{"id":"https://openalex.org/W2980109359","doi":"https://doi.org/10.24926/iip.v10i3.2026","title":"Hypothyroid Symptoms in Levothyroxine-Treated Patients","display_name":"Hypothyroid Symptoms in Levothyroxine-Treated Patients","publication_year":2019,"publication_date":"2019-10-09","ids":{"openalex":"https://openalex.org/W2980109359","doi":"https://doi.org/10.24926/iip.v10i3.2026","mag":"2980109359","pmid":"https://pubmed.ncbi.nlm.nih.gov/34007558","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8127082"},"language":"en","primary_location":{"id":"doi:10.24926/iip.v10i3.2026","doi":"https://doi.org/10.24926/iip.v10i3.2026","is_oa":true,"landing_page_url":"https://doi.org/10.24926/iip.v10i3.2026","pdf_url":"https://pubs.lib.umn.edu/index.php/innovations/article/download/2026/1662","source":{"id":"https://openalex.org/S2764355200","display_name":"INNOVATIONS in pharmacy","issn_l":"2155-0417","issn":["2155-0417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310316065","host_organization_name":"University of Minnesota Libraries Publishing","host_organization_lineage":["https://openalex.org/P4310316065"],"host_organization_lineage_names":["University of Minnesota Libraries Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INNOVATIONS in pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://pubs.lib.umn.edu/index.php/innovations/article/download/2026/1662","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045795993","display_name":"Maisha L. Kelly Freeman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83321563","display_name":"Samford University","ror":"https://ror.org/0040cz635","country_code":"US","type":"education","lineage":["https://openalex.org/I83321563"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maisha Freeman","raw_affiliation_strings":["Samford University, McWhorter School of Pharmacy","Samford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samford University, McWhorter School of Pharmacy","institution_ids":["https://openalex.org/I83321563"]},{"raw_affiliation_string":"Samford University","institution_ids":["https://openalex.org/I83321563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017690706","display_name":"Georges Adunlin","orcid":"https://orcid.org/0000-0002-6146-2802","observed_orcids":["https://orcid.org/0000-0002-6146-2802"]},"institutions":[{"id":"https://openalex.org/I83321563","display_name":"Samford University","ror":"https://ror.org/0040cz635","country_code":"US","type":"education","lineage":["https://openalex.org/I83321563"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georges A. Adunlin","raw_affiliation_strings":["Samford University, McWhorter School of Pharmacy","Samford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samford University, McWhorter School of Pharmacy","institution_ids":["https://openalex.org/I83321563"]},{"raw_affiliation_string":"Samford University","institution_ids":["https://openalex.org/I83321563"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021092827","display_name":"Candice J. Mercadel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83321563","display_name":"Samford University","ror":"https://ror.org/0040cz635","country_code":"US","type":"education","lineage":["https://openalex.org/I83321563"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candice Mercadel","raw_affiliation_strings":["Samford University, McWhorter School of Pharmacy","Proxsys Rx, LLC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samford University, McWhorter School of Pharmacy","institution_ids":["https://openalex.org/I83321563"]},{"raw_affiliation_string":"Proxsys Rx, LLC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112526170","display_name":"Sara E. Danzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47807954","display_name":"Queensborough Community College, CUNY","ror":"https://ror.org/03a4vma36","country_code":"US","type":"education","lineage":["https://openalex.org/I47807954"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Danzi","raw_affiliation_strings":["Queensborough Community College, NY","Queensborough Community College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensborough Community College, NY","institution_ids":["https://openalex.org/I47807954"]},{"raw_affiliation_string":"Queensborough Community College","institution_ids":["https://openalex.org/I47807954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109941383","display_name":"Irwin L. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irwin Klein","raw_affiliation_strings":["NYU School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU School of Medicine","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045795993"],"corresponding_institution_ids":["https://openalex.org/I83321563"],"apc_list":null,"apc_paid":null,"fwci":0.2635,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.64410072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":"3","first_page":"19","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/thyroid-hormone-replacement-therapy","display_name":"thyroid hormone replacement","score":0.8889999985694885},{"id":"https://openalex.org/keywords/treatment-satisfaction","display_name":"treatment satisfaction","score":0.7879999876022339},{"id":"https://openalex.org/keywords/maintenance-dose","display_name":"maintenance dose","score":0.41600000858306885},{"id":"https://openalex.org/keywords/symptom-persistence","display_name":"symptom persistence","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2775883008","wikidata":"https://www.wikidata.org/wiki/Q773449","display_name":"Levothyroxine","level":3,"score":0.8690376281738281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.511539101600647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3759821057319641},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33379796147346497},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3256070613861084},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.1353152096271515}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.24926/iip.v10i3.2026","doi":"https://doi.org/10.24926/iip.v10i3.2026","is_oa":true,"landing_page_url":"https://doi.org/10.24926/iip.v10i3.2026","pdf_url":"https://pubs.lib.umn.edu/index.php/innovations/article/download/2026/1662","source":{"id":"https://openalex.org/S2764355200","display_name":"INNOVATIONS in pharmacy","issn_l":"2155-0417","issn":["2155-0417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310316065","host_organization_name":"University of Minnesota Libraries Publishing","host_organization_lineage":["https://openalex.org/P4310316065"],"host_organization_lineage_names":["University of Minnesota Libraries Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INNOVATIONS in pharmacy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8127082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8127082","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Pharm","raw_type":"Text"},{"id":"pmid:34007558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34007558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovations in pharmacy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1f171af98ceb40bea518e86bf69e3d1d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1f171af98ceb40bea518e86bf69e3d1d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"INNOVATIONS in Pharmacy, Vol 10, Iss 3 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.24926/iip.v10i3.2026","doi":"https://doi.org/10.24926/iip.v10i3.2026","is_oa":true,"landing_page_url":"https://doi.org/10.24926/iip.v10i3.2026","pdf_url":"https://pubs.lib.umn.edu/index.php/innovations/article/download/2026/1662","source":{"id":"https://openalex.org/S2764355200","display_name":"INNOVATIONS in pharmacy","issn_l":"2155-0417","issn":["2155-0417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310316065","host_organization_name":"University of Minnesota Libraries Publishing","host_organization_lineage":["https://openalex.org/P4310316065"],"host_organization_lineage_names":["University of Minnesota Libraries Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INNOVATIONS in pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980109359.pdf","grobid_xml":"https://content.openalex.org/works/W2980109359.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1747119434","https://openalex.org/W1888479777","https://openalex.org/W1966602367","https://openalex.org/W2004525296","https://openalex.org/W2083513752","https://openalex.org/W2097165278","https://openalex.org/W2115931327","https://openalex.org/W2116587748","https://openalex.org/W2137843402","https://openalex.org/W2140936682","https://openalex.org/W2336907646","https://openalex.org/W2527838986","https://openalex.org/W2530107877","https://openalex.org/W2769269448","https://openalex.org/W2789751709","https://openalex.org/W2884223801","https://openalex.org/W4211084027","https://openalex.org/W4239283939","https://openalex.org/W6808820253"],"related_works":["https://openalex.org/W2769269448","https://openalex.org/W4388086328","https://openalex.org/W4389722644","https://openalex.org/W4383262852","https://openalex.org/W2970828691","https://openalex.org/W4394805325","https://openalex.org/W4394682834","https://openalex.org/W4412946073","https://openalex.org/W4406859303","https://openalex.org/W7126137524"],"abstract_inverted_index":{"PURPOSE:":[0],"Approximately":[1],"15%":[2],"of":[3,15,23,58,82,95,134,171,173,183],"patients":[4,38,47,61,96,176,185,228,250],"with":[5,9,19,62,251],"hypothyroidism":[6,75],"are":[7],"dissatisfied":[8],"their":[10],"treatment":[11,210],"due":[12],"to":[13,27,46,54,123,136,142,160,178,212,238,245],"persistence":[14],"residual":[16,63,234],"symptoms":[17,30,126,236],"associated":[18],"hypothyroidism.":[20,49],"The":[21,50,111,198],"purpose":[22],"this":[24],"study":[25,73],"was":[26,52,113],"compare":[28],"thyroid":[29,41,108,230,235],"using":[31,149],"the":[32,56,72,128,174,179,188,195,209,213],"hypothyroid":[33,60,66,249],"symptom":[34],"scale":[35,133],"(HSS)":[36],"in":[37,71,163,187,194,208],"receiving":[39,78,229],"stable":[40],"therapy":[42,232],"for":[43,87,107,248],"6":[44,90],"months":[45],"without":[48],"HSS":[51,112,201],"used":[53,159],"identify":[55],"percentage":[57],"levothyroxine-treated":[59],"or":[64,117],"persistent":[65,252],"symptoms.":[67,253],"METHODS:":[68],"Patients":[69,120],"included":[70,98],"had":[74],"and":[76,151,155,165,191],"were":[77,97,121,147,158,186,193,205],"a":[79,132],"stable/maintenance":[80],"dose":[81],"levothyroxine":[83],"sodium":[84],"therapy,":[85],"unchanged":[86],"at":[88],"least":[89],"months.":[91],"A":[92,169,181],"control":[93,196,214,239],"group":[94,190,215],"if":[99],"they":[100],"did":[101],"not":[102],"have":[103],"an":[104],"active":[105],"prescription":[106],"hormone":[109,231],"therapy.":[110],"administered":[114],"via":[115],"phone":[116],"face-to-face":[118],"interactions.":[119],"asked":[122],"score":[124],"10":[125],"over":[127],"past":[129],"month":[130],"on":[131],"0":[135],"4":[137],"(e.g.,":[138],"0,":[139],"absence":[140],"of,":[141],"4,":[143],"severe":[144],"symptoms).":[145],"Results":[146],"analyzed":[148],"descriptive":[150],"inferential":[152],"statistics.":[153],"T-tests":[154],"chi-squared":[156],"analysis":[157],"assess":[161],"differences":[162],"continuous":[164],"categorical":[166],"variables.":[167],"RESULTS:":[168],"total":[170,182,200],"68%":[172],"contacted":[175],"responded":[177],"survey.":[180],"302":[184],"intervention":[189],"273":[192],"group.":[197],"mean":[199],"scores":[202],"between":[203],"groups":[204],"significantly":[206],"higher":[207],"compared":[211,237],"(13.92":[216],"\u00b1":[217,220],"10.91":[218],"vs.10.07":[219],"7.85;":[221],"P":[222],"<":[223],"0.001).":[224],"CONCLUSION:":[225],"Significantly":[226],"more":[227],"experienced":[233],"patients.":[240],"Attempts":[241],"should":[242],"be":[243],"made":[244],"offer":[246],"alternatives":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}
