{"id":"https://openalex.org/W2980463587","doi":"https://doi.org/10.1016/j.jalz.2019.06.2958","title":"P2\u2010550: PLASMA MEASURES OF INFLAMMATION ASSOCIATED WITH CLINICAL PROGRESSION AND COGNITIVE DECLINE DURING PRECLINICAL AD","display_name":"P2\u2010550: PLASMA MEASURES OF INFLAMMATION ASSOCIATED WITH CLINICAL PROGRESSION AND COGNITIVE DECLINE DURING PRECLINICAL AD","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2980463587","doi":"https://doi.org/10.1016/j.jalz.2019.06.2958","mag":"2980463587"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2019.06.2958","doi":"https://doi.org/10.1016/j.jalz.2019.06.2958","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2019.06.2958","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2019.06.2958","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2019.06.2958","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015354687","display_name":"Alden L. Gross","orcid":"https://orcid.org/0000-0002-4678-0562","observed_orcids":["https://orcid.org/0000-0002-4678-0562"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alden L. Gross","raw_affiliation_strings":["Aging and Health Johns Hopkins Center on Aging and Health (COAH)  Baltimore MD USA","Johns Hopkins Bloomberg School of Public Health  Baltimore MD USA","Aging and Health, Johns Hopkins Center on Aging and Health (COAH), Baltimore, MD, USA","Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging and Health Johns Hopkins Center on Aging and Health (COAH)  Baltimore MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health  Baltimore MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Aging and Health, Johns Hopkins Center on Aging and Health (COAH), Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070005522","display_name":"Keenan A. Walker","orcid":"https://orcid.org/0000-0002-5989-9853","observed_orcids":["https://orcid.org/0000-0002-5989-9853"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keenan A. Walker","raw_affiliation_strings":["Johns Hopkins School of Medicine  Baltimore MD USA","Johns Hopkins School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins School of Medicine  Baltimore MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066802894","display_name":"Abhay Moghekar","orcid":"https://orcid.org/0000-0001-9464-1551","observed_orcids":["https://orcid.org/0000-0001-9464-1551"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhay Moghekar","raw_affiliation_strings":["Johns Hopkins School of Medicine  Baltimore MD USA","Johns Hopkins School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins School of Medicine  Baltimore MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038042352","display_name":"Corinne A. Pettigrew","orcid":"https://orcid.org/0000-0003-4264-275X","observed_orcids":["https://orcid.org/0000-0003-4264-275X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corinne Pettigrew","raw_affiliation_strings":["Johns Hopkins University School of Medicine  Baltimore MD USA","Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine  Baltimore MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005710176","display_name":"Anja Soldan","orcid":"https://orcid.org/0000-0002-6193-0418","observed_orcids":["https://orcid.org/0000-0002-6193-0418"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anja Soldan","raw_affiliation_strings":["Johns Hopkins University School of Medicine  Baltimore MD USA","Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine  Baltimore MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023514892","display_name":"Marilyn Albert","orcid":"https://orcid.org/0000-0002-8167-8985","observed_orcids":["https://orcid.org/0000-0002-8167-8985"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilyn S. Albert","raw_affiliation_strings":["Johns Hopkins University School of Medicine  Baltimore MD USA","Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine  Baltimore MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086987637","display_name":"Jeremy D Walston","orcid":"https://orcid.org/0000-0002-6965-2723","observed_orcids":["https://orcid.org/0000-0002-6965-2723"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Walston","raw_affiliation_strings":["Johns Hopkins School of Medicine  Baltimore MD USA","Johns Hopkins School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins School of Medicine  Baltimore MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015354687"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16250675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"7S_Part_16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.05950000137090683,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5837236642837524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5761365294456482},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5679969787597656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5500794053077698},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5293669700622559},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4746311902999878},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4541683495044708},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4474119544029236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3843936324119568},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38159263134002686},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3253363072872162},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2569350302219391},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08981457352638245}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2019.06.2958","doi":"https://doi.org/10.1016/j.jalz.2019.06.2958","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2019.06.2958","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2019.06.2958","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2019.06.2958","doi":"https://doi.org/10.1016/j.jalz.2019.06.2958","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2019.06.2958","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2019.06.2958","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2980463587.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1551592253","https://openalex.org/W2486559672","https://openalex.org/W2050558417","https://openalex.org/W4225914417","https://openalex.org/W2135436588","https://openalex.org/W3030144597","https://openalex.org/W2498374562","https://openalex.org/W2951371476","https://openalex.org/W2044757050","https://openalex.org/W4231524083"],"abstract_inverted_index":{"Inflammatory":[0],"responses":[1],"have":[2,13],"been":[3],"implicated":[4],"in":[5,45,152],"Alzheimer's":[6],"disease":[7],"(AD)":[8],"pathophysiological":[9],"processes.":[10],"Few":[11],"studies":[12],"also":[14,190],"evaluated":[15],"the":[16,36,108,138],"risk":[17,167],"of":[18,21,42,82,92,110,121,160,168,187,195,207],"non-inflammatory":[19,205],"markers":[20,81,206],"immune":[22,26,43,97,211],"functioning":[23],"(i.e.,":[24],"innate":[25,96,208],"activation":[27,44,98,212],"and":[28,49,53,95,100,123,140,145,204,209],"adaptive":[29,87,210],"immunity).":[30],"In":[31],"this":[32],"study,":[33],"we":[34],"examined":[35],"prospective":[37],"association":[38,109],"between":[39],"blood":[40,112,156],"biomarkers":[41],"cognitively":[46,65],"normal":[47,66,171],"individuals":[48],"subsequent":[50],"cognitive":[51,58,197,220],"decline":[52,198],"clinical":[54,217],"progression":[55,128,169,218],"to":[56,106,127,129,149,173],"mild":[57],"impairment":[59],"(MCI).":[60],"Plasma":[61],"was":[62,104,147],"collected":[63],"from":[64,170],"participants":[67],"(N=191;":[68],"mean":[69,73],"age":[70,136],"65.2":[71],"years;":[72],"follow-up":[74,200],"5.8":[75],"years).":[76],"Specimens":[77],"were":[78,163,189,213],"assayed":[79],"for":[80,143,154],"chronic":[83],"inflammation":[84],"(TNFR1,":[85],"IL-6),":[86],"immunity":[88],"(CD25,":[89],"a":[90],"marker":[91],"T-cell":[93],"activity),":[94],"(CD14":[99],"CD163).":[101],"Survival":[102],"analysis":[103],"used":[105,148],"evaluate":[107],"each":[111,155],"marker,":[113],"as":[114,116,137],"well":[115],"an":[117],"inflammatory":[118],"index":[119],"comprised":[120],"TNFR1":[122,162,188],"IL-6,":[124],"with":[125,135,165,192,216],"time":[126],"MCI.":[130],"Latent":[131],"growth":[132],"curve":[133],"modeling,":[134],"timescale":[139],"random":[141],"effects":[142],"person":[144],"time,":[146],"model":[150],"changes":[151],"cognition":[153,172],"marker.":[157],"Higher":[158],"levels":[159,186],"plasma":[161],"associated":[164,191,215],"greater":[166],"MCI":[174],"(HR:":[175],"3.27;":[176],"95%":[177],"confidence":[178],"interval,":[179],"CI:":[180],"1.27,":[181],"8.40)":[182],"(Table":[183,201],"1).":[184],"Elevated":[185],"steeper":[193],"rate":[194],"general":[196],"on":[199],"2).":[202],"IL-6":[203],"not":[214],"or":[219],"decline.":[221]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
