{"id":"https://openalex.org/W2980466588","doi":null,"title":"EFNB2 acts as the target of miR-557 to facilitate cell proliferation, migration and invasion in pancreatic ductal adenocarcinoma by bioinformatics analysis and verification.","display_name":"EFNB2 acts as the target of miR-557 to facilitate cell proliferation, migration and invasion in pancreatic ductal adenocarcinoma by bioinformatics analysis and verification.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2980466588","mag":"2980466588","pmid":"https://pubmed.ncbi.nlm.nih.gov/30662604","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6291708"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5310535","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6291708","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6291708","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068864772","display_name":"Yalu Zhang","orcid":"https://orcid.org/0000-0001-5939-6685","observed_orcids":["https://orcid.org/0000-0001-5939-6685","https://orcid.org/0000-0002-5278-0788"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yalu Zhang","raw_affiliation_strings":["Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102988211","display_name":"Rundong Zhang","orcid":"https://orcid.org/0000-0003-2078-524X","observed_orcids":["https://orcid.org/0000-0003-2078-524X"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rundong Zhang","raw_affiliation_strings":["Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101755486","display_name":"Xi Ding","orcid":"https://orcid.org/0000-0002-4050-599X","observed_orcids":["https://orcid.org/0000-0002-4050-599X"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Ding","raw_affiliation_strings":["Department of General Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068640231","display_name":"Kaixing Ai","orcid":"https://orcid.org/0000-0002-5552-7673","observed_orcids":["https://orcid.org/0000-0002-5552-7673"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaixing Ai","raw_affiliation_strings":["Department of General Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University Shanghai 200433, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1327,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.7192954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"11","first_page":"3514","last_page":"3528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ephrin-b2","display_name":"ephrin-B2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mirna-mrna-regulatory-network","display_name":"miRNA-mRNA regulatory network","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.906000018119812},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7860000133514404},{"id":"https://openalex.org/keywords/prognostic-genes","display_name":"prognostic genes","score":0.7099999785423279},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.6539999842643738},{"id":"https://openalex.org/keywords/3-utr-binding","display_name":"3' UTR binding","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.7749999761581421},{"id":"https://openalex.org/keywords/mir-196b","display_name":"miR-196b","score":0.996999979019165},{"id":"https://openalex.org/keywords/mir-203","display_name":"miR-203","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sw1990-cells","display_name":"SW1990 cells","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8105175495147705},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6802122592926025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6592991352081299},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5471488833427429},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5340449213981628},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5217172503471375},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5114189982414246},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43914031982421875},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4125913977622986},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3982263505458832},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.37818366289138794},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35876721143722534},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23443233966827393}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5310535","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6291708","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30662604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30662604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6291708","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6291708/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2980466588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30662604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5310535","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6291708","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1797628932","https://openalex.org/W1898960514","https://openalex.org/W1963549347","https://openalex.org/W1973096186","https://openalex.org/W1977918192","https://openalex.org/W1981889510","https://openalex.org/W1985213868","https://openalex.org/W1997670728","https://openalex.org/W2001954506","https://openalex.org/W2003003494","https://openalex.org/W2020541351","https://openalex.org/W2027711161","https://openalex.org/W2029583475","https://openalex.org/W2087133203","https://openalex.org/W2096173332","https://openalex.org/W2100239923","https://openalex.org/W2100268880","https://openalex.org/W2103017472","https://openalex.org/W2124603636","https://openalex.org/W2132097639","https://openalex.org/W2134118500","https://openalex.org/W2135810600","https://openalex.org/W2137709331","https://openalex.org/W2150782426","https://openalex.org/W2158697148","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2162674813","https://openalex.org/W2163274936","https://openalex.org/W2167898988","https://openalex.org/W2192136560","https://openalex.org/W2194697488","https://openalex.org/W2415018300","https://openalex.org/W2542315333","https://openalex.org/W2570618306","https://openalex.org/W2586323824","https://openalex.org/W2594989663","https://openalex.org/W2607129810","https://openalex.org/W2701714378","https://openalex.org/W2749613778","https://openalex.org/W2774546526","https://openalex.org/W2807388684","https://openalex.org/W2852490302","https://openalex.org/W3134530972","https://openalex.org/W4229719081","https://openalex.org/W4246689117"],"related_works":["https://openalex.org/W4367857137","https://openalex.org/W2069358113","https://openalex.org/W1660465980","https://openalex.org/W1423697405","https://openalex.org/W3038124608","https://openalex.org/W2092504600","https://openalex.org/W2908627801","https://openalex.org/W4415019966","https://openalex.org/W3130501074","https://openalex.org/W4286270420"],"abstract_inverted_index":{"This":[0],"study":[1],"aims":[2],"to":[3,219,233],"identify":[4],"the":[5,50,58,192,239],"pivotal":[6],"microRNAs":[7],"(miRNAs)":[8],"and":[9,11,24,35,37,44,56,66,92,101,113,115,139,176,183,212,217],"genes,":[10],"their":[12],"potential":[13],"regulatory":[14,78],"mechanisms":[15],"in":[16,72,146,155,178,251],"pancreatic":[17],"ductal":[18],"adenocarcinoma":[19],"(PDAC)":[20],"through":[21],"bioinformatics":[22,83],"analysis":[23,207],"experimental":[25],"verification.":[26],"We":[27],"comprehensively":[28],"analyzed":[29],"two":[30],"miRNA":[31],"microarray":[32,40],"datasets":[33,41],"(GSE32678":[34],"GSE43796)":[36],"three":[38],"gene":[39,241],"(GSE28735,":[42],"GSE41368":[43],"GSE71989),":[45],"which":[46],"were":[47,141],"downloaded":[48],"from":[49,161],"Gene":[51],"Expression":[52],"Omnibus":[53],"(GEO)":[54],"database,":[55],"identified":[57],"total":[59],"of":[60,96,108,117,194,242],"8":[61],"differentially":[62,68],"expressed":[63,69],"miRNAs":[64,110,216],"(DEMs)":[65],"257":[67],"genes":[70,91,119,218],"(DEGs)":[71],"common.":[73],"Next,":[74],"a":[75],"new":[76],"miRNA-mRNA":[77],"network":[79],"was":[80,104,152],"constructed":[81],"by":[82,99,196,236],"methods,":[84],"including":[85],"7":[86,109],"miRNAs,":[87],"58":[88,118],"putative":[89],"target":[90,240],"80":[93],"interaction":[94],"pairs":[95],"miRNA-mRNA.":[97],"Scrutinized":[98],"OncoLnc":[100],"GEPIA,":[102],"it":[103],"found":[105],"that":[106,169,188,230],"3":[107],"(miR-21,":[111],"miR-196b":[112],"miR-203)":[114],"20":[116],"(MXRA5,":[120],"EPYC,":[121],"ECT2,":[122],"COL12A1,":[123],"SLC6A14,":[124],"SLC7A2,":[125],"BTG2,":[126],"PDK4,":[127],"CTNND2,":[128],"NRP2,":[129],"PXDN,":[130],"CD109,":[131],"TGFBI,":[132],"LRRN1,":[133],"ITGA2,":[134],"DKK1,":[135],"GREM1,":[136],"EFNB2,":[137],"SEMA3C":[138],"NT5E)":[140],"notably":[142],"associated":[143],"with":[144,148,158],"prognosis":[145],"patients":[147],"PDAC.":[149,252],"Furthermore,":[150],"EFNB2":[151,170,195,231],"significantly":[153],"upregulated":[154],"PDAC":[156,234],"compared":[157],"normal":[159],"controls":[160],"different":[162],"public":[163],"databases.":[164],"Cellular":[165],"function":[166],"experiments":[167],"demonstrated":[168],"knockdown":[171],"inhibited":[172],"cell":[173],"proliferation,":[174],"migration":[175],"invasion":[177],"SW1990":[179],"cells.":[180],"Western":[181],"blot":[182],"luciferase":[184],"reporter":[185],"assays":[186],"revealed":[187],"miR-557":[189],"negatively":[190],"regulated":[191],"expression":[193,210],"directly":[197],"binging":[198],"its":[199],"3'":[200],"UTR.":[201],"In":[202,225],"conclusion,":[203],"we":[204],"performed":[205],"integrated":[206],"for":[208,222,247],"multiple":[209],"profiles,":[211],"provided":[213],"novel":[214],"candidate":[215],"be":[220],"exploited":[221],"functional":[223],"studies.":[224],"addition,":[226],"our":[227],"findings":[228],"suggested":[229],"contributes":[232],"progression":[235],"acting":[237],"as":[238],"miR-557.":[243],"It":[244],"is":[245],"useful":[246],"uncovering":[248],"miRNA-based":[249],"treatments":[250]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-10-25T00:00:00"}
