{"id":"https://openalex.org/W2980466853","doi":"https://doi.org/10.1182/blood.v120.21.4675.4675","title":"Lentiviral-mediated ho-1 gene transduced bone mesenchymal stem cells protects against acute graft-Versus-host disease in vitro and vivo","display_name":"Lentiviral-mediated ho-1 gene transduced bone mesenchymal stem cells protects against acute graft-Versus-host disease in vitro and vivo","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2980466853","doi":"https://doi.org/10.1182/blood.v120.21.4675.4675","mag":"2980466853"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.4675.4675","doi":"https://doi.org/10.1182/blood.v120.21.4675.4675","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.4675.4675","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065739638","display_name":"Jishi Wang","orcid":"https://orcid.org/0009-0007-1053-6588","observed_orcids":["https://orcid.org/0009-0007-1053-6588"]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jishi Wang","raw_affiliation_strings":["Hematology, Affiliated Hospital of Guiyang Medical College, Guiyang, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Affiliated Hospital of Guiyang Medical College, Guiyang, China,","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101490377","display_name":"Dan Ma","orcid":"https://orcid.org/0000-0002-9220-7898","observed_orcids":["https://orcid.org/0000-0002-9220-7898","https://orcid.org/0000-0001-5344-4674"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dan Ma","raw_affiliation_strings":["Laboratory of GuiZhou province Hematological Disease Diagnostic & Treat Centre, GuiYang, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of GuiZhou province Hematological Disease Diagnostic & Treat Centre, GuiYang, China,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058075739","display_name":"Yan Li","orcid":"https://orcid.org/0000-0003-2145-2869","observed_orcids":["https://orcid.org/0000-0003-2145-2869"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yan Li","raw_affiliation_strings":["Hematopoietic stem cell transplant center of GuiZhou province, GuiYang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematopoietic stem cell transplant center of GuiZhou province, GuiYang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036378520","display_name":"Qin Fang","orcid":"https://orcid.org/0000-0001-9492-5204","observed_orcids":["https://orcid.org/0000-0001-9492-5204"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qin Fang","raw_affiliation_strings":["Laboratory of GuiZhou province Hematological Disease Diagnostic & Treat Centre, GuiYang, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of GuiZhou province Hematological Disease Diagnostic & Treat Centre, GuiYang, China,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087726543","display_name":"Shuya Chen","orcid":"https://orcid.org/0000-0002-4855-8383","observed_orcids":["https://orcid.org/0000-0002-4855-8383"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shuya Chen","raw_affiliation_strings":["Laboratory of GuiZhou province Hematological Disease Diagnostic & Treat Centre, GuiYang, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of GuiZhou province Hematological Disease Diagnostic & Treat Centre, GuiYang, China,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113748549","display_name":"Jia Sun","orcid":"https://orcid.org/0009-0006-4526-8440","observed_orcids":["https://orcid.org/0009-0006-4526-8440"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jia Sun","raw_affiliation_strings":["Laboratory of GuiZhou province Hematological Disease Diagnostic & Treat Centre, GuiYang, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of GuiZhou province Hematological Disease Diagnostic & Treat Centre, GuiYang, China,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036378520","https://openalex.org/A5058075739","https://openalex.org/A5087726543","https://openalex.org/A5101490377","https://openalex.org/A5113748549"],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43739869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"120","issue":"21","first_page":"4675","last_page":"4675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.2964000105857849,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.8980000019073486},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stem-cells","display_name":"bone marrow-derived mesenchymal stem cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/lentiviral-transduction","display_name":"lentiviral transduction","score":0.859000027179718},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8510000109672546},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.5960000157356262},{"id":"https://openalex.org/keywords/stem-cell-homing","display_name":"stem cell homing","score":0.671999990940094},{"id":"https://openalex.org/keywords/balb-c-mouse-model","display_name":"BALB/c mouse model","score":0.6259999871253967},{"id":"https://openalex.org/keywords/transwell-assay","display_name":"transwell assay","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7931596040725708},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6199800968170166},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6023805141448975},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5050514340400696},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4981822967529297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48519662022590637},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4721032679080963},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4526890516281128},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.43062126636505127},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3423804044723511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32250869274139404},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.29726529121398926},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15669137239456177},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11195462942123413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06112384796142578},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.04983946681022644}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.4675.4675","doi":"https://doi.org/10.1182/blood.v120.21.4675.4675","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.4675.4675","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2490452461","https://openalex.org/W2588688756","https://openalex.org/W2348470415","https://openalex.org/W2590473494","https://openalex.org/W2419449468","https://openalex.org/W1964905392","https://openalex.org/W2582606243","https://openalex.org/W2014482299","https://openalex.org/W2403145592","https://openalex.org/W2524372494"],"abstract_inverted_index":{"Abstract":[0,1],"4675":[2],"Objective:":[3],"Bone":[4],"mesenchymal":[5,36],"stem":[6,37],"cells":[7,38],"(BMSCs)":[8],"possessing":[9],"immunoregulatory":[10,503],"activities":[11,504],"have":[12],"been":[13],"evaluated":[14],"in":[15,52,67,182,222,230,242,249,259,274,297,370,379,393,402,463,564],"the":[16,42,58,125,129,140,154,187,206,217,281,339,355,386,394,417,428,455,485,526,545],"treatment":[17,421],"of":[18,45,61,128,142,156,173,189,272,283,310,357,368,406,440,475,515,521,528,547,572,580,588,596,604],"graft-versus-host":[19],"disease":[20],"(GVHD).":[21],"In":[22,196,416,493,523],"this":[23],"study,":[24],"mice's":[25,33,88,92,201,334,548],"heme":[26],"oxygenase":[27],"1":[28],"(HO-1)":[29],"was":[30,69,104,177,191,347,442],"transduced":[31,48],"into":[32,151,216],"bone":[34,93,335,390],"marrow-derived":[35],"(mBMSCs),":[39],"we":[40,198],"assessed":[41],"immuno-suppressive":[43],"capacity":[44,172],"lentiviral":[46,499],"vector":[47],"BMSCs":[49,425,469,542],"expressing":[50],"HO-1":[51,89,159,174,263,331,369,423,467,486,511,555],"BALB/c":[53,200,218],"mice":[54,219,276,296,330,418],"aGVHD":[55,79,202,220,235,239,246,256,286,549,563],"model,":[56,420],"and":[57,95,113,121,124,153,158,166,211,269,293,305,317,337,349,362,431,434,438,460,477,535,554],"immuno-regulatory":[59],"effect":[60],"mBMSCs":[62,82,108,176,210,213,250,260,346,378,496],"on":[63],"alleviating":[64],"acute":[65],"GVHD":[66,273,419,436],"vivo":[68,231,524],"measured":[70],"to":[71,279,490,505,561],"provide":[72],"laboratory":[73],"data":[74],"for":[75,78,139,302],"gene":[76,133,332],"therapy":[77],"which":[80,102,134],"used":[81,489],"as":[83,290],"vehicles.":[84],"Methods:":[85],"We":[86,328],"cloned":[87,329],"cDNA":[90],"from":[91,295,333],"marrow":[94,336,391],"constructed":[96,338],"recombinant":[97,147,207,340],"lentivirus":[98],"vectors":[99,148,208,342,483,500],"(Lentivirus-V5-D-TOPO-HO-1-EGFP/Lentivirus\u2013V":[100],"5-D-TOPO-EGFP)":[101],"titer":[103],"1\u00d71011":[105],"pfu/mL.":[106],"These":[107],"were":[109,149,160,214,228,277,300,319,470,479,487],"separated,":[110],"cultured,":[111],"purified,":[112],"detected":[114,161,192,354,365],"by":[115,144,162,193],"morphology,":[116],"flow":[117],"cytometry,":[118],"osteogenic,":[119],"adipogenic":[120],"chondrogenic":[122],"induction,":[123],"mRNA":[126],"level":[127],"neural":[130],"ganglioside":[131],"GD2":[132],"is":[135],"a":[136,323,558],"surface":[137],"marker":[138],"identification":[141],"MSCs":[143],"RT-PCR.":[145],"Then":[146],"transferred":[150,497],"mBMSCs,":[152,516],"expression":[155,356,367],"EGFP":[157],"fluorescence":[163],"microscope,":[164],"RT-PCR":[165,361],"Western":[167,363],"blot":[168,364],"respectively.":[169,225],"The":[170,265,285],"immunsuppressive":[171],"over-expressing":[175,424,468],"investigated":[178],"using":[179,322],"transwell":[180],"assay":[181],"vitro.":[183],"And":[184],"before":[185],"infusion,":[186],"homing":[188,405,520],"MSC":[190],"Flow":[194],"cytometry.":[195],"addition,":[197],"established":[199],"model":[203,221,240,247,257],"after":[204],"Allo-HSCT,":[205],"tranfected":[209],"primary":[212],"injected":[215,241,248,258],"tail":[223],"vein,":[224],"Four":[226],"groups":[227],"separated":[229,348],"test":[232],"(Group":[233],"A:":[234],"control;":[236],"Group":[237,244,254,380,398,407],"B:":[238],"mBMSCs;":[243],"C:":[245],"transfected":[251,261],"with":[252,262,413,422,452,466,498],"EGFP;":[253],"D:":[255],"gene.)":[264],"survival,":[266],"body":[267,531],"weight":[268],"clinical":[270,433,533],"score":[271,534,537],"transplanted":[275],"monitored":[278],"evaluate":[280],"severity":[282],"aGVHD.":[284,507],"targeted":[287],"organ,":[288],"such":[289],"Liver,":[291],"intestine":[292],"lung":[294],"each":[298],"group":[299,372],"obtained":[301],"histological":[303],"examination":[304],"pathological":[306,435,536],"score.":[307],"Plasma":[308],"concentrations":[309],"interleukin":[311],"(IL)-2,":[312],"IL-4,":[313],"IL-6,":[314,458],"IL-10,":[315],"IFN-\u03b3":[316,459],"TNF-\u03b3":[318,461],"also":[320,518],"determined":[321],"Cytometric":[324],"Bead":[325],"Array.":[326],"Results:":[327],"adenovirus":[341],"(Lentivirus-V5-D-TOPO-HO-1-":[343],"EGFP/Lentivirus-V5-D-TOPO-EGFP)":[344],"successfully.":[345,351],"identified":[350],"Fluorescence":[352],"microscope":[353],"EGFP,":[358],"while":[359,404,473],"both":[360],"high":[366],"gene-transfected":[371],"cells.":[373],"It":[374],"clearly":[375],"showed":[376,409],"that":[377,513,540],"D":[381,408],"can":[382],"migrate":[383],"more":[384,444],"through":[385],"polycarbonate":[387],"filter":[388],"toward":[389],"micro-environment":[392],"lower":[395],"chamber":[396],"than":[397,447],"A,":[399],"B,":[400],"C":[401],"vitro,":[403],"similar":[410],"trend":[411],"compared":[412,451],"others":[414,448],"groups.":[415,449],"significantly":[426,471],"decreased":[427],"mortality":[429],"rate":[430],"attenuated":[432],"scores,":[437],"volume":[439],"spleen":[441],"not":[443],"obviously":[445],"enlarged":[446],"Moreover,":[450],"control":[453],"groups,":[454],"plasma":[456],"IL-2,":[457],"levels":[462],"recipients":[464],"infused":[465],"decreased,":[472],"those":[474],"IL-4":[476],"IL-10":[478],"increased.":[480],"Conclusion:":[481],"Lentiviral":[482],"carrying":[484],"successfully":[488],"transduce":[491],"mBMSCs.":[492],"our":[494],"report,":[495],"expressed":[501],"strongerly":[502],"alleviate":[506],"Not":[508],"only":[509],"did":[510],"enhance":[512],"migration":[514],"but":[517],"strengthen":[519],"MSCs.":[522],"experiments,":[525],"evidence":[527],"survival":[529],"rate,":[530],"weight,":[532],"fully":[538],"proved":[539],"HO-1-transduced":[541],"effectively":[543],"controlled":[544],"occurrence":[546],"following":[550],"allogeneic":[551],"BM":[552],"transplantation,":[553],"may":[556],"be":[557],"potential":[559],"target":[560],"overcome":[562],"vivo.":[565],"Disclosures:":[566],"Ma:":[567],"National":[568],"Natural":[569,577,585,593,601],"Science":[570,578,586,594,602],"Foundation":[571,579,587,595,603],"China:":[573,581,589,597,605],"Research":[574,582,590,598,606],"Funding.":[575,583,591,599,607],"Li:National":[576],"Fang:National":[584],"Chen:National":[592],"Sun:National":[600]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-25T00:00:00"}
