{"id":"https://openalex.org/W2979658992","doi":null,"title":"Immunotherapy Plus Stereotactic Radiosurgery: Building on the Promise of Precision Medicine for CNS Malignancies-PART 1: Principles of Combined Treatment.","display_name":"Immunotherapy Plus Stereotactic Radiosurgery: Building on the Promise of Precision Medicine for CNS Malignancies-PART 1: Principles of Combined Treatment.","publication_year":2018,"publication_date":"2018-02-15","ids":{"openalex":"https://openalex.org/W2979658992","mag":"2979658992","pmid":"https://pubmed.ncbi.nlm.nih.gov/29492951"},"language":"en","primary_location":{"id":"pmid:29492951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29492951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017786316","display_name":"Isabella Zhang","orcid":"https://orcid.org/0000-0002-0509-6270","observed_orcids":["https://orcid.org/0000-0002-0509-6270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabella Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017673781","display_name":"Silvia Chiara Formenti","orcid":"https://orcid.org/0000-0002-8227-8924","observed_orcids":["https://orcid.org/0000-0002-8227-8924"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia C Formenti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046534928","display_name":"Jonathan P.S. Knisely","orcid":"https://orcid.org/0000-0001-5975-8199","observed_orcids":["https://orcid.org/0000-0001-5975-8199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan P S Knisely","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9281,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.76805921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"32","issue":"2","first_page":"e28","last_page":"e32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7099999785423279},{"id":"https://openalex.org/keywords/stereotactic-radiosurgery","display_name":"stereotactic radiosurgery","score":1.0},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9629999995231628},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7710000276565552},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.5080000162124634},{"id":"https://openalex.org/keywords/fractionated-irradiation","display_name":"fractionated irradiation","score":0.6380000114440918},{"id":"https://openalex.org/keywords/treatment-sequencing","display_name":"treatment sequencing","score":0.671999990940094},{"id":"https://openalex.org/keywords/cns-malignancies","display_name":"CNS malignancies","score":0.7269999980926514},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.9432651400566101},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.846460223197937},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7475241422653198},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.531385600566864},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.45349442958831787},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3617006838321686},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.29256194829940796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2753485143184662},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20366129279136658},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1670788824558258}],"mesh":[{"descriptor_ui":"D000074324","descriptor_name":"Ipilimumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D016634","descriptor_name":"Radiosurgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:29492951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29492951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},{"id":"mag:2979658992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29492951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2889334295","https://openalex.org/W4313583801","https://openalex.org/W3156162798","https://openalex.org/W2987624518","https://openalex.org/W3213081427","https://openalex.org/W4385754380","https://openalex.org/W2733728111","https://openalex.org/W3006443866","https://openalex.org/W3032831355","https://openalex.org/W3086650356"],"abstract_inverted_index":{"The":[0],"role":[1],"of":[2,8,79,102,107,120,131],"systemic":[3,46,50,72],"therapy":[4],"in":[5,40,64,91,117],"the":[6,16,41,45,55,98,118,128,137,145],"treatment":[7,24,31,119],"intracranial":[9,74],"metastases":[10,95],"has":[11,35,58],"traditionally":[12],"been":[13,89],"limited":[14],"by":[15],"blood-brain":[17],"barrier,":[18],"and":[19,49,73,100,110,115,133,135,140],"radiation":[20,138],"therapy-either":[21],"with":[22,81,93],"whole-brain":[23],"or":[25,82,85],"stereotactic":[26,108],"radiosurgery-has":[27],"remained":[28],"a":[29,61],"primary":[30],"modality.":[32],"Recent":[33],"evidence":[34],"demonstrated":[36],"that":[37,142],"antigens":[38],"released":[39],"brain":[42,94,122],"can":[43,52],"inform":[44],"immune":[47],"system,":[48],"antibodies":[51],"traverse":[53],"into":[54],"brain.":[56],"This":[57],"led":[59],"to":[60,69,96],"renewed":[62],"interest":[63],"investigating":[65],"novel":[66],"immunotherapy":[67,134],"agents":[68],"treat":[70],"both":[71],"disease.":[75],"Currently,":[76],"several":[77],"trials":[78],"immunotherapy,":[80],"without":[83],"sequential":[84],"concurrent":[86],"radiation,":[87],"have":[88],"performed":[90],"patients":[92],"evaluate":[97,127],"safety":[99],"efficacy":[101],"combined":[103],"treatment.":[104],"Combined":[105],"use":[106],"radiosurgery":[109,132],"checkpoint":[111],"inhibitors":[112],"appears":[113],"safe":[114],"effective":[116],"various":[121],"metastases.":[123],"Future":[124],"studies":[125],"will":[126,143],"optimal":[129],"sequencing":[130],"assess":[136],"doses":[139],"fractionations":[141],"provide":[144],"best":[146],"tumor":[147],"response.":[148]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}
