{"id":"https://openalex.org/W2979446458","doi":"https://doi.org/10.14309/01.ajg.0000590456.10972.67","title":"231 Low Prevalence of Gastric and Duodenal Neoplasia in Patients With Colon Polyposis of Unknown Etiology","display_name":"231 Low Prevalence of Gastric and Duodenal Neoplasia in Patients With Colon Polyposis of Unknown Etiology","publication_year":2019,"publication_date":"2019-10-01","ids":{"openalex":"https://openalex.org/W2979446458","doi":"https://doi.org/10.14309/01.ajg.0000590456.10972.67","mag":"2979446458"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0000590456.10972.67","doi":"https://doi.org/10.14309/01.ajg.0000590456.10972.67","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0000590456.10972.67","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112749632","display_name":"Filsan Farah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filsan Farah","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058205947","display_name":"Andrew J. Kruger","orcid":"https://orcid.org/0000-0002-5141-4081","observed_orcids":["https://orcid.org/0000-0002-5141-4081"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Kruger","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067713698","display_name":"Rachel Pearlman","orcid":"https://orcid.org/0000-0002-9293-5860","observed_orcids":["https://orcid.org/0000-0002-9293-5860"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Pearlman","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012798070","display_name":"Heather Hampel","orcid":"https://orcid.org/0000-0001-7558-9794","observed_orcids":["https://orcid.org/0000-0001-7558-9794"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Hampel","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH;","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091084441","display_name":"Alice M. Hinton","orcid":"https://orcid.org/0000-0003-4505-4021","observed_orcids":["https://orcid.org/0000-0003-4505-4021"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Hinton","raw_affiliation_strings":["The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057640228","display_name":"Peter P. Stanich","orcid":"https://orcid.org/0000-0002-6844-640X","observed_orcids":["https://orcid.org/0000-0002-6844-640X"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter P. Stanich","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15667345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"114","issue":"1","first_page":"S136","last_page":"S136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-neoplasms","display_name":"stomach neoplasms","score":0.9010000228881836},{"id":"https://openalex.org/keywords/duodenal-neoplasms","display_name":"duodenal neoplasms","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ampullary-adenoma","display_name":"ampullary adenoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.7680000066757202},{"id":"https://openalex.org/keywords/gastric-cancer-risk","display_name":"gastric cancer risk","score":0.3889999985694885},{"id":"https://openalex.org/keywords/mutyh","display_name":"MUTYH","score":0.9990000128746033},{"id":"https://openalex.org/keywords/multigene-panel-testing","display_name":"multigene panel testing","score":0.7559999823570251},{"id":"https://openalex.org/keywords/variants-of-uncertain-significance","display_name":"variants of uncertain significance","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9244998693466187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7299961447715759},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7262905836105347},{"id":"https://openalex.org/C141496672","wikidata":"https://www.wikidata.org/wiki/Q14883437","display_name":"MUTYH","level":5,"score":0.7031365633010864},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5729045867919922},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5589776039123535},{"id":"https://openalex.org/C2780814781","wikidata":"https://www.wikidata.org/wiki/Q1369011","display_name":"Familial adenomatous polyposis","level":4,"score":0.5578638911247253},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42398127913475037},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.21471813321113586},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.19500353932380676},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09077119827270508},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0000590456.10972.67","doi":"https://doi.org/10.14309/01.ajg.0000590456.10972.67","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0000590456.10972.67","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4223958253","https://openalex.org/W4386272549","https://openalex.org/W2921780006","https://openalex.org/W2775356807","https://openalex.org/W4388817961","https://openalex.org/W4407239233","https://openalex.org/W4312216278","https://openalex.org/W4387750834","https://openalex.org/W2043785963","https://openalex.org/W4415540149"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Patients":[1],"with":[2,119,170,186,194,199,232,262,265,274,310,349],"\u226510":[3,100],"cumulative":[4,101,179],"colorectal":[5,102,204],"adenomas":[6,284],"without":[7,331],"identified":[8,286],"APC":[9,110],"or":[10,145,151,157,282],"MUTYH":[11,112],"mutations":[12],"are":[13],"labeled":[14],"as":[15],"colon":[16],"polyposis":[17,149,238],"of":[18,25,40,62,76,129,143,154,173,203,234,293,299,308,333,342,381],"unknown":[19],"etiology":[20],"(CPUE).":[21],"Two":[22],"small":[23],"series":[24],"CPUE":[26,41,71,87,350,382],"patients":[27,42,77,166,210,230,242,260,294,309,327,348],"compiled":[28],"prior":[29],"to":[30,58,376],"widespread":[31],"multi-gene":[32,354],"panel":[33,224,355],"genetic":[34,105,135],"testing":[35,106,225,356],"indicate":[36],"that":[37,351],"duodenal":[38,146,283,345],"screening":[39,66,115,367],"may":[43,362],"be":[44,363],"high":[45],"yield,":[46],"but":[47,251],"this":[48],"has":[49],"not":[50],"been":[51],"incorporated":[52],"into":[53],"guidelines.":[54],"Our":[55],"aim":[56],"was":[57,92,122,182,206,226,302,315,323,338],"investigate":[59],"the":[60,80,127,288,291,297,306,313,378],"prevalence":[61,298,314,341],"neoplastic":[63,300],"lesions":[64],"on":[65],"upper":[67],"endoscopy":[68],"(EGD)":[69],"in":[70,79,137,208,228,237,249,258,287,325,347,366],"patients.":[72,369,383],"METHODS:":[73],"Retrospective":[74],"review":[75],"followed":[78],"Hereditary":[81],"and":[82,111,113,196,212,271,344],"High-Risk":[83],"GI":[84],"Clinic":[85],"for":[86,240],"from":[88],"8/2014":[89],"through":[90],"3/2019":[91],"performed.":[93],"Inclusion":[94],"criteria":[95,132,161],"included":[96,133,246],"age":[97,172,269,278],"\u226518":[98],"years,":[99,296],"adenomas,":[103,191,312],"unrevealing":[104],"including":[107],"at":[108,268,277],"least":[109],"receiving":[114],"EGD":[116,118,245,319],"(baseline":[117],"ampullary":[120,247,275],"visualization":[121,248],"a":[123,138,152,339],"standard":[124],"recommendation":[125],"after":[126,320],"diagnosis":[128],"CPUE).":[130],"Exclusion":[131],"pathogenic":[134],"mutation":[136],"hereditary":[139],"cancer":[140,205],"gene,":[141],"history":[142,153,202],"gastric":[144,266,281,343],"neoplasia,":[147],"serrated":[148],"syndrome":[150],"abdominal":[155],"radiation":[156],"chemotherapy.":[158],"RESULTS:":[159],"Study":[160],"were":[162,256,285],"met":[163],"by":[164],"46":[165],"(31":[167],"M/15":[168],"F)":[169],"median":[171,178],"67":[174],"(range":[175,184],"30\u201382).":[176],"The":[177],"adenoma":[180,276],"count":[181],"24":[183],"10\u2013290),":[185],"17":[187],"(37%)":[188],"having":[189],"10\u201319":[190],"26":[192],"(57%)":[193],"20\u201399":[195],"3":[197],"(7%)":[198],"\u2265100.":[200],"A":[201,370],"noted":[207],"6":[209,241],"(13%)":[211],"8":[213],"(17%)":[214],"had":[215],"colectomy":[216],"(2":[217],"partial,":[218],"4":[219],"subtotal,":[220],"2":[221,259],"total).":[222],"Multi-gene":[223],"performed":[227,324],"42":[229],"(91%),":[231],"variants":[233],"uncertain":[235],"significance":[236],"genes":[239],"(13%).":[243],"Screening":[244],"all":[250],"1":[252,263,272],"patient.":[253],"Neoplastic":[254],"findings":[255,301],"found":[257],"(4%),":[261],"patient":[264,273],"adenocarcinoma":[267],"55":[270],"55.":[279],"No":[280],"cohort.":[289],"In":[290,305],"subset":[292,307],"\u226460":[295],"13%":[303],"(2/16).":[304],"\u226520":[311],"7%":[316],"(2/29).":[317],"Further":[318],"index":[321],"procedure":[322],"16":[326],"during":[328],"study":[329,373],"period":[330],"identification":[332],"additional":[334],"neoplasia.":[335],"CONCLUSION:":[336],"There":[337],"lower":[340],"neoplasia":[346],"primarily":[352],"received":[353],"than":[357],"previously":[358],"reported,":[359],"although":[360],"there":[361],"higher":[364],"yield":[365],"younger":[368],"large,":[371],"multi-center":[372],"is":[374],"needed":[375],"clarify":[377],"optimal":[379],"management":[380]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2019-10-18T00:00:00"}
