{"id":"https://openalex.org/W2979734487","doi":"https://doi.org/10.1182/blood.v128.22.4439.4439","title":"Regulation of Osteoblast Function in Myeloma Bone Disease By Semaphorin 4D","display_name":"Regulation of Osteoblast Function in Myeloma Bone Disease By Semaphorin 4D","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2979734487","doi":"https://doi.org/10.1182/blood.v128.22.4439.4439","mag":"2979734487"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.4439.4439","doi":"https://doi.org/10.1182/blood.v128.22.4439.4439","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.4439.4439","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052787074","display_name":"Attaya Suvannasankha","orcid":"https://orcid.org/0000-0001-9445-8781","observed_orcids":["https://orcid.org/0000-0001-9445-8781"]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Attaya Suvannasankha","raw_affiliation_strings":["Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Richard L. Roudebush VA Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Richard L. Roudebush VA Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111448144","display_name":"Colin Crean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Colin D Crean","raw_affiliation_strings":["Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Richard L. Roudebush VA Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Richard L. Roudebush VA Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057397039","display_name":"Douglas R. Tompkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas R Tompkins","raw_affiliation_strings":["Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Richard L. Roudebush VA Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Richard L. Roudebush VA Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083902061","display_name":"Jes\u00fas Delgado\u2010Calle","orcid":"https://orcid.org/0000-0002-2083-2774","observed_orcids":["https://orcid.org/0000-0002-2083-2774"]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus Delgado-Calle","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN","Richard L. Roudebush VA Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Richard L. Roudebush VA Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053404897","display_name":"Teresita Bellido","orcid":"https://orcid.org/0000-0002-8203-7004","observed_orcids":["https://orcid.org/0000-0002-8203-7004"]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Teresita M Bellido","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN","Richard L. Roudebush VA Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Richard L. Roudebush VA Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066907686","display_name":"G. David Roodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. David Roodman","raw_affiliation_strings":["Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Richard L. Roudebush VA Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Richard L. Roudebush VA Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003565243","display_name":"John M. Chirgwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110049","display_name":"Richard L. Roudebush VA Medical Center","ror":"https://ror.org/01zpmbk67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110049","https://openalex.org/I4210127612","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John M Chirgwin","raw_affiliation_strings":["Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","Richard L. Roudebush VA Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Richard L. Roudebush VA Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210110049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003565243","https://openalex.org/A5053404897","https://openalex.org/A5057397039","https://openalex.org/A5111448144"],"corresponding_institution_ids":["https://openalex.org/I4210110049","https://openalex.org/I4388446366","https://openalex.org/I4394709130"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.266,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.84087854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"128","issue":"22","first_page":"4439","last_page":"4439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sema4d","display_name":"Sema4D","score":0.9089999794960022},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/osteoblast-activity","display_name":"osteoblast activity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/myeloma-cells","display_name":"myeloma cells","score":0.5820000171661377},{"id":"https://openalex.org/keywords/bone-microenvironment","display_name":"bone microenvironment","score":0.8799999952316284},{"id":"https://openalex.org/keywords/osteolysis","display_name":"osteolysis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tumor-bone-interaction","display_name":"tumor-bone interaction","score":0.5139999985694885},{"id":"https://openalex.org/keywords/bone-targeted-therapy","display_name":"bone-targeted therapy","score":0.5730000138282776},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.6990000009536743},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bone-marrow-plasma-cells","display_name":"bone marrow plasma cells","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6609051823616028},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.614496111869812},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5877776741981506},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5741510987281799},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5447999835014343},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.4439196288585663},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.401308536529541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3978632688522339},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3730180561542511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3577033579349518},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35018178820610046},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34083864092826843},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16836687922477722},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.4439.4439","doi":"https://doi.org/10.1182/blood.v128.22.4439.4439","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.4439.4439","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2891020412","https://openalex.org/W2750819080","https://openalex.org/W2580537538","https://openalex.org/W2800820137","https://openalex.org/W2275021895","https://openalex.org/W2082693166","https://openalex.org/W2157222066","https://openalex.org/W2086012445","https://openalex.org/W2003746184","https://openalex.org/W2263267431"],"abstract_inverted_index":{"Abstract":[0],"Multiple":[1],"myeloma":[2],"(MM)":[3],"bone":[4,23,39,45,54,107,124,198,240,265,287,335,379,490],"disease":[5],"(MMBD)":[6],"is":[7,79,461],"characterized":[8],"by":[9,81,86,268,384,433],"activation":[10],"of":[11,15,137,153,168,179,202,224,245,279,292,338,357,376,412,421,444,483],"osteoclasts":[12,82],"and":[13,29,38,63,83,98,119,126,129,158,204,254,264,334,344,424,480],"suppression":[14],"osteoblastic":[16],"differentiation,":[17],"with":[18,48,256,315,397,428],"these":[19],"changes":[20,261],"in":[21,101,135,262,285,298,360,362,378,400,419,492],"the":[22,89,173,239,410,440,488],"microenvironment":[24,241],"supporting":[25],"MM":[26,36,68,120,138,155,163,188,230,243,250,271,286,299,307,316,333,398,413,426,436],"cell":[27,156,251,437],"growth":[28],"drug":[30],"resistance.":[31],"These":[32,220],"complex":[33],"interactions":[34],"between":[35],"cells":[37,40,105,161,164,189,201,231,272,300,308,317,371,399,414,427,446],"are":[41,74,133,353,368],"incompletely":[42],"understood.":[43],"Current":[44],"targeted":[46],"therapy":[47],"bisphosphonates":[49],"or":[50],"Denosumab":[51],"only":[52,64,381],"blocks":[53],"resorption":[55],"but":[56],"has":[57],"no":[58],"effect":[59,411],"on":[60,67,415],"osteoblast":[61,339,464],"activity":[62,485],"modest":[65],"effects":[66],"growth.":[69],"Therefore,":[70],"new":[71],"MMBD":[72],"treatments":[73],"needed.":[75],"Semaphorin-4D":[76],"(Sema4D;":[77],"CD100),":[78],"made":[80],"inhibits":[84],"osteoblasts":[85],"binding":[87],"to":[88,149,172,197,282,306,364,388,478],"Plexin":[90,130],"B":[91,131],"receptor.":[92],"Breast":[93],"cancers":[94,118],"also":[95],"express":[96,165,190,233],"Sema4d,":[97],"silencing":[99],"sema4D":[100,147,169,191,417],"MDA-MB-231":[102,174],"breast":[103,117,175],"cancer":[104,176],"suppresses":[106],"metastasis":[108],"(Yang":[109],"Y":[110],"et":[111,141,210,216,226],"al,":[112,142,211,217],"PLoS":[113],"One":[114],"2016).":[115],"Since":[116,392,459],"both":[121,332],"cause":[122],"osteolytic":[123],"destruction":[125],"soluble":[127],"Sema4D":[128,294,320,358,377,441,457,460,472,484],"levels":[132,167],"increased":[134,297,331,439],"sera":[136],"patients":[139],"(Terpos":[140],"2012),":[143],"we":[144,407],"tested":[145,409],"if":[146,238],"contributed":[148],"MMBD.":[150],"qPCR":[151],"analysis":[152],"human":[154,249],"lines":[157,252,438],"primary":[159],"CD138+":[160],"showed":[162],"high":[166],"mRNA,":[170],"comparing":[171],"cells.":[177],"Analysis":[178],"previously":[180],"reported":[181],"gene":[182],"expression":[183,244,295,359,418],"array":[184],"data":[185,467],"confirmed":[186],"that":[187,229,351,452,469,481],"at":[192],"a":[193,290,354,462,475],"higher":[194,319],"level":[195],"compared":[196,305],"marrow":[199],"plasma":[200],"MGUS":[203],"healthy":[205],"donors":[206],"(GenomicScape.com;":[207],"Zhan":[208],"F":[209],"Blood":[212],"2007;":[213],"Mattiolo":[214],"M":[215],"Oncogene,":[218],"2005).":[219],"results":[221],"plus":[222],"those":[223,283],"Terpos":[225],"al":[227],"suggest":[228,350,468],"commonly":[232],"Sema4D.":[234,246],"We":[235,247],"next":[236],"asked":[237],"increases":[242],"co-cultured":[248,314],"RPMI8226":[253],"JJN3":[255,425],"mouse":[257,275],"bones.":[258],"Species":[259],"-specific":[260],"tumor":[263],"were":[266,346],"evaluated":[267],"quantitative":[269],"RT-PCR.":[270],"engrafted":[273],"onto":[274],"bones,":[276],"increasing":[277],"markers":[278,337],"osteolysis":[280],"similar":[281],"seen":[284],"disease.":[288],"After":[289],"week":[291],"co-culture,":[293],"was":[296,380],"(mean":[301,325,447],"\u00b1SD;":[302,326,448],"4.2\u00b10.4;":[303],"p=0.023),":[304],"grown":[309],"alone.":[310],"In":[311],"addition,":[312],"bones":[313,323],"expressed":[318],"mRNA":[321,442],"than":[322,372],"alone":[324],"3.6\u00b10.21;":[327],"p=0.03).":[328],"While":[329],"co-culture":[330],"Sema4D,":[336],"activity,":[340],"Col1a1,":[341],"alkaline":[342],"phosphatase":[343],"osteocalcin":[345],"suppressed.":[347],"Preliminary":[348],"experiments":[349],"osteocytes":[352,393],"major":[355,476],"source":[356],"bone,":[361],"addition":[363],"active":[365],"osteoclasts,":[366],"which":[367],"much":[369],"rarer":[370],"osteocytes.":[373],"The":[374],"induction":[375],"partially":[382],"inhibited":[383],"100nM":[385],"zoledronic":[386],"acid":[387],"inhibit":[389],"osteoclast":[390],"activity.":[391],"can":[394],"physically":[395],"interact":[396],"vivo":[401],"(Delgado":[402],"Calle,":[403],"Cancer":[404],"Res":[405],"2016),":[406],"then":[408],"osteocyte":[416,456,470],"co-cultures":[420],"RPMI":[422],"8226":[423],"MOL-Y4":[429],"osteocytic":[430],"cells,":[431],"separated":[432],"transwells.":[434],"Both":[435],"content":[443],"MLO-Y4":[445],"3.1\u00b10.4;":[449],"p=0.036),":[450],"suggesting":[451],"myeloma-secreted":[453],"factors":[454],"regulate":[455],"expression.":[458],"potent":[463],"inhibitor,":[465],"our":[466],"-derived":[471],"may":[473],"be":[474],"contributor":[477],"MMBD,":[479],"neutralization":[482],"should":[486],"improve":[487],"suppressed":[489],"formation":[491],"MM.":[493],"Disclosures":[494],"Roodman:":[495],"Amgen:":[496],"Consultancy.":[497]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-10-18T00:00:00"}
