{"id":"https://openalex.org/W2979484804","doi":"https://doi.org/10.1186/s12888-019-2286-1","title":"Clozapine and desmethylclozapine: correlation with neutrophils and leucocytes counting in Mexican patients with schizophrenia","display_name":"Clozapine and desmethylclozapine: correlation with neutrophils and leucocytes counting in Mexican patients with schizophrenia","publication_year":2019,"publication_date":"2019-10-09","ids":{"openalex":"https://openalex.org/W2979484804","doi":"https://doi.org/10.1186/s12888-019-2286-1","mag":"2979484804","pmid":"https://pubmed.ncbi.nlm.nih.gov/31597566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6785871"},"language":"en","primary_location":{"id":"doi:10.1186/s12888-019-2286-1","doi":"https://doi.org/10.1186/s12888-019-2286-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12888-019-2286-1","pdf_url":"https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-019-2286-1","source":{"id":"https://openalex.org/S94610253","display_name":"BMC Psychiatry","issn_l":"1471-244X","issn":["1471-244X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-019-2286-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056771520","display_name":"Mayela Vaquero-Baez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mayela Vaquero-Baez","raw_affiliation_strings":["Doctorado en Ciencias Biologicas y de la Salud, Universidad Autonoma Metropolitana-Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctorado en Ciencias Biologicas y de la Salud, Universidad Autonoma Metropolitana-Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076208734","display_name":"Araceli D\u0131\u0301az-Ruiz","orcid":"https://orcid.org/0000-0002-1481-0966","observed_orcids":["https://orcid.org/0000-0002-1481-0966"]},"institutions":[{"id":"https://openalex.org/I4210147537","display_name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda","ror":"https://ror.org/05k637k59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210147537"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Araceli D\u00edaz-Ru\u00edz","raw_affiliation_strings":["Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda \"Dr Manuel Velasco Suarez\", Ave. Insurgentes Sur No. 3877, 14269, Ciudad de M\u00e9xico, D.F, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda \"Dr Manuel Velasco Suarez\", Ave. Insurgentes Sur No. 3877, 14269, Ciudad de M\u00e9xico, D.F, M\u00e9xico","institution_ids":["https://openalex.org/I4210147537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011592740","display_name":"Luis Antonio Trist\u00e1n-L\u00f3pez","orcid":"https://orcid.org/0000-0002-8033-0629","observed_orcids":["https://orcid.org/0000-0002-8033-0629"]},"institutions":[{"id":"https://openalex.org/I4210147537","display_name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda","ror":"https://ror.org/05k637k59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210147537"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Luis Trist\u00e1n-L\u00f3pez","raw_affiliation_strings":["Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda \"Dr Manuel Velasco Suarez\", Ave. Insurgentes Sur No. 3877, 14269, Ciudad de M\u00e9xico, D.F, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda \"Dr Manuel Velasco Suarez\", Ave. Insurgentes Sur No. 3877, 14269, Ciudad de M\u00e9xico, D.F, M\u00e9xico","institution_ids":["https://openalex.org/I4210147537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018199386","display_name":"Carlos Luis Avi\u00f1a-Cervantes","orcid":"https://orcid.org/0000-0002-6888-8873","observed_orcids":["https://orcid.org/0000-0002-6888-8873"]},"institutions":[{"id":"https://openalex.org/I4210147537","display_name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda","ror":"https://ror.org/05k637k59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210147537"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Carlos Avi\u00f1a-Cervantes","raw_affiliation_strings":["Divisi\u00f3n de Psiquiatr\u00eda, Instituto Nacional de Neurolog\u00eda, \"Dr Manuel Velasco Suarez\", Ciudad de M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisi\u00f3n de Psiquiatr\u00eda, Instituto Nacional de Neurolog\u00eda, \"Dr Manuel Velasco Suarez\", Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I4210147537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048161882","display_name":"Carlos Torner","orcid":"https://orcid.org/0000-0003-4127-7391","observed_orcids":["https://orcid.org/0000-0003-4127-7391"]},"institutions":[{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Carlos Torner","raw_affiliation_strings":["Doctorado en Ciencias Biologicas y de la Salud, Universidad Autonoma Metropolitana-Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctorado en Ciencias Biologicas y de la Salud, Universidad Autonoma Metropolitana-Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040168499","display_name":"Jes\u00fas Ram\u00edrez\u2010Berm\u00fadez","orcid":"https://orcid.org/0000-0003-2879-5258","observed_orcids":["https://orcid.org/0000-0003-2879-5258"]},"institutions":[{"id":"https://openalex.org/I4210147537","display_name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda","ror":"https://ror.org/05k637k59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210147537"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Ram\u00edrez-Berm\u00fadez","raw_affiliation_strings":["Divisi\u00f3n de Psiquiatr\u00eda, Instituto Nacional de Neurolog\u00eda, \"Dr Manuel Velasco Suarez\", Ciudad de M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisi\u00f3n de Psiquiatr\u00eda, Instituto Nacional de Neurolog\u00eda, \"Dr Manuel Velasco Suarez\", Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I4210147537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112310398","display_name":"Sergio Montes","orcid":"https://orcid.org/0000-0002-0138-0784","observed_orcids":["https://orcid.org/0000-0002-0138-0784"]},"institutions":[{"id":"https://openalex.org/I4210147537","display_name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda","ror":"https://ror.org/05k637k59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210147537"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Sergio Montes","raw_affiliation_strings":["Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda \"Dr Manuel Velasco Suarez\", Ave. Insurgentes Sur No. 3877, 14269, Ciudad de M\u00e9xico, D.F, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda \"Dr Manuel Velasco Suarez\", Ave. Insurgentes Sur No. 3877, 14269, Ciudad de M\u00e9xico, D.F, M\u00e9xico","institution_ids":["https://openalex.org/I4210147537"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032377993","display_name":"Camilo R\u0131\u0301os","orcid":"https://orcid.org/0000-0002-3216-0119","observed_orcids":["https://orcid.org/0000-0002-3216-0119"]},"institutions":[{"id":"https://openalex.org/I200362191","display_name":"Universidad Aut\u00f3noma Metropolitana","ror":"https://ror.org/02kta5139","country_code":"MX","type":"education","lineage":["https://openalex.org/I200362191"]},{"id":"https://openalex.org/I4210147537","display_name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda","ror":"https://ror.org/05k637k59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210147537"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Camilo R\u00edos","raw_affiliation_strings":["Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda \"Dr Manuel Velasco Suarez\", Ave. Insurgentes Sur No. 3877, 14269, Ciudad de M\u00e9xico, D.F, M\u00e9xico. crios@correo.xoc.uam.mx","Laboratorio de Neurofarmacolog\u00eda Molecular, Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana-Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico. crios@correo.xoc.uam.mx","Laboratorio de Neurofarmacolog\u00eda Molecular, Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana-Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda \"Dr Manuel Velasco Suarez\", Ave. Insurgentes Sur No. 3877, 14269, Ciudad de M\u00e9xico, D.F, M\u00e9xico. crios@correo.xoc.uam.mx","institution_ids":["https://openalex.org/I4210147537"]},{"raw_affiliation_string":"Laboratorio de Neurofarmacolog\u00eda Molecular, Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana-Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico. crios@correo.xoc.uam.mx","institution_ids":["https://openalex.org/I200362191"]},{"raw_affiliation_string":"Laboratorio de Neurofarmacolog\u00eda Molecular, Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana-Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I200362191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032377993"],"corresponding_institution_ids":["https://openalex.org/I200362191","https://openalex.org/I4210147537"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":2.1879,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86775991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"1","first_page":"295","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":1.0},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.6759999990463257},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.6840000152587891},{"id":"https://openalex.org/keywords/neutrophil-count","display_name":"neutrophil count","score":0.722000002861023},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hematological-adverse-events","display_name":"hematologic adverse events","score":0.9150000214576721},{"id":"https://openalex.org/keywords/clozapine-metabolites","display_name":"clozapine metabolites","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.6869999766349792},{"id":"https://openalex.org/keywords/plasma-drug-monitoring","display_name":"plasma concentration monitoring","score":0.5339999794960022},{"id":"https://openalex.org/keywords/mexican-patients","display_name":"Mexican patients","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.8807535171508789},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7603617906570435},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.48805367946624756},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.450560986995697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44184306263923645},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4270172715187073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4018273949623108},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.38729220628738403},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3410404920578003},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09233039617538452},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008800","descriptor_name":"Mexico","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12888-019-2286-1","doi":"https://doi.org/10.1186/s12888-019-2286-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12888-019-2286-1","pdf_url":"https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-019-2286-1","source":{"id":"https://openalex.org/S94610253","display_name":"BMC Psychiatry","issn_l":"1471-244X","issn":["1471-244X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6785871","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6785871","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"Text"},{"id":"pmid:31597566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31597566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7c412bddbc914520823385472c4928a7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c412bddbc914520823385472c4928a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Psychiatry, Vol 19, Iss 1, Pp 1-7 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12888-019-2286-1","doi":"https://doi.org/10.1186/s12888-019-2286-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12888-019-2286-1","pdf_url":"https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-019-2286-1","source":{"id":"https://openalex.org/S94610253","display_name":"BMC Psychiatry","issn_l":"1471-244X","issn":["1471-244X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979484804.pdf","grobid_xml":"https://content.openalex.org/works/W2979484804.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W227878633","https://openalex.org/W1501711344","https://openalex.org/W1837202277","https://openalex.org/W1906444297","https://openalex.org/W1963479676","https://openalex.org/W1995063674","https://openalex.org/W1995868913","https://openalex.org/W2036480935","https://openalex.org/W2044222389","https://openalex.org/W2047045529","https://openalex.org/W2069024810","https://openalex.org/W2078451304","https://openalex.org/W2084250773","https://openalex.org/W2116693941","https://openalex.org/W2135182273","https://openalex.org/W2147238434","https://openalex.org/W2171300878","https://openalex.org/W2222093164","https://openalex.org/W2327507814","https://openalex.org/W2612895336","https://openalex.org/W2756599600","https://openalex.org/W2763046479","https://openalex.org/W2768290393"],"related_works":["https://openalex.org/W1983231816","https://openalex.org/W4414063233","https://openalex.org/W227878633","https://openalex.org/W3153260470","https://openalex.org/W4404871507","https://openalex.org/W2756599600","https://openalex.org/W4387730667","https://openalex.org/W2995988993","https://openalex.org/W1608543641","https://openalex.org/W2467127311"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"The":[2,79,104,191,216],"aim":[3],"of":[4,26,48,57,91,101,122,139,218,229,239,247,261],"present":[5],"study":[6],"is":[7],"to":[8,19,44,74,88,108,212,257],"measure":[9,89],"plasma":[10,56,111,144,227,248],"clozapine":[11,15,195],"(CLZ)":[12],"and":[13,50,65,86,95,117,146,160,196,231,242],"N-desmethyl":[14],"(DMC)":[16],"as":[17,71,120],"biomarkers":[18],"correlate":[20,109],"drug":[21,235],"concentrations":[22,47,90],"with":[23,125,157],"the":[24,102,113,137,167,175,223,234,245,254,262],"appearance":[25],"preclinical":[27],"adverse":[28,76,181],"hematic":[29],"effects.":[30],"Methods":[31],"A":[32],"high-performance":[33],"liquid":[34],"chromatographic":[35],"method,":[36],"using":[37,130],"a":[38,72,126,131,150,188],"diode-array":[39],"(ultraviolet)":[40],"detector,":[41],"was":[42,83,164,172],"validated":[43],"obtain":[45],"reliable":[46],"CLZ":[49,92,110,116,118,143,147,170,204,230,249],"DMC,":[51,208],"its":[52],"main":[53],"metabolite,":[54],"in":[55,174,200,253],"41":[58],"schizophrenic":[59],"patients":[60],"taking":[61,115,233],"CLZ.":[62],"Blood":[63],"neutrophils":[64,159,241],"leucocytes":[66,161],"counting":[67,124,141],"were":[68,183],"concurrently":[69],"assessed":[70],"proxy":[73],"subclinical":[75],"reactions.":[77],"Results":[78],"analytical":[80],"method":[81,105],"employed":[82],"linear,":[84],"reproducible,":[85],"stable":[87],"between":[93,194],"30":[94],"1000":[96],"ng/mL,":[97],"while":[98],"12.5\u2013560":[99],"ng/mL":[100],"metabolite.":[103],"allowed":[106],"us":[107],"concentrations,":[112],"time":[114,232],"dose":[119],"determinants":[121,238],"neutrophils\u2019":[123],"R2":[127,151],"=":[128,152],"0.447,":[129],"multiple":[132],"regression":[133,168],"analysis":[134],"model.":[135,176],"Likewise,":[136],"correlation":[138,193],"leucocyte":[140],"vs":[142],"levels":[145,228],"time,":[148,225],"showed":[149],"0.461.":[153],"DMC":[154],"correlated":[155],"significantly":[156],"both":[158],"counting,":[162],"but":[163,206],"excluded":[165],"from":[166],"when":[169],"concentration":[171],"included":[173],"Finally,":[177],"no":[178],"other":[179],"hematological":[180],"reactions":[182],"recorded.":[184],"One":[185],"patient":[186],"presented":[187],"cardiovascular":[189],"complication.":[190],"negative":[192],"neutrophil":[197],"count":[198],"observed":[199],"patients,":[201],"suggest":[202],"that":[203,226],"itself,":[205],"not":[207],"could":[209],"be":[210,251],"related":[211],"hematologic":[213],"side-effects.":[214],"Conclusion":[215],"findings":[217],"this":[219],"study,":[220],"demonstrate":[221],"for":[222],"first":[224],"are":[236],"independent":[237],"blood":[240],"leucocytes,":[243],"so":[244],"monitoring":[246],"may":[250],"useful":[252],"clinic":[255],"practice":[256],"determine":[258],"safe":[259],"dosing":[260],"drug.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-10-18T00:00:00"}