{"id":"https://openalex.org/W2979533746","doi":null,"title":"Maillard products and coffee roasting products activate NF-\u03baB and Nrf2 in cell culture and intact human gut tissue ex vivo","display_name":"Maillard products and coffee roasting products activate NF-\u03baB and Nrf2 in cell culture and intact human gut tissue ex vivo","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2979533746","mag":"2979533746"},"language":"en","primary_location":{"id":"pmh:oai:ub.uni-erlangen.de-opus:1919","doi":null,"is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-fau/files/1919/original_TanjaSauerDissertation.doc","pdf_url":"https://opus4.kobv.de/opus4-fau/files/1919/original_TanjaSauerDissertation.doc","source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opus4.kobv.de/opus4-fau/files/1919/original_TanjaSauerDissertation.doc","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011368918","display_name":"Tanja Sauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tanja Sauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011368918"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.14180000126361847,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11745","display_name":"Potato Plant Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maillard-reaction-products","display_name":"Maillard reaction products","score":0.8759999871253967},{"id":"https://openalex.org/keywords/coffee-roasting","display_name":"coffee roasting","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nrf2-activation","display_name":"Nrf2 activation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8259999752044678},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9340000152587891},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6660000085830688},{"id":"https://openalex.org/keywords/coffee-bioactive-compounds","display_name":"coffee bioactive compounds","score":0.5019999742507935},{"id":"https://openalex.org/keywords/oxidative-stress-related-diseases","display_name":"oxidative stress-related diseases","score":0.5130000114440918},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.34299999475479126},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.6370000243186951},{"id":"https://openalex.org/keywords/intestinal-barrier-integrity","display_name":"intestinal barrier integrity","score":0.34299999475479126},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8698488473892212},{"id":"https://openalex.org/C140327455","wikidata":"https://www.wikidata.org/wiki/Q1228460","display_name":"Roasting","level":2,"score":0.8156583309173584},{"id":"https://openalex.org/C35378473","wikidata":"https://www.wikidata.org/wiki/Q647574","display_name":"Maillard reaction","level":2,"score":0.6626651287078857},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5267994999885559},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4971342384815216},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48667269945144653},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4574446380138397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3749500513076782},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.357022225856781},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.28001517057418823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11854657530784607},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ub.uni-erlangen.de-opus:1919","doi":null,"is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-fau/files/1919/original_TanjaSauerDissertation.doc","pdf_url":"https://opus4.kobv.de/opus4-fau/files/1919/original_TanjaSauerDissertation.doc","source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-024516066","doi":null,"is_oa":false,"landing_page_url":"https://open.fau.de/handle/openfau/1919","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"mag:2979533746","doi":null,"is_oa":false,"landing_page_url":"https://d-nb.info/1015888909/34","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ub.uni-erlangen.de-opus:1919","doi":null,"is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-fau/files/1919/original_TanjaSauerDissertation.doc","pdf_url":"https://opus4.kobv.de/opus4-fau/files/1919/original_TanjaSauerDissertation.doc","source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979533746.pdf","grobid_xml":"https://content.openalex.org/works/W2979533746.grobid-xml"},"referenced_works_count":219,"referenced_works":["https://openalex.org/W16443402","https://openalex.org/W34352644","https://openalex.org/W204754020","https://openalex.org/W1207588145","https://openalex.org/W1508032050","https://openalex.org/W1513659817","https://openalex.org/W1515492821","https://openalex.org/W1524312765","https://openalex.org/W1530276820","https://openalex.org/W1534551308","https://openalex.org/W1541649582","https://openalex.org/W1546509577","https://openalex.org/W1558003391","https://openalex.org/W1565131882","https://openalex.org/W1568529372","https://openalex.org/W1620810572","https://openalex.org/W1638074023","https://openalex.org/W1775296038","https://openalex.org/W1775749144","https://openalex.org/W1854884262","https://openalex.org/W1909526655","https://openalex.org/W1963991652","https://openalex.org/W1965247746","https://openalex.org/W1966527137","https://openalex.org/W1967999992","https://openalex.org/W1970968656","https://openalex.org/W1971209988","https://openalex.org/W1972043008","https://openalex.org/W1972840337","https://openalex.org/W1973564793","https://openalex.org/W1976056246","https://openalex.org/W1976108411","https://openalex.org/W1979034912","https://openalex.org/W1980021465","https://openalex.org/W1981133477","https://openalex.org/W1981513091","https://openalex.org/W1981559054","https://openalex.org/W1981718074","https://openalex.org/W1983348465","https://openalex.org/W1985623783","https://openalex.org/W1986711635","https://openalex.org/W1988317209","https://openalex.org/W1988545234","https://openalex.org/W1988847146","https://openalex.org/W1989355099","https://openalex.org/W1989373140","https://openalex.org/W1990056345","https://openalex.org/W1990224925","https://openalex.org/W1990551727","https://openalex.org/W1991265255","https://openalex.org/W1991534964","https://openalex.org/W1991631628","https://openalex.org/W1992011524","https://openalex.org/W1992710979","https://openalex.org/W1993098971","https://openalex.org/W1993290440","https://openalex.org/W1995263087","https://openalex.org/W1996684418","https://openalex.org/W1998555633","https://openalex.org/W1998608463","https://openalex.org/W1999234525","https://openalex.org/W1999759188","https://openalex.org/W2000586934","https://openalex.org/W2001626257","https://openalex.org/W2001851760","https://openalex.org/W2002467106","https://openalex.org/W2002607484","https://openalex.org/W2002807853","https://openalex.org/W2002893295","https://openalex.org/W2002912821","https://openalex.org/W2004757706","https://openalex.org/W2004771015","https://openalex.org/W2005602619","https://openalex.org/W2005604933","https://openalex.org/W2005822229","https://openalex.org/W2006456750","https://openalex.org/W2008577285","https://openalex.org/W2008854574","https://openalex.org/W2010414348","https://openalex.org/W2010520278","https://openalex.org/W2010713573","https://openalex.org/W2010899799","https://openalex.org/W2012444645","https://openalex.org/W2012553932","https://openalex.org/W2016293419","https://openalex.org/W2016405025","https://openalex.org/W2017486390","https://openalex.org/W2018185503","https://openalex.org/W2018264979","https://openalex.org/W2018906759","https://openalex.org/W2019933893","https://openalex.org/W2021283251","https://openalex.org/W2021734608","https://openalex.org/W2022020411","https://openalex.org/W2023196187","https://openalex.org/W2023677185","https://openalex.org/W2024038126","https://openalex.org/W2024170704","https://openalex.org/W2025587781","https://openalex.org/W2026204881","https://openalex.org/W2026221670","https://openalex.org/W2027383204","https://openalex.org/W2028528940","https://openalex.org/W2028659179","https://openalex.org/W2030039320","https://openalex.org/W2030232040","https://openalex.org/W2030954937","https://openalex.org/W2031503758","https://openalex.org/W2032173473","https://openalex.org/W2032662949","https://openalex.org/W2032670192","https://openalex.org/W2033349238","https://openalex.org/W2035203289","https://openalex.org/W2035692542","https://openalex.org/W2035759625","https://openalex.org/W2037141143","https://openalex.org/W2037581062","https://openalex.org/W2037673353","https://openalex.org/W2038016809","https://openalex.org/W2038468771","https://openalex.org/W2039042657","https://openalex.org/W2039133647","https://openalex.org/W2039197913","https://openalex.org/W2039684293","https://openalex.org/W2040637037","https://openalex.org/W2041177478","https://openalex.org/W2042458891","https://openalex.org/W2046585941","https://openalex.org/W2047964022","https://openalex.org/W2049775789","https://openalex.org/W2050145096","https://openalex.org/W2051581102","https://openalex.org/W2053542354","https://openalex.org/W2054646177","https://openalex.org/W2055909988","https://openalex.org/W2057961754","https://openalex.org/W2058331808","https://openalex.org/W2061184965","https://openalex.org/W2061681952","https://openalex.org/W2061810257","https://openalex.org/W2062205148","https://openalex.org/W2063695564","https://openalex.org/W2064452102","https://openalex.org/W2065579677","https://openalex.org/W2066674039","https://openalex.org/W2068221219","https://openalex.org/W2069584550","https://openalex.org/W2070895853","https://openalex.org/W2071952696","https://openalex.org/W2073760769","https://openalex.org/W2074315483","https://openalex.org/W2074931383","https://openalex.org/W2075124697","https://openalex.org/W2076262907","https://openalex.org/W2077531083","https://openalex.org/W2077547899","https://openalex.org/W2077951304","https://openalex.org/W2078947446","https://openalex.org/W2080275691","https://openalex.org/W2082297136","https://openalex.org/W2085224876","https://openalex.org/W2087260579","https://openalex.org/W2087513868","https://openalex.org/W2088342461","https://openalex.org/W2089324920","https://openalex.org/W2090150679","https://openalex.org/W2091382311","https://openalex.org/W2094156327","https://openalex.org/W2094646101","https://openalex.org/W2094781039","https://openalex.org/W2095411323","https://openalex.org/W2095523455","https://openalex.org/W2095544339","https://openalex.org/W2098587915","https://openalex.org/W2099239405","https://openalex.org/W2100170028","https://openalex.org/W2101444644","https://openalex.org/W2103479281","https://openalex.org/W2104251051","https://openalex.org/W2106697731","https://openalex.org/W2106891459","https://openalex.org/W2108655405","https://openalex.org/W2111413139","https://openalex.org/W2113338980","https://openalex.org/W2114918609","https://openalex.org/W2117192674","https://openalex.org/W2118150025","https://openalex.org/W2118170059","https://openalex.org/W2118368465","https://openalex.org/W2119143532","https://openalex.org/W2119150369","https://openalex.org/W2121189414","https://openalex.org/W2124569198","https://openalex.org/W2126160998","https://openalex.org/W2130834261","https://openalex.org/W2130961250","https://openalex.org/W2137836635","https://openalex.org/W2139563064","https://openalex.org/W2141098534","https://openalex.org/W2142541950","https://openalex.org/W2143245895","https://openalex.org/W2145334223","https://openalex.org/W2145356433","https://openalex.org/W2146141276","https://openalex.org/W2149564918","https://openalex.org/W2149870206","https://openalex.org/W2151892297","https://openalex.org/W2153935558","https://openalex.org/W2154632188","https://openalex.org/W2155456675","https://openalex.org/W2159022953","https://openalex.org/W2159634370","https://openalex.org/W2162856441","https://openalex.org/W2165109133","https://openalex.org/W2182105458","https://openalex.org/W2257822573","https://openalex.org/W2334246894","https://openalex.org/W2408578286","https://openalex.org/W4300872982"],"related_works":["https://openalex.org/W7058169752","https://openalex.org/W2025765388","https://openalex.org/W1973839695","https://openalex.org/W1980758854","https://openalex.org/W2095523455","https://openalex.org/W2316147573","https://openalex.org/W1969839296","https://openalex.org/W2162856441","https://openalex.org/W2061184965","https://openalex.org/W2801744738"],"abstract_inverted_index":{"Coffee":[0],"is":[1,350,408,421,782,1664,1714,1720,1726,1783,2155,2632,3322,3327],"one":[2,949,1551,1562],"of":[3,16,31,97,103,111,128,152,182,219,224,240,266,274,279,293,298,316,345,356,398,403,413,417,431,473,514,524,546,562,567,587,593,596,612,660,665,677,710,729,736,760,791,806,827,857,867,904,941,957,991,1019,1046,1060,1075,1096,1186,1225,1244,1325,1337,1370,1383,1391,1449,1455,1469,1496,1507,1511,1528,1557,1568,1606,1627,1732,1737,1741,1779,1794,1806,1843,1858,1866,1889,1900,1927,1931,1944,1953,1960,2029,2133,2140,2166,2173,2194,2213,2218,2230,2265,2298,2313,2343,2371,2379,2390,2415,2424,2432,2440,2491,2555,2565,2576,2608,2625,2639,2652,2803,2875,2882,2919,2928,2936,2960,2970,2984,3001,3009,3028,3032,3067,3087,3100,3104,3127,3132,3145,3161,3192,3230,3237,3261,3279,3291,3335,3352,3359],"the":[4,13,54,73,82,95,109,150,173,180,200,215,222,264,272,277,286,290,294,296,306,343,365,396,401,411,471,499,511,530,544,555,559,563,565,576,585,588,591,597,609,614,617,641,657,663,673,708,737,768,778,792,825,865,953,958,980,989,994,1006,1024,1047,1061,1076,1087,1097,1184,1191,1195,1222,1238,1241,1270,1291,1323,1329,1333,1399,1431,1446,1452,1456,1467,1494,1498,1516,1526,1547,1554,1558,1565,1569,1573,1595,1607,1615,1729,1739,1777,1788,1792,1841,1864,1887,1896,1925,1929,1938,1942,1956,1996,2002,2006,2025,2058,2070,2077,2097,2141,2149,2161,2164,2167,2171,2174,2190,2203,2211,2219,2223,2254,2263,2296,2350,2356,2413,2430,2438,2479,2485,2489,2501,2505,2568,2574,2588,2605,2622,2637,2646,2650,2771,2780,2801,2856,2872,2879,2917,2925,2942,2967,2973,2977,2981,2998,3007,3022,3026,3054,3065,3085,3096,3121,3125,3130,3143,3190,3259,3266,3280,3333],"most":[5,1784],"consumed":[6],"beverages":[7],"worldwide.":[8],"The":[9,522,885,964,1042,1094,1946,2040,2377],"characteristic":[10],"flavour":[11],"and":[12,38,43,46,89,127,136,142,168,184,193,210,217,226,255,271,281,320,374,382,391,484,558,616,635,725,748,813,824,851,877,946,984,1057,1071,1102,1112,1125,1138,1181,1221,1332,1386,1393,1463,1561,1600,1602,1624,1629,1651,1687,1744,1755,1757,1796,1879,1885,1898,1902,1918,1958,1971,2004,2017,2052,2090,2102,2192,2251,2272,2317,2442,2464,2504,2587,2602,2677,2682,2687,2774,2782,2797,2800,2805,2819,2888,2903,2914,2986,3003,3014,3098,3165,3185,3205,3239,3244,3276,3314,3367],"stimulating":[14],"effect":[15,1197,3306],"coffee":[17,50,56,86,129,2466,2496,2517,2530,2543,2557,2580,2643,2667,2699,2713,2743,2753,2769,2792,2814,2939,2946,2949,2971,3035,3070,3091,3105,3162,3204,3243,3343,3347],"are":[18,79,144,212,359,393,1083,1309,2127,2552,2559,2592,2976],"responsible":[19],"for":[20,124,157,327,342,765,831,862,971,1005,1054,1119,1167,1203,1216,1263,1318,1356,1584,1677,1685,1823,1913,2105,2472,2671,2691,2745,2894,2909,3111,3170,3197,3273,3332,3342],"its":[21,2672],"popularity.":[22],"Recent":[23],"epidemiological":[24,3339],"studies":[25,3340],"also":[26,427,447,580,749,795,967,1658,2208,2278,2286,2520,2539,2560,2662,3253,3328],"correlated":[27],"a":[28,59,112,177,310,339,406,432,439,480,491,858,890,925,1016,1038,1051,1131,1230,1285,1380,1476,1508,1519,1622,1666,1735,1874,2088,2131,2152,2198,2215,2257,2291,2368,2387,2421,2721,2761,2817,3049,3073,3270,3287,3304,3329,3349],"reduced":[29,658,1758,3350],"risk":[30,3351],"oxidative":[32,65,205,220,2072,2078,2098,2142,2162,2175,2205,2224,2352,2357,3212,3360],"stress-associated":[33,3361],"diseases":[34,67,3362],"such":[35,187,384,722,1977,2269,2547,2896,3363],"as":[36,100,188,385,387,389,693,702,704,723,1003,1044,1402,1458,1978,2065,2130,2270,2384,2386,2469,2545,2548,2562,2614,2897,3194,3284,3355,3357,3364],"Alzheimer\u2019s":[37,3365],"Parkinson\u2019s":[39],"disease,":[40],"brain,":[41],"liver":[42],"colon":[44,1567],"cancer":[45,3354],"diabetes":[47,3370],"mellitus":[48],"to":[49,133,331,361,438,479,490,534,600,672,745,754,773,882,900,911,973,1142,1145,1158,1165,1205,1249,1254,1266,1278,1290,1320,1339,1360,1409,1422,1425,1639,1669,1811,1819,1872,1915,1937,1988,2021,2068,2085,2107,2115,2157,2290,2310,2333,2345,2374,2484,2509,2522,2584,2636,2658,2663,2674,2694,2718,2833,2842,2865,2944,3021,3052,3135,3189,3233],"consumption.":[51],"To":[52,549,776,1365,1681],"date,":[53,1682],"bioactive":[55],"compounds":[57],"causing":[58,2262],"beneficial":[60,3305],"health":[61],"effects":[62,1672],"in":[63,85,179,214,276,285,364,400,443,449,475,505,508,526,539,569,662,712,820,834,993,1023,1086,1130,1135,1139,1177,1198,1398,1412,1461,1487,1490,1502,1515,1546,1633,1653,1659,1678,1706,1728,1751,1759,1791,1798,1816,1877,1882,1891,1895,1941,1955,2074,2087,2170,2189,2210,2282,2300,2338,2381,2397,2418,2435,2475,2478,2495,2515,2528,2541,2578,2618,2642,2645,2679,2728,2777,2816,2997,3011,3058,3076,3081,3095,3120,3124,3142,3265,3286],"these":[64,2629],"stress-related":[66],"have":[68],"not":[69,351,422,572,783,1001,1408,1611,1647,1694,1770,1828,1850,2245,2320,2348,2361,2429,2447,2534,2655,2756,2931,3080,3150,3180,3249],"been":[70,1695,2891],"identified.":[71],"In":[72,93,289,309,584,682,909,1150,1924,2019,2308,2596,2702,2711,2748,3129],"present":[74,287,1085,1514,2417,2434,2647],"study,":[75,295],"Maillard":[76,98,113,229,259,269,301,311,348,357,370,452,517,560,680,685,713,738,761,915,1021,1032,1092,1376,1453,1691,1724,1789,1861,1869,1981,2179,2456,2459,2476,2486,2589,2664,2974,3207],"products,":[77,916,1725,1790],"which":[78,119,159,322,377,486,637,695,1082,1283,1308,1405,1524,1663,1719,1782,1986,2010,2126,2243,2451,2551,2591,2899,3268],"formed":[80,428,2593,2627],"during":[81,204,429,757,789,800,1587,1951,2160,2572,2594],"roasting":[83,2968],"process":[84],"by":[87,228,268,300,305,347,415,516,575,581,603,631,640,651,822,920,1037,1106,1305,1375,1379,1614,1690,1710,1723,1746,1763,1787,1845,1852,1868,2054,2178,2249,2444,2455,2628,2813,3005,3039,3069,3183,3214,3222,3257],"carbonyls":[88],"amines,":[90],"were":[91,283,623,649,690,944,1089,1115,1127,1208,1214,1260,1541,1578,1598,1907,2185,2611,2689,2709,2736,2788,3118],"analysed.":[92,139,232],"detail,":[94],"role":[96,178,273,1876,2297,3008,3075],"products":[99,230,260,270,302,349,358,371,381,518,561,686,1022,1033,1377,1454,1471,1692,1870,1982,2180,2460,2477,2586,2590,2607,2631,2660,2969,2975,3208],"potential":[101],"triggers":[102],"cell":[104,249,1179,1192,1512,1604,1655,1800,2003],"signalling":[105,250,1036,2013,2267,3299],"was":[106,120,138,231,234,303,323,335,426,446,477,502,571,605,629,638,716,731,808,818,829,841,894,898,918,961,1029,1104,1154,1227,1274,1298,1372,1396,1406,1435,1521,1591,1610,1699,1708,1748,1838,1893,1922,1933,1949,1993,2035,2081,2181,2232,2236,2305,2329,2360,2394,2406,2452,2467,2493,2513,2526,2533,2538,2582,2654,2669,2726,2807,2811,2839,2860,2869,2906,2964,2990,2995,3017,3037,3062,3093,3139,3157,3179,3201,3300],"investigated.":[107,2182],"Therefore,":[108,815,2183],"ability":[110,2673],"model":[114,1668],"system":[115],"(a":[116,130],"ribose-lysine":[117],"mixture":[118,313,454,1390],"heated":[121,324,433,1477],"at":[122,325,495,519,740,750,763,786,797,810,872,875,879,889,998,1911,2110,2402,3114],"120\u00b0C":[123,326],"30":[125,328,2795],"min)":[126],"Maillard-rich":[131,3245],"beverage)":[132],"activate":[134,1649,2336,2675,2757,2912,2952],"NF-\u03baB":[135,141,148,209,225,280,1101,1124,1153,1411,1462,1484,1628,1650,1686,1704,1743,1795,1815,1878,2016,2271,2441,2463,2676,2706,2716,2764,2773,2804,2838,2858,2889,2902,2932,2954,2985,3002,3013,3029,3078,3193,3223],"Nrf2":[137,143,211,227,282,1103,1126,1226,1245,1272,1304,1326,1347,1352,1371,1419,1433,1464,1486,1630,1652,1688,1745,1797,1831,1844,1880,2134,2281,2303,2322,2337,2443,2678,2708,2724,2758,2775,2806,2810,2827,2876,2887,2913,2929,2956,3004,3015,3056,3082,3215,3231,3292,3298,3326],"Both,":[140,1123],"redox-sensitive":[145,1098],"transcription":[146,1099,1175,1499,3236],"factors.":[147],"regulates":[149],"expression":[151,3260],"genes":[153],"coding":[154],"amongst":[155,2779],"others":[156],"cytokines":[158],"control":[160,1148,1161,1281,1363,1428,1642,2118,2836,2866],"diverse":[161],"cellular":[162,1035],"processes":[163],"including":[164,2015,2046,2972],"immune":[165],"response,":[166],"inflammation":[167,3316],"stress":[169,2073,2079,2099,2143,2176,2206,2225,2353,2358,3213],"response.":[170],"Nrf2,":[171,2465],"on":[172,697,924,1210,1673,2222,3307],"other":[174,3317,3358],"hand,":[175],"plays":[176],"induction":[181,2264],"detoxifying":[183,3240],"antioxidant":[185,3238],"enzymes":[186],"\u03b3-glutamylcysteine":[189],"synthetase,":[190],"glutathione":[191],"synthetase":[192],"phase":[194],"II":[195],"NADPH:quinone":[196],"oxidoreductase":[197],"1":[198,838,2695,2739],"counteracting":[199],"unbalanced":[201],"redox":[202],"homeostasis":[203],"stress.":[206],"Since":[207,456,1863,2148,2284,2458,2567,2988],"both":[208,1174,1742,2499,2901],"involved":[213,363,1727,2449,2996],"development":[216,265],"balance":[218],"stress,":[221],"activation":[223,278,1095,1187,1288,1324,1626,1689,1705,1730,1740,1793,1842,1881,2304,2323,2439,2725,2776,2802,2874,2918,2927,2999,3016,3027,3191,3216,3224],"It":[233,1590,1992,2120,2532,2868,2905],"shown":[235,1004,1407,1700,2991,3285],"before":[236,1701,2992],"that":[237,424,780,1300,1593,1702,1717,1840,1995,2123,2238,2408,2536,2871,2908,2966,2993,3064,3176,3203,3325],"physiological":[238],"concentrations":[239,668,1809],"reactive":[241,1973],"oxygen":[242,582,636,642,1974,2506],"species":[243,1975],"(ROS)":[244,1976],"especially":[245,2399,3206,3264],"H2O2":[246,267,275,299,334,346,366,414,425,445,474,500,515,525,547,568,604,628,661,711,730,769,781,807,817,828,840,868,892,913,970,992,1039,1807,1853,1859,1867,1890,1920,1932,1939,1985,1999,2288,2299,2372,2380,2393,2416,2427,2433,2450,2492,2512,2525,2537,2577,2615,2626,2640,2653,2994,3010,3068,3089,3116,3138,3147,3178],"trigger":[247],"various":[248,719,1178,1654,1883,2680],"pathways":[251,2014,2268],"involving":[252],"NF-\u03baB,":[253],"PKC":[254],"MAPK":[256],"kinase.":[257],"Indeed,":[258,498,2076,3283,3338],"generate":[261,1984,2240],"H2O2.":[262,1979,2566],"Thus,":[263,419,656,1064,1200,1296,1518,1644,1712,1836,2057,2234,2327,2404,2649,2786,2962,3060,3199],"investigated":[284,1030,2468,2808,3018],"study.":[288,2648],"first":[291],"part":[292,1045],"generation":[297,344,513,728,805,826,956,1865,2490,2575,3066],"analysed":[304,1228,1894,2036],"FOXPCA":[307,577,589,2502],"assay.":[308],"reaction":[312,453,481,714,720,2487],"(Mrmh),":[314],"consisting":[315,1506],"0.5":[317],"M":[318],"D-ribose":[319],"L-lysine,":[321],"min,":[329],"up":[330,533,744,753,772,881,972,1141,1204,1248,1319,1421,1810,1818,1914,2106,2373,2508,2521,2717,2841,3134],"180":[332],"\u00b5M":[333,986,1813,2392,2426,2511,2524,3137],"detected.":[336],"Even":[337,1170],"though":[338,1171],"clear":[340],"mechanism":[341,407,1731],"published":[352],"yet,":[353],"some":[354],"substructures":[355],"suggested":[360,2870,3341],"be":[362,670,1473,1848,2063,2246],"formation.":[367],"Amongst":[368],"others,":[369],"with":[372,395,529,687,1091,1117,1190,1219,1293,1328,1440,1445,1582,1765,1808,1860,1909,2033,2187,2315,2365,2738,2768,2791,2938,3024,3034,3041,3045,3164,3303,3345],"enediol":[373],"enaminol":[375],"substructures,":[376],"tautomerize":[378],"from":[379,1543,1553,1564],"Amadori":[380],"dicarbonyls":[383],"methylglyoxal,":[386],"well":[388,703,2385,3356],"reductones":[390],"aminoreductones":[392],"associated":[394,3302],"production":[397],"ROS":[399,2008,2027,2045,2159,2260],"presence":[402,664,1897,1926,1957,2191,2212,3097,3126,3144],"metals.":[404],"Moreover,":[405,988,1466,2341,2720,3320],"proposed":[409,2237,2407,3202],"highlighting":[410],"formation":[412,472,709,2651],"autoxidation":[416],"\u03b1-hydroxyaldehydes.":[418],"it":[420,1028,1297,1698,1837,2235,2328,2405,2963,2989,3061,3200],"surprising":[423,2535],"caramelization":[430,1470],"ribose":[434,460,483,1392,1478],"solution":[435,461,467,1479,2370,2389,2423],"(ribh)":[436,1480],"but":[437,579,794,888,1009,1657,1826,1854,2277,2289,2428,2446,2661,2759,2849,2930,3079,3252],"lower":[440,504,798,891,1437,1548,1935,2292,2634],"extent":[441,493,2293],"than":[442,507,979,1442,2294,2396,3123,3217,3318],"Mrmh.":[444,537,1314,1403,2436,3198],"detected":[448,639,2514,2527],"an":[450,458,464,1388,1856,1989,2066,2470,3219,3234],"unheated":[451,459,465,1389],"(Mrmu).":[455],"neither":[457,1482,2705,2953],"(ribu)":[462],"nor":[463,1485,2707,2955],"lysine":[466,485,1394],"(lysu)":[468],"generated":[469,785,842,1722,1786,2287,2454],"H2O2,":[470,613,1718,1781,2047,2242],"Mrmu":[476,506,1441,2279,2285,2301,2316,2335,2346,2448],"related":[478],"between":[482,554,849,2794,2886],"can":[487,669,1472,1968,2062,2244,3293],"take":[488],"place":[489],"minor":[492],"even":[494],"room":[496],"temperature.":[497,726],"concentration":[501,532,545,566,646,1132,1331,1382,1448,1930,1940,2089,2414,2624,2818,2859],"significantly":[503,1128,1344,1934,2633,2714],"Mrmh":[509,527,540,570,645,667,793,821,861,897,917,982,1008,1118,1166,1172,1220,1267,1301,1330,1343,1450,1457,1583,1620,1645,1747,1846,1892,1910,1954,2034,2086,2188,2228,2239,2276,2398,2445],"underlining":[510],"enhanced":[512,1345,3235],"increased":[520,528,771,878,1014,1327,1417,2209],"temperatures.":[521],"amount":[523,659,866,990,1224,1888,2431,2638,3086],"sample":[531],"25":[535,542,859,1341],"mM":[536,860,1342],"However":[538],">":[541],"mM,":[543],"decreased.":[548],"rule":[550],"out":[551,940],"any":[552,816,1772,1830,2137],"interference":[553],"FOX":[556,598],"reagent":[557,599],"Mrmh,":[564,2295,2311,2334,3006,3025],"only":[573,784,1648,1851,2275,2656,3048,3250],"measured":[574,606,732,1105,3094,3140],"assay":[578,2042,2503],"electrodes.":[583,643],"case":[586],"assay,":[590],"oxidation":[592],"ferrous":[594],"ions":[595,602],"ferric":[601],"photometrically.":[607],"For":[608,625],"electrochemical":[610],"detection":[611,653],"Clark":[615],"Luminescent":[618],"Dissolved":[619],"Oxygen":[620],"(LDO)":[621],"electrodes":[622],"used.":[624,655],"this":[626,683,2023],"purpose,":[627],"decomposed":[630],"catalase":[632,823,1768,2318,3046],"into":[633,948],"water":[634,2834],"Similar":[644,2483,3020],"response":[647,1832,3221],"curves":[648],"observed":[650,895,3158],"all":[652,844,1084,1799],"methods":[654],"high":[666,751,1381],"attributed":[671,2583,2657],"radical":[674],"scavenging":[675],"activity":[676,3256],"antioxidative":[678,705,3255],"active":[679,950,959,965,995,1025,1311],"products.":[681,1862,2457,2665],"context,":[684],"reductone":[688],"structures":[689,694,2617],"already":[691,2612],"identified":[692,2613],"-depending":[696],"their":[698,1107],"concentration-":[699],"exhibit":[700],"pro-":[701],"activity.":[706],"Next,":[707,952,1572,2666,2730],"mixtures":[715,739,762],"monitored":[717,809,830,2494],"under":[718,843,1414],"conditions":[721,846],"pH":[724,742,746,901,905],"Enhanced":[727,3296],"directly":[733],"after":[734,907,1163,1229,1312,1354,1438,1443,1821,2031,2083,2145,2227,2363,2829,2846,2933,2957,3030,3090,3159,3225],"preparation":[735,790],"basic":[741],"values":[743],"10":[747],"temperatures":[752,788,799],"130\u00b0C.":[755],"Also":[756],"prolonged":[758,801,855],"incubation":[759,856,1334,1952,2229,2767,2935,2959,3103,3160],"37\u00b0C":[764,880,1912],"96":[766,832,863,974],"h,":[767,839,864,1322,2096,2855],"content":[770,1921,2378],"370":[774],"\u00b5M.":[775,853,884,2376,3153],"test":[777,1366,2481],"hypothesis":[779],"elevated":[787,2082,2362],"permanently":[796,968,1721,2241,2453],"storage,":[802],"de":[803,954],"novo":[804,955],"4\u00b0C,":[811,873],"25\u00b0C":[812,876,999],"37\u00b0C.":[814,2403],"removed":[819],"h":[833,975,1121,1207,1218,1233,1265,1358,1586,1825,1917,2109,2693,2799,2831,2848,3113],"each":[835],"sample.":[836],"After":[837,2094,2853,3102],"tested":[845,962,1397,2670],"reaching":[847,976,1349,2823],"levels":[848,978,1252,1353,1420,2113,2828,2845,3117,3148,3229],"50":[850],"100":[852],"During":[854,1237,1315,1534],"stayed":[869,1011,2103],"almost":[870],"constant":[871,1012,2104],"decreased":[874],"200":[883,2523],"same":[886,1400,1947,2480],"trend":[887,1948,2722,2762,3051,3156],"level":[893,1273,1434,2009,2028,2080,2100,2144,2177,2207,2226,2359],"when":[896,2400],"adjusted":[899],"5.5":[902],"instead":[903],"8":[906],"heating.":[908],"order":[910,2020],"enrich":[912],"generating":[914,2616],"fractionated":[919],"size":[921],"exclusion":[922],"chromatography":[923],"D-SaltTM":[926],"polyacrylamide":[927],"desalting":[928],"column":[929],"(cut":[930],"off":[931],"1.8":[932],"kDa).":[933],"Five":[934],"H2O2-generating":[935,1020],"fractions":[936,943],"(F5":[937],"-":[938,2696,2740,3108],"F9)":[939],"20":[942],"collected":[945],"unified":[947],"fraction.":[951,1026],"fraction":[960,966,996],"likewise.":[963,2307,3019],"produced":[969],"higher":[977,1251,1276,1287,1351,2112,2826,2844,2863,3119],"crude":[981,1007],"(100":[983],"260":[985],"H2O2).":[987],"incubated":[997,1090,1215,1908,2186,2401,2789],"did":[1000,1481,1646,1769,1827,2319,2347,2755,2951,3149],"decrease":[1002],"rather":[1010,1855,3210],"or":[1013,1378,2367],"indicating":[1015,1451],"successful":[1017],"enrichment":[1018],"Subsequently,":[1027],"if":[1031,1367],"modulate":[1034],"dependent":[1040,1133,2092,2821],"mechanism.":[1041],"intestine":[1043,1560],"gastrointestinal":[1048,1535,1549],"tract":[1049],"represents":[1050,3269],"primary":[1052,1151,1182,3271],"target":[1053,3272,3331],"food-induced":[1055,3274],"inter-":[1056,3275],"intracellular":[1058,1972,2007,2026,2044,2059,2124,2204,2259,2351,3277],"reactions":[1059,1307,3278],"human":[1062,1077,1503,1529,1537,1574,1635,1660,1760,1962,2732,2749,3167,3281],"body.":[1063,3282],"macrophages,":[1065,1752],"Caco-2":[1066,1113,1136,1753,2685,2703],"cells":[1067,1074,1081,1114,1137,1162,1282,1754,1884,1901,2250,2409,2681,2686,2704,2781,3146,3184],"(colorectal":[1068],"epithelial":[1069],"cells)":[1070],"HIMEC":[1072,1756],"(primary":[1073],"intestinal":[1078,1504,3297,3311,3315],"microvascular":[1079],"endothelium),":[1080],"intestine,":[1088],"mixtures.":[1093],"factors":[1100,1176,1500],"nuclear":[1108,1223,1242,1271,1346,1368,1418,1432,2857,2880,2982],"translocation.":[1109],"Firstly,":[1110],"macrophages":[1111,1140,1213,1259,1338,1413,1707,1817,1906,2030,2184,2231,2314,2339,2344,2688,2712,2778,2787,2937,3033],"stimulated":[1116,1579,2737],"2":[1120,1168,1217,1585,1824,2692,2746,2847,3171,3369],"(short-term).":[1122,2701],"activated":[1129,1155,1173,1814,2280,2715,2812,2840],"manner":[1134,2822],"5-fold":[1143],"compared":[1144,1157,1253,1277,1289,1359,1424,1638,1936,2114,2635,2832,2864],"PBS":[1146,1159,1279,1361,1426,1640,2116],"treated":[1147,1160,1280,1362,1427,1641,2117,2835],"cells.":[1149,1364,1429,1643,1945,2075,2119,2255,2837,2867],"HIMEC,":[1152],"2-fold":[1156,1625],"exposure":[1164,1444,2084,2342],"h.":[1169,1835,2147,2326,2747,3172],"lines":[1180],"cells,":[1183,1928,3133],"degree":[1185],"varied":[1188],"strongly":[1189],"type":[1193,3368],"showing":[1194],"maximum":[1196],"macrophages.":[1199,1211,1488,2283,2729,2961,3059,3101,3128],"long-term":[1201,1316,2934,2958,3226],"experiments":[1202,1255,1317,3023],"24":[1206,1264,1321,1357,1834,1916,2108,2325,2798,2830,3112],"conducted":[1209],"First,":[1212,1905,2684],"subsequent":[1231],"22":[1232],"post-incubation":[1234],"without":[1235,1256,3166],"stimulant.":[1236],"stimulant-free":[1239,1294],"post-incubation,":[1240],"translocation":[1243,1348,1369,2881,2983,3057],"continuously":[1246,1261,1983],"raised":[1247,1493],"8-fold":[1250],"post-incubation.":[1257,1295],"When":[1258],"exposed":[1262,2690],"(25":[1268],"mM),":[1269],"26-fold":[1275],"corresponds":[1284],"3-fold":[1286,2843],"experiment":[1292],"concluded":[1299,2330,2965,3063],"might":[1302,1847,2000,2011,2877,3071],"induce":[1303,1410,1483,1829,2012,2462,3218],"chain":[1306],"still":[1310,2861],"removing":[1313],"time.":[1335],"Exposure":[1336],"\u2265":[1340],"50-fold":[1350],"stimulation":[1355,1439,1527,1822,2032,2364,3031,3092],"indeed":[1373],"induced":[1374,1621,1849,2302,2760],"amino":[1384],"acids":[1385],"sugars,":[1387],"(Mrmu)":[1395],"way":[1401],"Mrmu,":[1404,2382,2419],"applied":[1415],"conditions,":[1416],"20-fold":[1423,2825],"However,":[1430,1697,1980,2519,2621,3043],"profoundly":[1436],"equivalent":[1447],"key":[1459,1875,2978],"players":[1460,2979],"activation.":[1465,2765,3083],"contribution":[1468],"excluded":[1474],"since":[1475],"This":[1489,2884],"vitro":[1491],"screening":[1492],"question":[1495],"how":[1497],"respond":[1501],"tissue":[1505,1531,1539,1576,1596,1608,1637,1662,1675,1762,1903,1964,2734,2751,2783,3169,3186],"wide":[1509],"range":[1510],"types":[1513,1656,1801],"intestine.":[1517,1571],"method":[1520],"successfully":[1522],"established":[1523],"allowed":[1525],"gut":[1530,1538,1575,1636,1661,1761,1963,2733,2750,3168,3267,3308],"ex":[1532,1580,1618,1631,1965],"vivo.":[1533,1619,1966],"endoscopy,":[1536],"samples":[1540,1577,1597,1609,2735,2784],"taken":[1542],"two":[1544],"localisations":[1545],"tract;":[1550],"biopsy":[1552,1563],"terminal":[1555],"ileum":[1556],"small":[1559],"ascending":[1566],"large":[1570],"vivo":[1581,1632,1679],"mucosa":[1588,1616],"oxygenation.":[1589],"demonstrated":[1592],"(i)":[1594],"uniform":[1599],"comparable,":[1601],"(ii)":[1603],"viability":[1605],"harmfully":[1612],"affected":[1613],"oxygenation":[1617],"2.8-fold":[1623],"intact":[1634,1961,2731],"considered":[1665,2561],"valuable":[1667],"study":[1670],"nutritional":[1671],"complex":[1674],"systems":[1676],"evaluations.":[1680],"defined":[1683],"mechanisms":[1684,3000],"had":[1693],"established.":[1696],"Maillard-induced":[1703],"inhibited":[1709],"catalase.":[1711,1766,3042],"there":[1713,3321],"growing":[1715,3323],"evidence":[1716,3324],"NF-\u03baB.":[1733,2883,2920],"As":[1734,2256],"matter":[1736],"fact,":[1738],"fully":[1749,2247,2411,3181],"abolished":[1750,3038],"co-treatment":[1764,2312,3040,3044],"Heat-inactivated":[1767],"show":[1771],"effect.":[1773],"These":[1774,2921,3173],"results":[1775,2922,3174],"reveal":[1776],"involvement":[1778,2165],"extracellular":[1780,1919,1970,1998,3088],"certainly":[1785],"tested.":[1802,2785],"Interestingly,":[1803],"pure":[1804,2369,2388,2422],"solutions":[1805],"500":[1812,2375,2391,2425],"13-fold":[1820],"within":[1833,2324],"hypothesized":[1839,1994],"interaction":[1857],"seems":[1871,2121],"play":[1873,3072],"tissue,":[1886],"absence":[1899,1943,1959,2193,3099,3122,3131],"respectively.":[1904],"measured.":[1923],"found":[1950,2540,2641,2727],"Cells":[1967],"detoxify":[1969,2412],"leads":[1987],"incomplete":[1990],"detoxification.":[1991],"residual":[1997],"penetrate":[2001,2253],"increases":[2005,2261],"Nrf2.":[2018,2273,2904,2987],"verify":[2022],"assumption,":[2024],"using":[2037],"2\u2019,7\u2019-dichlorofluorescein":[2038],"(DCF).":[2039],"DCF":[2041,2060],"determines":[2043],"peroxyl":[2048],"radicals,":[2049],"nitric":[2050],"oxide":[2051],"peroxynitrite":[2053],"fluorescence":[2055,2061],"signal.":[2056],"used":[2064],"index":[2067],"quantify":[2069],"overall":[2071,2623],"time":[2091,2820],"manner.":[2093],"4":[2095,2146,2697,2741,3109],"plateaued":[2101],"4-fold":[2111],"likely":[2122],"antioxidants,":[2125],"highly":[2128,2570],"expressed":[2129],"consequence":[2132],"activation,":[2135],"attenuate":[2136,2878],"further":[2138,3301],"increase":[2139,2172,2349],"NADPH":[2150,2168,2199,2220],"oxidase,":[2151],"membrane-bound":[2153],"enzyme,":[2154],"known":[2156],"produce":[2158],"burst,":[2163],"oxidase":[2169,2200,2221],"diphenyleneiodonium":[2195],"chloride":[2196],"(DPI),":[2197],"inhibitor.":[2201],"Since,":[2202],"DPI,":[2214],"major":[2216,2553,3074],"impact":[2217],"excluded.":[2233],"detoxified":[2248,3182],"thus":[2252],"consequence,":[2258],"intracellular,":[2266],"Not":[2274],"determined":[2306],"contrast":[2309],"reverse":[2321],"that,":[2331],"contrary":[2332,2943],"H2O2-independently.":[2340],"level.":[2354],"Likewise,":[2355],"ribh":[2366,2383],"less":[2395],"may":[2410,2923,3209,3247],"ribh,":[2420],"Consequently,":[2437],"clearly":[2461],"example":[2471,2910],"foods":[2473,3246],"rich":[2474],"systems.":[2482],"mixtures,":[2488],"extracts.":[2497],"With":[2498],"methods,":[2500],"electrodes,":[2507],"440":[2510],"roasted":[2516,2579,2619,2945],"extract.":[2518,2531,2940],"raw":[2529,2542,2556,2948],"extract":[2544,2581,2644,2668,2700,2744,2754,2793,2815,2950,3036,3106,3163],"polyphenols":[2546,2569],"chlorogenic":[2549,2609],"acid,":[2550,2600,2610],"components":[2554],"beans,":[2558],"potent":[2563],"generators":[2564],"degrade":[2571],"roasting,":[2573],"degradation":[2585,2606,2630,2659],"roasting.":[2595],"earlier":[2597],"studies,":[2598],"caffeic":[2599],"pyrogallol":[2601],"hydroxyhydroquinone":[2603],"(1,2,4-Benzenetriol),":[2604],"coffee.":[2620],"tissue.":[2683],"mg/mL":[2698,2742],"activated.":[2710],"4-fold.":[2719],"towards":[2723,2763],"samples,":[2752],"Short-term":[2766],"showed":[2770,3047],"highest":[2772],"next":[2790],"min":[2796],"time-dependently.":[2809],"nearly":[2824],"declined":[2850],"slightly":[2851],"thereafter.":[2852],"6":[2854],"1.7-fold":[2862],"pronounced":[2873,2926],"crosstalk":[2885],"has":[2890],"recently":[2892],"discussed":[2893,3195],"stimuli":[2895],"sulforaphane":[2898,2911],"regulate":[2900],"reported":[2907],"concomitantly":[2915],"repress":[2916],"explain":[2924],"On":[2941],"extract,":[2947],"triggering":[2980],"coffee-induced":[3012,3055,3077],"slight":[3050],"block":[3053],"Hence,":[3084,3242],"(1":[3107],"mg/mL)":[3110],"37\u00b0C,":[3115],"800":[3136],"whereas":[3141],"exceed":[3151],"230":[3152],"A":[3154],"similar":[3155],"indicate":[3175],"coffee-generated":[3177],"respectively":[3187],"leading":[3188],"above":[3196],"counteract":[3211],"inflammatory":[3220],"incubation.":[3227],"Activated":[3228],"lead":[3232],"enzymes.":[3241],"exert":[3248],"direct":[3251],"indirect":[3254],"inducing":[3258],"cytoprotective":[3262],"proteins":[3263],"mouse":[3288],"model,":[3289],"activators":[3290],"improve":[3294],"colitis.":[3295,3319],"barrier":[3309],"dysfunction,":[3310],"mucosal":[3312],"injury":[3313],"promising":[3330],"prevention":[3334],"colorectal":[3336,3353],"cancer.":[3337],"drinker":[3344],"regular":[3346],"consumption":[3348],"disease":[3366],"mellitus.":[3371]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}
