{"id":"https://openalex.org/W2979536720","doi":"https://doi.org/10.1242/dev.178665","title":"Endocrine and local signaling interact to regulate spermatogenesis in zebrafish: Follicle-stimulating hormone, retinoic acid and androgens","display_name":"Endocrine and local signaling interact to regulate spermatogenesis in zebrafish: Follicle-stimulating hormone, retinoic acid and androgens","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2979536720","doi":"https://doi.org/10.1242/dev.178665","mag":"2979536720","pmid":"https://pubmed.ncbi.nlm.nih.gov/31597660"},"language":"en","primary_location":{"id":"doi:10.1242/dev.178665","doi":"https://doi.org/10.1242/dev.178665","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.178665","pdf_url":"https://dev.biologists.org/content/develop/146/21/dev178665.full.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://dev.biologists.org/content/develop/146/21/dev178665.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048826626","display_name":"Diego Crespo","orcid":"https://orcid.org/0000-0001-8477-3390","observed_orcids":["https://orcid.org/0000-0001-8477-3390"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Diego Crespo","raw_affiliation_strings":["Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008397739","display_name":"Luiz H. C. Assis","orcid":"https://orcid.org/0000-0002-0907-3076","observed_orcids":["https://orcid.org/0000-0002-0907-3076"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Luiz H.C. Assis","raw_affiliation_strings":["Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112287937","display_name":"H. J. G. van de Kant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Henk J.G. van de Kant","raw_affiliation_strings":["Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039638986","display_name":"Sjors de Waard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjors de Waard","raw_affiliation_strings":["Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033377147","display_name":"Diego Safian","orcid":"https://orcid.org/0000-0001-5294-3228","observed_orcids":["https://orcid.org/0000-0001-5294-3228"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Diego Safian","raw_affiliation_strings":["Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064973695","display_name":"Moline Severino Lemos","orcid":"https://orcid.org/0000-0003-2533-8334","observed_orcids":["https://orcid.org/0000-0003-2533-8334"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Moline S. Lemos","raw_affiliation_strings":["Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil","Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059461784","display_name":"Jan Bogerd","orcid":"https://orcid.org/0000-0003-1120-7974","observed_orcids":["https://orcid.org/0000-0003-1120-7974"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan Bogerd","raw_affiliation_strings":["Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052975327","display_name":"R\u00fcdiger W. Schulz","orcid":"https://orcid.org/0000-0001-9115-669X","observed_orcids":["https://orcid.org/0000-0001-9115-669X"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2802153510","display_name":"Norwegian Institute of Marine Research","ror":"https://ror.org/05vg74d16","country_code":"NO","type":"facility","lineage":["https://openalex.org/I2802153510","https://openalex.org/I4210116418","https://openalex.org/I4210149801"]}],"countries":["NL","NO"],"is_corresponding":false,"raw_author_name":"R\u00fcdiger W. Schulz","raw_affiliation_strings":["Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","Research Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway","Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands","Research Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen NO-5817, Norway"],"raw_orcid":"https://orcid.org/0000-0001-9115-669X","affiliations":[{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Research Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway","institution_ids":["https://openalex.org/I2802153510"]},{"raw_affiliation_string":"Reproductive Biology Group, Division Developmental Biology, Department Biology, Science Faculty, Utrecht University, Utrecht 3584 CH, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Research Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen NO-5817, Norway","institution_ids":["https://openalex.org/I2802153510"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8983,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.84182306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"146","issue":"21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.9079999923706055},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9390000104904175},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.9890000224113464},{"id":"https://openalex.org/keywords/spermatogonia-differentiation","display_name":"spermatogonia differentiation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/meiosis","display_name":"meiosis","score":0.843999981880188},{"id":"https://openalex.org/keywords/spermatocyte-apoptosis","display_name":"spermatocyte apoptosis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/spermatid-apoptosis","display_name":"spermatid apoptosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/spermiogenesis","display_name":"spermiogenesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/negative-feedback-loop","display_name":"negative feedback loop","score":0.6620000004768372},{"id":"https://openalex.org/keywords/retinoic-acid-receptor","display_name":"retinoic acid receptor","score":0.7950000166893005},{"id":"https://openalex.org/keywords/germ-cells","display_name":"germ cells","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9502288103103638},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.7472018599510193},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7364581823348999},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.710222601890564},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.6312236189842224},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5756422877311707},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.5319201350212097},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5215097069740295},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.4447844922542572},{"id":"https://openalex.org/C102570824","wikidata":"https://www.wikidata.org/wiki/Q147807","display_name":"Follicle","level":2,"score":0.41117921471595764},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39451688528060913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.378704309463501},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.2632446885108948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18847224116325378},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13204658031463623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002066","descriptor_name":"Busulfan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004703","descriptor_name":"Endocrine System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013087","descriptor_name":"Spermatids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013090","descriptor_name":"Spermatocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013093","descriptor_name":"Spermatogonia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1242/dev.178665","doi":"https://doi.org/10.1242/dev.178665","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.178665","pdf_url":"https://dev.biologists.org/content/develop/146/21/dev178665.full.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"doi:10.1101/462408","doi":"https://doi.org/10.1101/462408","is_oa":true,"landing_page_url":"https://doi.org/10.1101/462408","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/11/05/462408.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:31597660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31597660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/388367","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/388367","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:develop:146/21/dev178665","doi":null,"is_oa":false,"landing_page_url":"http://dev.biologists.org/cgi/content/short/146/21/dev178665","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/388367","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/388367","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Development (Cambridge), 146(21). Company of Biologists Ltd","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1242/dev.178665","doi":"https://doi.org/10.1242/dev.178665","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.178665","pdf_url":"https://dev.biologists.org/content/develop/146/21/dev178665.full.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1429491158","display_name":null,"funder_award_id":"BIOTEK2021","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G22520324","display_name":null,"funder_award_id":"BIOTEK2021/HAVBRUK, SALMAT (n\u00b0 226221)","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G4817336763","display_name":null,"funder_award_id":"221648","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G5515979416","display_name":null,"funder_award_id":"BIOTEK2021/HAVBRUK","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G5784710409","display_name":null,"funder_award_id":"226221","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"}],"funders":[{"id":"https://openalex.org/F4320321010","display_name":"Universiteit Utrecht","ror":"https://ror.org/04pp8hn57"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979536720.pdf","grobid_xml":"https://content.openalex.org/works/W2979536720.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W1506430923","https://openalex.org/W1534336480","https://openalex.org/W1559313501","https://openalex.org/W1583964291","https://openalex.org/W1723001059","https://openalex.org/W1870040272","https://openalex.org/W1871304706","https://openalex.org/W1877167531","https://openalex.org/W1963571808","https://openalex.org/W1965799162","https://openalex.org/W1966534620","https://openalex.org/W1968863496","https://openalex.org/W1969565655","https://openalex.org/W1975340607","https://openalex.org/W1975748910","https://openalex.org/W1980154798","https://openalex.org/W1980976351","https://openalex.org/W1983570177","https://openalex.org/W1986485610","https://openalex.org/W1994950146","https://openalex.org/W1995006108","https://openalex.org/W1995329979","https://openalex.org/W1997226150","https://openalex.org/W2003668188","https://openalex.org/W2005195078","https://openalex.org/W2006044949","https://openalex.org/W2007631412","https://openalex.org/W2008606131","https://openalex.org/W2008757142","https://openalex.org/W2011385897","https://openalex.org/W2014834979","https://openalex.org/W2015761261","https://openalex.org/W2018632741","https://openalex.org/W2035087312","https://openalex.org/W2053175039","https://openalex.org/W2054448683","https://openalex.org/W2056735175","https://openalex.org/W2057322816","https://openalex.org/W2062058774","https://openalex.org/W2064332932","https://openalex.org/W2064496373","https://openalex.org/W2067233342","https://openalex.org/W2067595351","https://openalex.org/W2069544865","https://openalex.org/W2070385857","https://openalex.org/W2071923822","https://openalex.org/W2075553349","https://openalex.org/W2075812278","https://openalex.org/W2079232954","https://openalex.org/W2080377138","https://openalex.org/W2084155998","https://openalex.org/W2085025027","https://openalex.org/W2085064256","https://openalex.org/W2085747988","https://openalex.org/W2091028885","https://openalex.org/W2093339165","https://openalex.org/W2097065948","https://openalex.org/W2101283191","https://openalex.org/W2103006500","https://openalex.org/W2103017472","https://openalex.org/W2105036071","https://openalex.org/W2108234281","https://openalex.org/W2114468823","https://openalex.org/W2117199214","https://openalex.org/W2119720968","https://openalex.org/W2125549511","https://openalex.org/W2127647846","https://openalex.org/W2130949410","https://openalex.org/W2134526812","https://openalex.org/W2137399444","https://openalex.org/W2149934112","https://openalex.org/W2150582941","https://openalex.org/W2152239989","https://openalex.org/W2154166928","https://openalex.org/W2155268797","https://openalex.org/W2158217645","https://openalex.org/W2159675211","https://openalex.org/W2161533644","https://openalex.org/W2162780161","https://openalex.org/W2163094549","https://openalex.org/W2166187009","https://openalex.org/W2168003742","https://openalex.org/W2171776498","https://openalex.org/W2173990490","https://openalex.org/W2191459521","https://openalex.org/W2197381113","https://openalex.org/W2226222348","https://openalex.org/W2237266875","https://openalex.org/W2256552130","https://openalex.org/W2271700408","https://openalex.org/W2295267901","https://openalex.org/W2339862102","https://openalex.org/W2345484179","https://openalex.org/W2401033442","https://openalex.org/W2407523666","https://openalex.org/W2471773715","https://openalex.org/W2509517203","https://openalex.org/W2518240253","https://openalex.org/W2526104497","https://openalex.org/W2580908592","https://openalex.org/W2630834416","https://openalex.org/W2756230282","https://openalex.org/W2767205153","https://openalex.org/W2771129185","https://openalex.org/W2786929932","https://openalex.org/W2793005395","https://openalex.org/W2793643290","https://openalex.org/W2808260066","https://openalex.org/W2889674915","https://openalex.org/W2891558664","https://openalex.org/W2902685619","https://openalex.org/W2941252780","https://openalex.org/W2951231225"],"related_works":["https://openalex.org/W2899459641","https://openalex.org/W2162575869","https://openalex.org/W2518240253","https://openalex.org/W2908306934","https://openalex.org/W1873346408","https://openalex.org/W2053175039","https://openalex.org/W2626849847","https://openalex.org/W2968875636","https://openalex.org/W1870040272","https://openalex.org/W2154166928"],"abstract_inverted_index":{"gene.":[0],"While":[1],"RA":[2,18,33,50,55,113,131],"still":[3,68],"seems":[4],"important":[5,116],"for":[6,117],"spermatogenesis":[7,63,88,119],"in":[8,58,76],"fish,":[9],"it":[10],"is":[11,115,121],"not":[12,122],"known":[13],"which":[14],"stage(s)":[15],"respond":[16],"to":[17],"or":[19],"whether":[20],"its":[21],"effects":[22],"are":[23],"integrated":[24],"into":[25],"the":[26],"endocrine":[27],"regulation":[28],"of":[29,94,123,137],"spermatogenesis.":[30],"In":[31],"zebrafish,":[32],"promoted":[34],"spermatogonia":[35],"differentiation,":[36],"supported":[37],"androgen-stimulated":[38],"meiosis,":[39],"and":[40,43,66,105,130],"reduced":[41],"spermatocyte":[42],"spermatid":[44],"apoptosis.":[45],"Follicle-stimulating":[46],"hormone":[47],"(Fsh)":[48],"stimulated":[49],"production.":[51],"Expressing":[52],"a":[53,143],"dominant-negative":[54],"receptor":[56],"variant":[57],"germ":[59,133],"cells":[60],"clearly":[61],"disturbed":[62],"but":[64,92,120],"meiosis":[65],"spermiogenesis":[67],"took":[69],"place,":[70],"although":[71],"sperm":[72,106],"quality":[73,107],"was":[74,103],"low":[75],"6-month-old":[77],"adults.":[78],"This":[79],"condition":[80],"also":[81],"activated":[82],"Leydig":[83,138],"cells.":[84],"Three":[85],"months":[86],"later,":[87],"apparently":[89],"had":[90],"recovered,":[91],"doubling":[93],"testis":[95],"weight":[96],"demonstrated":[97],"hypertrophy,":[98],"apoptosis/DNA":[99],"damage":[100],"among":[101],"spermatids":[102],"high":[104],"remained":[108],"low.":[109],"We":[110],"conclude":[111],"that":[112],"signaling":[114],"zebrafish":[118],"crucial":[124],"relevance.":[125],"As":[126],"Fsh":[127],"stimulates":[128],"androgen":[129],"production,":[132],"cell-mediated,":[134],"RA-dependent":[135],"reduction":[136],"cell":[139],"activity":[140],"may":[141],"form":[142],"hitherto":[144],"unknown":[145],"intratesticular":[146],"negative-feedback":[147],"loop.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-10-18T00:00:00"}