{"id":"https://openalex.org/W2979712475","doi":"https://doi.org/10.1080/14760584.2019.1675520","title":"Vaccines against human respiratory syncytial virus in clinical trials, where are we now?","display_name":"Vaccines against human respiratory syncytial virus in clinical trials, where are we now?","publication_year":2019,"publication_date":"2019-10-03","ids":{"openalex":"https://openalex.org/W2979712475","doi":"https://doi.org/10.1080/14760584.2019.1675520","mag":"2979712475","pmid":"https://pubmed.ncbi.nlm.nih.gov/31587585"},"language":"en","primary_location":{"id":"doi:10.1080/14760584.2019.1675520","doi":"https://doi.org/10.1080/14760584.2019.1675520","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14760584.2019.1675520","pdf_url":null,"source":{"id":"https://openalex.org/S163950488","display_name":"Expert Review of Vaccines","issn_l":"1476-0584","issn":["1476-0584","1744-8395"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Vaccines","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014406644","display_name":"Iebe Rossey","orcid":"https://orcid.org/0000-0002-0795-972X","observed_orcids":["https://orcid.org/0000-0002-0795-972X"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210151194","display_name":"VIB-UGent Center for Medical Biotechnology","ror":"https://ror.org/04hbttm44","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I32597200","https://openalex.org/I4210151194"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Iebe Rossey","raw_affiliation_strings":["Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium","VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium","institution_ids":["https://openalex.org/I4210151194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070224625","display_name":"Xavier Saelens","orcid":"https://orcid.org/0000-0002-3861-6965","observed_orcids":["https://orcid.org/0000-0002-3861-6965","https://orcid.org/0000-0003-0686-0311"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210151194","display_name":"VIB-UGent Center for Medical Biotechnology","ror":"https://ror.org/04hbttm44","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I32597200","https://openalex.org/I4210151194"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Xavier Saelens","raw_affiliation_strings":["Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium","VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium","institution_ids":["https://openalex.org/I4210151194"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070224625"],"corresponding_institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210151194"],"apc_list":null,"apc_paid":null,"fwci":0.9485,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.67380952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"18","issue":"10","first_page":"1053","last_page":"1067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.9300000071525574},{"id":"https://openalex.org/keywords/rsv-vaccine-development","display_name":"RSV vaccine development","score":0.9210000038146973},{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.8550000190734863},{"id":"https://openalex.org/keywords/protein-subunit-vaccines","display_name":"subunit vaccine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/vaccine-trials","display_name":"vaccine clinical trials","score":0.722000002861023},{"id":"https://openalex.org/keywords/correlates-of-protection","display_name":"correlates of protection","score":0.8320000171661377},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.6389999985694885},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7233394384384155},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6111000776290894},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.545947253704071},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5246275067329407},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4501382112503052},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.44986769556999207},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4387713372707367},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.41928336024284363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15087950229644775},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018113","descriptor_name":"Respiratory Syncytial Virus, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018113","descriptor_name":"Respiratory Syncytial Virus, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D022223","descriptor_name":"Vaccines, Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022261","descriptor_name":"Respiratory Syncytial Virus Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/14760584.2019.1675520","doi":"https://doi.org/10.1080/14760584.2019.1675520","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14760584.2019.1675520","pdf_url":null,"source":{"id":"https://openalex.org/S163950488","display_name":"Expert Review of Vaccines","issn_l":"1476-0584","issn":["1476-0584","1744-8395"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Vaccines","raw_type":"journal-article"},{"id":"pmid:31587585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31587585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of vaccines","raw_type":"Journal Article"},{"id":"pmh:oai:archive.ugent.be:8631720","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/8631720","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1744-8395","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9943000078201294,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W173161621","https://openalex.org/W251016307","https://openalex.org/W1198307661","https://openalex.org/W1523096741","https://openalex.org/W1529869158","https://openalex.org/W1561908438","https://openalex.org/W1566141704","https://openalex.org/W1793912643","https://openalex.org/W1803643613","https://openalex.org/W1824053132","https://openalex.org/W1844315553","https://openalex.org/W1855993737","https://openalex.org/W1872463210","https://openalex.org/W1894593978","https://openalex.org/W1913350003","https://openalex.org/W1925238017","https://openalex.org/W1967389583","https://openalex.org/W1968605303","https://openalex.org/W1971781162","https://openalex.org/W1973047854","https://openalex.org/W1974542809","https://openalex.org/W1974546818","https://openalex.org/W1983091270","https://openalex.org/W1988459634","https://openalex.org/W1989501142","https://openalex.org/W1990167513","https://openalex.org/W1991100819","https://openalex.org/W2001197069","https://openalex.org/W2003169260","https://openalex.org/W2004529783","https://openalex.org/W2007023182","https://openalex.org/W2012853657","https://openalex.org/W2018164772","https://openalex.org/W2018801079","https://openalex.org/W2019896390","https://openalex.org/W2024624869","https://openalex.org/W2025040902","https://openalex.org/W2026944037","https://openalex.org/W2028447562","https://openalex.org/W2029668049","https://openalex.org/W2030200460","https://openalex.org/W2030577907","https://openalex.org/W2031967641","https://openalex.org/W2034196477","https://openalex.org/W2035005271","https://openalex.org/W2035985071","https://openalex.org/W2043056303","https://openalex.org/W2053347879","https://openalex.org/W2060138162","https://openalex.org/W2062985080","https://openalex.org/W2071441855","https://openalex.org/W2074242518","https://openalex.org/W2074675597","https://openalex.org/W2081114699","https://openalex.org/W2081356514","https://openalex.org/W2100223188","https://openalex.org/W2100312529","https://openalex.org/W2104898251","https://openalex.org/W2106220752","https://openalex.org/W2106450636","https://openalex.org/W2112760847","https://openalex.org/W2114653354","https://openalex.org/W2115517252","https://openalex.org/W2118919020","https://openalex.org/W2120949068","https://openalex.org/W2122557423","https://openalex.org/W2123817481","https://openalex.org/W2125818108","https://openalex.org/W2126114330","https://openalex.org/W2127951127","https://openalex.org/W2129222850","https://openalex.org/W2130386320","https://openalex.org/W2131013625","https://openalex.org/W2134249387","https://openalex.org/W2136540289","https://openalex.org/W2142222220","https://openalex.org/W2143018999","https://openalex.org/W2148326845","https://openalex.org/W2151007400","https://openalex.org/W2156516257","https://openalex.org/W2159482780","https://openalex.org/W2161433430","https://openalex.org/W2164616921","https://openalex.org/W2165195150","https://openalex.org/W2168204294","https://openalex.org/W2175169174","https://openalex.org/W2207946095","https://openalex.org/W2255929193","https://openalex.org/W2270869679","https://openalex.org/W2333994510","https://openalex.org/W2397498130","https://openalex.org/W2525010336","https://openalex.org/W2525729627","https://openalex.org/W2526746561","https://openalex.org/W2545404846","https://openalex.org/W2563378637","https://openalex.org/W2569589315","https://openalex.org/W2588612119","https://openalex.org/W2606043757","https://openalex.org/W2606445530","https://openalex.org/W2611361909","https://openalex.org/W2620586792","https://openalex.org/W2727509207","https://openalex.org/W2752147407","https://openalex.org/W2753834206","https://openalex.org/W2759073829","https://openalex.org/W2764027246","https://openalex.org/W2789458933","https://openalex.org/W2789501639","https://openalex.org/W2791210094","https://openalex.org/W2794724225","https://openalex.org/W2804055790","https://openalex.org/W2805948011","https://openalex.org/W2886278952","https://openalex.org/W2892614128","https://openalex.org/W2899088252","https://openalex.org/W2911905205","https://openalex.org/W2912205029","https://openalex.org/W2923745023","https://openalex.org/W2935814674","https://openalex.org/W2946193685","https://openalex.org/W2953999237","https://openalex.org/W2954638229","https://openalex.org/W2964871094","https://openalex.org/W2964965456","https://openalex.org/W4297062472","https://openalex.org/W4313309142"],"related_works":["https://openalex.org/W2085651049","https://openalex.org/W1973269612","https://openalex.org/W3012653577","https://openalex.org/W2905178768","https://openalex.org/W3103764286","https://openalex.org/W4402141263","https://openalex.org/W2045400943","https://openalex.org/W2963023560","https://openalex.org/W2808415597","https://openalex.org/W2105212538"],"abstract_inverted_index":{"Introduction:":[0],"Human":[1],"respiratory":[2],"syncytial":[3],"virus":[4,81],"(RSV)":[5],"is":[6,43,52,168,173],"a":[7,48,72,80,87],"major":[8],"health":[9],"threat":[10],"both":[11],"for":[12,62],"the":[13,17,35,37,69,94,128,131,191],"very":[14,44],"young":[15],"and":[16,25,91,109,138,147,163,184],"elderly.":[18],"With":[19],"yearly":[20],"3.2":[21],"million":[22],"hospital":[23],"admissions":[24],"approximately":[26],"118,000":[27],"deaths":[28],"due":[29],"to":[30,59],"RSV":[31,50,74,113,136,179,186],"in":[32,106,118,144],"children":[33],"across":[34],"globe,":[36],"impact":[38],"of":[39,47,53,71,97,133,193],"this":[40,123,171],"infectious":[41],"disease":[42],"high.":[45],"Development":[46],"safe":[49,183],"vaccine":[51,75,101,137,180,187],"utmost":[54],"importance":[55],"but":[56],"has":[57],"proven":[58],"be":[60,189],"challenging":[61],"several":[63,177],"reasons.":[64],"Researchers":[65],"are":[66,103,115,142],"faced":[67],"with":[68,152,176],"history":[70],"failed":[73],"trial,":[76],"difficult":[77],"target":[78],"populations,":[79],"that":[82,141,170],"naturally":[83],"does":[84],"not":[85],"induce":[86],"long-lasting":[88],"immune":[89],"response":[90],"ambiguity":[92],"concerning":[93,130],"optimal":[95],"correlate":[96],"protection.":[98],"Many":[99],"different":[100],"formats":[102],"being":[104,116],"tested":[105],"preclinical":[107],"models":[108],"about":[110],"30":[111],"candidate":[112],"vaccines":[114,140,162],"evaluated":[117],"clinical":[119,145,194],"trials.Areas":[120],"covered:":[121],"In":[122],"review":[124,156],"we":[125],"focus":[126],"on":[127,190],"difficulties":[129],"development":[132],"an":[134],"effective":[135,185],"discuss":[139],"currently":[143],"trials":[146],"how":[148],"they":[149],"have":[150],"dealt":[151],"these":[153],"challenges.":[154],"We":[155],"live-attenuated":[157],"vaccines,":[158,160],"vectored":[159],"subunit":[161],"particle-based":[164],"vaccines.Expert":[165],"opinion:":[166],"It":[167],"clear":[169],"field":[172],"progressing":[174],"rapidly":[175],"promising":[178],"candidates.":[181],"A":[182],"might":[188],"brink":[192],"implementation":[195],"soon.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-10-18T00:00:00"}