{"id":"https://openalex.org/W2979749217","doi":"https://doi.org/10.3389/fonc.2019.00951","title":"Investigation of Cervical Tumor Biopsies for Chromosomal Loss of Heterozygosity (LOH) and Microsatellite Instability (MSI) at the HLA II Locus in HIV-1/HPV Co-infected Women","display_name":"Investigation of Cervical Tumor Biopsies for Chromosomal Loss of Heterozygosity (LOH) and Microsatellite Instability (MSI) at the HLA II Locus in HIV-1/HPV Co-infected Women","publication_year":2019,"publication_date":"2019-10-15","ids":{"openalex":"https://openalex.org/W2979749217","doi":"https://doi.org/10.3389/fonc.2019.00951","mag":"2979749217","pmid":"https://pubmed.ncbi.nlm.nih.gov/31681558","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6803484"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2019.00951","doi":"https://doi.org/10.3389/fonc.2019.00951","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.00951","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.00951/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.00951/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019126315","display_name":"Ramadhani Chambuso","orcid":"https://orcid.org/0000-0001-8794-604X","observed_orcids":["https://orcid.org/0000-0001-8794-604X"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Ramadhani Chambuso","raw_affiliation_strings":["Department of Gynaecology, Morogoro Regional Referral Hospital, Morogoro, Tanzania","MRC Unit for Genomic and Precision Medicine, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology, Morogoro Regional Referral Hospital, Morogoro, Tanzania","institution_ids":[]},{"raw_affiliation_string":"MRC Unit for Genomic and Precision Medicine, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042408418","display_name":"Evelyn Kaambo","orcid":"https://orcid.org/0009-0008-9631-7251","observed_orcids":["https://orcid.org/0009-0008-9631-7251"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I217085601","display_name":"University of Namibia","ror":"https://ror.org/016xje988","country_code":"NA","type":"education","lineage":["https://openalex.org/I217085601"]}],"countries":["NA","ZA"],"is_corresponding":false,"raw_author_name":"Evelyn Kaambo","raw_affiliation_strings":["Department of Biochemistry and Medical Microbiology, University of Namibia School of Medicine, Windhoek, Namibia","Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Medical Microbiology, University of Namibia School of Medicine, Windhoek, Namibia","institution_ids":["https://openalex.org/I217085601"]},{"raw_affiliation_string":"Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039972749","display_name":"Lynette Denny","orcid":"https://orcid.org/0000-0001-7123-1373","observed_orcids":["https://orcid.org/0000-0001-7123-1373"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I2802258008","display_name":"Groote Schuur Hospital","ror":"https://ror.org/00c879s84","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I1307091933","https://openalex.org/I2802258008"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Lynette Denny","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa","South African Medical Research Council, Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I2802258008"]},{"raw_affiliation_string":"South African Medical Research Council, Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043922344","display_name":"Clive M. Gray","orcid":"https://orcid.org/0000-0002-9293-901X","observed_orcids":["https://orcid.org/0000-0002-9293-901X"]},"institutions":[{"id":"https://openalex.org/I107920810","display_name":"National Health Laboratory Service","ror":"https://ror.org/00znvbk37","country_code":"ZA","type":"government","lineage":["https://openalex.org/I107920810"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I2802258008","display_name":"Groote Schuur Hospital","ror":"https://ror.org/00c879s84","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I1307091933","https://openalex.org/I2802258008"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Clive M. Gray","raw_affiliation_strings":["Division of Immunology, Department of Pathology and National Health Laboratory Service, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa","Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Department of Pathology and National Health Laboratory Service, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa","institution_ids":["https://openalex.org/I107920810","https://openalex.org/I157614274","https://openalex.org/I2802258008"]},{"raw_affiliation_string":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005837112","display_name":"Anna\u2010Lise Williamson","orcid":"https://orcid.org/0000-0002-5467-1200","observed_orcids":["https://orcid.org/0000-0002-5467-1200"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Anna-Lise Williamson","raw_affiliation_strings":["Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa","South African Medical Research Council, Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"raw_affiliation_string":"South African Medical Research Council, Clinical Gynaecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030127351","display_name":"Monika Migdalska\u2010S\u0119k","orcid":"https://orcid.org/0000-0002-9856-0764","observed_orcids":["https://orcid.org/0000-0002-9856-0764"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Monika Migdalska-S\u0119k","raw_affiliation_strings":["Department of Biomedicine and Genetics, Medical University of Lodz, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Genetics, Medical University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008313887","display_name":"Gloudi Agenbag","orcid":"https://orcid.org/0000-0001-8503-4004","observed_orcids":["https://orcid.org/0000-0001-8503-4004"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gloudi Agenbag","raw_affiliation_strings":["Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa","MRC Unit for Genomic and Precision Medicine, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"raw_affiliation_string":"MRC Unit for Genomic and Precision Medicine, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083131117","display_name":"George Rebello","orcid":"https://orcid.org/0000-0002-0654-7598","observed_orcids":["https://orcid.org/0000-0002-0654-7598"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"George Rebello","raw_affiliation_strings":["MRC Unit for Genomic and Precision Medicine, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Unit for Genomic and Precision Medicine, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063841533","display_name":"Raj Ramesar","orcid":"https://orcid.org/0000-0001-5688-1634","observed_orcids":["https://orcid.org/0000-0001-5688-1634"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Raj Ramesar","raw_affiliation_strings":["Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa","MRC Unit for Genomic and Precision Medicine, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"raw_affiliation_string":"MRC Unit for Genomic and Precision Medicine, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5019126315"],"corresponding_institution_ids":["https://openalex.org/I157614274"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.9311,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74784732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"951","last_page":"951"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8679999709129333},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromosome-6p","display_name":"chromosome 6p","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cervical-precancerous-lesions","display_name":"cervical precancerous lesions","score":0.4300000071525574},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.5899999737739563},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.527999997138977},{"id":"https://openalex.org/keywords/buccal-dna","display_name":"buccal DNA","score":0.6290000081062317},{"id":"https://openalex.org/keywords/south-african-women","display_name":"South African women","score":0.5740000009536743},{"id":"https://openalex.org/keywords/hpv-genotyping","display_name":"HPV genotyping","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.7931012511253357},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6241075992584229},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5583176016807556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5468173027038574},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.5111730694770813},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.4564708173274994},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.440879225730896},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.40164268016815186},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37290722131729126},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34610456228256226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34111422300338745},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.31985995173454285},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29391366243362427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2711729407310486},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24405741691589355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24190887808799744},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.13382670283317566}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fonc.2019.00951","doi":"https://doi.org/10.3389/fonc.2019.00951","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.00951","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.00951/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5794231","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6803484","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6803484","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6803484","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:31681558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31681558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5f7b67f048284ff0946314dd5de55805","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5f7b67f048284ff0946314dd5de55805","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 9 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2019.00951","doi":"https://doi.org/10.3389/fonc.2019.00951","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.00951","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.00951/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4455342202","display_name":null,"funder_award_id":"64815","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G4797928690","display_name":null,"funder_award_id":"64815","funder_id":"https://openalex.org/F4320320672","funder_display_name":"South African Medical Research Council"},{"id":"https://openalex.org/G709418386","display_name":null,"funder_award_id":"004_94678","funder_id":"https://openalex.org/F4320326620","funder_display_name":"National Health Laboratory Service"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320672","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69"},{"id":"https://openalex.org/F4320324164","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79"},{"id":"https://openalex.org/F4320326620","display_name":"National Health Laboratory Service","ror":"https://ror.org/00znvbk37"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979749217.pdf","grobid_xml":"https://content.openalex.org/works/W2979749217.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1506338733","https://openalex.org/W1544851750","https://openalex.org/W1936981902","https://openalex.org/W1971800034","https://openalex.org/W1973624321","https://openalex.org/W1996641044","https://openalex.org/W1997166207","https://openalex.org/W2002882827","https://openalex.org/W2003155455","https://openalex.org/W2009382271","https://openalex.org/W2023410485","https://openalex.org/W2029295658","https://openalex.org/W2042243713","https://openalex.org/W2048014913","https://openalex.org/W2048376669","https://openalex.org/W2054646009","https://openalex.org/W2123636561","https://openalex.org/W2129883116","https://openalex.org/W2131826300","https://openalex.org/W2146836800","https://openalex.org/W2168745469","https://openalex.org/W2168895619","https://openalex.org/W2187192263","https://openalex.org/W2219705851","https://openalex.org/W2248595381","https://openalex.org/W2314004521","https://openalex.org/W2318581442","https://openalex.org/W2319247198","https://openalex.org/W2321725626","https://openalex.org/W2326284936","https://openalex.org/W2338582503","https://openalex.org/W2438505123","https://openalex.org/W2464839348","https://openalex.org/W2469270182","https://openalex.org/W2479485927","https://openalex.org/W2494011613","https://openalex.org/W2521351555","https://openalex.org/W2565490360","https://openalex.org/W2586159641","https://openalex.org/W2588022824","https://openalex.org/W2605196547","https://openalex.org/W2617635451","https://openalex.org/W2757106189","https://openalex.org/W2763103160","https://openalex.org/W2783526612","https://openalex.org/W2885701860","https://openalex.org/W2890198513","https://openalex.org/W2899338166","https://openalex.org/W2908202794","https://openalex.org/W2912975105","https://openalex.org/W2947099304","https://openalex.org/W2981365593","https://openalex.org/W3017871756","https://openalex.org/W6679699539"],"related_works":["https://openalex.org/W7096934040","https://openalex.org/W2770506410","https://openalex.org/W2352203480","https://openalex.org/W2009712907","https://openalex.org/W2001731408","https://openalex.org/W2338582503","https://openalex.org/W2947099304","https://openalex.org/W2007788356","https://openalex.org/W2368444688","https://openalex.org/W3036478709"],"abstract_inverted_index":{"Background":[0],"A":[1,122],"subset":[2,328],"of":[3,25,31,48,53,94,124,135,192,254,329],"women":[4,126,249,267],"who":[5],"are":[6,38],"co-infected":[7,248],"with":[8,112,127,176],"human":[9,16],"immunodeficiency":[10],"virus":[11],"type":[12],"1":[13],"(HIV)":[14],"and":[15,34,69,96,141,150,174,205,227,241,290],"papillomavirus":[17],"(HPV)":[18],"progress":[19],"rapidly":[20],"to":[21,114,171],"cervical":[22,107,128,148,312,323],"disease":[23,129,324],"regardless":[24],"high":[26],"CD4":[27],"counts.":[28],"Chromosomal":[29,158],"loss":[30],"heterozygosity":[32],"(LOH)":[33],"microsatellite":[35],"instability":[36],"(MSI)":[37],"early":[39],"frequent":[40],"genetic":[41,76],"alterations":[42,77],"occurring":[43],"in":[44,84,106,117,182,311,326],"solid":[45],"tumours.":[46],"Loss":[47],"an":[49,195],"allele":[50],"or":[51],"part":[52],"a":[54,183,199,206,251,327],"chromosome":[55,104],"can":[56,303],"have":[57,90],"multiple":[58],"functional":[59],"effects":[60],"on":[61,103],"immune":[62],"response":[63],"genes,":[64],"oncogenes,":[65],"DNA":[66,110,146,166,245,263],"damage-repair":[67],"genes":[68],"tumour":[70,82,108,262,313],"suppressor":[71],"genes.":[72],"To":[73],"characterise":[74],"the":[75,92,99,228,257,307],"that":[78],"may":[79,321],"influence":[80],"rapid":[81],"progression":[83,325],"some":[85],"HIV":[86,139,144,265,316,330],"positive":[87,140,331],"women,":[88],"we":[89],"compared":[91],"extent":[93],"LOH":[95,173],"MSI":[97,175],"at":[98,256,268,306],"HLA":[100,258,308],"II":[101,259,309],"locus":[102,160,260,310],"6p":[105],"biopsy":[109],"samples":[111],"regard":[113],"HIV/HPV":[115,247],"co-infection":[116,317],"South":[118],"African":[119],"women.":[120,332],"Methods":[121],"total":[123],"164":[125],"were":[130,138,143,154,210,217,232,236],"recruited":[131],"for":[132,156,190,212,219],"this":[133,320],"study,":[134],"which":[136],"74":[137],"90":[142],"seronegative.":[145],"from":[147,246,264],"tumours":[149],"matched":[151],"buccal":[152],"swabs":[153],"used":[155,170,211],"analyses.":[157,214],"single":[159],"assay":[161],"by":[162,224],"capillary":[163],"array":[164],"electrophoresis":[165],"microsatellites":[167],"analyses":[168],"was":[169],"study":[172],"six":[177],"fluorescently-labelled":[178],"oligonucleotide":[179],"primer":[180],"pairs":[181],"multiplex":[184],"PCR":[185],"amplification.":[186],"Pearson":[187],"chi-squared":[188],"test":[189,226],"homogeneity":[191],"proportions":[193],"using":[194],"exact":[196],"p":[197,240],"value,":[198],"two-proportion":[200],"Z-score":[201],"test,":[202],"ROC":[203],"curves":[204],"logistic":[207],"regression":[208],"model":[209],"statistical":[213],"All":[215,234],"p-values":[216,230],"corrected":[218],"false":[220],"discovery":[221],"rate":[222],"(FDR)":[223],"Benjamini-Hochberg":[225],"adjusted":[229],"(q-values)":[231],"reported.":[233],"tests":[235],"significant":[237],"when":[238],"both":[239],"q<0.05.":[242],"Results":[243],"Tumour":[244],"demonstrated":[250],"higher":[252],"frequency":[253],"LOH/MSI":[255,305],"than":[261],"seronegative":[266],"6p21.21":[269],"(D6S2447,":[270],"74.2%":[271],"versus":[272,279,286,294],"42.6%;":[273],"p=0.001,":[274],"q=0.003),":[275],"6p21.31":[276],"(D6S2881,":[277],"78.3%":[278],"42.9%;":[280],"p=0.002,":[281],"q=0.004),":[282],"6p21.32":[283],"(D6S2666,":[284],"79%":[285],"57.1%;":[287],"p=0.035,":[288],"q=0.052),":[289],"6p21.33":[291],"(D6S2746,":[292],"64.3%":[293],"29.4%;":[295],"p<0.001,":[296],"q<0.001),":[297],"respectively.":[298],"Conclusions":[299],"HPV":[300],"infection":[301],"alone":[302],"induce":[304],"DNA,":[314],"whereas":[315],"exacerbates":[318],"it,":[319],"accelerate":[322]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}