{"id":"https://openalex.org/W2980242376","doi":"https://doi.org/10.1182/blood.v126.23.279.279","title":"Targeting Neutrophil Aging and the Microbiota for the Treatment of Sickle Cell Disease","display_name":"Targeting Neutrophil Aging and the Microbiota for the Treatment of Sickle Cell Disease","publication_year":2015,"publication_date":"2015-12-03","ids":{"openalex":"https://openalex.org/W2980242376","doi":"https://doi.org/10.1182/blood.v126.23.279.279","mag":"2980242376"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v126.23.279.279","doi":"https://doi.org/10.1182/blood.v126.23.279.279","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.279.279","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010607078","display_name":"Dachuan Zhang","orcid":"https://orcid.org/0000-0002-1746-275X","observed_orcids":["https://orcid.org/0000-0002-1746-275X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dachuan Zhang","raw_affiliation_strings":["Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101911552","display_name":"Grace Chen","orcid":"https://orcid.org/0000-0001-6434-8696","observed_orcids":["https://orcid.org/0000-0001-6434-8696"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Grace Chen","raw_affiliation_strings":["Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005378909","display_name":"Deepa G. Manwani","orcid":"https://orcid.org/0000-0003-1057-1811","observed_orcids":["https://orcid.org/0000-0003-1057-1811"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4210135976","display_name":"Children's Hospital at Montefiore","ror":"https://ror.org/03n0fp725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa Manwani","raw_affiliation_strings":["Department of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4210135976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040852112","display_name":"Arthur Mortha","orcid":"https://orcid.org/0000-0003-2673-0485","observed_orcids":["https://orcid.org/0000-0003-2673-0485"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arthur Mortha","raw_affiliation_strings":["The Immunology Institute, Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Immunology Institute, Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048139641","display_name":"Chunliang Xu","orcid":"https://orcid.org/0000-0002-4514-8477","observed_orcids":["https://orcid.org/0000-0002-4514-8477"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chunliang Xu","raw_affiliation_strings":["Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049350088","display_name":"Jeremiah J. Faith","orcid":"https://orcid.org/0000-0002-2691-4500","observed_orcids":["https://orcid.org/0000-0002-2691-4500"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremiah J. Faith","raw_affiliation_strings":["The Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021442543","display_name":"Robert David Burk","orcid":"https://orcid.org/0000-0002-8376-8458","observed_orcids":["https://orcid.org/0000-0002-8376-8458"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert D. Burk","raw_affiliation_strings":["Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069728869","display_name":"Yuya Kunisaki","orcid":"https://orcid.org/0000-0003-0141-7038","observed_orcids":["https://orcid.org/0000-0003-0141-7038"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuya Kunisaki","raw_affiliation_strings":["Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110643039","display_name":"Jung\u2010Eun Jang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jung-Eun Jang","raw_affiliation_strings":["Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021389980","display_name":"Christoph Scheiermann","orcid":"https://orcid.org/0000-0002-9212-0995","observed_orcids":["https://orcid.org/0000-0002-9212-0995"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph Scheiermann","raw_affiliation_strings":["Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070354041","display_name":"Miriam M\u00e9rad","orcid":"https://orcid.org/0000-0002-4481-7827","observed_orcids":["https://orcid.org/0000-0002-4481-7827"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Merad","raw_affiliation_strings":["Gene and Cell Medicine, Mount Sinai Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene and Cell Medicine, Mount Sinai Medical Center, New York, NY","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044390727","display_name":"Paul S. Frenette","orcid":"https://orcid.org/0000-0003-0862-9922","observed_orcids":["https://orcid.org/0000-0003-0862-9922"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S. Frenette","raw_affiliation_strings":["Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021442543","https://openalex.org/A5040852112","https://openalex.org/A5048139641","https://openalex.org/A5049350088","https://openalex.org/A5069728869","https://openalex.org/A5101911552","https://openalex.org/A5110643039"],"corresponding_institution_ids":["https://openalex.org/I129975664","https://openalex.org/I98704320"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35810497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"126","issue":"23","first_page":"279","last_page":"279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/neutrophil-aging","display_name":"neutrophil aging","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8820000290870667},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antibiotic-treated-mice","display_name":"antibiotic-treated mice","score":0.7749999761581421},{"id":"https://openalex.org/keywords/vessel-occlusion","display_name":"vascular occlusion","score":0.777999997138977},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4390000104904175},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.640334963798523},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5451934933662415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49540841579437256},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4650951623916626},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.4378350079059601},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19114801287651062},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1256752610206604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v126.23.279.279","doi":"https://doi.org/10.1182/blood.v126.23.279.279","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v126.23.279.279","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1019178139","https://openalex.org/W2112671019","https://openalex.org/W2910992172","https://openalex.org/W2988521256","https://openalex.org/W2908929917","https://openalex.org/W2778831181","https://openalex.org/W4391389382","https://openalex.org/W4245215073","https://openalex.org/W2278689981","https://openalex.org/W2258979737"],"abstract_inverted_index":{"Abstract":[0],"Sickle":[1],"cell":[2,643],"disease":[3,644],"(SCD)":[4],"is":[5,549],"a":[6,20,139,265,581],"genetic":[7],"blood":[8,34,487],"disorder":[9],"characterized":[10],"by":[11,76,141,207,255,382,444],"repeated":[12],"episodes":[13],"of":[14,57,193,267,285,356,439,503,533,587,641,661],"vaso-occlusion,":[15],"in":[16,26,48,61,103,159,171,178,197,281,295,300,423,484,492,520,539,571,584,599,638,654],"which":[17,179,440,595],"neutrophils":[18,58,114,290,294,536,590],"play":[19],"primary":[21],"function":[22],"through":[23],"their":[24,62,98,301],"recruitment":[25],"inflamed":[27],"venules":[28],"and":[29,102,131,174,200,257,269,299,376,408,429,489,509,515,631,646],"interactions":[30,431],"with":[31,100,264,412,432,541,559],"sickle":[32,642],"red":[33],"cells":[35,225,239,396,615],"(sRBCs)":[36],"via":[37],"activated":[38,105,311],"\u03b1M\u03b22":[39],"integrin":[40,427],"(Mac-1).":[41],"Intravital":[42],"microscopy":[43],"analyses":[44,110],"revealed":[45,111,360],"considerable":[46],"heterogeneity":[47],"Mac-1":[49,86,312,426],"activation":[50,87,428],"on":[51,146,601],"adherent":[52,457],"neutrophils,":[53,74,95],"suggesting":[54,138],"that":[55,72,112,118,152,307,361,577,627,649],"subsets":[56],"differ":[59],"markedly":[60,442],"pro-inflammatory":[63],"activity":[64],"(Nat":[65],"Med":[66],"2009;":[67],"15:384).":[68],"Recently,":[69],"we":[70,96,150,166,277,528,566],"found":[71,190,576],"aged":[73,94,113,168,194,283,363,535,568,589],"marked":[75,582],"CD62Llo":[77],"CXCR4hi,":[78],"represented":[79],"an":[80],"overly":[81],"active":[82],"subset":[83,284],"exhibiting":[84],"enhanced":[85,121,486],"(Blood":[88],"2013;":[89],"122:324).":[90],"To":[91,162],"further":[92,652],"characterize":[93],"compared":[97,291,371,434,591],"transcriptome":[99],"control":[101],"vivo-":[104],"neutrophils.":[106],"Gene":[107],"set":[108],"enrichment":[109],"up-regulated":[115],"several":[116],"pathways":[117,134],"were":[119,441,537,596],"also":[120],"during":[122],"activation,":[123],"including":[124,512],"integrin,":[125],"leukocyte":[126],"adhesion,":[127,425],"toll-like":[128],"receptor":[129],"(TLR),":[130],"NF\u03baB":[132],"signalling":[133,259],"(P":[135,496,524],"<":[136,244,353,401,481,497,525,553,620],"0.05),":[137,482],"contribution":[140],"exogenous":[142],"inflammatory":[143],"mediators.":[144],"Based":[145],"the":[147,160,180,201,282,296,362,377,501,531,585,625,632],"expression":[148],"profile,":[149],"hypothesized":[151],"microbiota-derived":[153],"signals":[154],"may":[155,634],"influence":[156],"neutrophil":[157,169,195,251,364,424,458,569,629],"aging":[158,252,630],"circulation.":[161],"test":[163],"this":[164,572],"idea,":[165],"analyzed":[167],"numbers":[170,196,202,532,570,586],"antibiotics":[172],"(ABX)-treated":[173],"germ-free":[175],"(GF)":[176],"mice,":[177,298,375,437],"gut":[181],"microbiota":[182,383,445,633],"was":[183,253,366,379,506,517],"largely":[184],"depleted":[185],"or":[186,212,272,288,556],"deficient,":[187],"respectively.":[188],"We":[189,246,403,575],"significant":[191,279,421],"reductions":[192,280],"both":[198],"models,":[199],"could":[203],"be":[204,651],"significantly":[205,367,485,507,597],"restored":[206],"either":[208],"lipopolysaccharide":[209],"(LPS)":[210],"gavage":[211],"fecal":[213],"transplantation":[214],"(Ctrl":[215,605],"/":[216,218,221,223,230,232,235,237,314,317,321,327,330,334,340,343,347,386,389,392,394,448,450,453,455,462,464,470,472,606,608,611,613],"ABX":[217],"ABX+LPS:":[219],"98\u00b114":[220],"36\u00b111":[222],"107\u00b125":[224],"per":[226,240,324,337,350,397,459,467,476,478,616],"\u03bcl":[227,241,398,617],"blood;":[228,242],"SPF":[229],"GF":[231],"GF-FT:":[233],"56\u00b112":[234],"4\u00b11":[236],"15\u00b14":[238],"P":[243,352,400,480,619],"0.05).":[245,498,526,621],"next":[247],"investigated":[248],"whether":[249,530],"microbiota-driven":[250],"mediated":[254],"TLRs":[256],"Myd88":[258],"using":[260],"chimeric":[261],"mice":[262,358,411,419,495,505,523],"reconstituted":[263],"mixture":[266],"WT":[268,293,326,339],"Myd88,":[270,286],"TLR4":[271,287],"TLR2-deficient":[273,289],"hematopoietic":[274],"cells.":[275],"Interestingly,":[276],"observed":[278],"to":[292,303,310,372,414,435,562,592,663],"same":[297],"capacity":[302],"capture":[304],"fluosphere":[305],"beads":[306],"specifically":[308],"bound":[309],"(WT":[313],"LysM-cre/Myd88-flox:":[315],"10.4\u00b10.3":[316],"7.0\u00b10.6":[318],"%,":[319,332,345],"1.0\u00b10.1":[320,333],"0.4\u00b10.1":[322,335],"bead":[323,336,349,466],"cell;":[325,338,351,468],"Tlr4-/-:":[328],"10.3\u00b10.2":[329],"6.0\u00b10.2":[331],"Tlr2-/-:":[341],"10.0\u00b10.4":[342],"6.8\u00b10.5":[344],"1.3\u00b10.2":[346],"0.8\u00b10.1":[348],"0.01).":[354,402],"Analysis":[355],"SCD":[357,387,410,418,494,504,522,578],"(BERK)":[359],"population":[365],"increased":[368],"(by":[369],">10-fold)":[370],"hemizygous":[373],"(SA)":[374],"expansion":[378],"completely":[380],"abrogated":[381],"depletion":[384,446],"(SA":[385,447],"(SS)-Ctrl":[388],"SS-ABX:":[390,451],"71\u00b111":[391],"981\u00b1261":[393],"124\u00b127":[395],"blood,":[399,618],"then":[404],"challenged":[405],"SA,":[406],"untreated":[407],"ABX-treated":[409,493,521],"TNF-\u03b1":[413],"induce":[415],"acute":[416],"vaso-occlusion.":[417],"exhibited":[420,580],"increases":[422],"heterotypic":[430],"RBCs":[433],"SA":[436],"all":[438],"reduced":[443,598],"SS-Ctrl":[449],"6.4\u00b10.6":[452],"18.1\u00b11.0":[454],"11.2\u00b11.0":[456],"vessel;":[460],"0.5\u00b10.1":[461,471],"1.0\u00b10.2":[463],"0.3\u00b10.1":[465],"0.1\u00b10.1":[469],"0.2\u00b10.1":[473],"RBC":[474],"interaction":[475],"vessel":[477],"min;":[479],"resulting":[483],"flow":[488],"prolonged":[490],"survival":[491],"Most":[499],"interestingly,":[500],"splenomegaly":[502],"reduced,":[508],"liver":[510],"damage":[511],"fibrosis,":[513],"necrosis":[514],"inflammation":[516],"dramatically":[518],"alleviated":[519],"Finally,":[527],"evaluated":[529],"circulating":[534,588],"altered":[538],"patients":[540,558,579,600],"SCD.":[542],"As":[543],"Penicillin":[544,602],"V":[545,603],"antibiotic":[546],"prophylaxis":[547,604],"therapy":[548],"recommended":[550],"for":[551],"children":[552],"5":[554],"years":[555],"older":[557],"immune":[560],"defects":[561],"prevent":[563],"life-threatening":[564],"infections,":[565],"determined":[567],"patient":[573],"population.":[574],"increase":[583],"healthy":[593],"controls,":[594],"SS":[607],"SS-PV:":[609],"261\u00b140":[610],"1175\u00b1205":[612],"439\u00b187":[614],"Our":[622],"results":[623],"raise":[624],"possibility":[626],"targeting":[628],"have":[635],"broad":[636],"implications":[637],"our":[639],"understanding":[640],"pathogenesis":[645],"its":[647],"management":[648],"should":[650],"studied":[653],"clinical":[655],"trials.":[656],"Disclosures":[657],"No":[658],"relevant":[659],"conflicts":[660],"interest":[662],"declare.":[664]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}