{"id":"https://openalex.org/W2980057232","doi":"https://doi.org/10.1088/1361-6560/ab4c27","title":"The importance of dead material within a tumour on the dynamics in response to radiotherapy","display_name":"The importance of dead material within a tumour on the dynamics in response to radiotherapy","publication_year":2019,"publication_date":"2019-10-08","ids":{"openalex":"https://openalex.org/W2980057232","doi":"https://doi.org/10.1088/1361-6560/ab4c27","mag":"2980057232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31593931"},"language":"en","primary_location":{"id":"doi:10.1088/1361-6560/ab4c27","doi":"https://doi.org/10.1088/1361-6560/ab4c27","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1361-6560/ab4c27","pdf_url":"https://iopscience.iop.org/article/10.1088/1361-6560/ab4c27/pdf","source":{"id":"https://openalex.org/S20241394","display_name":"Physics in Medicine and Biology","issn_l":"0031-9155","issn":["0031-9155","1361-6560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physics in Medicine &amp; Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iopscience.iop.org/article/10.1088/1361-6560/ab4c27/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102790162","display_name":"Thomas D. Lewin","orcid":"https://orcid.org/0000-0002-6528-8936","observed_orcids":["https://orcid.org/0000-0002-6528-8936"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Thomas D Lewin","raw_affiliation_strings":["Author to whom correspondence should be addressed","Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6528-8936","affiliations":[{"raw_affiliation_string":"Author to whom correspondence should be addressed","institution_ids":[]},{"raw_affiliation_string":"Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087448925","display_name":"Helen  Mary Byrne","orcid":"https://orcid.org/0000-0003-1771-5910","observed_orcids":["https://orcid.org/0000-0003-1771-5910"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen M Byrne","raw_affiliation_strings":["Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025791169","display_name":"Philip K. Maini","orcid":"https://orcid.org/0000-0002-0146-9164","observed_orcids":["https://orcid.org/0000-0002-0146-9164"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip K Maini","raw_affiliation_strings":["Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061651754","display_name":"Jimmy J. Caudell","orcid":"https://orcid.org/0000-0001-6417-2483","observed_orcids":["https://orcid.org/0000-0001-6417-2483"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimmy J Caudell","raw_affiliation_strings":["Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065959120","display_name":"Eduardo G. Moros","orcid":"https://orcid.org/0000-0003-1964-2460","observed_orcids":["https://orcid.org/0000-0003-1964-2460"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo G Moros","raw_affiliation_strings":["Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1964-2460","affiliations":[{"raw_affiliation_string":"Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014796235","display_name":"Heiko Enderling","orcid":"https://orcid.org/0000-0002-9696-6410","observed_orcids":["https://orcid.org/0000-0002-9696-6410"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heiko Enderling","raw_affiliation_strings":["Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America","Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102790162"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":1.5367,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81764807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"65","issue":"1","first_page":"015007","last_page":"015007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/radiotherapy-response","display_name":"radiotherapy response","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-growth-modeling","display_name":"tumor growth modeling","score":0.6050000190734863},{"id":"https://openalex.org/keywords/fractionated-radiotherapy","display_name":"fractionated radiotherapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/radiation-induced-cell-death","display_name":"radiation-induced cell death","score":0.7910000085830688},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.824999988079071},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7629776000976562},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.6020503640174866},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5634462237358093},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5605005025863647},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.49252137541770935},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.46424612402915955},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.42491692304611206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3963531255722046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3694797158241272},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3176873028278351},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3093916177749634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25675737857818604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20592600107192993},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14279621839523315},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.10715198516845703},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08567020297050476},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D054893","descriptor_name":"Cone-Beam Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1088/1361-6560/ab4c27","doi":"https://doi.org/10.1088/1361-6560/ab4c27","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1361-6560/ab4c27","pdf_url":"https://iopscience.iop.org/article/10.1088/1361-6560/ab4c27/pdf","source":{"id":"https://openalex.org/S20241394","display_name":"Physics in Medicine and Biology","issn_l":"0031-9155","issn":["0031-9155","1361-6560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physics in Medicine &amp; Biology","raw_type":"journal-article"},{"id":"pmid:31593931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31593931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physics in medicine and biology","raw_type":"Journal Article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:8a9330d5-96da-46f3-b029-a655fcc04324","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:8a9330d5-96da-46f3-b029-a655fcc04324","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1088/1361-6560/ab4c27","doi":"https://doi.org/10.1088/1361-6560/ab4c27","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1361-6560/ab4c27","pdf_url":"https://iopscience.iop.org/article/10.1088/1361-6560/ab4c27/pdf","source":{"id":"https://openalex.org/S20241394","display_name":"Physics in Medicine and Biology","issn_l":"0031-9155","issn":["0031-9155","1361-6560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physics in Medicine &amp; Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7743085660","display_name":"Industrial Doctorate Centre: Systems Approaches to Biomedical Science","funder_award_id":"EP/G037280/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320311073","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980057232.pdf","grobid_xml":"https://content.openalex.org/works/W2980057232.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1491153233","https://openalex.org/W1512206713","https://openalex.org/W1529490909","https://openalex.org/W1573363574","https://openalex.org/W1970744454","https://openalex.org/W1971067034","https://openalex.org/W1976359085","https://openalex.org/W1981065559","https://openalex.org/W1990793341","https://openalex.org/W1995287452","https://openalex.org/W2004900984","https://openalex.org/W2005971420","https://openalex.org/W2006847833","https://openalex.org/W2007656391","https://openalex.org/W2016127716","https://openalex.org/W2020165283","https://openalex.org/W2022524530","https://openalex.org/W2023774039","https://openalex.org/W2025104440","https://openalex.org/W2026691590","https://openalex.org/W2034269086","https://openalex.org/W2034597521","https://openalex.org/W2038750244","https://openalex.org/W2045738912","https://openalex.org/W2046123202","https://openalex.org/W2048382566","https://openalex.org/W2053857652","https://openalex.org/W2061121026","https://openalex.org/W2062712893","https://openalex.org/W2069756888","https://openalex.org/W2077295250","https://openalex.org/W2077814905","https://openalex.org/W2089253822","https://openalex.org/W2096163540","https://openalex.org/W2100407324","https://openalex.org/W2103209526","https://openalex.org/W2111510713","https://openalex.org/W2116794878","https://openalex.org/W2119762775","https://openalex.org/W2120986496","https://openalex.org/W2139899744","https://openalex.org/W2155349542","https://openalex.org/W2162994584","https://openalex.org/W2163741151","https://openalex.org/W2286449377","https://openalex.org/W2297423937","https://openalex.org/W2344249767","https://openalex.org/W2476152999","https://openalex.org/W2518488580","https://openalex.org/W2550236854","https://openalex.org/W2590984159","https://openalex.org/W2593468720","https://openalex.org/W2609535107","https://openalex.org/W2712373469","https://openalex.org/W2728173650","https://openalex.org/W2799403899","https://openalex.org/W2807851146","https://openalex.org/W2896620711","https://openalex.org/W2938305903","https://openalex.org/W2943074672","https://openalex.org/W2951432721","https://openalex.org/W2974641100","https://openalex.org/W4229657088","https://openalex.org/W4234061814","https://openalex.org/W4241471078","https://openalex.org/W4249113534"],"related_works":["https://openalex.org/W2951432721","https://openalex.org/W2059136977","https://openalex.org/W2997098618","https://openalex.org/W2974641100","https://openalex.org/W2302071074","https://openalex.org/W2412190362","https://openalex.org/W2280635341","https://openalex.org/W3005897484","https://openalex.org/W2018416718","https://openalex.org/W3215036600"],"abstract_inverted_index":{"In":[0],"vivo":[1],"tumours":[2],"are":[3],"highly":[4],"heterogeneous,":[5],"often":[6],"comprising":[7],"regions":[8],"of":[9,28,44,73,97,124,162],"hypoxia":[10],"and":[11,53,75,116],"necrosis.":[12],"Radiotherapy":[13],"significantly":[14,128],"alters":[15],"the":[16,45,56,71,84,88,98,122,125,130,163,167],"intratumoural":[17],"composition.":[18],"Moreover,":[19],"radiation-induced":[20],"cell":[21],"death":[22],"may":[23,38,54,86,145],"occur":[24],"via":[25],"a":[26,41,62],"number":[27],"different":[29,34,104],"mechanisms":[30],"that":[31,68,140],"act":[32],"over":[33],"timescales.":[35],"Dead":[36],"material":[37,82,127,165],"therefore":[39],"occupy":[40],"significant":[42],"portion":[43],"tumour":[46,58,65,85,90,105,132,157],"volume":[47,106,133,158],"for":[48,70,120,141],"some":[49,142],"time":[50],"after":[51],"irradiation":[52],"affect":[55,87],"subsequent":[57],"dynamics.":[59,92],"We":[60,93,113],"present":[61],"three":[63],"phase":[64],"growth":[66],"model":[67,99],"accounts":[69],"effects":[72],"radiotherapy":[74,152],"use":[76,94],"it":[77,144],"to":[78,101,110,149],"investigate":[79],"how":[80],"dead":[81,126,164],"within":[83,166],"spatio-temporal":[89],"response":[91,109,153],"numerical":[95],"simulation":[96],"equations":[100],"characterise":[102],"qualitatively":[103],"dynamics":[107,134],"in":[108],"fractionated":[111],"radiotherapy.":[112],"demonstrate":[114],"examples,":[115],"associated":[117],"parameter":[118],"values,":[119],"which":[121],"properties":[123],"alter":[129],"observed":[131],"throughout":[135],"treatment.":[136],"These":[137],"simulations":[138],"suggest":[139],"cases":[143],"not":[146],"be":[147],"possible":[148],"accurately":[150],"predict":[151],"from":[154],"pre-treatment,":[155],"gross":[156],"measurements":[159],"without":[160],"consideration":[161],"tumour.":[168]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}
