{"id":"https://openalex.org/W2979739263","doi":"https://doi.org/10.18060/23439","title":"Xenograft Bone-Derived Collagen Scaffold for Myelomeningocele Management","display_name":"Xenograft Bone-Derived Collagen Scaffold for Myelomeningocele Management","publication_year":2019,"publication_date":"2019-10-08","ids":{"openalex":"https://openalex.org/W2979739263","doi":"https://doi.org/10.18060/23439","mag":"2979739263"},"language":"en","primary_location":{"id":"doi:10.18060/23439","doi":"https://doi.org/10.18060/23439","is_oa":true,"landing_page_url":"https://doi.org/10.18060/23439","pdf_url":"http://journals.iupui.edu/index.php/IMPRS/article/download/23439/22688","source":{"id":"https://openalex.org/S4210207624","display_name":"Proceedings of IMPRS","issn_l":"2641-2470","issn":["2641-2470"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316553","host_organization_name":"Indiana University School of Medicine","host_organization_lineage":["https://openalex.org/P4310316553"],"host_organization_lineage_names":["Indiana University School of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of IMPRS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://journals.iupui.edu/index.php/IMPRS/article/download/23439/22688","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082546120","display_name":"Sadid R Khan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sadid Khan","raw_affiliation_strings":["Weldon School of Biomedical Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Natalie Campbell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalie Campbell","raw_affiliation_strings":["Weldon School of Biomedical Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022822649","display_name":"Sam Fathizadeh","orcid":"https://orcid.org/0009-0002-7138-9386","observed_orcids":["https://orcid.org/0009-0002-7138-9386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sam Fathizadeh","raw_affiliation_strings":["College of Health and Human Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health and Human Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036987370","display_name":"Sean Bucherl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Bucherl","raw_affiliation_strings":["Weldon School of Biomedical Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019594592","display_name":"Eric A. Nauman","orcid":"https://orcid.org/0000-0002-8907-5716","observed_orcids":["https://orcid.org/0000-0002-8907-5716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Nauman, Ph.D.","raw_affiliation_strings":["Weldon School of Biomedical Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16743829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelomeningocele","display_name":"myelomeningocele","score":1.0},{"id":"https://openalex.org/keywords/spina-bifida","display_name":"spina bifida","score":0.9929999709129333},{"id":"https://openalex.org/keywords/collagen-scaffolds","display_name":"collagen scaffolds","score":0.9089999794960022},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.6629999876022339},{"id":"https://openalex.org/keywords/fetal-surgery","display_name":"fetal surgery","score":0.6700000166893005},{"id":"https://openalex.org/keywords/chiari-ii-malformation","display_name":"Chiari II malformation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hydrocephalus","display_name":"hydrocephalus","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bioactive-proteins","display_name":"bioactive proteins","score":0.6449999809265137},{"id":"https://openalex.org/keywords/mechanical-strength","display_name":"mechanical strength","score":0.6740000247955322},{"id":"https://openalex.org/keywords/biointegration","display_name":"biointegration","score":0.8939999938011169},{"id":"https://openalex.org/keywords/porcine-bone","display_name":"porcine bone","score":0.7300000190734863},{"id":"https://openalex.org/keywords/bovine-bone","display_name":"bovine bone","score":0.9039999842643738},{"id":"https://openalex.org/keywords/scaffold-permeability","display_name":"scaffold permeability","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.8163291811943054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4217797517776489},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3859999179840088},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.27338701486587524}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18060/23439","doi":"https://doi.org/10.18060/23439","is_oa":true,"landing_page_url":"https://doi.org/10.18060/23439","pdf_url":"http://journals.iupui.edu/index.php/IMPRS/article/download/23439/22688","source":{"id":"https://openalex.org/S4210207624","display_name":"Proceedings of IMPRS","issn_l":"2641-2470","issn":["2641-2470"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316553","host_organization_name":"Indiana University School of Medicine","host_organization_lineage":["https://openalex.org/P4310316553"],"host_organization_lineage_names":["Indiana University School of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of IMPRS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18060/23439","doi":"https://doi.org/10.18060/23439","is_oa":true,"landing_page_url":"https://doi.org/10.18060/23439","pdf_url":"http://journals.iupui.edu/index.php/IMPRS/article/download/23439/22688","source":{"id":"https://openalex.org/S4210207624","display_name":"Proceedings of IMPRS","issn_l":"2641-2470","issn":["2641-2470"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316553","host_organization_name":"Indiana University School of Medicine","host_organization_lineage":["https://openalex.org/P4310316553"],"host_organization_lineage_names":["Indiana University School of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of IMPRS","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9053999781608582,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979739263.pdf","grobid_xml":"https://content.openalex.org/works/W2979739263.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4223988455","https://openalex.org/W6893218154","https://openalex.org/W2274193412","https://openalex.org/W2159509883","https://openalex.org/W7010432283","https://openalex.org/W2313793042","https://openalex.org/W2020419207","https://openalex.org/W2497917132","https://openalex.org/W4237872335","https://openalex.org/W6889907161"],"abstract_inverted_index":{"Background":[0],"and":[1,38,41,75,90,99,111,120,129,154,167,184,195,208,224],"Hypothesis:":[2],"Spina":[3],"bifida":[4,54],"is":[5,55,143,155],"a":[6],"neural":[7],"tube":[8],"defect":[9],"resulting":[10],"from":[11],"an":[12,172],"incomplete":[13],"closure":[14],"of":[15,23,45,52,97,140,191,226,230],"the":[16,46,63,67,95,127,220,227],"caudal":[17],"neuropore.":[18],"The":[19,49,198],"most":[20],"debilitating":[21],"form":[22],"spina":[24,53,231],"bifida,":[25],"myelomeningocele":[26],"(MMC),":[27],"can":[28,85,178],"present":[29],"with":[30,34,115,150,181,186],"Chiari":[31],"II":[32],"malformation":[33],"concomitant":[35],"hydrocephalus,":[36],"bowel":[37],"bladder":[39],"abnormalities,":[40],"impaired":[42],"motor":[43],"function":[44],"lower":[47],"limbs.":[48],"incidence":[50],"rate":[51],"3.4":[56],"per":[57],"10,000":[58],"live":[59],"births":[60],"reported":[61],"within":[62],"US.":[64],"On":[65],"average,":[66],"US":[68],"spends":[69],"$1,176,000,000":[70],"annually":[71],"on":[72],"patient":[73],"management":[74,229],"treatment.":[76],"Advancements":[77],"in":[78],"existing":[79,214],"treatment":[80],"options,":[81],"namely":[82],"fetal":[83,98,135],"surgery,":[84],"greatly":[86],"decrease":[87],"neurological":[88],"injury":[89],"related":[91],"costs,":[92],"but":[93],"at":[94],"risk":[96],"maternal":[100],"complications.":[101],"Various":[102],"tissue":[103],"engineering":[104],"methods":[105,142],"have":[106],"been":[107],"proposed":[108,228],"including":[109],"biodegradable":[110],"synthetic":[112],"scaffolds,":[113],"seeded":[114,180],"or":[116,124,132],"without":[117],"bioactive":[118,182],"proteins":[119,183],"stem":[121],"cells,":[122],"sutured":[123],"glued":[125],"to":[126,157,170,213],"defect,":[128],"administered":[130,159],"fetoscopically":[131],"through":[133],"open":[134],"surgery.":[136],"However,":[137],"no":[138],"combination":[139],"these":[141],"fully":[144],"biointegratable,":[145],"watertight,":[146],"provides":[147],"complete":[148],"coverage":[149,190],"adequate":[151],"mechanical":[152,210,221],"strength,":[153,222],"able":[156],"be":[158,179],"fetoscopically.":[160],"Experimental":[161],"Design:":[162],"This":[163,216],"study":[164,217],"utilizes":[165],"bovine":[166],"porcine":[168],"bone":[169],"create":[171],"organic,":[173],"flexible":[174],"collagen":[175],"scaffold":[176],"that":[177],"attached":[185],"adhesive":[187],"for":[188,203],"successful":[189],"MMC":[192],"defects.":[193],"Conclusion":[194],"Potential":[196],"Impact:":[197],"natural":[199],"matrix":[200],"may":[201],"allow":[202],"quicker":[204],"host":[205],"cell":[206],"integration":[207],"greater":[209],"strength":[211],"compared":[212],"models.":[215],"will":[218],"characterize":[219],"permeability,":[223],"biointegration":[225],"bifida.":[232]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-10-18T00:00:00"}