{"id":"https://openalex.org/W2979872004","doi":"https://doi.org/10.1182/blood.v104.11.1450.1450","title":"Efficacy of Donor Lymphocyte Infusions in Myelodysplastic Syndromes Relapsing after Allogeneic Stem Cell Transplantation: Importance of Karyotype.","display_name":"Efficacy of Donor Lymphocyte Infusions in Myelodysplastic Syndromes Relapsing after Allogeneic Stem Cell Transplantation: Importance of Karyotype.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2979872004","doi":"https://doi.org/10.1182/blood.v104.11.1450.1450","mag":"2979872004"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.1450.1450","doi":"https://doi.org/10.1182/blood.v104.11.1450.1450","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.1450.1450","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037134717","display_name":"Dominik Selleslag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123377","display_name":"AZ Sint-Jan","ror":"https://ror.org/030h1vb90","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210123377"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dominik L.D. Selleslag","raw_affiliation_strings":["Hematology, AZ Sint-Jan AV, Brugge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, AZ Sint-Jan AV, Brugge, Belgium","institution_ids":["https://openalex.org/I4210123377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014064112","display_name":"Friedel Nollet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123377","display_name":"AZ Sint-Jan","ror":"https://ror.org/030h1vb90","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210123377"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Friedel Nollet","raw_affiliation_strings":["Hematology, AZ Sint-Jan AV, Brugge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, AZ Sint-Jan AV, Brugge, Belgium","institution_ids":["https://openalex.org/I4210123377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111653787","display_name":"Johan Billiet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123377","display_name":"AZ Sint-Jan","ror":"https://ror.org/030h1vb90","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210123377"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Johan Billiet","raw_affiliation_strings":["Hematology, AZ Sint-Jan AV, Brugge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, AZ Sint-Jan AV, Brugge, Belgium","institution_ids":["https://openalex.org/I4210123377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038886533","display_name":"Jan Van Droogenbroeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123377","display_name":"AZ Sint-Jan","ror":"https://ror.org/030h1vb90","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210123377"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Van Droogenbroeck","raw_affiliation_strings":["Hematology, AZ Sint-Jan AV, Brugge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, AZ Sint-Jan AV, Brugge, Belgium","institution_ids":["https://openalex.org/I4210123377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103745738","display_name":"Achiel Van Hoof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123377","display_name":"AZ Sint-Jan","ror":"https://ror.org/030h1vb90","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210123377"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Achiel Van Hoof","raw_affiliation_strings":["Hematology, AZ Sint-Jan AV, Brugge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, AZ Sint-Jan AV, Brugge, Belgium","institution_ids":["https://openalex.org/I4210123377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001394341","display_name":"Koen Van Eygen","orcid":"https://orcid.org/0000-0001-8285-906X","observed_orcids":["https://orcid.org/0000-0001-8285-906X"]},"institutions":[{"id":"https://openalex.org/I2800286501","display_name":"AZ Groeninge","ror":"https://ror.org/01cz3wf89","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800286501"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Koen Van Eygen","raw_affiliation_strings":["Oncology, AZ Groeninghe, Kortrijk, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, AZ Groeninghe, Kortrijk, Belgium","institution_ids":["https://openalex.org/I2800286501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111773078","display_name":"M. Hidajat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123377","display_name":"AZ Sint-Jan","ror":"https://ror.org/030h1vb90","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210123377"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Melanny Hidajat","raw_affiliation_strings":["Hematology, AZ Sint-Jan AV, Brugge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, AZ Sint-Jan AV, Brugge, Belgium","institution_ids":["https://openalex.org/I4210123377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006829635","display_name":"Arnold M. Criel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123377","display_name":"AZ Sint-Jan","ror":"https://ror.org/030h1vb90","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210123377"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Arnold Criel","raw_affiliation_strings":["Hematology, AZ Sint-Jan AV, Brugge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, AZ Sint-Jan AV, Brugge, Belgium","institution_ids":["https://openalex.org/I4210123377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001394341","https://openalex.org/A5006829635","https://openalex.org/A5014064112","https://openalex.org/A5111653787","https://openalex.org/A5111773078"],"corresponding_institution_ids":["https://openalex.org/I2800286501","https://openalex.org/I4210123377"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.4266,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.67891472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"104","issue":"11","first_page":"1450","last_page":"1450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donor-lymphocyte-infusion","display_name":"donor lymphocyte infusion","score":0.949999988079071},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/relapse-after-allogeneic-stem-cell-transplantation","display_name":"relapse after allogeneic stem cell transplantation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.8379999995231628},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.6980000138282776},{"id":"https://openalex.org/keywords/donor-chimerism","display_name":"donor chimerism","score":0.9079999923706055},{"id":"https://openalex.org/keywords/myeloablative-conditioning","display_name":"myeloablative conditioning","score":0.7049999833106995},{"id":"https://openalex.org/keywords/graft-versus-host-disease-prophylaxis","display_name":"graft-versus-host disease prophylaxis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cd3-t-cells","display_name":"CD3+ T cells","score":0.5249999761581421},{"id":"https://openalex.org/keywords/secondary-acute-myeloid-leukemia","display_name":"secondary acute myeloid leukemia","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.833478569984436},{"id":"https://openalex.org/C2780611847","wikidata":"https://www.wikidata.org/wiki/Q348922","display_name":"Busulfan","level":4,"score":0.8225187659263611},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.7406646609306335},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6206128597259521},{"id":"https://openalex.org/C2779695342","wikidata":"https://www.wikidata.org/wiki/Q5296800","display_name":"Donor lymphocyte infusion","level":4,"score":0.5836323499679565},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.5532094836235046},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.551582932472229},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5330286026000977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5116334557533264},{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.5063563585281372},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5034810900688171},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44772887229919434},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.43817728757858276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.1450.1450","doi":"https://doi.org/10.1182/blood.v104.11.1450.1450","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.1450.1450","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047533297","https://openalex.org/W1980212408","https://openalex.org/W1967140651","https://openalex.org/W1991802401","https://openalex.org/W2981162320","https://openalex.org/W4403499800","https://openalex.org/W3213229737","https://openalex.org/W2977561421","https://openalex.org/W2561980943","https://openalex.org/W2802485876"],"abstract_inverted_index":{"Abstract":[0],"Few":[1],"studies":[2],"have":[3,28],"reported":[4],"on":[5],"the":[6,54,131,149,173,177,183,251,280,299,303,318,341,372,397],"efficacy":[7],"of":[8,44,53,101,135,157,163,175,179,210,250,305,317,325,340,349,396,409,440,468],"donor":[9,196,262,307,469],"lymphocyte":[10],"infusions":[11,234],"(DLI)":[12],"for":[13,41,328,436],"myelodysplastic":[14],"syndromes":[15],"(MDS)":[16],"relapsing":[17,443],"after":[18,46,170,264,337,345,360,371,380,444],"T-cell":[19,125,445],"depleted":[20,126,446],"allogeneic":[21,47,447],"stem":[22,48,102,154,448],"cell":[23,49,449],"transplantation.":[24,50,450],"Since":[25],"1996":[26],"we":[27],"treated":[29],"11":[30,136,252,319,342],"patients":[31,55,87,116,144,151,253,268,320,343,364,399,411,442,459],"with":[32,78,127,146,259,288,400,412,460],"DLI":[33,176,243,301,346,374,406,431,451],"as":[34],"a":[35,42,161,255,322,401,413,422,433],"single":[36,414],"therapeutic":[37],"modality":[38],"(without":[39],"chemotherapy)":[40],"relapse":[43,334],"MDS":[45,77,158,441],"Median":[51],"age":[52],"was":[56,66,83,104,140,228],"56":[57],"years":[58],"(range":[59],"23":[60],"to":[61,167,190,202,216,232,357,405],"73":[62],"years).":[63],"Initial":[64],"diagnosis":[65],"RAEB":[67],"(4":[68],"patients),":[69,72],"RAEBt":[70],"(3":[71],"secondary":[73],"AML(3":[74],"patients)":[75],"and":[76,94,117,227,241,247,276,302,313,331,347,368],"fibrosis":[79],"(1":[80],"patient).":[81],"Conditioning":[82],"myeloablative":[84],"in":[85,96,107,114,120,130,133,142,148,182,230,454,458],"10":[86,115,219,225,386],"(":[88,417],"TBI":[89],"-Cyclophosphamide,":[90],"Busulfan-Cyclophosphamide":[91],"or":[92],"Busulfan-Melphalan)":[93],"non-myeloablative":[95],"1":[97,121,231,384],"patient":[98],"(Busulfan-Fludarabine-ATG).":[99],"Source":[100],"cells":[103,181],"peripheral":[105],"blood":[106],"all":[108,143],"patients.":[109,137],"Donors":[110],"were":[111,124,286],"HLA-identical":[112,392],"siblings":[113],"HLA-matched":[118],"unrelated":[119],"patient.":[122],"Allografts":[123],"Campath":[128],"1H":[129],"bag":[132],"8":[134],"GVHD":[138,291,377],"prophylaxis":[139],"cyclosporin":[141],"combined":[145],"methotrexate":[147],"3":[150,188,267,408,410],"receiving":[152],"unmodified":[153],"cells.":[155],"Relapse":[156],"occurred":[159],"at":[160,273,355,366],"median":[162],"123":[164],"days":[165,336,359,370],"(54":[166],"373":[168],"days)":[169],"allograft.":[171],"At":[172],"time":[174],"percentage":[178],"blast":[180],"bone":[184],"marrow":[185],"ranged":[186,198,213],"from":[187,199,214,279,333,352,375,391,475],"%":[189,192,201,204,261,439],"50":[191],"(median":[193,205,222,235],"6":[194,311,387,398],"%);":[195],"chimerism":[197,263,308,327],"14":[200],"91":[203],"72%).":[206],"The":[207],"total":[208],"dose":[209],"CD3":[211,388],"lymphocytes":[212,389,471],"0.1":[215],"30":[217,275,438],"x":[218,224,385],"7":[220,246],"/kg":[221,390],"0.6":[223],"7/kg)":[226],"administered":[229],"4":[233,329,348],"1).":[236],"Time":[237,296],"interval":[238,297],"between":[239,245,298,310],"first":[240,281,300,361,373],"second":[242],"varied":[244,309],"180":[248],"days.Three":[249],"achieved":[254,321],"durable":[256,284,423,455],"complete":[257,306,326],"remission":[258],"100":[260],"DLI.":[265,282,338,362],"These":[266],"are":[269],"currently":[270],"disease":[271,353],"free":[272],"20,":[274],"40":[277],"months":[278],"All":[283],"responses":[285],"associated":[287],"limited":[289],"chronic":[290],"requiring":[292],"temporary":[293],"immunosuppressive":[294],"therapy.":[295],"achievement":[304],"weeks":[312,330],"9":[314],"months.":[315],"One":[316],"short":[323],"state":[324],"died":[332,351,365],"146":[335],"Five":[339],"progressed":[344],"them":[350],"progression":[354],"29":[356],"112":[358],"Two":[363],"26":[367],"97":[369],"acute":[376],"grade":[378],"IV":[379],"having":[381],"received":[382],"only":[383],"sibling":[393],"donors.":[394],"None":[395],"complex":[402],"karyotype":[403],"responded":[404],"while":[407],"chromosomal":[415],"abnormality":[416],"t(1,14),":[418],"t(1,17),":[419],"t(1,3))":[420],"had":[421],"response":[424],"(p-value":[425],"=":[426],"0.01).":[427],"We":[428],"conclude":[429],"that":[430],"is":[432],"powerful":[434],"therapy":[435],"about":[437],"may":[452,472],"result":[453],"remissions":[456],"particularly":[457],"non-complex":[461],"cytogenetic":[462],"abnormalities.":[463],"However,":[464],"even":[465],"low":[466],"doses":[467],"T":[470],"cause":[473],"mortality":[474],"severe":[476],"GVHD.":[477]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2019-10-18T00:00:00"}
