{"id":"https://openalex.org/W2979724007","doi":"https://doi.org/10.1182/blood.v128.22.4175.4175","title":"Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma","display_name":"Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2979724007","doi":"https://doi.org/10.1182/blood.v128.22.4175.4175","mag":"2979724007"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.4175.4175","doi":"https://doi.org/10.1182/blood.v128.22.4175.4175","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.4175.4175","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080982554","display_name":"Salvia Sanjay Jain","orcid":"https://orcid.org/0000-0003-1566-9308","observed_orcids":["https://orcid.org/0000-0003-1566-9308"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salvia Jain","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112662346","display_name":"Abigail J. Washington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abigail J. Washington","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031452560","display_name":"Rebecca Karp Leaf","orcid":"https://orcid.org/0000-0002-9978-8779","observed_orcids":["https://orcid.org/0000-0002-9978-8779"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Karp Leaf","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047717753","display_name":"Parul Bhargava","orcid":"https://orcid.org/0000-0002-8505-9209","observed_orcids":["https://orcid.org/0000-0002-8505-9209"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Parul Bhargava","raw_affiliation_strings":["Hematopathology, Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematopathology, Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018201884","display_name":"Rachael A. Clark","orcid":"https://orcid.org/0000-0002-6105-5764","observed_orcids":["https://orcid.org/0000-0002-6105-5764","https://orcid.org/0000-0002-2725-3257"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachael Clark","raw_affiliation_strings":["Department of Dermatology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091128223","display_name":"Thomas Seth Kupper","orcid":"https://orcid.org/0000-0002-4229-2916","observed_orcids":["https://orcid.org/0000-0002-4229-2916"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas S. Kupper","raw_affiliation_strings":["Department of Dermatology, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102834605","display_name":"Dina Stroopinsky","orcid":"https://orcid.org/0000-0002-9749-2704","observed_orcids":["https://orcid.org/0000-0002-9749-2704"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dina Stroopinsky","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091120493","display_name":"Athalia Rachel Pyzer","orcid":"https://orcid.org/0000-0002-0506-1887","observed_orcids":["https://orcid.org/0000-0002-0506-1887"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Athalia Rachel Pyzer","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037637724","display_name":"Leandra Cole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leandra Cole","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071858483","display_name":"Myrna Rita Nahas","orcid":"https://orcid.org/0000-0002-6864-0931","observed_orcids":["https://orcid.org/0000-0002-6864-0931"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myrna R. Nahas","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056647004","display_name":"Arie Apel","orcid":"https://orcid.org/0000-0001-6269-9994","observed_orcids":["https://orcid.org/0000-0001-6269-9994"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arie Apel","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054346063","display_name":"Jacalyn M. Rosenblatt","orcid":"https://orcid.org/0000-0001-5582-8161","observed_orcids":["https://orcid.org/0000-0001-5582-8161"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacalyn Rosenblatt","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016770040","display_name":"Jon E. Arnason","orcid":"https://orcid.org/0000-0001-9038-7277","observed_orcids":["https://orcid.org/0000-0001-9038-7277"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Arnason","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067054634","display_name":"Donald W. Kufe","orcid":"https://orcid.org/0000-0001-5743-8888","observed_orcids":["https://orcid.org/0000-0001-5743-8888"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald Kufe","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052641327","display_name":"David Avigan","orcid":"https://orcid.org/0000-0003-4624-6017","observed_orcids":["https://orcid.org/0000-0003-4624-6017"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Avigan","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018201884","https://openalex.org/A5037637724","https://openalex.org/A5047717753","https://openalex.org/A5056647004","https://openalex.org/A5067054634","https://openalex.org/A5091120493","https://openalex.org/A5102834605","https://openalex.org/A5112662346"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.39183386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"128","issue":"22","first_page":"4175","last_page":"4175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-t-cell-lymphoma","display_name":"cutaneous T-cell lymphoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/muc1-c","display_name":"MUC1-C","score":0.9440000057220459},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9169999957084656},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/dna-methyltransferase-inhibition","display_name":"DNA methyltransferase inhibition","score":0.7129999995231628},{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tigar","display_name":"TIGAR","score":0.7509999871253967},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8410000205039978},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7139999866485596},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.8840000033378601},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.7855056524276733},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5557076930999756},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4922129213809967},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48732051253318787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4201980531215668},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3206440806388855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2238841950893402},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.18352648615837097},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.4175.4175","doi":"https://doi.org/10.1182/blood.v128.22.4175.4175","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.4175.4175","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115824726","https://openalex.org/W7099217665","https://openalex.org/W7098258624","https://openalex.org/W2903086665","https://openalex.org/W4205476563","https://openalex.org/W2584827013","https://openalex.org/W2017917786","https://openalex.org/W3003276210","https://openalex.org/W4283780153","https://openalex.org/W4220804957"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Cutaneous":[2],"T-cell":[3],"lymphoma":[4],"(CTCL)":[5],"is":[6,100,350],"a":[7,30,47,101,126,169,290,309],"heterogeneous":[8],"neoplasm":[9],"and":[10,36,56,59,67,122,158,167,174,196,200,208,219,243,273,288,307,314],"patients":[11,132,320,344],"with":[12,46,53,120,133,148,237,241,267,321,345],"relapsed/refractory":[13,346],"disease":[14,75],"exhibit":[15],"resistance":[16],"to":[17,96,107,144,177,185,198,206,256,271,330,331],"standard":[18],"cytotoxic":[19],"therapies.":[20],"We":[21,116],"have":[22],"previously":[23,105],"demonstrated":[24],"that":[25,88,118,139,299],"the":[26,83,91,151,189,246],"MUC1-C":[27,45,78,302],"oncoprotein":[28],"plays":[29],"critical":[31,176],"role":[32],"in":[33,41,64,65,68,111,146,182,188,211,276,289,343],"regulating":[34],"apoptosis":[35,55],"protection":[37],"from":[38],"oxidative":[39,97,109],"stress":[40,110,192],"CTCL.":[42,134,322],"Targeting":[43],"of":[44,61,71,93,141,153,161,172,191,214,229,262,280,312,319,340],"pharmacologic":[48],"inhibitor,":[49,104],"GO-203,":[50,149],"was":[51],"associated":[52],"late":[54],"early":[57,325],"necrosis":[58],"slowing":[60],"tumor":[62],"growth":[63],"vitro":[66],"vivo":[69],"models":[70],"CTCL,":[72],"respectively.":[73],"However,":[74],"responses":[76],"following":[77],"inhibition":[79,303],"were":[80],"incomplete":[81],"underscoring":[82],"need":[84],"for":[85,131,222,232,317],"combinatorial":[86,334],"strategies":[87],"could":[89],"exploit":[90],"vulnerability":[92],"CTCL":[94,142,281],"cells":[95,143],"signals.":[98],"Decitabine":[99],"DNA":[102,215,224],"methyltransferase":[103],"shown":[106],"modulate":[108],"acute":[112],"myeloid":[113],"leukemia":[114],"models.":[115],"hypothesized":[117],"treatment":[119,240,318],"decitabine":[121,145,209,242,272,300],"GO-203":[123,207,244,274],"would":[124],"present":[125],"potent":[127],"novel":[128,310],"therapeutic":[129],"combination":[130,147,311],"Method/Results:":[135],"Our":[136],"studies":[137],"demonstrate":[138],"exposure":[140,205,270],"increased":[150],"generation":[152],"reactive":[154],"oxygen":[155],"species":[156],"(ROS)":[157],"decreased":[159],"levels":[160],"scavenger":[162],"molecules,":[163],"NADPH,":[164],"glutathione":[165],"(GSH),":[166],"TIGAR,":[168],"p53-inducible":[170],"regulator":[171],"glycolysis":[173],"apoptosis,":[175],"intracellular":[178],"redox":[179,305,341],"homeostasis.":[180],"This":[181],"turn":[183],"led":[184],"marked":[186],"increase":[187],"ratio":[190],"activated":[193],"proteins;":[194],"phospho-p38":[195],"phospho-JNK":[197],"Total-p38":[199],"Total-JNK":[201],"repectively.":[202],"Further":[203],"dual":[204],"resulted":[210,275],"near":[212],"abrogation":[213],"methyl":[216],"transferase":[217],"1":[218],"3b":[220],"crucial":[221],"maintaining":[223],"methylation,":[225],"demonstrating":[226],"significant":[227],"synergy":[228],"these":[230,238,268],"agents":[231,316],"inducing":[233],"hypomethylation.":[234],"In":[235,265],"concert":[236,266],"findings,":[239,269],"upregulated":[245],"ROS":[247],"generating":[248],"enzyme,":[249],"NADPH":[250],"oxidase":[251],"4":[252],"(Nox4)":[253],"potentially":[254],"due":[255],"their":[257],"effect":[258],"on":[259,337],"epigenomic":[260],"regulation":[261],"this":[263,333],"protein.":[264],"heightened":[277],"apoptotic":[278],"death":[279],"cell":[282,348],"lines,":[283],"primary":[284],"patient":[285],"derived":[286],"samples":[287],"aggressive":[291],"murine":[292],"xenograft":[293],"model.":[294],"Conclusion:":[295],"These":[296],"findings":[297],"indicate":[298],"augments":[301],"induced":[304],"imbalance":[306],"provides":[308],"targeted":[313],"epigenetic":[315,338],"Accordingly":[323],"an":[324],"phase":[326],"multi-institution":[327],"clinical":[328],"trial":[329],"investigate":[332],"strategy":[335],"based":[336],"modulation":[339],"homeostasis":[342],"T":[347],"lymphomas":[349],"being":[351],"planned.":[352],"Disclosures":[353],"Rosenblatt:":[354],"Astex:":[355],"Research":[356,359,362],"Funding;":[357,360],"BMS:":[358],"DCPrime:":[361],"Funding.":[363],"Arnason:Gilead:":[364],"Consultancy.":[365],"Kufe:Genus":[366],"Oncology":[367],"LLC:":[368],"Consultancy,":[369],"Equity":[370],"Ownership.":[371]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2019-10-18T00:00:00"}
