{"id":"https://openalex.org/W2980242895","doi":"https://doi.org/10.1182/blood.v120.21.190.190","title":"Preliminary Results of a Phase II Open-Label, Randomized Study of the BH3 Mimetic Protein Navitoclax (ABT-263) with or without Rituximab for Treatment of Previously Untreated B-Cell Chronic Lymphocytic Leukemia","display_name":"Preliminary Results of a Phase II Open-Label, Randomized Study of the BH3 Mimetic Protein Navitoclax (ABT-263) with or without Rituximab for Treatment of Previously Untreated B-Cell Chronic Lymphocytic Leukemia","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2980242895","doi":"https://doi.org/10.1182/blood.v120.21.190.190","mag":"2980242895"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.190.190","doi":"https://doi.org/10.1182/blood.v120.21.190.190","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.190.190","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070465562","display_name":"Herbert Aaron Eradat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert Eradat","raw_affiliation_strings":["David Geffen School of Medicine, Los Angeles, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Geffen School of Medicine, Los Angeles, CA, USA,","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062322697","display_name":"Sebastian Grosicki","orcid":"https://orcid.org/0000-0003-2644-1050","observed_orcids":["https://orcid.org/0000-0003-2644-1050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebastian Grosicki","raw_affiliation_strings":["Oddzial Hematologiczny ZSM, Chorzo\u0301w, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oddzial Hematologiczny ZSM, Chorzo\u0301w, Poland,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071974261","display_name":"John Catalono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801874743","display_name":"Frankston Hospital","ror":"https://ror.org/051b68e86","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801874743","https://openalex.org/I4210120624"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"John Catalono","raw_affiliation_strings":["Oncology Unit, Frankston Hospital, Frankston, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, Frankston Hospital, Frankston, Australia,","institution_ids":["https://openalex.org/I2801874743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086484669","display_name":"Walter Cosolo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Walter Cosolo","raw_affiliation_strings":["John Fawkner Cancer Trial Centre, Coburg, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Fawkner Cancer Trial Centre, Coburg, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049753301","display_name":"Iryna Dyagil","orcid":"https://orcid.org/0000-0001-6643-4141","observed_orcids":["https://orcid.org/0000-0001-6643-4141"]},"institutions":[{"id":"https://openalex.org/I4210144782","display_name":"National Academy of Medical Sciences of Ukraine","ror":"https://ror.org/042dnf796","country_code":"UA","type":"government","lineage":["https://openalex.org/I4210144782"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"Irina Dyagil","raw_affiliation_strings":["Reseach Center for Radiation Medicine, Academy of Medical Sciences, Kiev, Ukraine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reseach Center for Radiation Medicine, Academy of Medical Sciences, Kiev, Ukraine,","institution_ids":["https://openalex.org/I4210144782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J Kipps","raw_affiliation_strings":["Moores Cancer Ctr., UCSD, La Jolla, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Ctr., UCSD, La Jolla, CA, USA,","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103492151","display_name":"Beiyao Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Beiyao Zheng","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA,","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110457420","display_name":"Sreeni Yalamanchili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sreeni Yalamanchili","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA,","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043786963","display_name":"Srikumar Sahasranaman","orcid":"https://orcid.org/0000-0002-0762-2967","observed_orcids":["https://orcid.org/0000-0002-0762-2967"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Srikumar Sahasranaman","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA,","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002714813","display_name":"Deborah Hurst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Hurst","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA,","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111875932","display_name":"William Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Ho","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA,","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040411677","display_name":"Halyna Pylypenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Halyna Pylypenko","raw_affiliation_strings":["Department of Hematology, Cherkassy Regional Oncological Center, Cherkassy, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Cherkassy Regional Oncological Center, Cherkassy, Ukraine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5040411677","https://openalex.org/A5043786963","https://openalex.org/A5049753301","https://openalex.org/A5071974261","https://openalex.org/A5086484669","https://openalex.org/A5103492151","https://openalex.org/A5110457420"],"corresponding_institution_ids":["https://openalex.org/I183934855","https://openalex.org/I2801874743","https://openalex.org/I4210144782"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.1553,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78707636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"120","issue":"21","first_page":"190","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/navitoclax","display_name":"navitoclax","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9490000009536743},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/previously-untreated-cll","display_name":"previously untreated CLL","score":0.6819999814033508},{"id":"https://openalex.org/keywords/bh3-mimetics","display_name":"BH3 mimetics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/bcl-2-inhibition","display_name":"BCL-2 inhibition","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.7540000081062317},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5920000076293945},{"id":"https://openalex.org/keywords/17p-deletion","display_name":"17p deletion","score":0.7170000076293945},{"id":"https://openalex.org/keywords/11q-deletion","display_name":"11q deletion","score":0.9950000047683716},{"id":"https://openalex.org/keywords/high-risk-cytogenetics","display_name":"high-risk cytogenetics","score":0.625},{"id":"https://openalex.org/keywords/binet-stage","display_name":"Binet stage","score":0.6079999804496765},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.46000000834465027},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7212854027748108},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.6154890060424805},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.5772896409034729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5365509986877441},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.44860413670539856},{"id":"https://openalex.org/C2779788671","wikidata":"https://www.wikidata.org/wiki/Q998803","display_name":"Tumor lysis syndrome","level":3,"score":0.43605679273605347},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4308059811592102},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.41121572256088257},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4111720621585846},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40432438254356384},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.39734017848968506},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3836419880390167},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3816383183002472},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.18764033913612366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1293385922908783},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.190.190","doi":"https://doi.org/10.1182/blood.v120.21.190.190","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.190.190","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2169008732","https://openalex.org/W2113278680","https://openalex.org/W2059322071","https://openalex.org/W2979637638","https://openalex.org/W2559562963","https://openalex.org/W2582812279","https://openalex.org/W2113810545","https://openalex.org/W2263912307","https://openalex.org/W2573476619","https://openalex.org/W2150680216"],"abstract_inverted_index":{"Abstract":[0,1],"190":[2],"Introduction:":[3],"Overexpression":[4],"of":[5,42,93,115,194,264,318,320,328,332,358,434,531,594,603,672,680,694],"Bcl-2":[6,681],"in":[7,45,50,84,208,324,368,508,537,634,664,688],"Chronic":[8],"Lymphocytic":[9],"Leukemia":[10],"(CLL)":[11],"is":[12],"associated":[13,589],"with":[14,117,127,214,373,580,585,590,636,657,666,690,696],"enhanced":[15],"CLL-cell":[16],"resistance":[17],"to":[18,64,74,79,87,90,134,158,227,418,423,428,438,452,462,467,535,542,555,559,612],"spontaneous":[19],"or":[20,175,199,220,322,330],"chemotherapy-induced":[21],"apoptosis.":[22],"The":[23,251,669],"BH3":[24,706],"mimetic":[25],"protein":[26],"navitoclax":[27,118,181,205,215,406,416,629],"(ABT-263)":[28],"specifically":[29],"inhibits":[30],"Bcl-2,":[31],"and":[32,36,38,112,119,146,155,245,266,273,296,352,391,398,456,464,477,492,561,616,630,650],"related":[33,437,466],"proteins":[34],"Bcl-xL":[35,65],"Bcl-w,":[37],"can":[39],"induce":[40],"apoptosis":[41],"CLL":[43,52,128,239,326,648],"cells":[44,327],"vitro.":[46],"Phase":[47,103],"I":[48],"evaluation":[49],"relapsed/refractory":[51],"patients":[53,280,413,649,665,695],"demonstrated":[54,651],"35%":[55,481],"overall":[56,342],"response":[57,240,268,475,526,540,558],"rate":[58,234,479,541],"(Roberts,":[59],"2012).":[60],"Dose-limiting":[61],"thrombocytopenia":[62],"due":[63,417,422,451,461,611],"inhibition":[66],"was":[67,231,235,253,291,306,339,407,480,641],"mitigated":[68],"using":[69],"a":[70,81,102,189,369,453,468,538,586,677],"lead-in":[71,192],"dosing":[72],"schedule":[73],"allow":[75],"the":[76,91,98,109,256,277,285,325,374,439,448,529,557,581,591,601,613],"bone":[77],"marrow":[78],"achieve":[80],"compensatory":[82],"increase":[83],"platelets":[85],"prior":[86],"dose":[88],"escalation":[89],"MTD":[92],"250":[94],"mg.":[95],"Based":[96],"on":[97,337,444,447,458,597],"promising":[99],"single-agent":[100],"data,":[101],"II":[104],"trial":[105,107],"randomized":[106,156,279],"compared":[108,372],"safety,":[110],"pharmacokinetics,":[111],"biologic":[113],"activity":[114,654],"treatment":[116,132,213,265,287,596,656,693],"rituximab":[120],"(RTX)":[121],"versus":[122],"RTX":[123,160,176,200,375,470,543,562,637,658,691],"alone.":[124],"Methods:":[125],"Patients":[126],"who":[129],"required":[130],"initial":[131,645],"according":[133],"iwCLL":[135,238],"criteria":[136,241],"(Hallek":[137],"et":[138],"al,":[139],"2008)":[140],"were":[141,281,298,362,402,502,513],"stratified":[142],"by":[143,237,515,583],"Binet":[144,299],"stage":[145,300],"high-risk":[147],"cytogenetic":[148],"features":[149],"(17p":[150],"deletion":[151,319,533],"and/or":[152,409],"11q":[153,321],"deletion),":[154],"1:1:1":[157],"receive":[159],"weekly":[161,638],"for":[162,177,183,201,276,345,482,486,494,505,519,647,692],"8":[163,178,202,522,640],"wks":[164,171,179,185,203,344,349,354,523],"(375":[165],"mg/m2":[166,170],"wk":[167],"1,":[168],"500":[169],"2\u20138)":[172],"(Arm":[173,197,223,545,563],"A),":[174,491],"plus":[180,204],"daily":[182,206],"12":[184,247,262,412],"(250":[186],"mg/day":[187],"following":[188],"7\u201314":[190],"day":[191],"period":[193],"100":[195],"mg/day)":[196],"B),":[198],"as":[207,644,660,662],"Arm":[209,225,228,346,350,355,459,483,487,495,509,569,598],"B,":[210,351,564],"but":[211],"continued":[212],"until":[216],"disease":[217],"progression,":[218],"relapse,":[219],"unacceptable":[221],"toxicity":[222],"C).":[224,356],"A":[226],"B":[229,460,488],"crossover":[230],"permitted.":[232],"Response":[233],"assessed":[236],"at":[242],"week":[243],"12,":[244],"every":[246],"weeks":[248,263,341],"during":[249],"follow-up.":[250],"study":[252,338,674],"stopped":[254,408],"after":[255,524],"last":[257],"patient":[258,617],"had":[259],"completed":[260],"\u2265":[261,521],"week-12":[267],"assessment.":[269,527],"Results:":[270],"Baseline":[271],"characteristics":[272],"prognostic":[274],"factors":[275],"118":[278],"generally":[282,403,642],"balanced":[283],"among":[284],"three":[286],"arms.":[288],"Median":[289,302,335],"age":[290],"63":[292],"years":[293],"(range":[294,309],"38\u201394),":[295],"55%":[297,485],"B+C.":[301],"baseline":[303],"lymphocyte":[304],"count":[305],"53,000":[307],"mm3":[308],"7,000\u2013552,000/mm3).":[310],"FISH":[311],"analyses":[312],"identified":[313],"higher":[314],"than":[315,655],"expected":[316],"rates":[317],"17p":[323,532,667],"32%":[329],"28%":[331],"patients,":[333],"respectively.":[334],"time":[336],"32":[340],"(24":[343],"A,":[347,484,546],"33":[348],"44":[353],"AEs":[357],"Grade":[359],"3\u20134":[360],"that":[361,676],"more":[363],"common":[364],"(>":[365],"5%":[366],"greater)":[367],"navitoclax-treated":[370],"arm":[371,376,450],"included":[377],"thrombocytopenia,":[378],"neutropenia,":[379,397],"leukopenia,":[380],"anemia,":[381],"GI":[382],"symptoms":[383],"(diarrhea,":[384],"abdominal":[385],"pain),":[386],"chills,":[387],"fatigue,":[388],"ALT/AST/bilirubin":[389],"elevations,":[390],"infusion-related":[392],"reactions":[393],"(to":[394],"RTX).":[395],"Thrombocytopenia,":[396],"hepatic":[399],"enzyme":[400],"elevations":[401],"reversible":[404],"when":[405,686],"dose-reduced;":[410],"however,":[411,600],"(15%)":[414],"discontinued":[415],"laboratory":[419],"abnormalities":[420],"(9":[421],"ALT":[424],"elevations).":[425],"Neutropenia":[426],"responded":[427],"growth":[429],"factors.":[430],"One":[431],"serious":[432],"event":[433],"epistaxis":[435],"occurred":[436,443],"thrombocytopenia.":[440],"Two":[441],"deaths":[442],"study,":[445],"one":[446,457],"RTX-only":[449],"pulmonary":[454],"embolus":[455],"hypotension":[463],"dyspnea":[465],"severe":[469],"infusion":[471],"reaction.":[472],"Investigator-assessed":[473],"objective":[474],"(CR":[476],"PR)":[478],"(p=0.19":[489],"vs":[490,498],"70%":[493],"C":[496],"(p=0.0034":[497],"A).":[499],"All":[500,511],"responses":[501,512,582,663],"PRs":[503],"except":[504],"2":[506],"CRs":[507],"C.":[510],"confirmed":[514],"CT":[516],"(and":[517],"BM":[518],"CR)":[520],"clinical":[525,653],"While":[528],"presence":[530],"appeared":[534,578],"result":[536],"lower":[539],"alone":[544,659],"ORR":[547,565,571],"18%,":[548],"2/11":[549],"pts),":[550],"it":[551],"did":[552,622],"not":[553,607,623],"appear":[554],"affect":[556],"ABT-263":[560,595],"73%,":[566],"8/11":[567],"pts);":[568],"C,":[570],"50%,":[572],"5/10":[573],"pts.":[574],"Limited":[575],"PFS":[576,588,604],"results":[577,671],"consistent":[579],"arm,":[584],"longer":[587,592],"duration":[593],"C;":[599],"magnitude":[602],"differences":[605],"could":[606,682],"be":[608,683],"precisely":[609],"quantified":[610],"limited":[614],"follow-up":[615],"number.":[618],"Preliminary":[619],"pharmacokinetic":[620],"analysis":[621],"detect":[624],"any":[625],"drug":[626],"interaction":[627],"between":[628],"RTX.":[631],"Conclusions:":[632],"Navitoclax":[633,709],"combination":[635,689],"\u00d7":[639],"well-tolerated":[643],"therapy":[646],"greater":[652],"well":[661],"deletion.":[668],"preliminary":[670],"this":[673],"indicate":[675],"BH3-mimetic":[678],"inhibitor":[679],"highly":[684],"effective":[685],"used":[687],"CLL.":[697],"Disclosures:":[698],"Eradat:":[699],"Genentech:":[700],"Research":[701,714],"Funding.":[702,715],"Off":[703],"Label":[704],"Use:":[705],"Mimetic":[707],"Protein":[708],"(ABT-263).":[710],"Catalono:Genentech:":[711],"Consultancy.":[712],"Kipps:Genentech:":[713],"Zheng:Genentech:":[716],"Employment.":[717,719,721,723,725],"Yalamanchili:Genentech:":[718],"Sahasranaman:Genentech:":[720],"Hurst:Genentech:":[722],"Ho:Genentech:":[724]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}