{"id":"https://openalex.org/W2979701699","doi":null,"title":"The Role of Kisspeptin Neurons in Mediating Prolactin-Induced Suppression of LH Secretion","display_name":"The Role of Kisspeptin Neurons in Mediating Prolactin-Induced Suppression of LH Secretion","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2979701699","mag":"2979701699"},"language":"en","primary_location":{"id":"pmh:oai:ourarchive.otago.ac.nz:10523/9613","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10523/9613","pdf_url":null,"source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R.J. Lien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"R.J. Lien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kisspeptin-neurons","display_name":"kisspeptin neurons","score":0.9919999837875366},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/luteinizing-hormone-secretion","display_name":"luteinizing hormone secretion","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pulsatile-lh-secretion","display_name":"pulsatile LH secretion","score":0.6909999847412109},{"id":"https://openalex.org/keywords/prolactin-receptor","display_name":"prolactin receptor","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hyperprolactinemia","display_name":"hyperprolactinemia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/infertility","display_name":"infertility","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gnrh-neurons","display_name":"GnRH neurons","score":0.9279999732971191},{"id":"https://openalex.org/keywords/stat5-phosphorylation","display_name":"STAT5 phosphorylation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C2776808119","wikidata":"https://www.wikidata.org/wiki/Q909371","display_name":"Kisspeptin","level":3,"score":0.9745252132415771},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7815147042274475},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.7706893682479858},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5785614252090454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5045768022537231},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4309757947921753},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34506434202194214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3318602740764618},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23657137155532837},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.11181530356407166},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.09667554497718811}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ourarchive.otago.ac.nz:10523/9613","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10523/9613","pdf_url":null,"source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:2979701699","doi":null,"is_oa":false,"landing_page_url":"https://ourarchive.otago.ac.nz/handle/10523/9613","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2939736542","https://openalex.org/W2111299253","https://openalex.org/W52943296","https://openalex.org/W1993041950","https://openalex.org/W2109374960","https://openalex.org/W4220668273","https://openalex.org/W4392957878","https://openalex.org/W3005683679","https://openalex.org/W2979304156","https://openalex.org/W2995768669"],"abstract_inverted_index":{"Hyperprolactinaemia":[0],"is":[1,10,97],"one":[2,107],"of":[3,20,94,108,169,197,202,208],"the":[4,17,25,39,43,74,89,109,179],"major":[5,110],"causes":[6],"for":[7],"infertility.":[8],"It":[9],"well-established":[11],"that":[12,68,78,91,102,141],"elevated":[13],"prolactin":[14,48,63,69,143,170,188],"levels":[15],"suppress":[16],"pulsatile":[18,33,81,118],"release":[19],"gonadotropin-releasing":[21],"hormone":[22,35],"(GnRH)":[23],"from":[24,38,124],"hypothalamus,":[26],"and":[27,129,148,200],"therefore":[28],"cause":[29],"a":[30,58,166,206],"reduction":[31],"in":[32,73,152,163,174,190],"luteinizing":[34],"(LH)":[36],"secretion":[37,96,151,160],"pituitary":[40],"gland.":[41],"However,":[42],"exact":[44],"mechanism":[45],"by":[46,99,193],"which":[47],"suppresses":[49],"fertility":[50],"remains":[51],"largely":[52],"unknown.":[53],"With":[54],"only":[55],"less":[56],"than":[57],"hundred":[59],"GnRH":[60,80,114],"neurons":[61,101,181,192],"express":[62],"receptors,":[64],"it":[65],"was":[66,161,184],"proposed":[67],"would":[70],"act":[71],"indirectly":[72],"underlying":[75],"neural":[76],"circuitry":[77],"regulates":[79],"secretion.":[82],"In":[83],"this":[84],"report,":[85],"we":[86],"have":[87],"tested":[88],"hypothesis":[90],"prolactin-induced":[92,156,195],"inhibition":[93],"LH":[95,119,130,146,150,159],"mediated":[98],"kisspeptin":[100,175,180,191],"are":[103],"known":[104],"to":[105,113,186],"be":[106],"excitatory":[111],"inputs":[112],"neurons.":[115,176],"To":[116,177],"evaluate":[117],"secretion,":[120],"serial":[121],"blood":[122],"samples":[123],"diestrous":[125],"mice":[126,164],"were":[127],"collected":[128],"measured":[131],"using":[132,194],"an":[133],"ultrasensitive":[134],"enzyme-linked":[135],"immunosorbent":[136],"assay":[137],"(ELISA).":[138],"We":[139],"demonstrated":[140],"acute":[142],"administration":[144],"decreases":[145],"pulses":[147],"mean":[149],"wildtype":[153],"mice.":[154],"This":[155],"suppression":[157],"on":[158],"lost":[162],"with":[165],"conditional":[167],"knock-out":[168],"receptors":[171],"(PRLRs)":[172],"specifically":[173],"locate":[178],"responsible,":[182],"immunohistochemistry":[183],"used":[185],"examine":[187],"responses":[189],"phosphorylation":[196],"signal":[198,210],"transducer":[199],"activator":[201],"transcription":[203],"5":[204],"as":[205],"marker":[207],"PRLR-mediated":[209],"transduction.":[211]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-10-18T00:00:00"}