{"id":"https://openalex.org/W2979827770","doi":"https://doi.org/10.1182/blood.v120.21.2990.2990","title":"Optimization of an Intra-Bone Hematopoietic Stem Cell Delivery Technique in a Swine Model.","display_name":"Optimization of an Intra-Bone Hematopoietic Stem Cell Delivery Technique in a Swine Model.","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2979827770","doi":"https://doi.org/10.1182/blood.v120.21.2990.2990","mag":"2979827770"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.2990.2990","doi":"https://doi.org/10.1182/blood.v120.21.2990.2990","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.2990.2990","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072164039","display_name":"Jeremy Mark Pantin","orcid":"https://orcid.org/0000-0001-7536-0623","observed_orcids":["https://orcid.org/0000-0001-7536-0623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy M Pantin","raw_affiliation_strings":["Dept. of Medicine/Hematology & Oncology, Georgia Health Sciences University, Augusta, GA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Medicine/Hematology & Oncology, Georgia Health Sciences University, Augusta, GA, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109400250","display_name":"Robert F. Hoyt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert F Hoyt","raw_affiliation_strings":["LAMS, NIH/NHLBI, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LAMS, NIH/NHLBI, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011834144","display_name":"\u00d6mer Aras","orcid":"https://orcid.org/0000-0003-1758-0542","observed_orcids":["https://orcid.org/0000-0003-1758-0542"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Omer Aras","raw_affiliation_strings":["Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086010156","display_name":"Marcus Y. Chen","orcid":"https://orcid.org/0000-0003-0743-9369","observed_orcids":["https://orcid.org/0000-0003-0743-9369"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marcus Y Chen","raw_affiliation_strings":["Cardiology Branch, NIH/NHLBI, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Branch, NIH/NHLBI, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015519992","display_name":"Noriko Sato","orcid":"https://orcid.org/0000-0002-9372-1725","observed_orcids":["https://orcid.org/0000-0002-9372-1725"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Noriko Sato","raw_affiliation_strings":["Molecular Imaging Branch, NIH/NCI, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, NIH/NCI, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082080836","display_name":"Peter L. Choyke","orcid":"https://orcid.org/0000-0003-1086-8826","observed_orcids":["https://orcid.org/0000-0003-1086-8826"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter Choyke","raw_affiliation_strings":["Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112507028","display_name":"Richard W. Childs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Childs","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011834144","https://openalex.org/A5015519992","https://openalex.org/A5082080836","https://openalex.org/A5086010156","https://openalex.org/A5109400250"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210140884"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40627886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"21","first_page":"2990","last_page":"2990"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.6299999952316284},{"id":"https://openalex.org/keywords/bone-marrow-homing","display_name":"bone marrow homing","score":0.5270000100135803},{"id":"https://openalex.org/keywords/g-csf-mobilization","display_name":"G-CSF mobilization","score":0.777999997138977},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6553157567977905},{"id":"https://openalex.org/C2779079599","wikidata":"https://www.wikidata.org/wiki/Q3774464","display_name":"Iliac crest","level":2,"score":0.6428770422935486},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6231849789619446},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6199688911437988},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.43960732221603394},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.38261938095092773},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3495182394981384},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27063700556755066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1643671989440918},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.2990.2990","doi":"https://doi.org/10.1182/blood.v120.21.2990.2990","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.2990.2990","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6000000238418579,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987798536","https://openalex.org/W2043283112","https://openalex.org/W2002473600","https://openalex.org/W2006110922","https://openalex.org/W105615574","https://openalex.org/W2018022711","https://openalex.org/W2050841999","https://openalex.org/W2160776291","https://openalex.org/W2141828778","https://openalex.org/W2381526079"],"abstract_inverted_index":{"Abstract":[0,1],"2990":[2],"Introduction":[3],"Transplantation":[4],"of":[5,18,35,70,105,117,124,175,280,336,408,412,451,485,539,559,568,577,588,600,658,668],"allogeneic":[6],"hematopoietic":[7],"progenitor":[8],"cells":[9,151,165,182,284,456,493,560,569,603],"(HPC)":[10],"is":[11,24],"an":[12,62],"effective":[13],"treatment":[14],"for":[15,28,65,149,273,346,476],"a":[16,98,250,322,352,528],"variety":[17],"hematological":[19],"diseases.":[20],"Intravenous":[21],"(IV)":[22],"injection":[23,233,310,335,376,407,436,450,484,515,531],"the":[25,33,38,52,66,79,93,103,109,115,122,172,216,226,235,278,296,419,429,434,443,463,474,498,506,523,554,562,571,580,589,593,605,611,628],"routine":[26],"method":[27,64],"HPC":[29,45,71,134,633,662],"transplantation,":[30],"based":[31],"on":[32,201,321],"concept":[34],"\u201choming\u201d":[36],"to":[37,91,113,120,348,362,478,553,570,604,610,623,642,653,670],"bone":[39,80,111,162,500,524,582,606],"marrow.":[40],"To":[41,222],"date,":[42],"intrabone":[43],"(IB)":[44],"transplantation":[46,95,634,648],"has":[47,81],"largely":[48],"been":[49,84],"investigated":[50],"in":[51,59,72,78,210,418,460,473,497,505,519,547,584,627,635,656],"preclinical":[53],"setting":[54],"with":[55,102,188,237,244,267,316,351,565],"only":[56],"limited":[57,552],"application":[58],"humans.":[60,636],"Furthermore,":[61,508],"optimized":[63,646],"direct":[67,231],"IB":[68,94,131,208,232,294,309,375,391,406,483,514,598,632,647],"infusion":[69,301,392,538,576,599],"humans":[73],"which":[74],"maximizes":[75],"cellular":[76,281,364,585,625],"retention":[77,558],"not":[82],"yet":[83],"developed.":[85],"In":[86,385,535,595],"this":[87,645],"study,":[88],"we":[89],"aimed":[90],"optimize":[92],"procedure":[96],"using":[97,126,143,152,186,197,215,249,311,331],"large":[99],"animal":[100,193],"model":[101],"goal":[104],"retaining":[106],"HPCs":[107,125,578,601],"within":[108,561],"pelvic":[110,581],"and":[112,180,228,261,277,313,319,329,366],"explore":[114],"feasibility":[116],"radionuclide":[118],"labeling":[119],"assess":[121,363],"trafficking":[123],"PET/CT":[127,354],"imaging":[128],"early":[129],"after":[130,433],"transplantation.":[132],"Methods":[133],"collection:":[135],"a)":[136],"Human":[137,259],"HPCswere":[138],"mobilized":[139],"from":[140,171,428],"healthy":[141],"volunteers":[142],"G-CSF":[144],"then":[145,157,177,270,286],"were":[146,158,166,178,184,195,265,271,285,305,344,377,393],"positively":[147],"selected":[148],"CD34+":[150,260,455],"immuno-magnetic":[153],"beads":[154],"(MiltenyiBiotec,":[155],"MA)":[156,361],"cryopreserved.":[159],"b)":[160],"Porcine":[161],"marrow":[163,227,563,590,607,629],"(BM)":[164],"aspirated":[167],"(approximately":[168],"40":[169],"ml)":[170],"iliac":[173,421,445,499,555],"crest":[174],"swine":[176,199,262,461,488,542],"filtered":[179],"mononuclear":[181],"(MNCs)":[183],"isolated":[185],"Ficoll-Paque\u2122":[187],"density":[189],"gradient":[190],"separation.":[191],"All":[192],"procedures":[194],"conducted":[196],"domestic":[198],"(Susscrofadomesticus)":[200],"NHLBI":[202],"Animal":[203],"Use":[204],"Committee":[205],"approved":[206],"protocols.":[207],"access":[209,431],"animals":[211],"was":[212,240,468,516,533,551],"initially":[213],"achieved":[214],"OnControl":[217],"driver":[218],"(Vidacare":[219],"Corp.":[220],"TX).":[221],"evaluate":[223],"flow":[224],"through":[225],"venous":[229],"drainage,":[230],"into":[234,288,295,442,579,592],"hemipelvis":[236],"iopamidol-370":[238],"contrast":[239,413],"performed":[241],"under":[242],"anesthesia":[243],"dynamic":[245,423],"CT":[246,424],"images":[247,343,425],"acquired":[248,314,345],"320-detector":[251],"row":[252],"scanner":[253],"(Aquilion":[254],"One,":[255],"Toshiba":[256],"Medical,":[257],"Japan).":[258],"BM":[263,489],"MNCs":[264,490],"labeled":[266,337,453,487,541],"Zirconium-89":[268],"(89Zr)":[269],"assessed":[272],"viability,":[274],"cell":[275],"number,":[276],"level":[279],"radioactivity.":[282],"Radiolabeled":[283],"injected":[287],"pigs":[289],"either":[290],"IV":[291,459],"or":[292,491,544],"directly":[293],"porcine":[297],"pelvis":[298],"at":[299,414],"different":[300,416],"rates.":[302],"Intramarrow(IM)":[303],"pressures":[304,371,388,619],"measured":[306],"continuously":[307],"during":[308,372,389],"Millarcatheters":[312],"simultaneously":[315],"intra-arterial":[317],"pressure":[318],"electrocardiography":[320],"PowerLab":[323],"data":[324,614],"acquisition":[325],"system":[326,355],"(ADInstruments,":[327],"CO)":[328],"analyzed":[330],"LabChart":[332],"7.":[333],"After":[334],"cells,":[338],"positron":[339],"emission":[340],"tomography":[341],"(PET)":[342],"up":[347,477],"180":[349],"minutes":[350],"clinical":[353],"(Gemini":[356],"TF,":[357],"Philips":[358],"Medical":[359],"Systems,":[360],"distribution":[365],"homing.":[367],"Results":[368],"Peak":[369],"IM":[370,387,618],"bolus":[373,512],"hand":[374,405,449,482,513,575],"high,":[378],"substantially":[379],"exceeding":[380],"systemic":[381],"systolic":[382],"arterial":[383,400],"pressures.":[384,401],"contrast,":[386,536,596],"slow":[390,537,597],"significantly":[394],"lower,":[395],"remaining":[396],"well":[397,438,502],"below":[398],"diastolic":[399],"During":[402],"manual":[403,448],"sequential":[404],"5":[409],"ml":[410],"aliquots":[411],"two":[415],"sites":[417],"ipsilateral":[420,444,530],"crest,":[422],"revealed":[426,494],"leakage":[427,567,586,609],"initial":[430],"site":[432,532],"first":[435],"as":[437,439,501,503],"immediate":[440],"drainage":[441],"vein.":[446],"Following":[447],"89Zr":[452,486,540],"human":[454],"(89Zr-hCD34+)":[457],"given":[458],"via":[462],"external":[464],"jugular":[465],"vein,":[466],"there":[467],"persistent":[469],"PET":[470,495,509,548],"activity":[471,496,504,510,549],"noted":[472,518],"lungs":[475],"3":[479],"hrs.":[480],"Bolus":[481],"89Zr-hCD34+":[492],"lungs.":[507,572,594,612],"following":[511,631],"also":[517],"surrounding":[520],"tissues":[521],"outside":[522],"when":[525],"more":[526],"than":[527],"single":[529],"used.":[534],"BMMNCs":[543],"89Zr-hCD34+cells":[545],"resulted":[546],"that":[550],"bone,":[556],"indicating":[557],"space":[564,591,630],"no":[566],"Conclusion":[573],"Rapid":[574],"results":[583],"out":[587],"localizes":[602],"without":[608],"These":[613],"suggest":[615],"maintaining":[616],"low":[617,661],"may":[620],"be":[621,640,651],"critical":[622],"maximize":[624],"trapping":[626],"Further":[637],"study":[638],"will":[639],"required":[641],"determine":[643],"whether":[644],"approach":[649],"can":[650],"used":[652],"improve":[654],"engraftment":[655],"recipients":[657],"transplants":[659],"containing":[660],"numbers.":[663],"Disclosures:":[664],"No":[665],"relevant":[666],"conflicts":[667],"interest":[669],"declare.":[671]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
