{"id":"https://openalex.org/W2979536155","doi":"https://doi.org/10.1182/blood.v104.11.3437.3437","title":"A Monoclonal Antibody to High Molecular Weight Kininogen Reduces Inflammation in the HLA-B27 Transgenic Rat Model of Inflammatory Bowel Disease and Arthritis.","display_name":"A Monoclonal Antibody to High Molecular Weight Kininogen Reduces Inflammation in the HLA-B27 Transgenic Rat Model of Inflammatory Bowel Disease and Arthritis.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2979536155","doi":"https://doi.org/10.1182/blood.v104.11.3437.3437","mag":"2979536155"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.3437.3437","doi":"https://doi.org/10.1182/blood.v104.11.3437.3437","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.3437.3437","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109057691","display_name":"Robin A. Pixley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin A. Pixley","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006468559","display_name":"Irma M. S\u00e1inz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Irma M. Sainz","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111777574","display_name":"James C. Keith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"James C. Keith","raw_affiliation_strings":["Cardiovascular and Metabolic Disease Research, Weyth Research, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolic Disease Research, Weyth Research, Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009021123","display_name":"Irma Isordia\u2010Salas","orcid":"https://orcid.org/0000-0002-8986-2330","observed_orcids":["https://orcid.org/0000-0002-8986-2330"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Irma Isordia-Salas","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075815577","display_name":"Yelena Leatherby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yelena Leatherby","raw_affiliation_strings":["Cardiovascular and Metabolic Disease Research, Weyth Research, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolic Disease Research, Weyth Research, Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050107318","display_name":"Leo M. Albert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leo M. Albert","raw_affiliation_strings":["Cardiovascular and Metabolic Disease Research, Weyth Research, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolic Disease Research, Weyth Research, Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006468559","https://openalex.org/A5009021123","https://openalex.org/A5075815577","https://openalex.org/A5111777574"],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3588575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"11","first_page":"3437","last_page":"3437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.9890000224113464},{"id":"https://openalex.org/keywords/kallikrein-kinin-system","display_name":"kallikrein-kinin system","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hla-b27-transgenic-rats","display_name":"HLA-B27 transgenic rats","score":0.9639999866485596},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/colonic-inflammation","display_name":"colonic inflammation","score":0.847000002861023},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/prekallikrein","display_name":"prekallikrein","score":0.9210000038146973},{"id":"https://openalex.org/keywords/factor-xi","display_name":"factor XI","score":0.5709999799728394},{"id":"https://openalex.org/keywords/factor-xii","display_name":"factor XII","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/joint-diseases","display_name":"joint diseases","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2779244835","wikidata":"https://www.wikidata.org/wiki/Q538432","display_name":"Synovitis","level":3,"score":0.7163232564926147},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6930160522460938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6466724872589111},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5527526140213013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.515684962272644},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.49406149983406067},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4772903025150299},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4514656066894531},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37413910031318665},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34697940945625305},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08827072381973267}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.3437.3437","doi":"https://doi.org/10.1182/blood.v104.11.3437.3437","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.3437.3437","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2124956424","https://openalex.org/W1988946696","https://openalex.org/W2144901303","https://openalex.org/W4313385399","https://openalex.org/W150771453","https://openalex.org/W2052268627","https://openalex.org/W2413205805","https://openalex.org/W2038564379","https://openalex.org/W2221519970","https://openalex.org/W1432638043"],"abstract_inverted_index":{"Abstract":[0],"The":[1,47,149],"HLA-B27":[2,69,87],"rat":[3,23],"is":[4],"a":[5,41,51,107,154],"well-characterized":[6],"model":[7],"of":[8,18,25,31,49,59,76,109,122,132,165,171,181,193,258],"human":[9,272],"bowel":[10,195,274],"disease,":[11],"rheumatoid":[12],"arthritis":[13,207],"and":[14,44,112,127,139,142,161,177,206,234,247,276],"psoriasis.":[15],"Previous":[16],"studies":[17],"chronic":[19],"inflammation":[20],"in":[21,67,222,271],"other":[22],"models":[24],"inflammatory":[26,194,273],"disease":[27,196,275],"have":[28,268],"demonstrated":[29],"activation":[30],"the":[32,68,95,113,130,133,135,140,182,190],"kallilrein-kinin":[33],"system":[34],"(KKS)":[35],"as":[36,38,106],"well":[37],"modulation":[39],"by":[40,169,252],"kallikrein":[42],"inhibitor":[43],"HK":[45,187,248],"deficiency.":[46],"effects":[48],"C11C1,":[50,255],"monoclonal":[52,183,253,262],"antibody":[53,184,254,263],"acting":[54],"to":[55,85,201,212,229,240,264,267],"inhibit":[56],"cellular":[57],"binding":[58],"high":[60],"molecular":[61],"weight":[62],"kininogen":[63,265],"(HK),":[64],"were":[65,83,97,116,137,147,152,250],"studied":[66],"transgenic":[70,88],"rat.":[71],"Thrice":[72],"weekly":[73],"intraperitoneal":[74],"injections":[75],"C11C1":[77],"(1.9":[78],"mg/kg)":[79],"or":[80],"IgG1":[81],"(6mg/kg)":[82],"given":[84],"male":[86],"rats":[89,96],"for":[90,119,157],"3":[91],"weeks,":[92],"beginning":[93],"when":[94],"23":[98],"weeks":[99],"old.":[100],"Stool":[101],"character":[102],"was":[103,167],"scored":[104,117],"daily":[105,118],"measure":[108],"intestinal":[110],"inflammation,":[111,159],"rear":[114],"limbs":[115],"clinical":[120,191],"signs":[121],"arthritis,":[123],"tarsal":[124,143],"joint":[125,144],"swelling":[126],"erythema.":[128],"At":[129],"end":[131],"experiment":[134],"animals":[136],"euthanized,":[138],"colon":[141],"histologic":[145],"lesions":[146,224],"examined.":[148],"histology":[150],"sections":[151],"assigned":[153],"numerical":[155],"score":[156],"colonic":[158,223],"synovitis,":[160],"cartilage":[162],"damage.":[163],"Activation":[164],"KKS":[166,259],"assessed":[168],"assays":[170],"plasma":[172],"prekallikrein,":[173],"HK,":[174],"factor":[175,178],"XI,":[176],"XII.":[179],"Administration":[180],"directed":[185],"against":[186],"rapidly":[188],"decreased":[189],"scores":[192],"from":[197,208,225,236],"3.0":[198],"\u00b1":[199,203,210,214,227,231,238,242],"0":[200,211],"1.2":[202],"0.2":[204],"(p<0.005)":[205],"12.0":[209],"0.8":[213,215,228,239],"(p<0.001).":[216],"Histologic":[217],"analyses":[218],"confirmed":[219],"significant":[220],"reductions":[221],"7.7":[226],"2.8":[230],"0.9":[232],"(p=0.004)":[233],"synovitis":[235],"9.5":[237],"5.0":[241],"1.0":[243],"(p=0.009).":[244],"Decreased":[245],"prekallikrein":[246],"levels":[249],"reversed":[251],"providing":[256],"evidence":[257],"activation.":[260],"A":[261],"appears":[266],"therapeutic":[269],"potential":[270],"arthropathies.":[277]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-10-18T00:00:00"}