{"id":"https://openalex.org/W2980120153","doi":"https://doi.org/10.3390/v11100923","title":"Novel Mutations Evading Avian Immunity around the Receptor Binding Site of the Clade 2.3.2.1c Hemagglutinin Gene Reduce Viral Thermostability and Mammalian Pathogenicity","display_name":"Novel Mutations Evading Avian Immunity around the Receptor Binding Site of the Clade 2.3.2.1c Hemagglutinin Gene Reduce Viral Thermostability and Mammalian Pathogenicity","publication_year":2019,"publication_date":"2019-10-09","ids":{"openalex":"https://openalex.org/W2980120153","doi":"https://doi.org/10.3390/v11100923","mag":"2980120153","pmid":"https://pubmed.ncbi.nlm.nih.gov/31600990","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6832455"},"language":"en","primary_location":{"id":"doi:10.3390/v11100923","doi":"https://doi.org/10.3390/v11100923","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/v11100923","pdf_url":"https://www.mdpi.com/1999-4915/11/10/923/pdf?version=1571726339","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4915/11/10/923/pdf?version=1571726339","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008371927","display_name":"Se-Hee An","orcid":"https://orcid.org/0000-0002-2206-1299","observed_orcids":["https://orcid.org/0000-0002-2206-1299"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Se-Hee An","raw_affiliation_strings":["Laboratory of Avian Diseases ,","Laboratory of Avian Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Avian Diseases ,","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Avian Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002578800","display_name":"Chung-Young Lee","orcid":"https://orcid.org/0000-0003-3037-7581","observed_orcids":["https://orcid.org/0000-0003-3037-7581"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung-Young Lee","raw_affiliation_strings":["Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039001154","display_name":"Seung-Min Hong","orcid":"https://orcid.org/0000-0001-5488-8445","observed_orcids":["https://orcid.org/0000-0001-5488-8445"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Min Hong","raw_affiliation_strings":["Laboratory of Avian Diseases ,","Laboratory of Avian Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Avian Diseases ,","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Avian Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057441397","display_name":"Chang\u2010Seon Song","orcid":"https://orcid.org/0000-0002-4158-6402","observed_orcids":["https://orcid.org/0000-0002-4158-6402"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang-Seon Song","raw_affiliation_strings":["Laboratory of Avian Diseases , College of Veterinary Medicine , Konkuk University , 05029 , Seoul , Republic of Korea","Laboratory of Poultry Medicine , Department of Farm Animal Medicine ,","Laboratory of Avian Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Avian Diseases , College of Veterinary Medicine , Konkuk University , 05029 , Seoul , Republic of Korea","institution_ids":["https://openalex.org/I24062138"]},{"raw_affiliation_string":"Laboratory of Poultry Medicine , Department of Farm Animal Medicine ,","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Avian Diseases, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100374317","display_name":"Jae\u2010Hong Kim","orcid":"https://orcid.org/0000-0003-2224-3516","observed_orcids":["https://orcid.org/0000-0003-2224-3516","https://orcid.org/0000-0003-1968-2753"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Hong Kim","raw_affiliation_strings":["Laboratory of Avian Diseases ,","Research Institute for Veterinary Science , College of Veterinary Medicine , Seoul National University , 08826 Seoul , Republic of Korea;","Laboratory of Avian Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea","Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Avian Diseases ,","institution_ids":[]},{"raw_affiliation_string":"Research Institute for Veterinary Science , College of Veterinary Medicine , Seoul National University , 08826 Seoul , Republic of Korea;","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]},{"raw_affiliation_string":"Laboratory of Avian Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012128553","display_name":"Hyuk\u2010Joon Kwon","orcid":"https://orcid.org/0000-0001-9107-7860","observed_orcids":["https://orcid.org/0000-0001-9107-7860"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyuk-Joon Kwon","raw_affiliation_strings":["College of Veterinary Medicine and BK21","PLUS for Veterinary Science , Seoul National University , 1 , Gwanak-ro , Seoul , 88026 , Republic of Korea;","Farm Animal Clinical Training and Research Center (FACTRC), GBST, Seoul National University, Kangwon-do 88026, Korea","Laboratory of Poultry Medicine, Department of Farm Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea","Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea"],"raw_orcid":"https://orcid.org/0000-0001-9107-7860","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine and BK21","institution_ids":[]},{"raw_affiliation_string":"PLUS for Veterinary Science , Seoul National University , 1 , Gwanak-ro , Seoul , 88026 , Republic of Korea;","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Farm Animal Clinical Training and Research Center (FACTRC), GBST, Seoul National University, Kangwon-do 88026, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Laboratory of Poultry Medicine, Department of Farm Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012128553"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":0.392,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.62741131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"10","first_page":"923","last_page":"923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h5n1-avian-influenza","display_name":"H5N1 avian influenza","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"hemagglutinin","score":0.878000020980835},{"id":"https://openalex.org/keywords/receptor-binding-sites","display_name":"receptor binding sites","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antigenic-evolution","display_name":"antigenic evolution","score":0.7179999947547913},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.5600000023841858},{"id":"https://openalex.org/keywords/recombinant-viruses","display_name":"recombinant virus","score":0.6669999957084656},{"id":"https://openalex.org/keywords/pathogenicity-in-mice","display_name":"mouse pathogenicity","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8638085126876831},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.7785648107528687},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.7218225002288818},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6884853839874268},{"id":"https://openalex.org/C25365240","wikidata":"https://www.wikidata.org/wiki/Q1897151","display_name":"Reverse genetics","level":4,"score":0.5497142672538757},{"id":"https://openalex.org/C129470801","wikidata":"https://www.wikidata.org/wiki/Q5370234","display_name":"Embryonated","level":3,"score":0.45963436365127563},{"id":"https://openalex.org/C2781216036","wikidata":"https://www.wikidata.org/wiki/Q902494","display_name":"Thermostability","level":3,"score":0.4481219947338104},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.40525150299072266},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3735896646976471},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34687092900276184},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.12216499447822571},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071436","descriptor_name":"Thermotolerance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001717","descriptor_name":"Birds","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/v11100923","doi":"https://doi.org/10.3390/v11100923","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/v11100923","pdf_url":"https://www.mdpi.com/1999-4915/11/10/923/pdf?version=1571726339","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},{"id":"doi:10.20944/preprints201909.0323.v1","doi":"https://doi.org/10.20944/preprints201909.0323.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201909.0323.v1","pdf_url":"https://www.preprints.org/manuscript/201909.0323/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:5830409","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6832455","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6832455","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6832455","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Text"},{"id":"pmid:31600990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31600990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:05f7dd19aa31415b92f20e468d4cb82a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/05f7dd19aa31415b92f20e468d4cb82a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses, Vol 11, Iss 10, p 923 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/v11100923","doi":"https://doi.org/10.3390/v11100923","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/v11100923","pdf_url":"https://www.mdpi.com/1999-4915/11/10/923/pdf?version=1571726339","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980120153.pdf","grobid_xml":"https://content.openalex.org/works/W2980120153.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W121869627","https://openalex.org/W134344862","https://openalex.org/W1482228598","https://openalex.org/W1570034014","https://openalex.org/W1756431049","https://openalex.org/W1879002995","https://openalex.org/W1924711334","https://openalex.org/W1960802388","https://openalex.org/W1969169898","https://openalex.org/W1977548126","https://openalex.org/W1984412128","https://openalex.org/W1984416131","https://openalex.org/W1990747840","https://openalex.org/W2009296046","https://openalex.org/W2011983340","https://openalex.org/W2017618875","https://openalex.org/W2020316997","https://openalex.org/W2029589872","https://openalex.org/W2037679259","https://openalex.org/W2043226713","https://openalex.org/W2048967324","https://openalex.org/W2056298444","https://openalex.org/W2057700014","https://openalex.org/W2058963806","https://openalex.org/W2062740562","https://openalex.org/W2064281959","https://openalex.org/W2075570540","https://openalex.org/W2079655614","https://openalex.org/W2082973915","https://openalex.org/W2088597004","https://openalex.org/W2094757978","https://openalex.org/W2097708737","https://openalex.org/W2102838269","https://openalex.org/W2112170460","https://openalex.org/W2120658521","https://openalex.org/W2132848815","https://openalex.org/W2136998030","https://openalex.org/W2148061808","https://openalex.org/W2154116964","https://openalex.org/W2158340151","https://openalex.org/W2160575854","https://openalex.org/W2162694815","https://openalex.org/W2168988686","https://openalex.org/W2193331226","https://openalex.org/W2284810530","https://openalex.org/W2335136255","https://openalex.org/W2396488765","https://openalex.org/W2461342062","https://openalex.org/W2565948122","https://openalex.org/W2751578357","https://openalex.org/W2755157456","https://openalex.org/W2769154101","https://openalex.org/W2807598240","https://openalex.org/W2888080759","https://openalex.org/W2946088712","https://openalex.org/W2971932444","https://openalex.org/W4232292723","https://openalex.org/W4240204662","https://openalex.org/W4240389369","https://openalex.org/W6600009415","https://openalex.org/W6600193737","https://openalex.org/W6601101692","https://openalex.org/W6601748698","https://openalex.org/W6607508031","https://openalex.org/W6681586502"],"related_works":["https://openalex.org/W2019769551","https://openalex.org/W3043315188","https://openalex.org/W2059782458","https://openalex.org/W1563068640","https://openalex.org/W2287199977","https://openalex.org/W3116736580","https://openalex.org/W2793818135","https://openalex.org/W2000106706","https://openalex.org/W3108630267","https://openalex.org/W3019092342"],"abstract_inverted_index":{"Since":[0],"2007,":[1],"highly":[2],"pathogenic":[3],"clade":[4,15,34,76],"2.3.2":[5],"H5N1":[6],"avian":[7,116,129,163],"influenza":[8],"A":[9],"(A(H5N1))":[10],"viruses":[11,24,39],"have":[12],"evolved":[13],"to":[14,161],"2.3.2.1a,":[16],"b,":[17],"and":[18,29,36,43,80,100,108,117,120,132],"c;":[19],"currently":[20],"only":[21],"2.3.2.1c":[22,77],"A(H5N1)":[23,38,78,87],"circulate":[25],"in":[26,94,115,122],"wild":[27],"birds":[28],"poultry.":[30],"During":[31],"antigenic":[32],"evolution,":[33],"2.3.2.1a":[35],"c":[37],"acquired":[40,160],"both":[41,106],"S144N":[42,55],"V223I":[44],"mutations":[45,110,139,148,158],"around":[46],"the":[47,71,75,102,145,151,156],"receptor":[48,130,142],"binding":[49],"site":[50],"of":[51,74,153],"hemagglutinin":[52],"(HA),":[53],"with":[54],"generating":[56],"an":[57],"N-glycosylation":[58],"sequon.":[59],"We":[60],"introduced":[61],"single":[62],"or":[63],"combined":[64,146],"reverse":[65,147],"mutations,":[66],"N144S":[67,107,125],"and/or":[68],"I223V,":[69],"into":[70],"HA":[72],"gene":[73],"virus":[79,104],"generated":[81],"PR8-derived,":[82],"2":[83],"+":[84],"6":[85],"recombinant":[86,103],"viruses.":[88],"When":[89],"we":[90],"compared":[91],"replication":[92,113],"efficiency":[93,114],"embryonated":[95],"chicken":[96],"eggs,":[97],"mammalian":[98,118,141,172],"cells,":[99],"mice,":[101],"containing":[105],"I223V":[109],"showed":[111],"increased":[112,140,150],"hosts":[119],"pathogenicity":[121],"mice.":[123],"The":[124],"mutation":[126],"significantly":[127],"decreased":[128],"affinity":[131],"egg":[133],"white":[134],"inhibition,":[135],"but":[136],"not":[137],"all":[138],"affinity.":[143],"Interestingly,":[144],"dramatically":[149],"thermostability":[152,168],"HA.":[154],"Therefore,":[155],"adaptive":[157],"possibly":[159],"evade":[162],"immunity":[164],"may":[165],"decrease":[166],"viral":[167],"as":[169,171],"well":[170],"pathogenicity.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2019-10-18T00:00:00"}