{"id":"https://openalex.org/W2980242660","doi":null,"title":"Gene expression profile of endoscopically active and inactive ulcerative colitis: preliminary data.","display_name":"Gene expression profile of endoscopically active and inactive ulcerative colitis: preliminary data.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2980242660","mag":"2980242660","pmid":"https://pubmed.ncbi.nlm.nih.gov/29556621"},"language":"en","primary_location":{"id":"pmid:29556621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29556621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034382418","display_name":"Cristian George \u0162ieranu","orcid":"https://orcid.org/0000-0001-5348-0341","observed_orcids":["https://orcid.org/0000-0001-5348-0341"]},"institutions":[{"id":"https://openalex.org/I4210161296","display_name":"Institutul Clinic Fundeni","ror":"https://ror.org/05w6fx554","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210161296"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Cristian George \u0162ieranu","raw_affiliation_strings":["Department of Gastroenterology II, \"Fundeni\" Clinical Institute, Bucharest, Romania; teodora.manuc@gmail.com","Department of Gastroenterology II, Fundeni Clinical Institute, Bucharest, Romania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology II, \"Fundeni\" Clinical Institute, Bucharest, Romania; teodora.manuc@gmail.com","institution_ids":["https://openalex.org/I4210161296"]},{"raw_affiliation_string":"Department of Gastroenterology II, Fundeni Clinical Institute, Bucharest, Romania;","institution_ids":["https://openalex.org/I4210161296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052912870","display_name":"Maria Dobre","orcid":"https://orcid.org/0000-0002-1376-4021","observed_orcids":["https://orcid.org/0000-0002-1376-4021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Dobre","raw_affiliation_strings":["teodora.manuc@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"teodora.manuc@gmail.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027223109","display_name":"Teodora Ecaterina Manuc","orcid":"https://orcid.org/0000-0002-0589-4571","observed_orcids":["https://orcid.org/0000-0002-0589-4571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teodora Ecaterina M\u0103nuc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014860872","display_name":"Elena Milanesi","orcid":"https://orcid.org/0000-0003-2753-3395","observed_orcids":["https://orcid.org/0000-0003-2753-3395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Milanesi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081731661","display_name":"Iancu Emil Ple\u015fea","orcid":"https://orcid.org/0000-0003-2686-3878","observed_orcids":["https://orcid.org/0000-0003-2686-3878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iancu Emil Ple\u015fea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005753743","display_name":"Caterina Popa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caterina Popa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023716466","display_name":"Mircea M\u0103nuc","orcid":"https://orcid.org/0000-0003-1142-5859","observed_orcids":["https://orcid.org/0000-0003-1142-5859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mircea M\u0103nuc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016561069","display_name":"Ioana \u0162ieranu","orcid":"https://orcid.org/0000-0002-1344-7667","observed_orcids":["https://orcid.org/0000-0002-1344-7667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioana \u0162ieranu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070930784","display_name":"Carmen Monica Preda","orcid":"https://orcid.org/0000-0002-2675-7971","observed_orcids":["https://orcid.org/0000-0002-2675-7971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Monica Preda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110925462","display_name":"Mihai Mircea Diculescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mihai Mircea Diculescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075096587","display_name":"Elena Mirela Ionescu","orcid":"https://orcid.org/0000-0002-3950-4308","observed_orcids":["https://orcid.org/0000-0002-3950-4308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Mirela Ionescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009998951","display_name":"Gabriel Becheanu","orcid":"https://orcid.org/0000-0003-1627-8907","observed_orcids":["https://orcid.org/0000-0003-1627-8907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Becheanu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9638,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.75672615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"58","issue":"4","first_page":"1301","last_page":"1307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.777999997138977},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.5239999890327454},{"id":"https://openalex.org/keywords/mucosal-healing","display_name":"mucosal healing","score":0.8149999976158142},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.9409999847412109},{"id":"https://openalex.org/keywords/isg15","display_name":"ISG15","score":0.9200000166893005},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.859000027179718},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.8669999837875366},{"id":"https://openalex.org/keywords/reg1a","display_name":"REG1A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ykl-40","display_name":"YKL-40","score":0.9990000128746033},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.7459999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5049999952316284},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.6919999718666077},{"id":"https://openalex.org/keywords/colonic-mucosa","display_name":"colonic mucosa","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7508845329284668},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5760802030563354},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5196776986122131},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48390039801597595},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4835476875305176},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47486329078674316},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4707755744457245},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4484335780143738},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44059431552886963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.415127158164978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38809722661972046},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3776395320892334},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30095863342285156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26546093821525574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14048686623573303},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":true},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:29556621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29556621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","raw_type":"Journal Article"},{"id":"mag:2980242660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29556621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2587102995","https://openalex.org/W2792459718","https://openalex.org/W2136497025","https://openalex.org/W2999389300","https://openalex.org/W2182543537","https://openalex.org/W2999871518","https://openalex.org/W2115487110","https://openalex.org/W3210186795","https://openalex.org/W2802411199","https://openalex.org/W6958097753"],"abstract_inverted_index":{"AIM:":[0],"Multiple":[1],"cytokines":[2],"and":[3,10,55,80,123,128,141,150,172,187],"chemokines":[4],"related":[5],"to":[6,29,144,177,201,218,222,257],"immune":[7,117,215],"response,":[8,118,216],"apoptosis":[9],"inflammation":[11],"have":[12],"been":[13],"identified":[14],"as":[15],"molecules":[16],"implicated":[17,113,250],"in":[18,43,52,66,114,139,156,192,212,241,244,251],"ulcerative":[19],"colitis":[20],"(UC)":[21],"pathogenesis.":[22],"The":[23],"aim":[24],"of":[25,37,40,132,169,184,239,248],"this":[26],"study":[27],"was":[28,102,189],"identify":[30],"the":[31,67,92,167,193,202,213,223,236],"differences":[32],"at":[33],"gene":[34,237],"expression":[35,100],"level":[36],"a":[38,159,181,209,231],"panel":[39],"candidate":[41],"genes":[42,112,130,152,249],"mucosa":[44],"from":[45],"patients":[46,51,71],"with":[47,73,77,158],"active":[48,74],"UC":[49,70,224,240,252],"(UCA),":[50],"remission":[53,203,225],"(UCR),":[54],"normal":[56],"controls.":[57,178],"PATIENTS,":[58],"MATERIALS":[59],"AND":[60],"METHODS:":[61],"Eleven":[62],"individuals":[63,93],"were":[64,134,174],"enrolled":[65],"study:":[68],"eight":[69],"(four":[72],"lesions,":[75],"four":[76],"mucosal":[78,95],"healing)":[79],"three":[81,129],"controls":[82],"without":[83],"inflammatory":[84],"bowel":[85],"disease":[86],"(IBD)":[87],"seen":[88],"on":[89],"endoscopy.":[90],"All":[91],"underwent":[94],"biopsy":[96],"during":[97],"colonoscopy.":[98],"Gene":[99],"profile":[101,238],"evaluated":[103],"by":[104],"polymerase":[105],"chain":[106],"reaction":[107],"(PCR)":[108],"array,":[109],"investigating":[110],"84":[111,133],"apoptosis,":[115],"inflammation,":[116],"cellular":[119],"adhesion,":[120],"tissue":[121],"remodeling":[122],"mucous":[124],"secretion.":[125],"RESULTS:":[126],"Seventeen":[127],"out":[131],"found":[135],"significantly":[136],"differentially":[137],"expressed":[138],"UCA":[140,157,194],"UCR":[142,165],"compared":[143,176],"controls,":[145],"respectively.":[146],"In":[147,164],"particular,":[148],"REG1A":[149],"CHI3L1":[151],"reported":[153],"an":[154],"up-regulation":[155,183],"fold":[160],"difference":[161],"above":[162],"200.":[163],"patients,":[166],"levels":[168,198],"CASP1,":[170],"LYZ":[171,188],"ISG15":[173,197],"different":[175,242],"However,":[179],"since":[180],"significant":[182],"both":[185],"CASP1":[186],"observed":[190],"also":[191],"group,":[195],"only":[196],"remained":[199],"associated":[200,221],"state.":[204,226],"CONCLUSIONS:":[205],"ISG15,":[206],"that":[207],"plays":[208],"key":[210],"role":[211],"innate":[214],"seemed":[217],"be":[219,255],"specifically":[220],"These":[227],"preliminary":[228],"data":[229],"represent":[230],"starting":[232],"point":[233],"for":[234],"defining":[235],"stages":[243],"Romanian":[245],"population.":[246],"Identification":[247],"pathogenesis":[253],"could":[254],"useful":[256],"select":[258],"new":[259],"therapeutic":[260],"targets.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-10-18T00:00:00"}