid":"https://orcid.org/0000-0002-8558-4521","observed_orcids":["https://orcid.org/0000-0002-8558-4521"]},"institutions":[{"id":"https://openalex.org/I4210113277","display_name":"Chaohu Hospital of Anhui Medical University","ror":"https://ror.org/0234wv516","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113277"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Fang Hou","raw_affiliation_strings":["Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China","institution_ids":["https://openalex.org/I4210113277"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072090945","display_name":"Hailong Xia","orcid":"https://orcid.org/0009-0000-3915-1226","observed_orcids":["https://orcid.org/0009-0000-3915-1226"]},"institutions":[{"id":"https://openalex.org/I4210113277","display_name":"Chaohu Hospital of Anhui Medical University","ror":"https://ror.org/0234wv516","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113277"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Long Xia","raw_affiliation_strings":["Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China.E-mail: xhl1999cn @163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China.E-mail: xhl1999cn @163.com","institution_ids":["https://openalex.org/I4210113277"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210113277"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.29507394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"26","issue":"5","first_page":"1502","last_page":"1506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/henoch-schonlein-purpura","display_name":"IgA vasculitis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.996999979019165},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-13","display_name":"matrix metalloproteinase-13","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunopathogenesis","display_name":"immunopathogenesis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/skin-lesions","display_name":"skin lesions","score":0.8180000185966492},{"id":"https://openalex.org/keywords/acute-phase","display_name":"acute phase","score":0.8489999771118164},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8555418252944946},{"id":"https://openalex.org/C2780013240","wikidata":"https://www.wikidata.org/wiki/Q1035319","display_name":"Henoch-Schonlein purpura","level":4,"score":0.8499753475189209},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5904582142829895},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5846090912818909},{"id":"https://openalex.org/C47348012","wikidata":"https://www.wikidata.org/wiki/Q99486570","display_name":"Interleukin 17","level":3,"score":0.5593793392181396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5010182857513428},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.49836111068725586},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4710167646408081},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.4217618405818939},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40692710876464844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37003999948501587},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.35740938782691956},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3313766419887543},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3284928500652313},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.19909623265266418},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.11159363389015198},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06137317419052124}],"mesh":[{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011695","descriptor_name":"IgA Vasculitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011695","descriptor_name":"IgA Vasculitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011695","descriptor_name":"IgA Vasculitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:30295275","doi":"https://doi.org/10.7534/j.issn.1009-2137.2018.05.041","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30295275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"Journal Article"},{"id":"mag:2980475449","doi":"https://doi.org/10.7534/j.issn.1009-2137.2018.05.041","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30295275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3029738751","https://openalex.org/W3029078760","https://openalex.org/W2100872976","https://openalex.org/W2087289419","https://openalex.org/W1991181552","https://openalex.org/W2095537245","https://openalex.org/W4210254540","https://openalex.org/W2093162313","https://openalex.org/W3030458261","https://openalex.org/W3111296451"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"explore":[2],"the":[3,11,26,57,99,201],"immunopathogenesis":[4],"of":[5,13,28,36,45,60,78,83,89,101,107,121,131,138,170,176,204],"Henoch-Schonlein":[6],"purpara":[7],"(HSP)":[8],"by":[9,54,73],"detecting":[10],"levels":[12,59,130],"Th17":[14,39,102,192],"cells,":[15,193],"IL-17":[16,29,61,79,132,171,194],"and":[17,25,48,62,67,75,86,133,154,163,195],"matrix":[18],"metallo":[19],"proteinase-13":[20],"(MMP-13)":[21],"in":[22,30,42,64,80,104,118,146,172,184,200],"peripheral":[23,43,119],"blood":[24,44,106,120],"expression":[27,76],"skin":[31,81,87,173],"lesions":[32],"at":[33,135],"acate":[34],"phase":[35,137],"HSP.":[37,205],"METHODS:":[38],"cell":[40],"ratio":[41,100],"HSP":[46,65,84,108,139,177],"group":[47,51,66,70,85,92,109,123,148,178,186],"healthy":[49,68,90],"control":[50,69,91,122,147,185],"was":[52,93,111,180],"defected":[53,72],"flow":[55],"cytometry,":[56],"plasma":[58,129],"MMP-13":[63,134,196],"were":[71,140],"ELISA,":[74],"level":[77],"lesion":[82],"tissue":[88,175],"deternined":[94],"by:":[95],"immunohistochemistry":[96],"method.":[97],"RESULTS:":[98],"cells":[103],"periphral":[105],"(1.21\u00b10.59%)":[110],"very":[112,141],"signif":[113],"cantly":[114],"higher":[115,143,181],"than":[116,144,182],"that":[117,183],"(0.71\u00b10.26%)":[124],"(":[125,188],"t=4.907,":[126],"P<0.01).":[127,165,190],"The":[128,166],"acute":[136],"significantly":[142],"those":[145],"(64.58\u00b136.21)":[149],"pg/ml":[150,153,156,159],"vs":[151,157],"(26.16\u00b114.90)":[152],"(17.57\u00b15.40)":[155],"(11.53\u00b14.40)":[158],"respectively":[160],"(t=6.183,":[161],"P<0.01":[162],"t=5.022,":[164],"integrool":[167],"optical":[168],"density":[169],"lesin":[174],"(7.26\u00b12.34)":[179],"(4.61\u00b11.82)":[187],"t=2.877,":[189],"CONCLUSION:":[191],"may":[197],"be":[198],"involved":[199],"immunological":[202],"pathogenesis":[203]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
