{"id":"https://openalex.org/W2979452437","doi":null,"title":"Low-grade chronic inflammation mediated by mast cells in fibromyalgia: role of IL-37.","display_name":"Low-grade chronic inflammation mediated by mast cells in fibromyalgia: role of IL-37.","publication_year":2018,"publication_date":"2018-03-01","ids":{"openalex":"https://openalex.org/W2979452437","mag":"2979452437","pmid":"https://pubmed.ncbi.nlm.nih.gov/29684996"},"language":"en","primary_location":{"id":"pmid:29684996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29684996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Editorial"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000139771","display_name":"Filiberto Mastrangelo","orcid":"https://orcid.org/0000-0002-3746-5675","observed_orcids":["https://orcid.org/0000-0002-3746-5675","https://orcid.org/0000-0001-6050-5703"]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Mastrangelo","raw_affiliation_strings":["Department of Medical Science and Biotechnology, University of Foggia, Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science and Biotechnology, University of Foggia, Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021355853","display_name":"Ilias Frydas","orcid":"https://orcid.org/0000-0002-0133-709X","observed_orcids":["https://orcid.org/0000-0002-0133-709X"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I Frydas","raw_affiliation_strings":["Faculty of Parasitology, Aristotle University of Thessaloniki, Macedonia, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Parasitology, Aristotle University of Thessaloniki, Macedonia, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071941913","display_name":"Gianpaolo Ronconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Ronconi","raw_affiliation_strings":["UOS Clinica dei Pazienti del Territorio, Policlinico Gemelli, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOS Clinica dei Pazienti del Territorio, Policlinico Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010719890","display_name":"Spyridon K. Kritas","orcid":"https://orcid.org/0000-0002-3540-9928","observed_orcids":["https://orcid.org/0000-0002-3540-9928"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S K Kritas","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases, Aristotle University of Thessaloniki, Macedonia, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases, Aristotle University of Thessaloniki, Macedonia, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021257221","display_name":"Lucia Tettamanti","orcid":"https://orcid.org/0000-0003-1558-5729","observed_orcids":["https://orcid.org/0000-0003-1558-5729"]},"institutions":[{"id":"https://openalex.org/I115752224","display_name":"University of Insubria","ror":"https://ror.org/00s409261","country_code":"IT","type":"education","lineage":["https://openalex.org/I115752224"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Tettamanti","raw_affiliation_strings":["Department of Medical and Morphological Science, University of Insubria, Varese, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Morphological Science, University of Insubria, Varese, Italy","institution_ids":["https://openalex.org/I115752224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043479380","display_name":"Alessandro Caraffa","orcid":"https://orcid.org/0000-0002-7733-6413","observed_orcids":["https://orcid.org/0000-0002-7733-6413"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Al Caraffa","raw_affiliation_strings":["Department of Pharmacology, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078492160","display_name":"C D Ovidio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C D Ovidio","raw_affiliation_strings":["Section of Legal Medicine, Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Legal Medicine, Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018983637","display_name":"Al\u00ec Younes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Younes","raw_affiliation_strings":["Department of Anesthesiology, \u0091Santo Spirito\u0092 Hospital, Pescara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, \u0091Santo Spirito\u0092 Hospital, Pescara, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086971584","display_name":"Carla Enrica Gallenga","orcid":"https://orcid.org/0000-0002-7426-8603","observed_orcids":["https://orcid.org/0000-0002-7426-8603"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C E Gallenga","raw_affiliation_strings":["Department of Biomedical Sciences and Specialist Surgery, Section of Ophthalmology, University of Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and Specialist Surgery, Section of Ophthalmology, University of Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058886831","display_name":"Paolo Conti","orcid":"https://orcid.org/0000-0001-5610-435X","observed_orcids":["https://orcid.org/0000-0001-5610-435X"]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Conti","raw_affiliation_strings":["Immunology Division, Postgraduate Medical School, University of Chieti-Pescara, Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Division, Postgraduate Medical School, University of Chieti-Pescara, Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"2","first_page":"195","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibromyalgia","display_name":"fibromyalgia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/il-37","display_name":"IL-37","score":0.9670000076293945},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/il-1-cytokine-family","display_name":"IL-1 family cytokines","score":0.7889999747276306},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8759999871253967},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.7850000262260437},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.6809999942779541},{"id":"https://openalex.org/keywords/chronic-widespread-pain","display_name":"chronic widespread pain","score":0.6209999918937683},{"id":"https://openalex.org/keywords/mast-cell-mediators","display_name":"mast cell mediators","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2777831278","wikidata":"https://www.wikidata.org/wiki/Q540571","display_name":"Fibromyalgia","level":2,"score":0.8006166219711304},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7894636392593384},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.762235164642334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6802316904067993},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5914745926856995},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5899170637130737},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5858429670333862},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.44459304213523865},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43829959630966187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20054376125335693},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07793211936950684}],"mesh":[{"descriptor_ui":"D005356","descriptor_name":"Fibromyalgia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:29684996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29684996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Editorial"},{"id":"pmh:oai:irinsubria.uninsubria.it:11383/2075157","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11383/2075157","pdf_url":null,"source":{"id":"https://openalex.org/S4377196351","display_name":"IrInSubria (University of Insubria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I115752224","host_organization_name":"University of Insubria","host_organization_lineage":["https://openalex.org/I115752224"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:sfera.unife.it:11392/2592965","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11392/2592965","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2979452437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29684996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2995392946","https://openalex.org/W3006395328","https://openalex.org/W2959356991","https://openalex.org/W2336936051","https://openalex.org/W2085814582","https://openalex.org/W2072866578","https://openalex.org/W2064227077","https://openalex.org/W3000188275","https://openalex.org/W161190954","https://openalex.org/W3090912378"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"observed":[3],"that":[4],"acute":[5],"stress":[6],"causes":[7],"the":[8,36,86,139,142,149],"activation":[9],"of":[10,58,60,77,119],"TH1":[11],"cells,":[12],"while":[13],"TH2":[14],"cells":[15,89],"regulate":[16],"and":[17,53,63,101,110,124,148],"act":[18],"on":[19],"chronic":[20,43],"inflammation.":[21],"Fibromyalgia":[22],"(FM)":[23],"is":[24,40,65,72,104,113],"a":[25,105,132],"chronic,":[26],"idiopathic":[27],"disorder":[28],"which":[29],"affects":[30],"about":[31],"twelve":[32],"million":[33],"people":[34],"in":[35,75,85,92,115,128,154],"United":[37],"States.":[38],"FM":[39,70,93,129],"characterized":[41],"by":[42,94,108,126],"widespread":[44],"pain,":[45],"fatigue,":[46],"aching,":[47],"joint":[48],"stiffness,":[49],"depression,":[50],"cognitive":[51],"dysfunction":[52],"non-restorative":[54],"sleep.":[55],"The":[56,117],"mechanism":[57],"induction":[59],"muscle":[61],"pain":[62],"inflammation":[64],"not":[66],"yet":[67],"clear.":[68],"In":[69],"there":[71],"an":[73],"increase":[74],"reactivity":[76],"central":[78],"neurons":[79],"with":[80],"increased":[81],"sensitivity":[82],"localized":[83],"mainly":[84],"CNS.":[87],"Mast":[88],"are":[90],"involved":[91],"releasing":[95],"proinflammatory":[96],"cytokines,":[97],"chemokines,":[98],"chemical":[99],"mediators,":[100],"PGD2.":[102],"TNF":[103,125],"cytokine":[106,152],"generated":[107],"MCs":[109],"its":[111],"level":[112],"higher":[114],"FM.":[116,155],"inhibition":[118],"pro-inflammatory":[120],"IL-1":[121],"family":[122],"members":[123],"IL-37":[127,153],"could":[130],"have":[131],"therapeutic":[133],"effect.":[134],"Here,":[135],"we":[136],"report":[137],"for":[138],"first":[140],"time":[141],"relationship":[143],"between":[144],"MCs,":[145],"inflammatory":[146],"cytokines":[147],"new":[150],"anti-inflammatory":[151]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-18T00:00:00"}