{"id":"https://openalex.org/W2979640636","doi":"https://doi.org/10.1001/jama.2019.12976","title":"Unexpected Harm From an Intensive COPD Intervention","display_name":"Unexpected Harm From an Intensive COPD Intervention","publication_year":2019,"publication_date":"2019-10-08","ids":{"openalex":"https://openalex.org/W2979640636","doi":"https://doi.org/10.1001/jama.2019.12976","mag":"2979640636","pmid":"https://pubmed.ncbi.nlm.nih.gov/31593255"},"language":"en","primary_location":{"id":"doi:10.1001/jama.2019.12976","doi":"https://doi.org/10.1001/jama.2019.12976","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jama.2019.12976","pdf_url":"https://jamanetwork.com/journals/jama/articlepdf/2752449/jama_rinne_2019_ed_190079.pdf","source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jamanetwork.com/journals/jama/articlepdf/2752449/jama_rinne_2019_ed_190079.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056549921","display_name":"Seppo T. Rinne","orcid":"https://orcid.org/0000-0002-8662-1224","observed_orcids":["https://orcid.org/0000-0002-8662-1224"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4405272782","display_name":"Center for Health Optimization and Implementation Research","ror":"https://ror.org/04q2rbm50","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405272782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seppo T. Rinne","raw_affiliation_strings":["Center for Healthcare Organization & Implementation Research, Veterans Affairs, Bedford, Massachusetts","The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Healthcare Organization & Implementation Research, Veterans Affairs, Bedford, Massachusetts","institution_ids":["https://openalex.org/I4405272782"]},{"raw_affiliation_string":"The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034425520","display_name":"Peter K. Lindenauer","orcid":"https://orcid.org/0000-0002-8414-0507","observed_orcids":["https://orcid.org/0000-0002-8414-0507"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210123955","display_name":"Baystate Health","ror":"https://ror.org/02x011m46","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123955"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter K. Lindenauer","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester","Institute for Healthcare Delivery and Population Science, Department of Medicine, University of Massachusetts Medical School\u2013Baystate, Springfield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Institute for Healthcare Delivery and Population Science, Department of Medicine, University of Massachusetts Medical School\u2013Baystate, Springfield","institution_ids":["https://openalex.org/I166722992","https://openalex.org/I4210123955"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067072009","display_name":"David H. Au","orcid":"https://orcid.org/0000-0001-8207-4975","observed_orcids":["https://orcid.org/0000-0001-8207-4975"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Au","raw_affiliation_strings":["Center of Innovation for Veteran-Centered & Value-Driven Care, VA Puget Sound Health Care System, Seattle, Washington","Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Innovation for Veteran-Centered & Value-Driven Care, VA Puget Sound Health Care System, Seattle, Washington","institution_ids":["https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4439,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.82495294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"322","issue":"14","first_page":"1357","last_page":"1357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/copd-self-management","display_name":"COPD self-management","score":0.6679999828338623},{"id":"https://openalex.org/keywords/care-transitions","display_name":"care transitions","score":0.9629999995231628},{"id":"https://openalex.org/keywords/copd-hospitalization","display_name":"COPD hospitalization","score":0.6740000247955322},{"id":"https://openalex.org/keywords/emergency-department-visits","display_name":"emergency department visits","score":0.7789999842643738},{"id":"https://openalex.org/keywords/unintended-harm","display_name":"unintended harm","score":0.5080000162124634},{"id":"https://openalex.org/keywords/retraction","display_name":"retraction","score":0.5929999947547913},{"id":"https://openalex.org/keywords/reanalysis","display_name":"reanalysis","score":0.5009999871253967},{"id":"https://openalex.org/keywords/copd-prevention","display_name":"COPD prevention","score":0.5070000290870667},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.7129999995231628},{"id":"https://openalex.org/keywords/copd-exacerbation-risk","display_name":"COPD exacerbation risk","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8562052249908447},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.5273523926734924},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.34040531516075134}],"mesh":[{"descriptor_ui":"D000069341","descriptor_name":"Transitional Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073278","descriptor_name":"Self-Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026741","descriptor_name":"Physical Therapy Modalities","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D033182","descriptor_name":"Intention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/jama.2019.12976","doi":"https://doi.org/10.1001/jama.2019.12976","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jama.2019.12976","pdf_url":"https://jamanetwork.com/journals/jama/articlepdf/2752449/jama_rinne_2019_ed_190079.pdf","source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:31593255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31593255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1001/jama.2019.12976","doi":"https://doi.org/10.1001/jama.2019.12976","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jama.2019.12976","pdf_url":"https://jamanetwork.com/journals/jama/articlepdf/2752449/jama_rinne_2019_ed_190079.pdf","source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G971281072","display_name":null,"funder_award_id":"IK2 HX002248","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979640636.pdf","grobid_xml":"https://content.openalex.org/works/W2979640636.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1701934766","https://openalex.org/W1980268472","https://openalex.org/W2004220265","https://openalex.org/W2022113560","https://openalex.org/W2031162656","https://openalex.org/W2036326371","https://openalex.org/W2100389803","https://openalex.org/W2341946021","https://openalex.org/W2583265473","https://openalex.org/W2742059773","https://openalex.org/W2900727221","https://openalex.org/W2980031789","https://openalex.org/W2980172796"],"related_works":["https://openalex.org/W2914353320","https://openalex.org/W2980172796","https://openalex.org/W4379537538","https://openalex.org/W3109295643","https://openalex.org/W4214563032","https://openalex.org/W4254867086","https://openalex.org/W4393866686","https://openalex.org/W1979518810","https://openalex.org/W2098812160","https://openalex.org/W4221126983"],"abstract_inverted_index":{"Science":[0],"and":[1,23,41,124,131,149,187,210,239,313,325,371],"sound":[2],"clinical":[3,170,351],"care":[4,185,207,227,236,265,380],"both":[5,311],"rely":[6],"on":[7,45,139,281,353],"honest":[8],"reporting":[9,373],"and,":[10],"when":[11],"necessary,":[12],"self-correction.In":[13],"this":[14,109,333,344],"issue":[15],"of":[16,20,25,34,47,69,75,101,108,119,135,172,192,224,233,284,292,303,378],"JAMA,":[17],"the":[18,26,60,73,78,82,85,90,102,126,140,193,200,214,218,222,254,263,287,290,293,298,307,315,341,384,390],"Notice":[19],"Retraction":[21],"1":[22],"republication":[24],"article":[27],"by":[28,59,84,162,392],"Aboumatar":[29,163],"et":[30,164,394],"al":[31,165,395],"titled,":[32],"\"Effect":[33],"a":[35,57,98,168,173],"Hospital-Initiated":[36],"Program":[37],"Combining":[38],"Transitional":[39],"Care":[40],"Long-term":[42],"Self-management":[43],"Support":[44],"Outcomes":[46],"Patients":[48],"Hospitalized":[49],"With":[50],"Chronic":[51],"Obstructive":[52],"Pulmonary":[53],"Disease,\"":[54],"2":[55,229,274,288],"represent":[56],"commitment":[58],"authors":[61,86,121,151,316],"to":[62,104,156,330,355,368],"ensure":[63],"an":[64,70,129,153],"accurate":[65],"scientific":[66],"record.Following":[67],"discovery":[68],"error":[71,127],"in":[72,112,128,146,199,253,262,383],"analysis":[74],"data":[76],"from":[77,96],"initial":[79,160],"report,":[80],"3":[81,166],"reanalysis":[83,215],"now":[87],"shows":[88],"that":[89,142,182,197,217,397],"study's":[91],"original":[92],"conclusion":[93],"changed":[94],"remarkably":[95],"showing":[97,105],"strong":[99],"benefit":[100,370],"intervention":[103,181,201,219,255,309,334],"harm.The":[106],"results":[107,191,294,319],"study,":[110],"as":[111],"all":[113,364],"high-quality":[114],"research,":[115,148],"are":[116,144],"important":[117],"regardless":[118],"outcome.The":[120],"have":[122,359],"acknowledged":[123],"addressed":[125],"open":[130],"transparent":[132],"way.The":[133],"integrity":[134],"science":[136],"is":[137,328,346],"built":[138],"principle":[141],"scientists":[143],"forthright":[145],"their":[147,158],"these":[150,318],"adopted":[152],"earnest":[154],"approach":[155],"amend":[157],"error.The":[159],"study":[161,308,386,391],"was":[167,248,277,295,310,335],"randomized":[169],"trial":[171],"3-month":[174],"intensive":[175],"chronic":[176,188],"obstructive":[177],"pulmonary":[178],"disease":[179,189],"(COPD)":[180],"combined":[183],"transitional":[184],"support":[186],"self-management.While":[190],"retracted":[194],"publication":[195],"suggested":[196],"patients":[198,402],"group":[202,256,266],"had":[203],"fewer":[204],"COPD-related":[205,225,234],"acute":[206,226,235,339,379],"events":[208,237,381],"(hospitalizations":[209,238],"emergency":[211,240],"department":[212,241],"visits),":[213],"demonstrated":[216],"substantially":[220],"increased":[221,301,338,376],"risk":[223,302,377],"events.":[228],"The":[230,375],"mean":[231],"number":[232],"visits)":[242],"per":[243],"participant":[244],"at":[245],"6":[246],"months":[247],"1.40":[249],"(95%":[250,259],"CI,":[251,260,270],"1.01-1.79)":[252],"vs":[257],"0.72":[258],"0.46-0.97)":[261],"usual":[264],"(difference,":[267],"0.68":[268],"[95%":[269],"0.22-1.15];P":[271],"=":[272],".004).":[273],"Although":[275],"there":[276],"no":[278],"significant":[279],"effect":[280],"health-related":[282],"quality":[283],"life":[285],"between":[286],"groups,":[289],"direction":[291],"consistent":[296,347],"with":[297,306,323,337,348,363,389,403],"primary":[299],"findings.The":[300],"harm":[304],"associated":[305,336],"unexpected":[312],"important.As":[314],"indicated,":[317],"should":[320],"be":[321],"interpreted":[322],"caution,":[324],"additional":[326],"research":[327],"needed":[329],"understand":[331],"why":[332],"events.At":[340],"same":[342],"time,":[343],"work":[345],"other":[349],"literature.Numerous":[350],"trials":[352],"strategies":[354],"prevent":[356],"COPD":[357],"hospitalizations":[358],"produced":[360],"conflicting":[361],"results,":[362],"recent":[365],"studies":[366],"failing":[367],"demonstrate":[369],"some":[372],"harm.4":[374],"found":[382,398],"current":[385],"has":[387],"parallels":[388],"Fan":[393],"5":[396],"higher":[399],"mortality":[400],"among":[401]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}