{"id":"https://openalex.org/W2979818639","doi":"https://doi.org/10.1182/blood.v114.22.3813.3813","title":"Increased Proliferation Induced by Constitutive Activation of the Src-Kinase Lyn and Aberrant mTOR Signaling in AML Is Abrogated by the EGFR-Inhibitor Erlotinib.","display_name":"Increased Proliferation Induced by Constitutive Activation of the Src-Kinase Lyn and Aberrant mTOR Signaling in AML Is Abrogated by the EGFR-Inhibitor Erlotinib.","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W2979818639","doi":"https://doi.org/10.1182/blood.v114.22.3813.3813","mag":"2979818639"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v114.22.3813.3813","doi":"https://doi.org/10.1182/blood.v114.22.3813.3813","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.3813.3813","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084675513","display_name":"Simone Boehrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210091279","display_name":"Universit\u00e9 Sorbonne Paris Nord","ror":"https://ror.org/0199hds37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210091279"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210129146","display_name":"H\u00f4pital Avicenne","ror":"https://ror.org/03n6vs369","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Simone Boehrer","raw_affiliation_strings":["Hopital Avicenne, AP-HP, Universite\u0301 Paris XIII and 1INSERM 848, Institut Gustave Roussy, Bobigny, France,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Avicenne, AP-HP, Universite\u0301 Paris XIII and 1INSERM 848, Institut Gustave Roussy, Bobigny, France,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210091279","https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071827163","display_name":"Lorenzo Galluzzi","orcid":"https://orcid.org/0000-0003-2257-8500","observed_orcids":["https://orcid.org/0000-0003-2257-8500"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Lorenzo Galluzzi","raw_affiliation_strings":["Institut Gustave Roussy, INSERM U848, Villejuif, France,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, INSERM U848, Villejuif, France,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007605254","display_name":"Lionel Ad\u00e8s","orcid":"https://orcid.org/0000-0002-9020-8766","observed_orcids":["https://orcid.org/0000-0002-9020-8766"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210091279","display_name":"Universit\u00e9 Sorbonne Paris Nord","ror":"https://ror.org/0199hds37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210091279"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210129146","display_name":"H\u00f4pital Avicenne","ror":"https://ror.org/03n6vs369","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lionel Ades","raw_affiliation_strings":["Hopital Avicenne, AP-HP, Universite\u0301 Paris XIII and 1INSERM 848, Institut Gustave Roussy, Bobigny, France,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Avicenne, AP-HP, Universite\u0301 Paris XIII and 1INSERM 848, Institut Gustave Roussy, Bobigny, France,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210091279","https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037013767","display_name":"Celine Fouassier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Celine Fouassier","raw_affiliation_strings":["Institut Gustave Roussy, INSERM U848, Villejuif, France,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, INSERM U848, Villejuif, France,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054745373","display_name":"Claude Gardin","orcid":"https://orcid.org/0000-0001-9934-3748","observed_orcids":["https://orcid.org/0000-0001-9934-3748"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210129146","display_name":"H\u00f4pital Avicenne","ror":"https://ror.org/03n6vs369","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Claude Gardin","raw_affiliation_strings":["Hopital Avicenne, AP-HP, Universite\u0301 Paris XIII, Bobigny, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Avicenne, AP-HP, Universite\u0301 Paris XIII, Bobigny, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014838075","display_name":"Pierre Fenaux","orcid":"https://orcid.org/0000-0002-0468-3553","observed_orcids":["https://orcid.org/0000-0002-0468-3553"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210091279","display_name":"Universit\u00e9 Sorbonne Paris Nord","ror":"https://ror.org/0199hds37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210091279"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210129146","display_name":"H\u00f4pital Avicenne","ror":"https://ror.org/03n6vs369","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Fenaux","raw_affiliation_strings":["Hopital Avicenne, AP-HP, Universite\u0301 Paris XIII and 1INSERM 848, Institut Gustave Roussy, Bobigny, France,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Avicenne, AP-HP, Universite\u0301 Paris XIII and 1INSERM 848, Institut Gustave Roussy, Bobigny, France,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210091279","https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075296559","display_name":"Guido Kroemer","orcid":"https://orcid.org/0000-0002-9334-4405","observed_orcids":["https://orcid.org/0000-0002-9334-4405"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Guido Kroemer","raw_affiliation_strings":["Institut Gustave Roussy, INSERM U848, Villejuif, France,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, INSERM U848, Villejuif, France,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5037013767","https://openalex.org/A5054745373","https://openalex.org/A5071827163","https://openalex.org/A5075296559","https://openalex.org/A5084675513"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802","https://openalex.org/I4210091279","https://openalex.org/I4210097159","https://openalex.org/I4210129146"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44478208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"114","issue":"22","first_page":"3813","last_page":"3813"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9269999861717224},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.777999997138977},{"id":"https://openalex.org/keywords/lyn-kinase","display_name":"Lyn kinase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.7900000214576721},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.7390000224113464},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6480000019073486},{"id":"https://openalex.org/keywords/pp2","display_name":"PP2","score":0.49300000071525574},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.699999988079071},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.625},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.5879999995231628},{"id":"https://openalex.org/keywords/kg-1-cells","display_name":"KG-1 cells","score":0.6980000138282776},{"id":"https://openalex.org/keywords/piceatannol","display_name":"piceatannol","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.951184868812561},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.7428250908851624},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6772003173828125},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.6694560050964355},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5708215832710266},{"id":"https://openalex.org/C2779976819","wikidata":"https://www.wikidata.org/wiki/Q7582406","display_name":"Src family kinase","level":4,"score":0.5534574389457703},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4948720335960388},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4844096302986145},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4738215208053589},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.44656825065612793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4292146563529968},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3866618871688843},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3679817318916321},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.34985458850860596},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16373354196548462},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1398545801639557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06384438276290894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v114.22.3813.3813","doi":"https://doi.org/10.1182/blood.v114.22.3813.3813","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.3813.3813","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086896374","https://openalex.org/W2580810949","https://openalex.org/W2332993025","https://openalex.org/W2582478466","https://openalex.org/W1979389466","https://openalex.org/W2002393876","https://openalex.org/W7095142036","https://openalex.org/W2550978857","https://openalex.org/W2082183475","https://openalex.org/W2036716522"],"abstract_inverted_index":{"Abstract":[0,1],"3813":[2],"Poster":[3],"Board":[4],"III-749":[5],"Background":[6],"Aberrant":[7],"activation":[8,24,300,399],"of":[9,25,38,87,124,156,168,189,224,262,276,316,330,340,346,354,363,371,378,396,409,422,429,435,463,479,490,494,499,513],"intracellular":[10],"tyrosine":[11],"kinases":[12],"(such":[13],"as":[14,20,22,365],"the":[15,36,64,98,154,164,186,190,241,245,253,274,282,290,313,317,341,347,355,360,427,441,445,460,476,487,511],"Src":[16],"family":[17],"kinases,":[18],"SFK)":[19],"well":[21],"constitutive":[23,187],"mTOR":[26,308,318,356,398,500],"signaling":[27],"contribute":[28],"to":[29,47,209,240,375,392,402,458,475],"leukemogenesis":[30],"by":[31,105,135,172,176,212,226,230,244,252,288,332,443],"inducing":[32],"pro-proliferative":[33,305],"signals":[34],"in":[35,51,69,72,75,89,153,195,198,235,279,301,416,451,481,507,510],"majority":[37],"AML":[39,78,117,200,302,514],"cases.":[40],"Both":[41],"pathways":[42],"are":[43],"considered":[44],"\u2013":[45,54],"due":[46],"their":[48],"restricted":[49],"deregulation":[50],"neoplastic":[52],"cells":[53,112,264,380],"attractive":[55],"therapeutic":[56,477],"targets.":[57],"We":[58,95,413,469],"and":[59,71,77,113,121,137,145,163,175,197,267,323,345,384,425,454,466,484],"others":[60],"provided":[61],"evidence":[62,296,489],"that":[63,100,284,297,415],"epidermal-growth-factor-receptor":[65],"(EGFR)-inhibitor":[66],"erlotinib":[67,101,134,184,227,268,336,367,385,419,447,480],"has":[68],"vivo":[70,115],"vitro":[73],"efficacy":[74],"MDS":[76],"(Boehrer":[79],"et":[80],"al.,":[81],"Blood,":[82],"2008),":[83],"but":[84,250],"its":[85,213,218,304,495],"mode":[86],"action":[88],"these":[90],"EGFR-negative":[91,452],"blasts":[92],"remained":[93],"elusive.":[94],"thus":[96],"tested":[97,130],"hypothesis":[99],"exhibits":[102,448],"anti-leukemic":[103],"activity":[104,450],"targeting":[106],"SFK.":[107],"Methods":[108],"In":[109,148],"erlotinib-sensitive":[110],"KG-1":[111,196,263,379,417],"ex":[114],"patient":[116],"blast":[118],"cells,":[119,201,418],"expression":[120,421],"phosphorylation":[122,188,314,339],"status":[123,315],"individual":[125],"SFK":[126,191,246],"(Lyn,":[127],"Syk)":[128],"was":[129,170,228],"under":[131,411],"incubation":[132,331],"with":[133,265,281,381,497],"immunobloting":[136],"FACS-analysis,":[138],"while":[139,202],"concomitantly":[140],"assessing":[141],"proliferation/cell":[142],"cycle":[143,233],"distribution":[144],"apoptosis":[146],"(FACS-analysis).":[147],"addition,":[149],"experiments":[150],"were":[151],"recapitulated":[152,239],"presence":[155],"SRC-family":[157],"inhibitors":[158,498],"(PP2,":[159],"Piceatannol,":[160],"BAY":[161,258],"61-3606)":[162],"mTOR-inhibitor":[165],"rapamycine.":[166],"Induction":[167],"autophagy":[169,403,410],"determined":[171],"immunoblot":[173,333],"analysis":[174],"ultastructural":[177],"assessment":[178],"using":[179],"electron":[180],"microscopy":[181],"(EM).":[182],"Results":[183],"abrogated":[185],"Lyn":[192,299],"(immunoblot,":[193],"FACS)":[194],"patient-derived":[199],"having":[203],"no":[204,270],"impact":[205],"on":[206,273],"p-Syk":[207],"(reported":[208],"be":[210],"decreased":[211],"\u201csister\u201d":[214],"compound":[215],"gefitinib)":[216],"or":[217,257,515],"downstream":[219],"target":[220],"p-Cbl.":[221],"Moreover,":[222],"inhibition":[223,395],"p-Lyn":[225],"accompanied":[229],"a":[231,472,491],"cell":[232],"arrest":[234],"G1,":[236],"an":[237,369],"effect":[238],"same":[242,291,361],"extent":[243,275,362],"inhibitor":[247,357],"PP2":[248,266],"(10mM),":[249],"not":[251,508],"Syk-inhibitors":[254],"Piceatannol":[255],"(10mM)":[256],"61-3606":[259],"(50nM).":[260],"Co-incubation":[261],"had":[269],"additive/synergistic":[271],"effects":[272,306,462],"G1":[277],"arrest,":[278],"accordance":[280],"notion,":[283],"both":[285,382,433],"agents":[286],"function":[287],"inhibiting":[289],"target/pathway.":[292],"Since":[293,394],"there":[294],"is":[295],"aberrant":[298,397,464],"confers":[303],"via":[307],"signaling,":[309],"we":[310,405],"next":[311,406],"assessed":[312,407],"targets":[319],"p70S6":[320,344],"kinase":[321,343],"(Thr389)":[322],"4E-BP1":[324],"(Ser65).":[325],"As":[326],"demonstrated":[327],"after":[328],"4h":[329],"analysis,":[334],"10mM":[335,366],"significantly":[337],"diminished":[338],"G1-regulating":[342],"translation":[348],"repressor":[349],"4E-PB1.":[350],"Noteworthy,":[351],"whereas":[352],"10nM":[353],"rapamycin":[358,383],"induced":[359],"G1-arrest":[364,388],"(ie":[368],"increase":[370],"about":[372],"10%":[373],"compared":[374,391],"controls),":[376],"co-incubation":[377],"further":[386],"increased":[387],"(by":[389],"15-20%":[390],"controls).":[393],"can":[400],"lead":[401],"(\u201cself-eating\u201d),":[404],"parameters":[408],"erlotinib.":[412],"showed":[414],"up-regulates":[420],"LCII":[423],"(immunoblot)":[424],"induces":[426],"appearance":[428],"autophagic":[430],"vacuolation":[431],"(EM),":[432],"correlates":[434],"autophagy.":[436],"Conclusions":[437],"These":[438],"results":[439],"delineate":[440],"pathway":[442],"which":[444],"EGFR-inhibitor":[446],"antileukemic":[449],"AML,":[453],"demonstrate":[455],"erlotinib's":[456],"capacity":[457],"antagonize":[459],"pro-survival":[461],"Lyn-":[465],"mTOR-mediated":[467],"signaling.":[468,501],"therefore":[470],"provide":[471],"mechanistic":[473],"explanation":[474],"benefit":[478,493],"AML/MDS":[482],"patients,":[483],"also":[485],"give":[486],"first":[488],"potential":[492],"combination":[496],"Disclosures:":[502],"Off":[503],"Label":[504],"Use:":[505],"Erlotinib":[506],"approved":[509],"treatment":[512],"MDS.":[516],"Fenaux:cELGENE:":[517],"Research":[518,521],"Funding;":[519],"AMGEN:":[520],"Funding.":[522]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-10-18T00:00:00"}
