{"id":"https://openalex.org/W2980401808","doi":"https://doi.org/10.1016/j.cobme.2019.09.012","title":"Global sensitivity analysis of biological multiscale models","display_name":"Global sensitivity analysis of biological multiscale models","publication_year":2019,"publication_date":"2019-09-01","ids":{"openalex":"https://openalex.org/W2980401808","doi":"https://doi.org/10.1016/j.cobme.2019.09.012","mag":"2980401808","pmid":"https://pubmed.ncbi.nlm.nih.gov/32864523","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7450543"},"language":"en","primary_location":{"id":"doi:10.1016/j.cobme.2019.09.012","doi":"https://doi.org/10.1016/j.cobme.2019.09.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cobme.2019.09.012","pdf_url":null,"source":{"id":"https://openalex.org/S2898133657","display_name":"Current Opinion in Biomedical Engineering","issn_l":"2468-4511","issn":["2468-4511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Biomedical Engineering","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7450543","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083006834","display_name":"Marissa Renardy","orcid":"https://orcid.org/0000-0003-4856-3788","observed_orcids":["https://orcid.org/0000-0003-4856-3788"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa Renardy","raw_affiliation_strings":["University of Michigan Medical School, Department of Microbiology and Immunology","University of Michigan Medical School, Department of Microbiology and Immunology, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, Department of Microbiology and Immunology","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"University of Michigan Medical School, Department of Microbiology and Immunology, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017379122","display_name":"Caitlin Hult","orcid":"https://orcid.org/0000-0002-2641-2180","observed_orcids":["https://orcid.org/0000-0002-2641-2180"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin Hult","raw_affiliation_strings":["University of Michigan Medical School, Department of Microbiology and Immunology","University of Michigan, Department of Chemical Engineering","University of Michigan Medical School, Department of Microbiology and Immunology, USA","University of Michigan, Department of Chemical Engineering, USA"],"raw_orcid":"https://orcid.org/0000-0002-2641-2180","affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, Department of Microbiology and Immunology","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"University of Michigan, Department of Chemical Engineering","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"University of Michigan Medical School, Department of Microbiology and Immunology, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"University of Michigan, Department of Chemical Engineering, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephanie Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Evans","raw_affiliation_strings":["University of Michigan Medical School, Department of Microbiology and Immunology","University of Michigan Medical School, Department of Microbiology and Immunology, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, Department of Microbiology and Immunology","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"University of Michigan Medical School, Department of Microbiology and Immunology, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066699569","display_name":"Jennifer J. Linderman","orcid":"https://orcid.org/0000-0002-1519-5088","observed_orcids":["https://orcid.org/0000-0002-1519-5088"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer J. Linderman","raw_affiliation_strings":["University of Michigan, Department of Chemical Engineering","University of Michigan, Department of Chemical Engineering, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Department of Chemical Engineering","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"University of Michigan, Department of Chemical Engineering, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067786863","display_name":"Denise E. Kirschner","orcid":"https://orcid.org/0000-0002-1053-2591","observed_orcids":["https://orcid.org/0000-0002-1053-2591"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Denise E. Kirschner","raw_affiliation_strings":["University of Michigan Medical School, Department of Microbiology and Immunology","University of Michigan Medical School, Department of Microbiology and Immunology, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, Department of Microbiology and Immunology","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"University of Michigan Medical School, Department of Microbiology and Immunology, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066699569","https://openalex.org/A5067786863"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":3830,"currency":"USD","value_usd":3830},"apc_paid":null,"fwci":0.8108,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.79082774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"11","issue":null,"first_page":"109","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10928","display_name":"Probabilistic and Robust Engineering Design","score":0.4490000009536743,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10928","display_name":"Probabilistic and Robust Engineering Design","score":0.4490000009536743,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.2709999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13286","display_name":"Modeling and Simulation Systems","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/global-sensitivity-analysis","display_name":"global sensitivity analysis","score":1.0},{"id":"https://openalex.org/keywords/multi-compartment-model","display_name":"multi-compartment model","score":0.8669999837875366},{"id":"https://openalex.org/keywords/uncertainty-quantification","display_name":"uncertainty quantification","score":0.8560000061988831},{"id":"https://openalex.org/keywords/model-reduction","display_name":"model reduction","score":0.7829999923706055},{"id":"https://openalex.org/keywords/parameter-uncertainty","display_name":"parameter uncertainty","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6468613743782043},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3856930136680603},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12690392136573792},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cobme.2019.09.012","doi":"https://doi.org/10.1016/j.cobme.2019.09.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cobme.2019.09.012","pdf_url":null,"source":{"id":"https://openalex.org/S2898133657","display_name":"Current Opinion in Biomedical Engineering","issn_l":"2468-4511","issn":["2468-4511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:32864523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32864523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in biomedical engineering","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7450543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7450543","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Biomed Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7450543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7450543","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Biomed Eng","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5044230080","display_name":"A Multi-scale systems pharmacology approach to TB therapy","funder_award_id":"U01HL131072","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6541289098","display_name":"Predicting protective T-cell responses in Tuberculosis using a systems biology approach","funder_award_id":"R01AI123093","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W170336801","https://openalex.org/W1575092331","https://openalex.org/W1590063568","https://openalex.org/W1909791347","https://openalex.org/W1967819170","https://openalex.org/W1979034309","https://openalex.org/W1988540551","https://openalex.org/W2011923356","https://openalex.org/W2014751703","https://openalex.org/W2020160984","https://openalex.org/W2035363534","https://openalex.org/W2035588631","https://openalex.org/W2037062161","https://openalex.org/W2038669746","https://openalex.org/W2067267791","https://openalex.org/W2068034671","https://openalex.org/W2069103780","https://openalex.org/W2091655212","https://openalex.org/W2098363069","https://openalex.org/W2100762957","https://openalex.org/W2107478147","https://openalex.org/W2111020654","https://openalex.org/W2113188550","https://openalex.org/W2115445832","https://openalex.org/W2121674498","https://openalex.org/W2132635773","https://openalex.org/W2141890333","https://openalex.org/W2152803686","https://openalex.org/W2153906060","https://openalex.org/W2160556418","https://openalex.org/W2170967684","https://openalex.org/W2255905195","https://openalex.org/W2569832249","https://openalex.org/W2581174902","https://openalex.org/W2584007713","https://openalex.org/W2751370007","https://openalex.org/W2779535723","https://openalex.org/W2799393161","https://openalex.org/W2807294233","https://openalex.org/W2807369386","https://openalex.org/W2883819989","https://openalex.org/W2888887152","https://openalex.org/W2901644353","https://openalex.org/W2920851774","https://openalex.org/W2920980265","https://openalex.org/W4237151101","https://openalex.org/W4242753776","https://openalex.org/W4251980961","https://openalex.org/W6667855471"],"related_works":["https://openalex.org/W115381311","https://openalex.org/W2152803686","https://openalex.org/W2941329205","https://openalex.org/W2013591251","https://openalex.org/W2111020654","https://openalex.org/W2241116293","https://openalex.org/W1990095133","https://openalex.org/W3180866220","https://openalex.org/W2028208994","https://openalex.org/W4293353730"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-10-25T00:00:00"}