{"id":"https://openalex.org/W2979826786","doi":null,"title":"Voluntary Oral Methamphetamine Reveals Susceptibilities to Spatial Memory Deficits, Decreased Dopamine Marker Expression and Increased Neuroinflammation in the Hippocampus of Male and Female Mice","display_name":"Voluntary Oral Methamphetamine Reveals Susceptibilities to Spatial Memory Deficits, Decreased Dopamine Marker Expression and Increased Neuroinflammation in the Hippocampus of Male and Female Mice","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2979826786","mag":"2979826786"},"language":"en","primary_location":{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-4436","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/3511","pdf_url":"https://academicworks.cuny.edu/gc_etds/3511","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://academicworks.cuny.edu/gc_etds/3511","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089353076","display_name":"Jorge A. Avila","orcid":"https://orcid.org/0000-0003-4692-6645","observed_orcids":["https://orcid.org/0000-0003-4692-6645"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jorge A. Avila","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4692-6645","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089353076"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.9340000152587891},{"id":"https://openalex.org/keywords/spatial-memory-impairment","display_name":"spatial memory impairment","score":0.746999979019165},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.5960000157356262},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.7070000171661377},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9459999799728394},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7950000166893005},{"id":"https://openalex.org/keywords/women-s-vulnerability","display_name":"women's vulnerability","score":0.7639999985694885},{"id":"https://openalex.org/keywords/adolescent-vulnerability","display_name":"adolescent vulnerability","score":0.8130000233650208},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.49000000953674316},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/drug-seeking-behavior","display_name":"drug-seeking behavior","score":0.46299999952316284},{"id":"https://openalex.org/keywords/medication-preferences","display_name":"drug preference","score":0.4269999861717224},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.5040000081062317},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.7910000085830688},{"id":"https://openalex.org/keywords/dopamine-d3-receptor","display_name":"dopamine D3 receptor","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8707929849624634},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7931377291679382},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.7915812730789185},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6731094121932983},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5522475242614746},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.42268359661102295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37816551327705383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36489778757095337},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3592100441455841},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.10464966297149658}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-4436","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/3511","pdf_url":"https://academicworks.cuny.edu/gc_etds/3511","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"dissertation"},{"id":"mag:2979826786","doi":null,"is_oa":false,"landing_page_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=4436&context=gc_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-4436","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/3511","pdf_url":"https://academicworks.cuny.edu/gc_etds/3511","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979826786.pdf","grobid_xml":"https://content.openalex.org/works/W2979826786.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W27830552","https://openalex.org/W1011237665","https://openalex.org/W1421120328","https://openalex.org/W1484275259","https://openalex.org/W1499607736","https://openalex.org/W1508866308","https://openalex.org/W1513285718","https://openalex.org/W1561294879","https://openalex.org/W1644437176","https://openalex.org/W1683600212","https://openalex.org/W1963765887","https://openalex.org/W1966130297","https://openalex.org/W1966707689","https://openalex.org/W1970459988","https://openalex.org/W1970606114","https://openalex.org/W1978363134","https://openalex.org/W1979176326","https://openalex.org/W1984824485","https://openalex.org/W1986528761","https://openalex.org/W1990086122","https://openalex.org/W1990374107","https://openalex.org/W1991249144","https://openalex.org/W1992749381","https://openalex.org/W1993087404","https://openalex.org/W1994909073","https://openalex.org/W1997596082","https://openalex.org/W2002480560","https://openalex.org/W2003074165","https://openalex.org/W2004349171","https://openalex.org/W2007383758","https://openalex.org/W2017930136","https://openalex.org/W2019860362","https://openalex.org/W2020142342","https://openalex.org/W2020680049","https://openalex.org/W2030030436","https://openalex.org/W2030055333","https://openalex.org/W2030865965","https://openalex.org/W2037243883","https://openalex.org/W2039668681","https://openalex.org/W2040347331","https://openalex.org/W2040690369","https://openalex.org/W2044199335","https://openalex.org/W2045512359","https://openalex.org/W2045669174","https://openalex.org/W2056512090","https://openalex.org/W2058972512","https://openalex.org/W2064835843","https://openalex.org/W2068540484","https://openalex.org/W2072812706","https://openalex.org/W2072956511","https://openalex.org/W2073422014","https://openalex.org/W2078802567","https://openalex.org/W2087723693","https://openalex.org/W2088935764","https://openalex.org/W2089558078","https://openalex.org/W2091602135","https://openalex.org/W2092112738","https://openalex.org/W2093377694","https://openalex.org/W2093656025","https://openalex.org/W2093894007","https://openalex.org/W2098139332","https://openalex.org/W2099671309","https://openalex.org/W2101674265","https://openalex.org/W2102478882","https://openalex.org/W2114999108","https://openalex.org/W2117792476","https://openalex.org/W2127188314","https://openalex.org/W2127367225","https://openalex.org/W2137070227","https://openalex.org/W2144176813","https://openalex.org/W2144902190","https://openalex.org/W2149275773","https://openalex.org/W2163407153","https://openalex.org/W2168462544","https://openalex.org/W2234297428","https://openalex.org/W2286968510","https://openalex.org/W2334486395","https://openalex.org/W2339971928","https://openalex.org/W2342383856","https://openalex.org/W2625498710","https://openalex.org/W2767397051","https://openalex.org/W2792813804"],"related_works":["https://openalex.org/W6997435808","https://openalex.org/W2785832209","https://openalex.org/W3203708184","https://openalex.org/W4380987025","https://openalex.org/W4412643859","https://openalex.org/W2007859086","https://openalex.org/W2561063447","https://openalex.org/W14902739","https://openalex.org/W4413451898","https://openalex.org/W2170403601"],"abstract_inverted_index":{"Methamphetamine":[0,70,289],"is":[1,204,869,890,1068],"an":[2,56,254,749,809,1267],"addictive":[3],"illicit":[4],"psychostimulant":[5,1011],"that":[6,43,59,154,198,315,323,350,427,480,516,572,595,652,679,790,822,860,868,885,951,962,992,1039,1048,1075,1106,1157,1158,1181,1187,1214,1246,1259,1282],"produces":[7,875],"lasting":[8],"neurochemical":[9,115,159,196,248,296,431,580,695,713,876,1280],"and":[10,38,49,84,105,158,178,185,188,195,212,246,263,295,378,430,485,510,521,563,578,616,664,674,712,719,744,770,782,916,936,980,983,1018,1052,1063,1092,1143,1153,1173,1178,1227,1233,1262,1279,1315,1337,1343],"behavioral":[11,82,194,244,294,533,577,711,743,866,1019,1177,1278,1336],"changes.":[12,249,1254],"The":[13,128,138,694,1061,1323],"mechanisms":[14,129,260,398,1105],"underlying":[15,130,261,399,618,1104],"these":[16,41,131,142,569,857],"deficits":[17,42,160,197,245,297,534,581,598,632,834,1180,1339],"have":[18,312,333,390,650,1044,1351,1361],"been":[19,960],"characterized":[20,230,334,1353],"in":[21,108,152,220,227,253,300,321,335,343,368,383,407,423,469,551,583,590,601,629,644,728,740,804,844,853,896,902,934,965,1010,1025,1079,1087,1094,1099,1110,1211,1222,1230,1276,1298,1303,1312,1356],"animal":[22,585],"models":[23,31,164,302,337,586],"using":[24,633,943],"extremely":[25],"high":[26],"doses.":[27],"Currently,":[28],"better":[29],"translational":[30],"are":[32,136,324,702,996,1271],"needed":[33],"to":[34,76,98,126,134,145,165,237,256,266,292,375,393,417,450,484,491,610,671,690,726,734,753,797,892,912,955,971,1002,1090,1122,1129,1145,1148,1273,1318,1333,1385],"understand":[35,257],"the":[36,47,78,85,156,170,193,224,231,234,258,267,284,329,369,384,397,409,419,528,538,552,576,579,596,602,605,608,617,625,659,708,736,755,805,815,836,845,854,897,906,909,932,1026,1050,1059,1095,1100,1103,1150,1164,1175,1196,1202,1231,1264,1277,1335,1370,1375],"onset":[37],"progression":[39,79,709],"of":[40,64,80,103,141,169,173,233,286,346,396,412,421,505,524,607,627,655,661,688,707,710,738,767,841,850,908,941,1016,1021,1042,1058,1065,1142,1192,1204,1236,1266,1295,1377],"more":[44,1330],"accurately":[45],"reflect":[46],"gradual":[48],"voluntary":[50,90,148,410,464,1166],"dosing":[51],"parameters":[52],"as":[53,298,444,554,587,589,685,799,1381],"chosen":[54],"by":[55,698,716,720,871,1341],"abuser.":[57],"To":[58,269,461,1115],"end,":[60],"a":[61,74,89,147,435,440,452,475,495,544,686,772,784,794,1055,1131,1169,1240,1290,1329],"new":[62,918,1367],"model":[63,151,236,609],"methamphetamine":[65,135,149,189,241,413,592,942,963,1043,1088,1146,1283,1320,1342,1386],"administration,":[66],"labeled":[67],"Voluntary":[68,287],"Oral":[69,288],"Administration":[71,290],"(VOMA),":[72],"offers":[73],"means":[75],"examine":[77],"neurotoxicity,":[81],"deficits,":[83,432,746],"addiction":[86,1012,1023],"process":[87],"through":[88,556,760,801,1260],"consumption":[91,242,426,1167],"framework.":[92],"Female":[93],"populations":[94,967],"show":[95,113,991],"consistent":[96],"vulnerabilities":[97,265],"methamphetamine,":[99,120,211],"including":[100,176,973,1374],"greater":[101,106],"severity":[102],"abuse,":[104],"shifts":[107,1221],"psychological":[109],"health.":[110],"Females":[111],"also":[112,363,703,1288],"increased":[114,122,561,978],"susceptibilities":[116,133,172,954,1355],"during":[117,1345],"abstinence":[118,546,628,656,699,721,739,774,786,861,874,1242,1344],"from":[119,700,730,862,1054],"exhibiting":[121],"grey-matter":[123],"loss":[124],"compared":[125,1001],"controls.":[127],"female-specific":[132,264],"unknown.":[137,1114],"overall":[139],"GOAL":[140],"studies":[143,225,389,649,922,1360],"was":[144,251,472,777,1208],"establish":[146],"administration":[150,216,442,467,497,541,1057,1127,1160],"mice":[153,207,322,446,481,507,526,759,1136,1194,1213,1238,1245,1357],"recapitulates":[155],"cognitive":[157,429,614,642,761],"shown":[161,651,950,1038,1074],"with":[162,309,439,1085,1263],"previous":[163,301,584,1035,1071,1359],"further":[166],"our":[167,271,336,394,1126],"understanding":[168,395,408,706],"long-term":[171,641,828],"at-risk":[174],"populations,":[175],"adolescent":[177,758,910],"female":[179,966,994,1118,1193,1237],"subjects.":[180],"Rodents":[181],"can":[182,191,356,574,639,657,681,968,1284],"exhibit":[183,953,1251],"drug-preference":[184],"drug-seeking":[186],"behaviors,":[187],"challenges":[190],"reproduce":[192],"human":[199,591],"addicts":[200],"show.":[201],"However,":[202,1029,1102],"it":[203,1364],"unclear":[205],"if":[206],"would":[208,218,722,1137,1162],"voluntarily":[209],"consume":[210,492],"what":[213],"effects":[214,372],"this":[215,221,228,344,1030,1066,1076,1108,1159,1256,1348],"design":[217,438,443,752,1128,1161,1326],"produce":[219,238,293,575,640,827,893,1107,1163,1174,1340],"mice.":[222],"Thus,":[223],"presented":[226],"dissertation":[229],"utility":[232,285,420,606],"VOMA":[235,422,573,634,751,781,819,863,944,1248,1325],"1.":[239,386],"naturalistic":[240,1331],"2.":[243],"3.":[247],"This":[250,667,883,904,1206],"done":[252],"effort":[255],"4.":[259],"adolescent-":[262],"drug.":[268,1060],"achieve":[270],"GOAL,":[272],"we":[273,332,433,747,1124,1270,1287,1350],"carried":[274],"out":[275,463],"three":[276],"(3)":[277,847],"specific":[278,691],"aims:":[279],"Specific":[280,621,928],"Aim":[281,622,929],"1:":[282],"Determine":[283],"(VOMA)":[291,468],"seen":[299,800],"[Chapter":[303,635,945],"2]":[304],"In":[305,415,732],"modeling":[306],"MA":[307,354,400,425,456,466,471,493,637,701,717,768,798,888,914],"abuse":[308,638,718,1387],"rodents,":[310],"researchers":[311],"developed":[313],"paradigms":[314],"inject":[316],"neurotoxic":[317],"or":[318,455],"binge":[319,1080],"doses":[320,355,1041,1141,1297],"10":[325],"times":[326],"higher":[327,999],"than":[328,1358],"lower":[330,557,564],"limits":[331],"1":[338],"(reviewed":[339],"in2).":[340],"Previous":[341,947],"work":[342,948,981,1036,1072],"line":[345],"research":[347,1314],"has":[348,949,959,1037,1073,1327,1365],"found":[349,515,789,821,1186],"two":[351],"(2)":[352,548,807,838,1219],"30mg/kg":[353],"acutely":[357,864],"increase":[358,364],"spatial":[359,365,436,811],"working-memory":[360,366,520,812,1191],"performance":[361,523,867],"but":[362,403,647,1070,1301],"errors":[367],"long-term.":[370],"These":[371,387,532],"were":[373,447,482,489,508,512,535,599,1215],"correlated":[374],"decreased":[376,984],"DA":[377,1097,1111],"synaptic":[379],"plasticity":[380],"maker":[381],"expression":[382,840,849],"hippocampus":[385,603,846,855,1232],"prior":[388,1147],"contributed":[391],"significantly":[392],"toxicity":[401],"2,":[402],"offered":[404],"very":[405],"little":[406],"nature":[411,1062],"administration.":[414],"order":[416,733],"characterize":[418,612,735],"producing":[424,741],"produced":[428,715],"combined":[434],"cognition":[437],"drug":[441,540,1022],"follows:":[445],"randomly":[448],"assigned":[449],"either":[451],"water/control":[453],"group":[454],"for":[457,920,977,1007,1383],"28":[458],"consecutive":[459],"days.":[460],"carry":[462],"oral":[465],"mice,":[470],"mixed":[473],"into":[474,1217,1369],"palatable":[476],"sweetened":[477],"oatmeal":[478],"flake":[479],"drawn":[483],"ingested":[486],"orally.":[487],"Mice":[488],"allowed":[490],"throughout":[494],"3-hour":[496],"period,":[498,1134],"within":[499],"15":[500],"min":[501],"intervals.":[502],"Following":[503],"28-days":[504],"VOMA,":[506,1123,1261],"sacrificed,":[509],"tissues":[511],"collected.":[513],"We":[514,788,820,1155,1185],"VOMA:":[517,791],"(1)":[518,792,824,1189],"Decreased":[519,1190],"reference-memory":[522],"male":[525,1212,1299],"on":[527,814,835,988,1195],"radial":[529,1197],"arm":[530,1198],"maze.":[531],"observed":[536,555,582,600,879,1210,1289],"after":[537,683,764,771,780,783,818,1201,1239],"28-day":[539],"period":[542,1172],"over":[543,1168],"2-week":[545,1241],"period.":[547,775,787,1243],"Increased":[549,839],"neurotoxicity":[550],"hippocampus,":[553],"dopamine":[558],"marker":[559,566],"expression,":[560],"neuroinflammation,":[562],"synaptic-plasticity":[565],"expression.":[567],"Overall,":[568,856,1255],"results":[570,858],"indicate":[571,678,859],"well":[588],"addicts.":[593],"Additionally,":[594,1034],"molecular":[597,619,745,894,1179,1253,1306,1338],"highlights":[604,905,1013],"easily":[611],"correlative":[613],"behaviors":[615],"shifts.":[620],"2:":[623],"Characterize":[624,931],"role":[626,737,1376],"perpetuating":[630],"methamphetamine-induced":[631],"3]":[636],"impairments":[643],"abstinent":[645],"individuals3-5":[646],"other":[648,676],"long":[653],"periods":[654],"improve":[658],"recovery":[660,729],"decision":[662],"making-skills":[663],"emotional":[665],"symptoms6.":[666],"may":[668],"help":[669],"individuals":[670],"avert":[672],"relapse":[673,680],"yet,":[675],"reports":[677],"occur":[682],"abstinence7,":[684],"result":[687],"exposure":[689,769,889,915],"environmental":[692],"cues8.":[693],"pathways":[696],"affected":[697],"unclear.":[704],"An":[705],"changes":[714,877,895,1281],"provide":[723,1309],"pharmacological":[724,921],"targets":[725],"aid":[727,1265],"addiction.":[731,1321],"MA-induced":[742,926],"used":[748],"acute":[750,810,887,913],"do":[754],"following:":[756],"put":[757],"assessments":[762],"directly":[763,779,817,880],"14":[765],"days":[766],"prolonged":[773],"Tissue":[776],"collected":[778],"4-week":[785],"Produced":[793,808],"transient":[795],"sensitization":[796],"behavior":[802,935,1053],"analyses":[803],"drug-context":[806],"deficit":[813,1207],"RAM":[816,837],"abstinence:":[823],"Did":[825],"not":[826,878,900,1209,1250,1302],"working-memory,":[829],"reference":[830],"learning,":[831],"nor":[832],"retention":[833],"neuroinflammatory":[842],"markers":[843,1382],"Modulated":[848],"monoamine":[851],"proteins":[852],"affects":[865],"ameliorated":[870],"abstinence.":[872],"Further,":[873],"following":[881,938],"VOMA.":[882,1205,1218],"demonstrates":[884],"even":[886],"sufficient":[891],"brain":[898,911,1051],"despite":[899],"manifesting":[901],"behavior.":[903],"susceptibility":[907],"provides":[917],"avenues":[919],"aimed":[923],"at":[924,998],"preventing":[925],"deficits.":[927],"3:":[930],"sex-differences":[933,1275,1371],"neurochemistry":[937],"escalating":[939,1040,1140,1296],"dose":[940],"4]":[946],"females":[952],"psychostimulant-addiction":[956],"9-12.":[957],"It":[958],"reported":[961,1292],"use":[964],"be":[969,1183],"attributed":[970],"factors":[972],"weight":[974],"loss,":[975],"desire":[976],"energy":[979],"output,":[982],"exhaustion":[985],"13-14.":[986],"Data":[987],"drug-rehabilitation":[989],"admissions":[990],"young":[993],"participants":[995],"admitted":[997],"rates":[1000],"males":[1003],"15.":[1004],"One":[1005],"hypothesis":[1006],"sex":[1008],"differences":[1009],"estrogen\u2019s":[1014],"facilitation":[1015],"neuronal":[1017],"development":[1020],"processes":[1024],"brain.":[1027],"16-18.":[1028],"idea":[1031],"remains":[1032],"untested.":[1033],"intrinsic":[1045],"neuroprotective":[1046,1223,1293,1378],"qualities":[1047],"protect":[1049],"chronic":[1056],"source":[1064],"neuroprotection":[1067],"unclear,":[1069],"phenomenon":[1077],"occurs":[1078],"injection":[1081],"models,":[1082],"19-20,":[1083],"associated":[1084],"decreases":[1086,1093],"binding":[1089],"DAT":[1091],"resulting":[1096],"availability":[1098],"synapse.":[1101],"change":[1109],"sensitivity":[1112],"remain":[1113],"test":[1116],"how":[1117],"subjects":[1119],"respond":[1120],"differentially":[1121],"modified":[1125],"include":[1130],"10-day":[1132],"escalation":[1133],"wherein":[1135],"receive":[1138],"gradually":[1139],"access":[1144,1152],"receiving":[1149],"maximum":[1151],"dose.":[1154],"hypothesized":[1156],"maximal":[1165,1176],"shorter":[1170],"(18-day)":[1171],"could":[1182],"observed.":[1184],"Escalation-VOMA:":[1188],"maze":[1199],"shortly":[1200],"conclusion":[1203],"placed":[1216],"Discrete":[1220],"signaling":[1224,1380],"(D1,":[1225],"ER\u03b1":[1226],"Akt/GSK3\u03b2":[1228],"pathway)":[1229],"nucleus":[1234],"accumbens":[1235],"Male":[1244],"underwent":[1247],"did":[1249],"any":[1252],"study":[1257],"showed":[1258],"escalating-dose":[1268],"design,":[1269],"able":[1272],"observe":[1274],"produce.":[1285],"Interestingly,":[1286],"previously":[1291],"effect":[1294],"subjects,":[1300],"females.":[1304],"Our":[1305],"investigations":[1307],"will":[1308],"future":[1310],"direction":[1311],"basic":[1313],"clinical":[1316],"endeavors":[1317],"target":[1319],"Conclusion:":[1322],"novel":[1324],"provided":[1328,1366],"approach":[1332],"investigating":[1334],"adolescence.":[1346],"With":[1347],"model,":[1349],"successfully":[1352],"longer-term":[1354],"shown.":[1362],"Furthermore,":[1363],"insights":[1368],"surrounding":[1372],"meth-abuse,":[1373],"pathway":[1379],"susceptibilities/resilience":[1384]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}
