{"id":"https://openalex.org/W2979800294","doi":"https://doi.org/10.1523/jneurosci.1566-19.2019","title":"Tiam1 is Critical for Glutamatergic Synapse Structure and Function in the Hippocampus","display_name":"Tiam1 is Critical for Glutamatergic Synapse Structure and Function in the Hippocampus","publication_year":2019,"publication_date":"2019-10-09","ids":{"openalex":"https://openalex.org/W2979800294","doi":"https://doi.org/10.1523/jneurosci.1566-19.2019","mag":"2979800294","pmid":"https://pubmed.ncbi.nlm.nih.gov/31597723","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6867819"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1566-19.2019","doi":"https://doi.org/10.1523/jneurosci.1566-19.2019","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1566-19.2019","pdf_url":"https://www.jneurosci.org/content/jneuro/39/47/9306.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/39/47/9306.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008703233","display_name":"Sadhna Rao","orcid":"https://orcid.org/0000-0001-6859-0236","observed_orcids":["https://orcid.org/0000-0001-6859-0236"]},"institutions":[{"id":"https://openalex.org/I4210129690","display_name":"Department of Biological Sciences","ror":"https://ror.org/038rjvd86","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sadhna Rao","raw_affiliation_strings":["Department of Biological Sciences, and","1Department of Biological Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, and","institution_ids":["https://openalex.org/I4210129690"]},{"raw_affiliation_string":"1Department of Biological Sciences, and","institution_ids":["https://openalex.org/I4210129690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017247610","display_name":"Yuni Kay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129690","display_name":"Department of Biological Sciences","ror":"https://ror.org/038rjvd86","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yuni Kay","raw_affiliation_strings":["Department of Biological Sciences, and","1Department of Biological Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, and","institution_ids":["https://openalex.org/I4210129690"]},{"raw_affiliation_string":"1Department of Biological Sciences, and","institution_ids":["https://openalex.org/I4210129690"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066863619","display_name":"Bruce E. Herring","orcid":"https://orcid.org/0000-0002-6974-5911","observed_orcids":["https://orcid.org/0000-0002-6974-5911"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210129690","display_name":"Department of Biological Sciences","ror":"https://ror.org/038rjvd86","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Bruce E. Herring","raw_affiliation_strings":["Department of Biological Sciences, and bherring@usc.edu","The Bridge Institute, University of Southern California, Los Angeles, California 90089","1Department of Biological Sciences, and","2The Bridge Institute, University of Southern California, Los Angeles, California 90089"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, and bherring@usc.edu","institution_ids":[]},{"raw_affiliation_string":"The Bridge Institute, University of Southern California, Los Angeles, California 90089","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"1Department of Biological Sciences, and","institution_ids":["https://openalex.org/I4210129690"]},{"raw_affiliation_string":"2The Bridge Institute, University of Southern California, Los Angeles, California 90089","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2932,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.770886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"39","issue":"47","first_page":"9306","last_page":"9315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tiam1","display_name":"Tiam1","score":1.0},{"id":"https://openalex.org/keywords/rhogef","display_name":"RhoGEF","score":0.8560000061988831},{"id":"https://openalex.org/keywords/glutamatergic-synapses","display_name":"glutamatergic synapses","score":0.972000002861023},{"id":"https://openalex.org/keywords/dentate-granule-cells","display_name":"dentate gyrus granule cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9430000185966492},{"id":"https://openalex.org/keywords/schaffer-collateral-ca1-synapses","display_name":"Schaffer collateral-CA1 synapses","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6449999809265137},{"id":"https://openalex.org/keywords/synaptic-development","display_name":"synaptic development","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C2776168963","wikidata":"https://www.wikidata.org/wiki/Q7168164","display_name":"Perforant path","level":4,"score":0.8163985013961792},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.8129256367683411},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7665156126022339},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.7307535409927368},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.6807838678359985},{"id":"https://openalex.org/C2911154596","wikidata":"https://www.wikidata.org/wiki/Q7168164","display_name":"Perforant Pathway","level":5,"score":0.5441348552703857},{"id":"https://openalex.org/C154559735","wikidata":"https://www.wikidata.org/wiki/Q7514768","display_name":"Silent synapse","level":5,"score":0.5277726650238037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.526972770690918},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5065373182296753},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.4546610713005066},{"id":"https://openalex.org/C99223954","wikidata":"https://www.wikidata.org/wiki/Q5419646","display_name":"Excitatory synapse","level":4,"score":0.4146578907966614},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.2815726399421692},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25812065601348877},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.16922935843467712},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.11878320574760437},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11308008432388306},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.09122508764266968},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075684","descriptor_name":"T-Lymphoma Invasion and Metastasis-inducing Protein 1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000075684","descriptor_name":"T-Lymphoma Invasion and Metastasis-inducing Protein 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.1566-19.2019","doi":"https://doi.org/10.1523/jneurosci.1566-19.2019","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1566-19.2019","pdf_url":"https://www.jneurosci.org/content/jneuro/39/47/9306.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6867819","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6867819","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:31597723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31597723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1566-19.2019","doi":"https://doi.org/10.1523/jneurosci.1566-19.2019","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1566-19.2019","pdf_url":"https://www.jneurosci.org/content/jneuro/39/47/9306.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3465643812","display_name":"Kalirin-7's role in synaptic transmission, plasticity and learning and memory","funder_award_id":"R00MH103398","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7120906853","display_name":"Uncovering the Role of TRIO in Synaptic Function and Autism Spectrum Disorder","funder_award_id":"R01NS112480","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8487524403","display_name":"Kalirin-7's role in synaptic transmission, plasticity and learning and memory","funder_award_id":"K99MH103398","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320308324","display_name":"McKnight Foundation","ror":"https://ror.org/003ghvj67"},{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979800294.pdf","grobid_xml":"https://content.openalex.org/works/W2979800294.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1494623690","https://openalex.org/W1500337621","https://openalex.org/W1510981253","https://openalex.org/W1657343628","https://openalex.org/W1798313689","https://openalex.org/W1855713874","https://openalex.org/W1887383255","https://openalex.org/W1937980604","https://openalex.org/W1965670425","https://openalex.org/W1972334605","https://openalex.org/W1977679299","https://openalex.org/W1983097317","https://openalex.org/W1986627859","https://openalex.org/W1989143807","https://openalex.org/W1998195598","https://openalex.org/W2000209446","https://openalex.org/W2003944475","https://openalex.org/W2010850820","https://openalex.org/W2011965698","https://openalex.org/W2023517550","https://openalex.org/W2031746153","https://openalex.org/W2033133179","https://openalex.org/W2035203219","https://openalex.org/W2037221789","https://openalex.org/W2037670359","https://openalex.org/W2040071727","https://openalex.org/W2045964630","https://openalex.org/W2047970216","https://openalex.org/W2052689712","https://openalex.org/W2062317659","https://openalex.org/W2066622533","https://openalex.org/W2069863147","https://openalex.org/W2072923404","https://openalex.org/W2074540355","https://openalex.org/W2075497451","https://openalex.org/W2076658236","https://openalex.org/W2078677652","https://openalex.org/W2079054696","https://openalex.org/W2080423414","https://openalex.org/W2082691527","https://openalex.org/W2086256856","https://openalex.org/W2087157604","https://openalex.org/W2090025294","https://openalex.org/W2091000930","https://openalex.org/W2103222728","https://openalex.org/W2106081526","https://openalex.org/W2113144462","https://openalex.org/W2119442942","https://openalex.org/W2123491442","https://openalex.org/W2124748602","https://openalex.org/W2130183688","https://openalex.org/W2130409730","https://openalex.org/W2134581110","https://openalex.org/W2154655439","https://openalex.org/W2166751395","https://openalex.org/W2272445359","https://openalex.org/W2330763603","https://openalex.org/W2343439038","https://openalex.org/W2581105217","https://openalex.org/W2587224222","https://openalex.org/W2752164686","https://openalex.org/W2755544091","https://openalex.org/W2804368056","https://openalex.org/W2805906842","https://openalex.org/W2887260371","https://openalex.org/W2944452573","https://openalex.org/W2949408665"],"related_works":["https://openalex.org/W4399619873","https://openalex.org/W3110756252","https://openalex.org/W4387665689","https://openalex.org/W4405812636","https://openalex.org/W7158929934","https://openalex.org/W4410523137","https://openalex.org/W426037137","https://openalex.org/W3010378692","https://openalex.org/W7098293639","https://openalex.org/W2048361100"],"abstract_inverted_index":{"Mounting":[0],"evidence":[1,216],"suggests":[2],"numerous":[3],"glutamatergic":[4,84,182,205,224,239,288,312],"synapse":[5,141,183,206,240,313],"subtypes":[6,14],"exist":[7],"in":[8,80,86,99,113,161,174,194,208,226,247,269,284,295,298,315],"the":[9,45,52,68,81,155,195,220,227,253,258,273,285],"brain,":[10],"and":[11,38,96,122,149,197],"that":[12,55,108,135,278],"these":[13,166,186,303],"are":[15],"likely":[16],"defined":[17],"by":[18],"unique":[19,58,78,200,307],"molecular":[20,30,53,202,221,309],"regulatory":[21,255],"mechanisms.":[22],"Recent":[23],"work":[24],"has":[25],"identified":[26],"substantial":[27],"divergence":[28],"of":[29,44,83,93,103,110,138,159,204,215,223,238,257,272,287,311],"composition":[31],"between":[32],"commonly":[33,296],"studied":[34,297],"Schaffer":[35,299],"collateral":[36],"synapses":[37,43,85,225],"perforant":[39,61,139,289],"path\u2013dentate":[40,290],"gyrus":[41,291],"(DG)":[42],"hippocampus.":[46],"However,":[47],"little":[48],"is":[49,143],"known":[50],"about":[51],"mechanisms":[54],"may":[56],"confer":[57],"properties":[59],"to":[60,126,219,265],"path\u2013DG":[62,140],"synapses.":[63,167,301],"Here":[64,250],"we":[65,251],"investigate":[66,252],"whether":[67],"RhoGEF":[69,259],"(Rho":[70],"guanine\u2013nucleotide":[71,230],"exchange":[72,231],"factor)":[73],"protein":[74,260],"Tiam1":[75,111,160,163,172,193,279],"plays":[76,280],"a":[77,91,151,189,199,281,306],"role":[79,153,191,256,283],"regulation":[82,207,314],"dentate":[87,114,209,274,316],"granule":[88,115,210,270,317],"neurons":[89,116,177,271],"using":[90],"combination":[92],"molecular,":[94],"electrophysiological,":[95],"imaging":[97],"approaches":[98],"rat":[100],"entorhino-hippocampal":[101],"slices":[102],"both":[104],"sexes.":[105],"We":[106,132,276],"find":[107,134,277],"inhibition":[109],"function":[112,121,142,164,241],"reduces":[117],"synaptic":[118,254],"AMPA":[119],"receptor":[120],"causes":[123],"dendritic":[124],"spines":[125],"adopt":[127],"an":[128],"elongated":[129],"filopodia-like":[130],"morphology.":[131],"also":[133,243],"Tiam1's":[136],"support":[137],"dependent":[144],"on":[145,181],"its":[146],"GEF":[147],"domain":[148,158],"identify":[150,188],"potential":[152],"for":[154,192],"auto-inhibitory":[156],"PH":[157],"regulating":[162],"at":[165],"In":[168],"marked":[169],"contrast,":[170],"reduced":[171],"expression":[173,263],"CA1":[175],"pyramidal":[176],"produced":[178],"no":[179],"effect":[180],"development.":[184],"Together,":[185,302],"data":[187,304],"critical":[190,282],"hippocampus":[196],"reveal":[198,305],"Tiam1-mediated":[201],"program":[203,310],"neurons.":[211,318],"SIGNIFICANCE":[212],"STATEMENTSeveral":[213],"lines":[214],"independently":[217],"point":[218],"diversity":[222],"brain.":[228],"Rho":[229],"factor":[232],"(RhoGEF)":[233],"proteins":[234],"as":[235],"powerful":[236],"modulators":[237],"have":[242],"become":[244],"increasingly":[245],"appreciated":[246],"recent":[248],"years.":[249],"Tiam1,":[261],"whose":[262],"appears":[264],"be":[266],"remarkably":[267],"enriched":[268],"gyrus.":[275],"development":[286],"synapses,":[292],"but":[293],"not":[294],"collateral\u2013CA1":[300],"RhoGEF-mediated":[308]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}
