{"id":"https://openalex.org/W2979639074","doi":"https://doi.org/10.14309/01.ajg.0000590276.82262.6d","title":"186 Anaerobic Versus Aerobically Prepared Fecal Microbiota Transplantation Capsules: A Pilot Comparative Cohort Analysis Using a Novel Sequencing Approach","display_name":"186 Anaerobic Versus Aerobically Prepared Fecal Microbiota Transplantation Capsules: A Pilot Comparative Cohort Analysis Using a Novel Sequencing Approach","publication_year":2019,"publication_date":"2019-10-01","ids":{"openalex":"https://openalex.org/W2979639074","doi":"https://doi.org/10.14309/01.ajg.0000590276.82262.6d","mag":"2979639074"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0000590276.82262.6d","doi":"https://doi.org/10.14309/01.ajg.0000590276.82262.6d","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0000590276.82262.6d","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046033691","display_name":"Gina M. Mendolia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086101","display_name":"OpenBiome","ror":"https://ror.org/00hf4ew78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210086101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gina M. Mendolia","raw_affiliation_strings":["OpenBiome, Somerville, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OpenBiome, Somerville, MA;","institution_ids":["https://openalex.org/I4210086101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070970211","display_name":"Haixin Sarah Bi","orcid":"https://orcid.org/0000-0001-9525-1977","observed_orcids":["https://orcid.org/0000-0001-9525-1977"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haixin S. Bi","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA;","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079523598","display_name":"Zain Kassam","orcid":"https://orcid.org/0000-0002-2183-2223","observed_orcids":["https://orcid.org/0000-0002-2183-2223"]},"institutions":[{"id":"https://openalex.org/I4210147203","display_name":"Finch Therapeutics (United States)","ror":"https://ror.org/04cyj7b39","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147203"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zain Kassam","raw_affiliation_strings":["FInch Therapeutics, Somerville, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FInch Therapeutics, Somerville, MA;","institution_ids":["https://openalex.org/I4210147203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003626223","display_name":"Nathaniel D. Chu","orcid":"https://orcid.org/0000-0001-8557-975X","observed_orcids":["https://orcid.org/0000-0001-8557-975X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel Chu","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA;","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110307349","display_name":"Mark B Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147203","display_name":"Finch Therapeutics (United States)","ror":"https://ror.org/04cyj7b39","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147203"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Smith","raw_affiliation_strings":["FInch Therapeutics, Somerville, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FInch Therapeutics, Somerville, MA;","institution_ids":["https://openalex.org/I4210147203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091119492","display_name":"Eric J. Alm","orcid":"https://orcid.org/0000-0001-8294-9364","observed_orcids":["https://orcid.org/0000-0001-8294-9364"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Alm","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA;","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062915181","display_name":"Jessica Ravikoff Allegretti","orcid":"https://orcid.org/0000-0003-3585-2425","observed_orcids":["https://orcid.org/0000-0003-3585-2425","https://orcid.org/0000-0002-1175-1024"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica R. Allegretti","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.1943,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54342323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"114","issue":"1","first_page":"S114","last_page":"S114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/recurrent-clostridioides-difficile-infection","display_name":"recurrent Clostridium difficile infection","score":0.878000020980835},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7749999761581421},{"id":"https://openalex.org/keywords/clinical-cure","display_name":"clinical cure","score":0.6449999809265137},{"id":"https://openalex.org/keywords/microbiota-diversity","display_name":"microbiome diversity","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C5140985","wikidata":"https://www.wikidata.org/wiki/Q483866","display_name":"Anaerobic exercise","level":2,"score":0.89762943983078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8294164538383484},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.5821546912193298},{"id":"https://openalex.org/C137923570","wikidata":"https://www.wikidata.org/wiki/Q2121103","display_name":"Fecal bacteriotherapy","level":4,"score":0.5439136624336243},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5221707820892334},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4805505871772766},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.47832298278808594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46979770064353943},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4602242112159729},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.45543771982192993},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4142996072769165},{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.3850419819355011},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.29080915451049805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12346598505973816},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.11711329221725464},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.0951891839504242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0000590276.82262.6d","doi":"https://doi.org/10.14309/01.ajg.0000590276.82262.6d","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0000590276.82262.6d","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2978833033","https://openalex.org/W4389237628","https://openalex.org/W2997079353","https://openalex.org/W2754526860","https://openalex.org/W2902610036","https://openalex.org/W2963424654","https://openalex.org/W4220827127","https://openalex.org/W3205045605","https://openalex.org/W2755608235","https://openalex.org/W4296311492"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Fecal":[1],"microbiota":[2],"transplantation":[3],"(FMT)":[4],"capsules":[5,19,56,118],"have":[6],"emerged":[7],"as":[8],"a":[9,71,85,113,209],"therapeutic":[10],"option":[11],"for":[12,101,226,318],"recurrent":[13,242],"C.difficile":[14],"infection":[15],"(rCDI).":[16],"Standard":[17],"FMT":[18,55,349],"are":[20],"prepared":[21,57,135,348],"under":[22,136,140],"aerobic":[23,59,141],"conditions;":[24],"however,":[25],"anaerobic":[26,33,63,137,176],"processing":[27],"limits":[28],"oxygen's":[29],"impact":[30],"on":[31],"healthy":[32,125],"microbes,":[34],"may":[35,43],"enhance":[36],"microbial":[37,197,283],"community":[38,284],"viability,":[39],"improve":[40],"engraftment,":[41],"and":[42,79,129,138,150,181,192,204,217,249,268,288,295,311,320,332,355],"in":[44,66,325,368,371],"turn":[45],"increase":[46],"efficacy.":[47],"Thus,":[48],"we":[49],"compared":[50],"the":[51,164,257,340],"engraftment":[52,221,369],"profiles":[53,370],"of":[54,89,103,116,119,240,353],"by":[58,302],"(AER)":[60],"versus":[61,346],"an":[62,175],"process":[64],"(ANA)":[65],"rCDI":[67,90],"patients.":[68],"We":[69,83],"applied":[70],"novel":[72,210],"DNA-sequencing":[73],"method":[74],"(PMA-seq)":[75],"to":[76,110,147,159,343],"differentiate":[77],"living":[78],"dead":[80,356],"microbes.":[81],"METHODS:":[82],"conducted":[84],"prospective":[86],"cohort":[87],"study":[88,342,361],"patients":[91,244],"(3":[92],"or":[93,122,307],"more":[94],"confirmed":[95],"episodes":[96],"within":[97],"1":[98,310],"year)":[99],"eligible":[100],"standard":[102,120],"care":[104],"FMT.":[105],"Subjects":[106],"were":[107,127,157,168,179,199,223,245,254,330,364],"enrolled":[108,246],"sequentially":[109],"receive":[111],"either":[112],"single":[114],"administration":[115],"30":[117],"AER":[121,248,258,319],"ANA.":[123],"3":[124],"donors":[126],"use":[128],"stool":[130,151,166,182],"donation":[131],"was":[132,145,214,229,322],"split;":[133],"half":[134,139],"conditions.":[142],"This":[143,359],"technique":[144],"used":[146],"address":[148],"donor":[149],"specific":[152],"confounding":[153],"effects.":[154],"All":[155],"measures":[156],"taken":[158],"manage":[160],"oxygen":[161],"exposure,":[162],"otherwise":[163],"split":[165],"samples":[167,183],"treated":[169],"identically.":[170],"ANA":[171,269,287,321],"preparations":[172],"occurred":[173],"inside":[174],"chamber.":[177],"Patients":[178],"assessed,":[180],"collected":[184],"at":[185,231,315],"72":[186],"hours,":[187],"10":[188,241],"days,":[189],"4":[190],"weeks":[191,194],"8":[193,233,317],"post-FMT.":[195],"Gut":[196],"communities":[198],"profiled":[200],"via":[201,235],"shotgun":[202,304],"metagenomic":[203,305],"16S":[205],"sequencing.":[206],"Additionally,":[207],"PMA-seq,":[208],"species-specific":[211],"live-dead":[212],"assay":[213],"conducted.":[215],"Pre":[216],"post":[218],"treatment":[219],"microbiome":[220],"outcomes":[222,285],"analyzed.":[224],"Assessment":[225],"clinical":[227],"cure":[228,314],"done":[230],"week":[232,316],"[testing":[234],"(GDH/EIA)].":[236],"RESULTS:":[237],"A":[238],"total":[239],"CDI":[243],"(5":[247],"5":[250],"ANA).":[251],"Relevant":[252],"characteristics":[253],"similar":[255],"between":[256],"[mean":[259,271],"age:":[260,272],"73":[261],"(SD":[262,275],"=":[263,276],"15.9),":[264],"mean":[265,278],"recurrence":[266,279],"3.4]":[267],"groups":[270],"67.1":[273],"years":[274],"18.7),":[277],"3.0].":[280],"Overall,":[281],"gut":[282],"from":[286],"AER,":[289],"including":[290,351],"alpha":[291],"diversity,":[292],"beta":[293],"diversity":[294],"relative":[296],"abundances,":[297],"did":[298],"not":[299],"vary":[300],"substantially":[301],"16S,":[303],"sequencing":[306],"PMA-seq":[308],"(Figures":[309],"2).":[312],"Clinical":[313],"100%":[323],"(5/5":[324],"each":[326],"group).":[327],"Both":[328],"formulations":[329],"safe":[331],"well-tolerated.":[333],"CONCLUSION:":[334],"To":[335],"our":[336],"knowledge,":[337],"this":[338],"is":[339],"first":[341],"compare":[344],"aerobically":[345],"anaerobically":[347],"capsules,":[350],"assessment":[352],"live":[354],"specific-microbial":[357],"profiles.":[358],"pilot":[360],"suggested":[362],"there":[363],"no":[365],"significant":[366],"differences":[367],"rCDI.":[372]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2019-10-18T00:00:00"}
