{"id":"https://openalex.org/W2979824923","doi":"https://doi.org/10.1146/annurev-ento-011019-024918","title":"The Global Expansion of Dengue: How Aedes aegypti Mosquitoes Enabled the First Pandemic Arbovirus","display_name":"The Global Expansion of Dengue: How Aedes aegypti Mosquitoes Enabled the First Pandemic Arbovirus","publication_year":2019,"publication_date":"2019-10-08","ids":{"openalex":"https://openalex.org/W2979824923","doi":"https://doi.org/10.1146/annurev-ento-011019-024918","mag":"2979824923","pmid":"https://pubmed.ncbi.nlm.nih.gov/31594415"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-ento-011019-024918","doi":"https://doi.org/10.1146/annurev-ento-011019-024918","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-ento-011019-024918","pdf_url":null,"source":{"id":"https://openalex.org/S92576693","display_name":"Annual Review of Entomology","issn_l":"0066-4170","issn":["0066-4170","1545-4487"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Entomology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029644779","display_name":"Oliver J. Brady","orcid":"https://orcid.org/0000-0002-3235-2129","observed_orcids":["https://orcid.org/0000-0002-3235-2129"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oliver J. Brady","raw_affiliation_strings":["Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, United Kingdom","Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, United Kingdom;","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031889135","display_name":"Simon Iain Hay","orcid":"https://orcid.org/0000-0002-0611-7272","observed_orcids":["https://orcid.org/0000-0002-0611-7272"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I3143470655","display_name":"Institute for Health Metrics and Evaluation","ror":"https://ror.org/02684h094","country_code":"US","type":"facility","lineage":["https://openalex.org/I3143470655"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon I. Hay","raw_affiliation_strings":["Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington 98121, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington 98121, USA;","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I3143470655"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6085,"has_fulltext":false,"cited_by_count":422,"citation_normalized_percentile":{"value":0.97165116,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"65","issue":"1","first_page":"191","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14053","display_name":"Dengue and Mosquito Control Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12606","display_name":"Diptera species taxonomy and behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue","display_name":"dengue","score":0.9869999885559082},{"id":"https://openalex.org/keywords/aedes-aegypti","display_name":"Aedes aegypti","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mosquito-vectors","display_name":"mosquito vectors","score":0.6060000061988831},{"id":"https://openalex.org/keywords/invasive-species","display_name":"invasive species","score":0.6340000033378601},{"id":"https://openalex.org/keywords/mosquito-bionomics","display_name":"mosquito bionomics","score":0.781000018119812},{"id":"https://openalex.org/keywords/urbanization","display_name":"urbanization","score":0.5690000057220459},{"id":"https://openalex.org/keywords/geographic-heterogeneity","display_name":"geographic heterogeneity","score":0.6050000190734863},{"id":"https://openalex.org/keywords/dengue-risk","display_name":"dengue risk","score":0.7390000224113464},{"id":"https://openalex.org/keywords/vector-control","display_name":"vector control","score":0.7799999713897705},{"id":"https://openalex.org/keywords/emerging-infectious-diseases","display_name":"emerging infectious diseases","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2777775583","wikidata":"https://www.wikidata.org/wiki/Q1148004","display_name":"Aedes aegypti","level":3,"score":0.8862555027008057},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.8633490800857544},{"id":"https://openalex.org/C2778116200","wikidata":"https://www.wikidata.org/wiki/Q630622","display_name":"Arbovirus","level":3,"score":0.8508467674255371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.761162281036377},{"id":"https://openalex.org/C2780688631","wikidata":"https://www.wikidata.org/wiki/Q310911","display_name":"Aedes","level":3,"score":0.6090748906135559},{"id":"https://openalex.org/C20137635","wikidata":"https://www.wikidata.org/wiki/Q84266661","display_name":"Bionomics","level":3,"score":0.6077495813369751},{"id":"https://openalex.org/C2781273456","wikidata":"https://www.wikidata.org/wiki/Q243257","display_name":"Chikungunya","level":3,"score":0.5752555131912231},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.5308229327201843},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.49548375606536865},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4426299035549164},{"id":"https://openalex.org/C2779131611","wikidata":"https://www.wikidata.org/wiki/Q154874","display_name":"Yellow fever","level":3,"score":0.43714338541030884},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.4332415759563446},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39121150970458984},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.25398895144462585},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.2481479048728943},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18974018096923828},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.17291608452796936},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.06665465235710144},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072138","descriptor_name":"Mosquito Vectors","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000330","descriptor_name":"Aedes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063147","descriptor_name":"Animal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev-ento-011019-024918","doi":"https://doi.org/10.1146/annurev-ento-011019-024918","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-ento-011019-024918","pdf_url":null,"source":{"id":"https://openalex.org/S92576693","display_name":"Annual Review of Entomology","issn_l":"0066-4170","issn":["0066-4170","1545-4487"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Entomology","raw_type":"journal-article"},{"id":"pmid:31594415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31594415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of entomology","raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.lshtm.ac.uk:4655868","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.lshtm.ac.uk/view/creators/eideobra.html>;","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8546933582","display_name":"Estimating the burden of dengue, chikungunya and Zika in Latin America","funder_award_id":"206471/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W81413626","https://openalex.org/W121203912","https://openalex.org/W778596373","https://openalex.org/W1603776221","https://openalex.org/W1729017034","https://openalex.org/W1841056794","https://openalex.org/W1967032136","https://openalex.org/W1967519805","https://openalex.org/W1970794063","https://openalex.org/W1972095223","https://openalex.org/W1973509312","https://openalex.org/W1974553284","https://openalex.org/W1976841934","https://openalex.org/W1983876149","https://openalex.org/W1984710011","https://openalex.org/W1990268963","https://openalex.org/W1993268068","https://openalex.org/W1996883424","https://openalex.org/W2004106419","https://openalex.org/W2010207445","https://openalex.org/W2012210128","https://openalex.org/W2015611314","https://openalex.org/W2017266174","https://openalex.org/W2022042750","https://openalex.org/W2025675035","https://openalex.org/W2028106690","https://openalex.org/W2029878680","https://openalex.org/W2036406967","https://openalex.org/W2038726452","https://openalex.org/W2041726738","https://openalex.org/W2045828408","https://openalex.org/W2049744921","https://openalex.org/W2052056237","https://openalex.org/W2052805597","https://openalex.org/W2056298081","https://openalex.org/W2056614797","https://openalex.org/W2057714704","https://openalex.org/W2058647993","https://openalex.org/W2059180816","https://openalex.org/W2062504884","https://openalex.org/W2064738366","https://openalex.org/W2082960368","https://openalex.org/W2084485529","https://openalex.org/W2084497367","https://openalex.org/W2092335867","https://openalex.org/W2092383132","https://openalex.org/W2096551676","https://openalex.org/W2097791007","https://openalex.org/W2101707423","https://openalex.org/W2101729662","https://openalex.org/W2102728752","https://openalex.org/W2104024599","https://openalex.org/W2113180976","https://openalex.org/W2124659818","https://openalex.org/W2126789944","https://openalex.org/W2128131098","https://openalex.org/W2128179764","https://openalex.org/W2128442442","https://openalex.org/W2131222241","https://openalex.org/W2131384895","https://openalex.org/W2132582148","https://openalex.org/W2135468575","https://openalex.org/W2142812366","https://openalex.org/W2147557549","https://openalex.org/W2149671007","https://openalex.org/W2150604056","https://openalex.org/W2150812798","https://openalex.org/W2153166259","https://openalex.org/W2155742778","https://openalex.org/W2157345729","https://openalex.org/W2159061711","https://openalex.org/W2159886246","https://openalex.org/W2159993117","https://openalex.org/W2160142452","https://openalex.org/W2166283055","https://openalex.org/W2167361947","https://openalex.org/W2172696428","https://openalex.org/W2179314165","https://openalex.org/W2187937073","https://openalex.org/W2205335187","https://openalex.org/W2205703891","https://openalex.org/W2235552558","https://openalex.org/W2255246881","https://openalex.org/W2265624047","https://openalex.org/W2271242314","https://openalex.org/W2299228959","https://openalex.org/W2320307170","https://openalex.org/W2329703118","https://openalex.org/W2333289204","https://openalex.org/W2333736406","https://openalex.org/W2338936985","https://openalex.org/W2341602971","https://openalex.org/W2409707370","https://openalex.org/W2478427978","https://openalex.org/W2521048183","https://openalex.org/W2525424881","https://openalex.org/W2560496028","https://openalex.org/W2586742724","https://openalex.org/W2586756644","https://openalex.org/W2590061388","https://openalex.org/W2603245055","https://openalex.org/W2617274523","https://openalex.org/W2620380452","https://openalex.org/W2737124609","https://openalex.org/W2738161666","https://openalex.org/W2753458334","https://openalex.org/W2757326195","https://openalex.org/W2761119009","https://openalex.org/W2765619750","https://openalex.org/W2776694869","https://openalex.org/W2784354529","https://openalex.org/W2792998631","https://openalex.org/W2793228617","https://openalex.org/W2803273577","https://openalex.org/W2804005571","https://openalex.org/W2805123769","https://openalex.org/W2807989886","https://openalex.org/W2887096161","https://openalex.org/W2897832107","https://openalex.org/W2898415061","https://openalex.org/W2900744933","https://openalex.org/W2910185668","https://openalex.org/W2912654919","https://openalex.org/W2936380919","https://openalex.org/W2950420258","https://openalex.org/W2950860230","https://openalex.org/W2952094509","https://openalex.org/W4236955018","https://openalex.org/W4239421637","https://openalex.org/W4246438352"],"related_works":["https://openalex.org/W4414321816","https://openalex.org/W3159616154","https://openalex.org/W4400942543","https://openalex.org/W2883162659","https://openalex.org/W2319052263","https://openalex.org/W4414046338","https://openalex.org/W7100097488","https://openalex.org/W7161628305","https://openalex.org/W4211101161","https://openalex.org/W1480904053"],"abstract_inverted_index":{"Dengue":[0],"is":[1,16,32,46],"an":[2],"emerging":[3],"viral":[4],"disease":[5,92],"principally":[6],"transmitted":[7],"by":[8,60],"the":[9,19,47,66,76],"Aedes":[10],"(":[11],"Stegomyia)":[12],"aegypti":[13,52,80],"mosquito.":[14],"It":[15],"one":[17],"of":[18,39,50,68,78],"fastest-growing":[20],"global":[21,126],"infectious":[22],"diseases,":[23],"with":[24],"100\u2013400":[25],"million":[26],"new":[27,55],"infections":[28],"a":[29,36,54,85,105],"year,":[30],"and":[31,70,89,119],"now":[33],"entrenched":[34],"in":[35,75,100],"growing":[37],"number":[38],"tropical":[40],"megacities.":[41],"Behind":[42],"this":[43],"rapid":[44],"rise":[45],"simple":[48],"adaptation":[49],"Ae.":[51,79],"to":[53,83,113,123],"entomological":[56],"niche":[57],"carved":[58],"out":[59],"human":[61],"habitation.":[62],"This":[63],"review":[64],"describes":[65],"expansion":[67],"dengue":[69,117],"explores":[71],"how":[72],"key":[73,106],"changes":[74],"ecology":[77],"allowed":[81],"it":[82],"become":[84],"successful":[86],"invasive":[87],"species":[88],"highly":[90],"efficient":[91],"vector.":[93],"We":[94],"argue":[95],"that":[96,109],"characterizing":[97],"geographic":[98],"heterogeneity":[99],"mosquito":[101],"bionomics":[102],"will":[103,110],"be":[104],"research":[107],"priority":[108],"enable":[111],"us":[112],"better":[114],"understand":[115],"future":[116],"risk":[118],"design":[120],"control":[121],"strategies":[122],"reverse":[124],"its":[125],"spread.":[127]},"counts_by_year":[{"year":2026,"cited_by_count":62},{"year":2025,"cited_by_count":71},{"year":2024,"cited_by_count":85},{"year":2023,"cited_by_count":69},{"year":2022,"cited_by_count":54},{"year":2021,"cited_by_count":45},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-10-18T00:00:00"}
