{"id":"https://openalex.org/W2979476768","doi":"https://doi.org/10.1177/0022034519880157","title":"Microbial Interactions in Oral Communities Mediate Emergent Biofilm Properties","display_name":"Microbial Interactions in Oral Communities Mediate Emergent Biofilm Properties","publication_year":2019,"publication_date":"2019-10-07","ids":{"openalex":"https://openalex.org/W2979476768","doi":"https://doi.org/10.1177/0022034519880157","mag":"2979476768","pmid":"https://pubmed.ncbi.nlm.nih.gov/31590609","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6927214"},"language":"en","primary_location":{"id":"doi:10.1177/0022034519880157","doi":"https://doi.org/10.1177/0022034519880157","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0022034519880157","pdf_url":null,"source":{"id":"https://openalex.org/S62865007","display_name":"Journal of Dental Research","issn_l":"0022-0345","issn":["0022-0345","1544-0591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6927214","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078839621","display_name":"Patricia I. Diaz","orcid":"https://orcid.org/0000-0002-9501-1145","observed_orcids":["https://orcid.org/0000-0002-9501-1145"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.I. Diaz","raw_affiliation_strings":["Division of Periodontology, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, UConn Health, Farmington, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Periodontology, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, UConn Health, Farmington, CT, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076186001","display_name":"Alex M. Valm","orcid":"https://orcid.org/0000-0002-8286-080X","observed_orcids":["https://orcid.org/0000-0002-8286-080X"]},"institutions":[{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A.M. Valm","raw_affiliation_strings":["Department of Biological Sciences, University at Albany, SUNY, Albany, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-8286-080X","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University at Albany, SUNY, Albany, NY, USA","institution_ids":["https://openalex.org/I392282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076186001"],"corresponding_institution_ids":["https://openalex.org/I392282"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":8.8367,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.98594347,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"99","issue":"1","first_page":"18","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.17000000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dental-plaque","display_name":"dental plaque","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.8140000104904175},{"id":"https://openalex.org/keywords/interspecies-interactions","display_name":"interspecies interactions","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cross-feeding","display_name":"cross-feeding","score":0.7129999995231628},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.7319999933242798},{"id":"https://openalex.org/keywords/chemical-communication","display_name":"chemical communication","score":0.5720000267028809},{"id":"https://openalex.org/keywords/microbial-virulence","display_name":"microbial virulence","score":0.5910000205039978},{"id":"https://openalex.org/keywords/biofilm-persistence","display_name":"biofilm persistence","score":0.7120000123977661},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.765999972820282},{"id":"https://openalex.org/keywords/oral-diseases","display_name":"oral diseases","score":0.8830000162124634},{"id":"https://openalex.org/keywords/microbial-networks","display_name":"microbial networks","score":0.5090000033378601},{"id":"https://openalex.org/keywords/archaea","display_name":"archaea","score":0.5249999761581421},{"id":"https://openalex.org/keywords/fungi","display_name":"fungi","score":0.671999990940094},{"id":"https://openalex.org/keywords/viruses","display_name":"viruses","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6738333702087402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5329117774963379},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3572874069213867},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.35134953260421753},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.24478799104690552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23858901858329773}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1177/0022034519880157","doi":"https://doi.org/10.1177/0022034519880157","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0022034519880157","pdf_url":null,"source":{"id":"https://openalex.org/S62865007","display_name":"Journal of Dental Research","issn_l":"0022-0345","issn":["0022-0345","1544-0591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6683085","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6927214","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6927214","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6927214","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Dent Res","raw_type":"Text"},{"id":"pmid:31590609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31590609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of dental research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:6683085","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6927214","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2888014724","display_name":"Systems level imaging to reveal oral microbial community structure and assembly","funder_award_id":"R03DE028042","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5834711875","display_name":null,"funder_award_id":"DE023967","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W857372192","https://openalex.org/W1486437305","https://openalex.org/W1487366254","https://openalex.org/W1545724794","https://openalex.org/W1591485721","https://openalex.org/W1866398940","https://openalex.org/W1946221762","https://openalex.org/W1966131360","https://openalex.org/W1969100588","https://openalex.org/W1969966908","https://openalex.org/W1977824944","https://openalex.org/W1992007782","https://openalex.org/W2003750215","https://openalex.org/W2005421221","https://openalex.org/W2019239212","https://openalex.org/W2019452514","https://openalex.org/W2038286189","https://openalex.org/W2043893006","https://openalex.org/W2045878113","https://openalex.org/W2049358854","https://openalex.org/W2053830048","https://openalex.org/W2060831484","https://openalex.org/W2064146024","https://openalex.org/W2067475510","https://openalex.org/W2071352479","https://openalex.org/W2076069550","https://openalex.org/W2076187086","https://openalex.org/W2080580603","https://openalex.org/W2088297260","https://openalex.org/W2091337262","https://openalex.org/W2093250796","https://openalex.org/W2096528548","https://openalex.org/W2098252888","https://openalex.org/W2102275848","https://openalex.org/W2105033070","https://openalex.org/W2107923138","https://openalex.org/W2119407979","https://openalex.org/W2119610831","https://openalex.org/W2121748291","https://openalex.org/W2123235711","https://openalex.org/W2124198277","https://openalex.org/W2125265838","https://openalex.org/W2126700118","https://openalex.org/W2128769815","https://openalex.org/W2136438408","https://openalex.org/W2142092938","https://openalex.org/W2144667661","https://openalex.org/W2145028525","https://openalex.org/W2153375130","https://openalex.org/W2154818633","https://openalex.org/W2159340830","https://openalex.org/W2167783345","https://openalex.org/W2168694247","https://openalex.org/W2169530108","https://openalex.org/W2171961740","https://openalex.org/W2175259778","https://openalex.org/W2252298505","https://openalex.org/W2328663077","https://openalex.org/W2461426999","https://openalex.org/W2466892747","https://openalex.org/W2508695471","https://openalex.org/W2544423525","https://openalex.org/W2561177951","https://openalex.org/W2563122700","https://openalex.org/W2586303391","https://openalex.org/W2593718734","https://openalex.org/W2615414024","https://openalex.org/W2616923088","https://openalex.org/W2626920017","https://openalex.org/W2735942520","https://openalex.org/W2754851756","https://openalex.org/W2765970410","https://openalex.org/W2769943976","https://openalex.org/W2777482520","https://openalex.org/W2778862281","https://openalex.org/W2784379180","https://openalex.org/W2800799562","https://openalex.org/W2802273451","https://openalex.org/W2808636390","https://openalex.org/W2886248596","https://openalex.org/W2890492987","https://openalex.org/W2895933660","https://openalex.org/W2896937938","https://openalex.org/W2897037806","https://openalex.org/W2900580314","https://openalex.org/W2903048549","https://openalex.org/W2904273842","https://openalex.org/W2915052332","https://openalex.org/W2921193540","https://openalex.org/W2945644675","https://openalex.org/W2952931038"],"related_works":["https://openalex.org/W2112101348","https://openalex.org/W1875514519","https://openalex.org/W2966110995","https://openalex.org/W2593718734","https://openalex.org/W4245601710","https://openalex.org/W4248040217","https://openalex.org/W4234240297","https://openalex.org/W4229679853","https://openalex.org/W2765371812","https://openalex.org/W4243658827"],"abstract_inverted_index":{"Oral":[0],"microbial":[1],"communities":[2,24],"are":[3,31,112],"extraordinarily":[4],"complex":[5,109],"in":[6,26,64],"taxonomic":[7],"composition":[8],"and":[9,18,34,47,54,73,80,85,92,126,141],"comprise":[10],"interdependent":[11],"biological":[12],"systems.":[13],"The":[14,121],"bacteria,":[15],"archaea,":[16],"fungi,":[17],"viruses":[19],"that":[20,69,88,100],"thrive":[21],"within":[22,129],"these":[23,146],"engage":[25],"extensive":[27],"cell-cell":[28,71],"interactions,":[29,76],"which":[30],"both":[32],"beneficial":[33],"antagonistic.":[35],"Direct":[36],"physical":[37],"interactions":[38,72,128],"among":[39],"individual":[40,95],"cells":[41],"mediate":[42,70],"large-scale":[43],"architectural":[44],"biofilm":[45],"arrangements":[46],"provide":[48],"spatial":[49,143],"proximity":[50],"for":[51],"chemical":[52],"communication":[53],"metabolic":[55,75],"cooperation.":[56],"In":[57],"this":[58],"review,":[59],"we":[60],"summarize":[61],"recent":[62],"work":[63],"identifying":[65],"specific":[66],"molecular":[67],"components":[68],"describe":[74],"such":[77],"as":[78],"cross-feeding":[79],"exchange":[81],"of":[82,94,118,123,138,160,164,172],"electron":[83],"acceptors":[84],"small":[86],"molecules,":[87],"modify":[89],"the":[90,116,135,149,161,170],"growth":[91],"virulence":[93],"species.":[96],"We":[97],"argue,":[98],"however,":[99],"although":[101],"pairwise":[102],"interaction":[103],"models":[104],"have":[105],"provided":[106],"useful":[107],"information,":[108],"community-like":[110],"systems":[111],"needed":[113],"to":[114,134,154,169,175],"study":[115],"properties":[117,137,147,163],"oral":[119,130,155,177],"communities.":[120,178],"networks":[122,166],"multiple":[124],"synergistic":[125],"antagonistic":[127],"biofilms":[131],"give":[132],"rise":[133],"emergent":[136],"persistence,":[139],"stability,":[140],"long-range":[142],"structure,":[144],"with":[145],"mediating":[148],"dysbiotic":[150],"transitions":[151],"from":[152],"health":[153],"diseases.":[156],"A":[157],"better":[158],"understanding":[159],"fundamental":[162],"interspecies":[165],"will":[167],"lead":[168],"development":[171],"effective":[173],"strategies":[174],"manipulate":[176]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-10-18T00:00:00"}