{"id":"https://openalex.org/W2979728169","doi":"https://doi.org/10.1039/c9bm01112a","title":"Ligand targeting and peptide functionalized polymers as non-viral carriers for gene therapy","display_name":"Ligand targeting and peptide functionalized polymers as non-viral carriers for gene therapy","publication_year":2019,"publication_date":"2019-10-10","ids":{"openalex":"https://openalex.org/W2979728169","doi":"https://doi.org/10.1039/c9bm01112a","mag":"2979728169","pmid":"https://pubmed.ncbi.nlm.nih.gov/31657368"},"language":"en","primary_location":{"id":"doi:10.1039/c9bm01112a","doi":"https://doi.org/10.1039/c9bm01112a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c9bm01112a","pdf_url":null,"source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Khan Muhammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Khan Muhammad","raw_affiliation_strings":["P. R. China","School of Chemical Engineering and Technology","Tianjin 300350","Tianjin University","School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Chemical Engineering and Technology","institution_ids":[]},{"raw_affiliation_string":"Tianjin 300350","institution_ids":[]},{"raw_affiliation_string":"Tianjin University","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101570833","display_name":"Jing Zhao","orcid":"https://orcid.org/0000-0002-5995-4189","observed_orcids":["https://orcid.org/0000-0002-5995-4189"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhao","raw_affiliation_strings":["P. R. China","School of Chemical Engineering and Technology","Tianjin 300350","Tianjin University","School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Chemical Engineering and Technology","institution_ids":[]},{"raw_affiliation_string":"Tianjin 300350","institution_ids":[]},{"raw_affiliation_string":"Tianjin University","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101407055","display_name":"Ihsan Ullah","orcid":"https://orcid.org/0000-0001-5655-4975","observed_orcids":["https://orcid.org/0000-0001-5655-4975","https://orcid.org/0000-0002-5697-1514","https://orcid.org/0000-0002-8256-8147","https://orcid.org/0000-0002-9620-7975","https://orcid.org/0009-0005-6630-9486"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ihsan Ullah","raw_affiliation_strings":["P. R. China","School of Chemical Engineering and Technology","Tianjin 300350","Tianjin University","School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Chemical Engineering and Technology","institution_ids":[]},{"raw_affiliation_string":"Tianjin 300350","institution_ids":[]},{"raw_affiliation_string":"Tianjin University","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101552887","display_name":"Jintang Guo","orcid":"https://orcid.org/0000-0001-5058-8306","observed_orcids":["https://orcid.org/0000-0001-5058-8306"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210151209","display_name":"Collaborative Innovation Center of Chemical Science and Engineering Tianjin","ror":"https://ror.org/0225a5s12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I162868743","https://openalex.org/I205237279","https://openalex.org/I4210151209"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jintang Guo","raw_affiliation_strings":["Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)","P. R. China","School of Chemical Engineering and Technology","Tianjin 300350","Tianjin University","Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin 300350, P. R. China","School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-5058-8306","affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)","institution_ids":["https://openalex.org/I4210151209"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Chemical Engineering and Technology","institution_ids":[]},{"raw_affiliation_string":"Tianjin 300350","institution_ids":[]},{"raw_affiliation_string":"Tianjin University","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin 300350, P. R. China","institution_ids":["https://openalex.org/I4210151209"]},{"raw_affiliation_string":"School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011274857","display_name":"Xiang\u2010Kui Ren","orcid":"https://orcid.org/0000-0001-7894-9361","observed_orcids":["https://orcid.org/0000-0001-7894-9361"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210151209","display_name":"Collaborative Innovation Center of Chemical Science and Engineering Tianjin","ror":"https://ror.org/0225a5s12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I162868743","https://openalex.org/I205237279","https://openalex.org/I4210151209"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang-kui Ren","raw_affiliation_strings":["Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)","P. R. China","School of Chemical Engineering and Technology","Tianjin 300350","Tianjin University","Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin 300350, P. R. China","School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-7894-9361","affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)","institution_ids":["https://openalex.org/I4210151209"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Chemical Engineering and Technology","institution_ids":[]},{"raw_affiliation_string":"Tianjin 300350","institution_ids":[]},{"raw_affiliation_string":"Tianjin University","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin 300350, P. R. China","institution_ids":["https://openalex.org/I4210151209"]},{"raw_affiliation_string":"School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102862673","display_name":"Yakai Feng","orcid":"https://orcid.org/0000-0002-4511-0874","observed_orcids":["https://orcid.org/0000-0002-4511-0874"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210151209","display_name":"Collaborative Innovation Center of Chemical Science and Engineering Tianjin","ror":"https://ror.org/0225a5s12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I162868743","https://openalex.org/I205237279","https://openalex.org/I4210151209"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yakai Feng","raw_affiliation_strings":["Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)","P. R. China","School of Chemical Engineering and Technology","Tianjin 300350","Tianjin University","Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin 300350, P. R. China","Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, P. R. China","School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-4511-0874","affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)","institution_ids":["https://openalex.org/I4210151209"]},{"raw_affiliation_string":"P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Chemical Engineering and Technology","institution_ids":[]},{"raw_affiliation_string":"Tianjin 300350","institution_ids":[]},{"raw_affiliation_string":"Tianjin University","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin), Tianjin 300350, P. R. China","institution_ids":["https://openalex.org/I4210151209"]},{"raw_affiliation_string":"Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, P. R. China","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, P. R. China","institution_ids":["https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102862673"],"corresponding_institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210151209"],"apc_list":null,"apc_paid":null,"fwci":0.514,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.47941841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"64","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonviral-gene-delivery","display_name":"non-viral gene delivery","score":0.8050000071525574},{"id":"https://openalex.org/keywords/polymeric-gene-carriers","display_name":"polymeric gene carriers","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ligand-targeting","display_name":"ligand targeting","score":0.8420000076293945},{"id":"https://openalex.org/keywords/peptide-functionalization","display_name":"peptide functionalization","score":0.878000020980835},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.8169999718666077},{"id":"https://openalex.org/keywords/nuclear-entry","display_name":"nuclear entry","score":0.5170000195503235},{"id":"https://openalex.org/keywords/dna-protection","display_name":"DNA protection","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.765999972820282},{"id":"https://openalex.org/keywords/colloidal-stability","display_name":"colloidal stability","score":0.621999979019165},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5874813795089722},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5034653544425964},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.4838465750217438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4784000813961029},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.454453706741333},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4368118345737457},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43450841307640076},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4330884516239166},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.41141799092292786},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.4108167588710785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3623969554901123},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3254692852497101},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2437509298324585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1730865240097046},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.162747323513031},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.14489862322807312},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11873918771743774}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/c9bm01112a","doi":"https://doi.org/10.1039/c9bm01112a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c9bm01112a","pdf_url":null,"source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},{"id":"pmid:31657368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31657368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1792633618","display_name":null,"funder_award_id":"21875157","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1947738469","display_name":null,"funder_award_id":"2013DFG52040","funder_id":"https://openalex.org/F4320335830","funder_display_name":"International Science and Technology Cooperation Programme"},{"id":"https://openalex.org/G2970260245","display_name":"\u57fa\u4e8ePOSS\u7684\u9010\u7ea7\u9776\u5411\u57fa\u56e0\u9012\u9001\u7cfb\u7edf\u4fc3\u8fdb\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u589e\u6b96\u7814\u7a76","funder_award_id":"51673145","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3731780568","display_name":"\u9176\u54cd\u5e94\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u9009\u62e9\u578b\u57fa\u56e0\u9012\u9001\u8868\u9762\u7684\u6784\u5efa\u53ca\u5176\u4fc3\u8fdb\u5185\u76ae\u5316\u7684\u7814\u7a76","funder_award_id":"51873149","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6990598717","display_name":null,"funder_award_id":"31370969","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7853870873","display_name":null,"funder_award_id":"2016 YFC1100300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335830","display_name":"International Science and Technology Cooperation Programme","ror":"https://ror.org/00bsdxt65"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":165,"referenced_works":["https://openalex.org/W270877285","https://openalex.org/W817808178","https://openalex.org/W1893534297","https://openalex.org/W1916992273","https://openalex.org/W1963825171","https://openalex.org/W1964415483","https://openalex.org/W1968866426","https://openalex.org/W1969779551","https://openalex.org/W1970375274","https://openalex.org/W1970853504","https://openalex.org/W1976031346","https://openalex.org/W1979391760","https://openalex.org/W1985938464","https://openalex.org/W1986755260","https://openalex.org/W1987846184","https://openalex.org/W1990478234","https://openalex.org/W1990986747","https://openalex.org/W1992529637","https://openalex.org/W1994533056","https://openalex.org/W1995956587","https://openalex.org/W1997216252","https://openalex.org/W1997993853","https://openalex.org/W1998697301","https://openalex.org/W1999732094","https://openalex.org/W2003110090","https://openalex.org/W2004068369","https://openalex.org/W2004788835","https://openalex.org/W2004851551","https://openalex.org/W2007261993","https://openalex.org/W2008033906","https://openalex.org/W2009451653","https://openalex.org/W2018415799","https://openalex.org/W2019375221","https://openalex.org/W2022723336","https://openalex.org/W2023665828","https://openalex.org/W2024341039","https://openalex.org/W2025028210","https://openalex.org/W2026712777","https://openalex.org/W2027876233","https://openalex.org/W2028152693","https://openalex.org/W2028325904","https://openalex.org/W2030141620","https://openalex.org/W2030972248","https://openalex.org/W2033578921","https://openalex.org/W2034474981","https://openalex.org/W2037684467","https://openalex.org/W2039551908","https://openalex.org/W2041667200","https://openalex.org/W2043088466","https://openalex.org/W2044002020","https://openalex.org/W2047649932","https://openalex.org/W2049598700","https://openalex.org/W2050832092","https://openalex.org/W2054221036","https://openalex.org/W2054275694","https://openalex.org/W2057387129","https://openalex.org/W2059620682","https://openalex.org/W2061183130","https://openalex.org/W2061279150","https://openalex.org/W2066223920","https://openalex.org/W2066915153","https://openalex.org/W2069047046","https://openalex.org/W2069975235","https://openalex.org/W2070909031","https://openalex.org/W2073026167","https://openalex.org/W2075238581","https://openalex.org/W2077370946","https://openalex.org/W2079933337","https://openalex.org/W2080688395","https://openalex.org/W2085088081","https://openalex.org/W2089674263","https://openalex.org/W2091651723","https://openalex.org/W2094399039","https://openalex.org/W2096698886","https://openalex.org/W2103029026","https://openalex.org/W2106005174","https://openalex.org/W2110033583","https://openalex.org/W2116539034","https://openalex.org/W2116885047","https://openalex.org/W2121660570","https://openalex.org/W2128168622","https://openalex.org/W2136365615","https://openalex.org/W2145093335","https://openalex.org/W2150092048","https://openalex.org/W2159071021","https://openalex.org/W2162194950","https://openalex.org/W2166984808","https://openalex.org/W2167793054","https://openalex.org/W2170255011","https://openalex.org/W2173852131","https://openalex.org/W2183660437","https://openalex.org/W2186930964","https://openalex.org/W2192915678","https://openalex.org/W2219182836","https://openalex.org/W2252517645","https://openalex.org/W2276655573","https://openalex.org/W2278039621","https://openalex.org/W2314519512","https://openalex.org/W2317941603","https://openalex.org/W2318642195","https://openalex.org/W2321877594","https://openalex.org/W2322755200","https://openalex.org/W2332595677","https://openalex.org/W2333901123","https://openalex.org/W2336517685","https://openalex.org/W2343896234","https://openalex.org/W2346372219","https://openalex.org/W2400295113","https://openalex.org/W2407282945","https://openalex.org/W2411320849","https://openalex.org/W2412314183","https://openalex.org/W2412837586","https://openalex.org/W2415790089","https://openalex.org/W2437935337","https://openalex.org/W2469608959","https://openalex.org/W2483007317","https://openalex.org/W2512735660","https://openalex.org/W2520629744","https://openalex.org/W2527474055","https://openalex.org/W2562506779","https://openalex.org/W2568479119","https://openalex.org/W2579555493","https://openalex.org/W2581981818","https://openalex.org/W2582791923","https://openalex.org/W2587267057","https://openalex.org/W2599207623","https://openalex.org/W2601705653","https://openalex.org/W2605885227","https://openalex.org/W2612372251","https://openalex.org/W2618875195","https://openalex.org/W2724769154","https://openalex.org/W2725941071","https://openalex.org/W2735156556","https://openalex.org/W2740271812","https://openalex.org/W2742244542","https://openalex.org/W2751141790","https://openalex.org/W2767827896","https://openalex.org/W2776106451","https://openalex.org/W2784816225","https://openalex.org/W2792995236","https://openalex.org/W2793567263","https://openalex.org/W2795911681","https://openalex.org/W2799282718","https://openalex.org/W2803480574","https://openalex.org/W2806270978","https://openalex.org/W2806471025","https://openalex.org/W2808745541","https://openalex.org/W2809134565","https://openalex.org/W2888204346","https://openalex.org/W2893241206","https://openalex.org/W2897941002","https://openalex.org/W2910011068","https://openalex.org/W2911609376","https://openalex.org/W2916459218","https://openalex.org/W2921058416","https://openalex.org/W2925144410","https://openalex.org/W2925232714","https://openalex.org/W2926554098","https://openalex.org/W2937906399","https://openalex.org/W2938850518","https://openalex.org/W2942020708","https://openalex.org/W2943331511","https://openalex.org/W2954338576","https://openalex.org/W2983048398","https://openalex.org/W4226329146"],"related_works":["https://openalex.org/W2065792250","https://openalex.org/W2000844060","https://openalex.org/W2087004282","https://openalex.org/W2062890596","https://openalex.org/W170931920","https://openalex.org/W2754321746","https://openalex.org/W2086731246","https://openalex.org/W4393282065","https://openalex.org/W7162695589","https://openalex.org/W100974"],"abstract_inverted_index":{"Polymeric":[0],"gene":[1,58,118,132,142,163],"carriers":[2,59,70,113,135],"have":[3,53,71],"been":[4,54,72],"developed":[5,73],"to":[6,56,82,107],"deliver":[7],"therapeutic":[8],"genes":[9],"for":[10,60,116],"treating":[11],"various":[12,68],"genetic":[13],"diseases.":[14],"They":[15],"may":[16],"diminish":[17],"the":[18,41,46,103,129,137,149,155],"problems":[19],"related":[20],"with":[21,77],"viral":[22],"vectors":[23],"in":[24,45,154],"terms":[25],"of":[26,48,128,141,157],"safety,":[27],"immunogenicity":[28],"and":[29,37,74,80,105,133,136,139,147,152,160],"mutagenesis.":[30],"But":[31],"inefficient":[32],"endosomal":[33],"release,":[34],"cytoplasmic":[35],"transport":[36],"nuclear":[38],"entry":[39],"are":[40,114],"main":[42],"limiting":[43],"issues":[44],"usage":[47],"polymeric":[49,69,112,134],"carriers.":[50,143,164],"Different":[51],"strategies":[52],"proposed":[55],"functionalize":[57],"individually":[61],"overcoming":[62],"these":[63],"barriers.":[64],"Towards":[65],"this":[66,121],"aim,":[67],"further":[75],"modified":[76],"certain":[78],"ligands":[79],"peptides":[81],"achieve":[83],"properties":[84],"like":[85],"good":[86],"cargo":[87],"DNA":[88],"protection,":[89],"excellent":[90],"colloidal":[91],"stability,":[92],"high":[93],"cellular":[94],"uptake":[95],"efficiency,":[96],"efficient":[97,100,117],"endo/lysosome":[98],"escape,":[99],"import":[101],"into":[102],"nucleus":[104],"specificity":[106],"target":[108],"cells.":[109],"These":[110],"multifunctional":[111],"beneficial":[115],"delivery.":[119],"In":[120],"review,":[122],"we":[123],"provide":[124],"a":[125],"comprehensive":[126],"summary":[127],"interaction":[130],"between":[131],"mechanism":[138],"challenges":[140],"We":[144],"also":[145],"highlight":[146],"discuss":[148],"recent":[150],"developments":[151],"advancements":[153],"synthesis":[156],"ligand":[158],"targeting":[159],"peptide":[161],"functionalized":[162]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-10-18T00:00:00"}
