{"id":"https://openalex.org/W2980434065","doi":"https://doi.org/10.1101/806687","title":"Neural signatures of loss of consciousness and its recovery by thalamic stimulation","display_name":"Neural signatures of loss of consciousness and its recovery by thalamic stimulation","publication_year":2019,"publication_date":"2019-10-17","ids":{"openalex":"https://openalex.org/W2980434065","doi":"https://doi.org/10.1101/806687","mag":"2980434065"},"language":"en","primary_location":{"id":"doi:10.1101/806687","doi":"https://doi.org/10.1101/806687","is_oa":true,"landing_page_url":"https://doi.org/10.1101/806687","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/10/17/806687.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2019/10/17/806687.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003441990","display_name":"Jacob Donoghue","orcid":"https://orcid.org/0000-0002-8845-5098","observed_orcids":["https://orcid.org/0000-0002-8845-5098"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob A. Donoghue","raw_affiliation_strings":["The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011803882","display_name":"Andr\u00e9 M. Bastos","orcid":"https://orcid.org/0000-0003-1804-4418","observed_orcids":["https://orcid.org/0000-0003-1804-4418"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 M. Bastos","raw_affiliation_strings":["The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037284574","display_name":"Jorge Yanar","orcid":"https://orcid.org/0000-0003-1416-3567","observed_orcids":["https://orcid.org/0000-0003-1416-3567"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Yanar","raw_affiliation_strings":["The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042760897","display_name":"Simon Kornblith","orcid":"https://orcid.org/0000-0002-9088-2443","observed_orcids":["https://orcid.org/0000-0002-9088-2443"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon Kornblith","raw_affiliation_strings":["The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087158524","display_name":"Meredith K. Mahnke","orcid":"https://orcid.org/0000-0002-7125-9031","observed_orcids":["https://orcid.org/0000-0002-7125-9031"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith Mahnke","raw_affiliation_strings":["The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030321614","display_name":"Emery N. Brown","orcid":"https://orcid.org/0000-0003-2668-7819","observed_orcids":["https://orcid.org/0000-0003-2668-7819"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emery N. Brown","raw_affiliation_strings":["The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084251670","display_name":"Earl K. Miller","orcid":"https://orcid.org/0000-0002-0582-6958","observed_orcids":["https://orcid.org/0000-0002-0582-6958"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Earl K. Miller","raw_affiliation_strings":["The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084251670"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loss-of-consciousness","display_name":"loss of consciousness","score":0.8669999837875366},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.8479999899864197},{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9300000071525574},{"id":"https://openalex.org/keywords/thalamic-deep-brain-stimulation","display_name":"thalamic stimulation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cortical-oscillations","display_name":"cortical oscillations","score":0.7549999952316284},{"id":"https://openalex.org/keywords/local-field-potentials","display_name":"local field potentials","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cortical-synchrony","display_name":"cortical synchronization","score":0.628000020980835},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.6819999814033508},{"id":"https://openalex.org/keywords/anesthesia-recovery","display_name":"anesthesia recovery","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2776470351","wikidata":"https://www.wikidata.org/wiki/Q12829165","display_name":"Unconsciousness","level":2,"score":0.9878600835800171},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.831734299659729},{"id":"https://openalex.org/C17329761","wikidata":"https://www.wikidata.org/wiki/Q7709509","display_name":"Thalamic stimulator","level":5,"score":0.787071943283081},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7252231240272522},{"id":"https://openalex.org/C117838684","wikidata":"https://www.wikidata.org/wiki/Q533483","display_name":"Local field potential","level":2,"score":0.6907972693443298},{"id":"https://openalex.org/C186720457","wikidata":"https://www.wikidata.org/wiki/Q7087","display_name":"Consciousness","level":2,"score":0.6144556999206543},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.5470779538154602},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.49642854928970337},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.44443386793136597},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.415690153837204},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3219132423400879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22809788584709167},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.14967402815818787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08091983199119568},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/806687","doi":"https://doi.org/10.1101/806687","is_oa":true,"landing_page_url":"https://doi.org/10.1101/806687","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/10/17/806687.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/806687","doi":"https://doi.org/10.1101/806687","is_oa":true,"landing_page_url":"https://doi.org/10.1101/806687","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/10/17/806687.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.46000000834465027}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3522989319","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007753","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980434065.pdf","grobid_xml":"https://content.openalex.org/works/W2980434065.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W961072635","https://openalex.org/W1971168247","https://openalex.org/W1977518154","https://openalex.org/W1988881714","https://openalex.org/W1996236451","https://openalex.org/W1999567494","https://openalex.org/W2002996884","https://openalex.org/W2015303758","https://openalex.org/W2015304937","https://openalex.org/W2033624480","https://openalex.org/W2044670283","https://openalex.org/W2078690814","https://openalex.org/W2086338669","https://openalex.org/W2094205817","https://openalex.org/W2094850439","https://openalex.org/W2105612509","https://openalex.org/W2109690662","https://openalex.org/W2119132304","https://openalex.org/W2132796361","https://openalex.org/W2135894974","https://openalex.org/W2137456793","https://openalex.org/W2140125514","https://openalex.org/W2144895779","https://openalex.org/W2160419313","https://openalex.org/W2164470519","https://openalex.org/W2166073443","https://openalex.org/W2227520796","https://openalex.org/W2317325433","https://openalex.org/W2514213849","https://openalex.org/W2737674920","https://openalex.org/W2898524098","https://openalex.org/W2906197736","https://openalex.org/W2913125551","https://openalex.org/W3045498045"],"related_works":["https://openalex.org/W3159289346","https://openalex.org/W2737674920","https://openalex.org/W7165571949","https://openalex.org/W2135817947","https://openalex.org/W2955872220","https://openalex.org/W2981406065","https://openalex.org/W2015304937","https://openalex.org/W2516662944","https://openalex.org/W4402367685","https://openalex.org/W4320913212"],"abstract_inverted_index":{"Abstract":[0],"We":[1,12],"know":[2],"that":[3,102],"general":[4],"anesthesia":[5],"produces":[6],"unconsciousness":[7,27],"but":[8],"not":[9],"quite":[10],"how.":[11],"recorded":[13],"neural":[14],"activity":[15],"from":[16,88],"the":[17,80,100],"frontal,":[18],"parietal,":[19],"and":[20,23,60,78,92],"temporal":[21],"cortices":[22],"thalamus":[24,68],"while":[25],"maintaining":[26],"in":[28,43],"non-human":[29],"primates":[30],"(NHPs)":[31],"with":[32,54],"propofol.":[33],"Unconsciousness":[34,85],"was":[35],"marked":[36],"by":[37,99],"slow":[38,89],"frequency":[39,63,90],"(\u223c1":[40],"Hz)":[41,65],"oscillations":[42],"local":[44,48],"field":[45],"potentials,":[46],"entraining":[47],"spiking":[49],"to":[50,70],"Up":[51],"states":[52,56],"alternating":[53],"Down":[55],"of":[57,83,94],"little":[58],"spiking,":[59],"decreased":[61],"higher":[62],"(>4":[64],"coherence.":[66],"The":[67],"contributed":[69],"cortical":[71,104],"rhythms.":[72],"Its":[73],"stimulation":[74],"\u201cawakened\u201d":[75],"anesthetized":[76],"NHPs":[77],"reversed":[79],"electrophysiologic":[81],"features":[82],"unconsciousness.":[84],"thus":[86],"resulted":[87],"hypersynchrony":[91],"loss":[93],"high-frequency":[95],"dynamics,":[96],"partly":[97],"mediated":[98],"thalamus,":[101],"disrupts":[103],"communication/integration.":[105]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-10-25T00:00:00"}