{"id":"https://openalex.org/W2979962292","doi":"https://doi.org/10.3390/antibiotics8040180","title":"Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases","display_name":"Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases","publication_year":2019,"publication_date":"2019-10-09","ids":{"openalex":"https://openalex.org/W2979962292","doi":"https://doi.org/10.3390/antibiotics8040180","mag":"2979962292","pmid":"https://pubmed.ncbi.nlm.nih.gov/31600972","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963541"},"language":"en","primary_location":{"id":"doi:10.3390/antibiotics8040180","doi":"https://doi.org/10.3390/antibiotics8040180","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/antibiotics8040180","pdf_url":"https://www.mdpi.com/2079-6382/8/4/180/pdf?version=1570621489","source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-6382/8/4/180/pdf?version=1570621489","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022214476","display_name":"Manesh Nautiyal","orcid":"https://orcid.org/0000-0002-6432-4579","observed_orcids":["https://orcid.org/0000-0002-6432-4579"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Manesh Nautiyal","raw_affiliation_strings":["KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-6432-4579","affiliations":[{"raw_affiliation_string":"KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079213469","display_name":"Bharat Kacheshwar Gadakh","orcid":"https://orcid.org/0000-0001-6814-4818","observed_orcids":["https://orcid.org/0000-0001-6814-4818"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bharat Gadakh","raw_affiliation_strings":["KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042091478","display_name":"Steff De Graef","orcid":"https://orcid.org/0000-0003-2558-3890","observed_orcids":["https://orcid.org/0000-0003-2558-3890"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Steff De Graef","raw_affiliation_strings":["KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Biocrystallography, Herestraat 49 BOX 822, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-2558-3890","affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Biocrystallography, Herestraat 49 BOX 822, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066722637","display_name":"Lu-Ping Pang","orcid":"https://orcid.org/0000-0002-8224-9250","observed_orcids":["https://orcid.org/0000-0002-8224-9250"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Luping Pang","raw_affiliation_strings":["KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Biocrystallography, Herestraat 49 BOX 822, 3000 Leuven, Belgium","KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Biocrystallography, Herestraat 49 BOX 822, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015840701","display_name":"Masroor Ahmed Khan","orcid":"https://orcid.org/0000-0003-1362-136X","observed_orcids":["https://orcid.org/0000-0003-1362-136X"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Masroor Khan","raw_affiliation_strings":["KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Xun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Yi Xun","raw_affiliation_strings":["KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056154663","display_name":"Jef Rozenski","orcid":"https://orcid.org/0000-0001-9624-5536","observed_orcids":["https://orcid.org/0000-0001-9624-5536"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jef Rozenski","raw_affiliation_strings":["KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-9624-5536","affiliations":[{"raw_affiliation_string":"KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055955896","display_name":"Arthur A. Van Aerschot","orcid":"https://orcid.org/0000-0003-3528-8588","observed_orcids":["https://orcid.org/0000-0003-3528-8588"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Arthur Van Aerschot","raw_affiliation_strings":["KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-3528-8588","affiliations":[{"raw_affiliation_string":"KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 BOX 1030, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055955896"],"corresponding_institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"],"apc_list":{"value":1200,"currency":"CHF","value_usd":1216},"apc_paid":{"value":1200,"currency":"CHF","value_usd":1216},"fwci":0.0728,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.33073784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8","issue":"4","first_page":"180","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoacyl-trna-synthetase-inhibitors","display_name":"aminoacyl-tRNA synthetase inhibitors","score":0.9549999833106995},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.718999981880188},{"id":"https://openalex.org/keywords/sarcina-lutea","display_name":"Sarcina lutea","score":0.9319999814033508},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5839999914169312},{"id":"https://openalex.org/keywords/bacterial-membrane-permeability","display_name":"bacterial membrane permeability","score":0.6819999814033508},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.4620000123977661},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.8240138292312622},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.5826981067657471},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.5708119869232178},{"id":"https://openalex.org/C2910418148","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Amino Acyl-tRNA Synthetases","level":5,"score":0.5239443778991699},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48110121488571167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3939923644065857},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.15399551391601562},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/antibiotics8040180","doi":"https://doi.org/10.3390/antibiotics8040180","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/antibiotics8040180","pdf_url":"https://www.mdpi.com/2079-6382/8/4/180/pdf?version=1570621489","source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},{"id":"pmid:31600972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31600972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6963541","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6963541/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics (Basel)","raw_type":"Text"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/642638","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/642638","pdf_url":"https://lirias.kuleuven.be/retrieve/ea94af84-44ca-4622-8bbc-b5be4463c550","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antibiotics-Basel, vol. 8 (4), Art.No. ARTN 180","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:ad75fea30d8442fb823e1cc75a1150a8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ad75fea30d8442fb823e1cc75a1150a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antibiotics, Vol 8, Iss 4, p 180 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antibiotics8040180","doi":"https://doi.org/10.3390/antibiotics8040180","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/antibiotics8040180","pdf_url":"https://www.mdpi.com/2079-6382/8/4/180/pdf?version=1570621489","source":{"id":"https://openalex.org/S2736332253","display_name":"Antibiotics","issn_l":"2079-6382","issn":["2079-6382"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1777447918","display_name":null,"funder_award_id":"20100225E7","funder_id":"https://openalex.org/F4320327336","funder_display_name":"Vlaamse regering"},{"id":"https://openalex.org/G2287072989","display_name":null,"funder_award_id":"3M14022","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G2388234233","display_name":"Rational design of tRNA synthetase inhibitors as new antibacterials.","funder_award_id":"G077814N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5989760077","display_name":null,"funder_award_id":"1S53516N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G6056032534","display_name":null,"funder_award_id":"3M14022","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G635744581","display_name":"Synthesis and biological evaluation of albomycin and aminoacyl sulfonamide analogues as potential aaRS inhibitors.","funder_award_id":"12A3916N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G6955061358","display_name":null,"funder_award_id":"G0A4616N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G8765543804","display_name":null,"funder_award_id":"G077814N; G0A4616N; 12A3916N; 1S53516N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979962292.pdf","grobid_xml":"https://content.openalex.org/works/W2979962292.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1509732336","https://openalex.org/W1563650227","https://openalex.org/W1965878806","https://openalex.org/W1983754526","https://openalex.org/W1984956671","https://openalex.org/W1985029412","https://openalex.org/W1993924528","https://openalex.org/W2016386575","https://openalex.org/W2026399160","https://openalex.org/W2028093584","https://openalex.org/W2031931314","https://openalex.org/W2039932426","https://openalex.org/W2040186990","https://openalex.org/W2058680960","https://openalex.org/W2062011807","https://openalex.org/W2072150471","https://openalex.org/W2073684330","https://openalex.org/W2084944706","https://openalex.org/W2088581909","https://openalex.org/W2100356537","https://openalex.org/W2122319025","https://openalex.org/W2135732933","https://openalex.org/W2140710502","https://openalex.org/W2151488009","https://openalex.org/W2159785306","https://openalex.org/W2175546597","https://openalex.org/W2239738725","https://openalex.org/W2300011769","https://openalex.org/W2322777826","https://openalex.org/W2333020680","https://openalex.org/W2593634873","https://openalex.org/W2613613983","https://openalex.org/W2783412510","https://openalex.org/W2791896513","https://openalex.org/W2794327236","https://openalex.org/W2896971423","https://openalex.org/W2910534695","https://openalex.org/W2917868259","https://openalex.org/W2937896526","https://openalex.org/W4248107770","https://openalex.org/W4251128326"],"related_works":["https://openalex.org/W7051693825","https://openalex.org/W6986177801","https://openalex.org/W7060919818","https://openalex.org/W1966284687","https://openalex.org/W2040227470","https://openalex.org/W2133658255","https://openalex.org/W2065329713","https://openalex.org/W2031364460","https://openalex.org/W2357141908","https://openalex.org/W4248835809"],"abstract_inverted_index":{"Emerging":[0],"antibiotic":[1],"resistance":[2],"in":[3,10,75,124,175,186,210],"pathogenic":[4],"bacteria":[5],"and":[6,69,104],"reduction":[7],"of":[8,35,48,55,61,80,95,120,151,188,221,238,251],"compounds":[9,172,224],"the":[11,17,46,59,96,110,118,132,146,152,162,203,222,228,245],"existing":[12,32,122],"antibiotics":[13],"discovery":[14],"pipeline":[15],"is":[16],"most":[18],"critical":[19],"concern":[20],"for":[21,45],"healthcare":[22],"professionals.":[23],"A":[24],"potential":[25],"solution":[26],"aims":[27],"to":[28,65,86,101,127,202],"explore":[29],"new":[30,167],"or":[31,154,185],"targets/compounds.":[33],"Inhibition":[34],"bacterial":[36,111,133],"aminoacyl-tRNA":[37],"synthetase":[38],"(aaRSs)":[39],"could":[40,83],"be":[41,84],"one":[42],"such":[43],"target":[44],"development":[47],"antibiotics.":[49],"The":[50,88,196],"aaRSs":[51],"are":[52,92],"a":[53,72,141,156,179],"group":[54],"enzymes":[56,82],"that":[57],"catalyze":[58],"transfer":[60],"an":[62,125],"amino":[63],"acid":[64],"their":[66,102,129],"cognate":[67],"tRNA":[68],"therefore":[70],"play":[71],"pivotal":[73],"role":[74],"translation.":[76],"Thus,":[77],"selective":[78],"inhibition":[79],"these":[81,121],"detrimental":[85],"microbes.":[87],"5\u2032-O-(N-(L-aminoacyl))":[89],"sulfamoyladenosines":[90],"(aaSAs)":[91],"potent":[93],"inhibitors":[94],"respective":[97],"aaRSs,":[98],"however":[99],"due":[100],"polarity":[103],"charged":[105],"nature":[106],"they":[107],"cannot":[108],"cross":[109],"membranes.":[112],"In":[113],"this":[114],"work,":[115],"we":[116],"increased":[117],"lipophilicity":[119],"aaSAs":[123],"effort":[126],"promote":[128],"penetration":[130],"through":[131],"membrane.":[134],"Two":[135],"strategies":[136],"were":[137,173],"followed,":[138],"either":[139,178],"attaching":[140],"(permanent)":[142],"alkyl":[143],"moiety":[144,160],"at":[145,161],"adenine":[147],"ring":[148],"via":[149],"alkylation":[150],"N6-position":[153],"introducing":[155],"lipophilic":[157],"biodegradable":[158],"prodrug":[159],"alpha-terminal":[163],"amine,":[164],"totaling":[165],"eight":[166],"aaSA":[168,205],"analogues.":[169],"All":[170],"synthesized":[171],"evaluated":[174],"vitro":[176],"using":[177],"purified":[180],"Escherichia":[181],"coli":[182],"aaRS":[183],"enzyme":[184],"presence":[187],"total":[189],"cellular":[190,211],"extract":[191],"obtained":[192],"from":[193],"E.":[194],"coli.":[195],"prodrugs":[197],"showed":[198,233],"comparable":[199],"inhibitory":[200,235],"activity":[201],"parent":[204],"analogues,":[206],"indicating":[207],"metabolic":[208],"activation":[209],"extracts,":[212],"but":[213],"had":[214],"little":[215],"effect":[216],"on":[217],"bacteria.":[218],"During":[219],"evaluation":[220],"N6-alkylated":[223],"against":[225,241,254],"different":[226],"microbes,":[227],"N6-octyl":[229],"containing":[230],"congener":[231],"6b":[232],"minimum":[234],"concentration":[236],"(MIC)":[237],"12.5":[239],"\u00b5M":[240,253],"Sarcina":[242],"lutea":[243],"while":[244],"dodecyl":[246],"analogue":[247],"6c":[248],"displayed":[249],"MIC":[250],"6.25":[252],"Candida":[255],"albicans.":[256]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-10-18T00:00:00"}