{"id":"https://openalex.org/W2979784686","doi":"https://doi.org/10.1182/blood.v108.11.3262.3262","title":"BCR-ABL Specific Sequences Are Required To Prevent Ph+ Acute Lymphoblastic Leukemia in Syngeneic Mice by DNA Vaccination.","display_name":"BCR-ABL Specific Sequences Are Required To Prevent Ph+ Acute Lymphoblastic Leukemia in Syngeneic Mice by DNA Vaccination.","publication_year":2006,"publication_date":"2006-11-16","ids":{"openalex":"https://openalex.org/W2979784686","doi":"https://doi.org/10.1182/blood.v108.11.3262.3262","mag":"2979784686"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v108.11.3262.3262","doi":"https://doi.org/10.1182/blood.v108.11.3262.3262","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v108.11.3262.3262","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066742697","display_name":"Joachim K\u00f6chling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Ko\u0308chling","raw_affiliation_strings":["(Intr. by Andreas Neubauer)","Department of Pediatric Oncology, Charite\u0301 Campus Virchow Clinic, Berlin, Germany","Department of Pediatrics, University Schleswig Holstein, Campus Lu\u0308beck, Lu\u0308beck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Intr. by Andreas Neubauer)","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric Oncology, Charite\u0301 Campus Virchow Clinic, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pediatrics, University Schleswig Holstein, Campus Lu\u0308beck, Lu\u0308beck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108514280","display_name":"Javier Prada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Javier Prada","raw_affiliation_strings":["(Intr. by Andreas Neubauer)","Department of Pediatric Oncology, Charite\u0301 Campus Virchow Clinic, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Intr. by Andreas Neubauer)","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric Oncology, Charite\u0301 Campus Virchow Clinic, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101407940","display_name":"Masoud Bahrami","orcid":"https://orcid.org/0000-0002-5006-3582","observed_orcids":["https://orcid.org/0000-0002-5006-3582"]},"institutions":[{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Masoud Bahrami","raw_affiliation_strings":["(Intr. by Andreas Neubauer)","Department of Pediatric Hematology, Childrens Hospital, University of Tu\u0308bingen, Tu\u0308bingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Intr. by Andreas Neubauer)","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric Hematology, Childrens Hospital, University of Tu\u0308bingen, Tu\u0308bingen, Germany","institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026147449","display_name":"Sven A. K\u00f6nig-Merediz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sven A. Ko\u0308nig Merediz","raw_affiliation_strings":["(Intr. by Andreas Neubauer)","Mologen Molecular Medicines, S.L., Madrid, Spain","(Intr. by Andreas Neubauer); Mologen Molecular Medicines, S.L., Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Intr. by Andreas Neubauer)","institution_ids":[]},{"raw_affiliation_string":"Mologen Molecular Medicines, S.L., Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"(Intr. by Andreas Neubauer); Mologen Molecular Medicines, S.L., Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007570262","display_name":"Renata Stripecke","orcid":"https://orcid.org/0000-0001-7756-8460","observed_orcids":["https://orcid.org/0000-0001-7756-8460"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renata Stripecke","raw_affiliation_strings":["(Intr. by Andreas Neubauer)","Institute for Genetic Medicine, University of Southern California, Los Angeles, USA","(Intr. by Andreas Neubauer); Institute for Genetic Medicine, University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Intr. by Andreas Neubauer)","institution_ids":[]},{"raw_affiliation_string":"Institute for Genetic Medicine, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"(Intr. by Andreas Neubauer); Institute for Genetic Medicine, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023612088","display_name":"Karl Seeger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Seeger","raw_affiliation_strings":["(Intr. by Andreas Neubauer)","Department of Pediatric Oncology, Charite\u0301 Campus Virchow Clinic, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Intr. by Andreas Neubauer)","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric Oncology, Charite\u0301 Campus Virchow Clinic, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111974352","display_name":"G\u00fcnter Henze","orcid":"https://orcid.org/0000-0001-6517-3736","observed_orcids":["https://orcid.org/0000-0001-6517-3736"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gu\u0308nter Henze","raw_affiliation_strings":["(Intr. by Andreas Neubauer)","Department of Pediatric Oncology, Charite\u0301 Campus Virchow Clinic, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Intr. by Andreas Neubauer)","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric Oncology, Charite\u0301 Campus Virchow Clinic, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109178247","display_name":"Burghardt Wittig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164298","display_name":"Mologen (Germany)","ror":"https://ror.org/05kd99h55","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210164298"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Burghardt Wittig","raw_affiliation_strings":["(Intr. by Andreas Neubauer)","Institut fu\u0308r Molekularbiologie und Bioinformatik, Charite Universita\u0308tsmedizin, Campus Benjamin Franklin, Berlin, Germany","Mologen, AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Intr. by Andreas Neubauer)","institution_ids":[]},{"raw_affiliation_string":"Institut fu\u0308r Molekularbiologie und Bioinformatik, Charite Universita\u0308tsmedizin, Campus Benjamin Franklin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Mologen, AG, Berlin, Germany","institution_ids":["https://openalex.org/I4210164298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101840522","display_name":"Manuel Schmidt","orcid":"https://orcid.org/0000-0003-2073-2789","observed_orcids":["https://orcid.org/0000-0003-2073-2789"]},"institutions":[{"id":"https://openalex.org/I4210164298","display_name":"Mologen (Germany)","ror":"https://ror.org/05kd99h55","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210164298"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manuel Schmidt","raw_affiliation_strings":["(Intr. by Andreas Neubauer)","Mologen, AG, Berlin, Germany","(Intr. by Andreas Neubauer); Mologen, AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Intr. by Andreas Neubauer)","institution_ids":[]},{"raw_affiliation_string":"Mologen, AG, Berlin, Germany","institution_ids":["https://openalex.org/I4210164298"]},{"raw_affiliation_string":"(Intr. by Andreas Neubauer); Mologen, AG, Berlin, Germany","institution_ids":["https://openalex.org/I4210164298"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35306305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108","issue":"11","first_page":"3262","last_page":"3262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-chromosome-positive-acute-lymphoblastic-leukemia","display_name":"Philadelphia chromosome-positive acute lymphoblastic leukemia","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.8429999947547913},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.9169999957084656},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cpg-adjuvant","display_name":"CpG adjuvant","score":0.8700000047683716},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.878000020980835},{"id":"https://openalex.org/keywords/tumor-free-survival","display_name":"tumor-free survival","score":0.4580000042915344},{"id":"https://openalex.org/keywords/syngeneic-mouse-model","display_name":"syngeneic mouse model","score":0.6539999842643738},{"id":"https://openalex.org/keywords/tel-aml1","display_name":"TEL-AML1","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5860199332237244},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5421319007873535},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5309412479400635},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.47946107387542725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4600643217563629},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.4300779402256012},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.4230020046234131},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4160693883895874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3711199462413788},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3627244830131531},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.33707675337791443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v108.11.3262.3262","doi":"https://doi.org/10.1182/blood.v108.11.3262.3262","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v108.11.3262.3262","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2597041708","https://openalex.org/W2073633978","https://openalex.org/W2014315961","https://openalex.org/W2576763346","https://openalex.org/W2547581485","https://openalex.org/W2574545919","https://openalex.org/W1860254846","https://openalex.org/W1977913554","https://openalex.org/W2076666674","https://openalex.org/W2016667073"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"70":[2],"\u2013":[3],"80":[4],"%":[5],"of":[6,21,51,90,100,115,137,165,201,225,235],"children":[7],"with":[8,23,40,53,102,204,257,318],"childhood":[9],"acute":[10],"lymphoblastic":[11],"leukemia":[12,54,84,91],"(ALL)":[13],"can":[14,326],"be":[15],"cured":[16],"by":[17,108,227,244],"poly-chemo-therapy,":[18],"the":[19,69,77,87,98,109,169,232,236,281,285,303],"prognosis":[20],"patients":[22,39],"Philadelphia":[24],"chromosome":[25],"positive":[26],"(Ph+)":[27],"ALL":[28,42,333],"remains":[29],"poor.":[30],"Therefore,":[31],"new":[32],"relapse":[33],"prevention":[34],"strategies":[35],"are":[36],"needed":[37],"for":[38,133],"Ph+":[41,332],"during":[43],"remission.":[44],"We":[45,155],"have":[46,270],"shown":[47,271],"previously,":[48],"that":[49,159,249,276,293,315],"vaccination":[50,256,317],"mice":[52,101,166,187,202,266,328],"cell":[55,73,92,110,287],"lines":[56],"modified":[57],"to":[58,79,185,220,260,264],"express":[59],"costimulatory":[60],"molecules":[61],"and":[62,81,163,177,188,191,198,213,263,290,312,324],"cytokines":[63],"induce":[64],"a":[65,124,330],"systemic":[66],"immunity":[67],"against":[68,329],"syngeneic":[70],"BCR-ABLp185":[71,125,319],"expressing":[72],"line":[74,111],"BM185.":[75,112],"However,":[76],"difficulties":[78],"culture":[80],"transfect":[82],"human":[83],"cells":[85,279,283,296],"limit":[86],"clinical":[88],"application":[89],"based":[93,104],"vaccines.":[94],"Thus,":[95],"we":[96,142,269,291,309],"evaluated":[97],"pre-immunization":[99],"DNA":[103,305],"vaccines":[105],"subsequently":[106],"challenged":[107],"Ballistic":[113],"transfer":[114],"minimalistic":[116],"immunogenically":[117],"defined":[118],"gene":[119],"expression":[120],"(MIDGE)":[121],"vectors":[122],"encoding":[123],"fusion":[126,320],"specific":[127,161,250,321],"peptide":[128],"or":[129,207,210],"GM-CSF":[130,208,214,323],"were":[131,181,242,280],"used":[132,143],"in":[134,272,284,302],"vivo":[135],"transfection":[136],"murine":[138],"skin.":[139],"In":[140,195],"addition,":[141],"double":[144],"stem-loop":[145],"immunomodulators":[146],"(dSLIM),":[147],"containing":[148],"three":[149],"CpG-motifs":[150],"as":[151],"non-specific":[152],"immune":[153],"adjuvant.":[154],"provide":[156,310],"survival":[157,175,179,200],"data":[158,241,314],"shows":[160],"immunization":[162],"protection":[164],"which":[167,247],"received":[168],"complete":[170],"vaccine":[171,233,288,306],"BCR-ABL/GM-CSF/dSLIM.":[172],"Mean":[173],"tumor-free":[174,197],"(p=0.019)":[176],"overall":[178,199],"(p=0.008)":[180],"significantly":[182,217,253],"longer":[183,218],"compared":[184,219,259],"non-vaccinated":[186,221],"26.7%":[189],"survived":[190],"never":[192],"developed":[193],"leukemia.":[194],"contrast,":[196],"immunized":[203],"either":[205],"dSLIM":[206,212,325],"alone":[209],"both":[211],"was":[215,252],"not":[216],"mice.":[222],"Similarly,":[223],"substitution":[224],"BCR-ABL":[226],"irrelevant":[228],"TEL-AML1":[229],"sequences":[230],"abolished":[231],"efficacy":[234],"BCR-ABL/GM-CSF/dSLIM":[237,258],"vaccine.":[238],"The":[239],"biometrical":[240,311],"confirmed":[243],"CTL":[245],"assays":[246],"showed":[248],"lysis":[251],"higher":[254],"after":[255],"GM-CSF/dSLIM":[261],"(p<0.05)":[262],"nai\u0308ve":[265],"(p<0.005).":[267],"Previously,":[268],"T-cell":[273],"depletion":[274],"studies":[275],"CD8+":[277,294],"T":[278,295],"effector":[282],"BM185":[286,304],"model":[289],"suggest":[292],"also":[297],"play":[298],"an":[299],"essential":[300],"role":[301],"model.":[307],"Together,":[308],"functional":[313],"DNA-based":[316],"sequences,":[322],"protect":[327],"lethal":[331],"challenge.":[334]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2019-10-18T00:00:00"}
