{"id":"https://openalex.org/W2979413794","doi":"https://doi.org/10.1182/blood.v120.21.2055.2055","title":"Impact of Operator Techniques On Quality of Bone Marrow Assessment","display_name":"Impact of Operator Techniques On Quality of Bone Marrow Assessment","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2979413794","doi":"https://doi.org/10.1182/blood.v120.21.2055.2055","mag":"2979413794"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.2055.2055","doi":"https://doi.org/10.1182/blood.v120.21.2055.2055","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.2055.2055","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019564077","display_name":"Oreofe Olukemi Odejide","orcid":"https://orcid.org/0000-0002-8117-7224","observed_orcids":["https://orcid.org/0000-0002-8117-7224"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Oreofe O Odejide","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082924494","display_name":"Daniel J. DeAngelo","orcid":"https://orcid.org/0000-0001-7865-2306","observed_orcids":["https://orcid.org/0000-0001-7865-2306"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel J. DeAngelo","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110167899","display_name":"Angel M. Cronin","orcid":"https://orcid.org/0000-0002-9589-1154","observed_orcids":["https://orcid.org/0000-0002-9589-1154"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Angel M. Cronin","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045954413","display_name":"Zachary A. Bernazzoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zachary A. Bernazzoli","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037393862","display_name":"Joseph O. Jacobson","orcid":"https://orcid.org/0000-0001-8634-5891","observed_orcids":["https://orcid.org/0000-0001-8634-5891"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph O. Jacobson","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058975989","display_name":"Scott J. Rodig","orcid":"https://orcid.org/0000-0003-1761-9769","observed_orcids":["https://orcid.org/0000-0003-1761-9769"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott J. Rodig","raw_affiliation_strings":["Brigham and Women's Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077877686","display_name":"Teresa J. Mazeika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Teresa J. Mazeika","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056559207","display_name":"Kristofer D. Earles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristofer D. Earles","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091710463","display_name":"Gregory Alan Abel","orcid":"https://orcid.org/0000-0003-1100-2813","observed_orcids":["https://orcid.org/0000-0003-1100-2813"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory A. Abel","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019564077","https://openalex.org/A5037393862","https://openalex.org/A5045954413","https://openalex.org/A5056559207","https://openalex.org/A5058975989","https://openalex.org/A5077877686","https://openalex.org/A5082924494","https://openalex.org/A5110167899"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43950299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"21","first_page":"2055","last_page":"2055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-biopsy","display_name":"bone marrow biopsy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bone-marrow-aspiration","display_name":"bone marrow aspiration","score":0.8450000286102295},{"id":"https://openalex.org/keywords/operator-technique","display_name":"operator technique","score":0.8899999856948853},{"id":"https://openalex.org/keywords/specimen-quality","display_name":"sample quality","score":0.9520000219345093},{"id":"https://openalex.org/keywords/core-length","display_name":"core length","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lateral-decubitus-position","display_name":"lateral decubitus position","score":0.8080000281333923},{"id":"https://openalex.org/keywords/needle-redirection","display_name":"needle redirection","score":0.902999997138977},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7649999856948853},{"id":"https://openalex.org/keywords/diagnostic-yield","display_name":"diagnostic yield","score":0.8240000009536743},{"id":"https://openalex.org/keywords/needle-type","display_name":"needle type","score":0.3840000033378601},{"id":"https://openalex.org/keywords/operator-variability","display_name":"operator variability","score":0.4099999964237213},{"id":"https://openalex.org/keywords/quality-improvement","display_name":"quality improvement","score":0.3790000081062317},{"id":"https://openalex.org/keywords/bone-marrow-staging","display_name":"bone marrow staging","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7962466478347778},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6364570260047913},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6260015964508057},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5305652618408203},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.46402886509895325},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4291732907295227},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3415505290031433},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33809465169906616},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.1761816143989563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1368364691734314}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.2055.2055","doi":"https://doi.org/10.1182/blood.v120.21.2055.2055","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.2055.2055","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1721643154","https://openalex.org/W2887315563","https://openalex.org/W1516459005","https://openalex.org/W2783684863","https://openalex.org/W4417016404","https://openalex.org/W2783130769","https://openalex.org/W2987740817","https://openalex.org/W2590547286","https://openalex.org/W2883022168","https://openalex.org/W4310096576"],"abstract_inverted_index":{"Abstract":[0,1],"2055":[2],"Background:":[3],"Although":[4,434],"bone":[5,52,82,207,276,400,461],"marrow":[6,53,83,208,277,401,462],"aspiration":[7],"and":[8,16,55,120,137,166,206,215,227,231,256,284,339],"biopsy":[9,84,209,386],"have":[10],"been":[11],"utilized":[12],"in":[13,87,142,418,460],"the":[14,29,36,45,97,113,116,143,149,170,183,196,252,275,376],"diagnosis":[15],"staging":[17],"of":[18,32,38,47,60,93,107,129,133,139,157,162,172,247,268,274,296,324,346,363,390,398,409,429,464,471],"hematologic":[19],"malignancies":[20],"for":[21,51,178],"almost":[22],"a":[23,88,130,134,163,179,191,266,287,405,431],"century,":[24],"little":[25],"is":[26,299],"known":[27],"about":[28],"potential":[30],"impact":[31,46],"operator":[33,48,76,114,204,233,241,297,306,422,456],"techniques":[34,49,62,205,242,298,423,457],"on":[35,154,194],"quality":[37,158,210],"specimens":[39,327,358,368,463],"obtained.":[40],"We":[41,146],"aimed":[42],"to":[43,56,71,79,239,366,473],"characterize":[44,240],"used":[50],"biopsies,":[54,382],"determine":[57],"if":[58,182],"any":[59],"these":[61],"are":[63],"associated":[64,310,320,342,437,446],"with":[65,259,311,321,343,438,447],"specimen":[66,89,181],"quality.":[67,248,466],"Methods:":[68],"From":[69],"April":[70],"July":[72],"2012,":[73],"we":[74,175,250,403],"recorded":[75],"data":[77,104,451],"corresponding":[78],"all":[80],"consecutive":[81],"procedures":[85,263],"resulting":[86,150],"performed":[90,264],"as":[91,160],"part":[92],"routine":[94],"care":[95],"at":[96],"Dana-Farber":[98],"Cancer":[99],"Institute":[100],"(Boston,":[101],"MA).":[102],"These":[103],"included":[105],"type":[106],"needle":[108,117],"used,":[109],"whether":[110],"or":[111,125,190,198],"not":[112,425,444],"redirected":[115],"between":[118,203,254],"aspirate":[119,140,197],"biopsy,":[121],"patient":[122,223],"position":[123,318],"(prone":[124],"lateral":[126,316],"decubitus),":[127],"use":[128,132],"drill,":[131],"measuring":[135],"stylet,":[136],"volume":[138],"obtained":[141],"first":[144],"pull.":[145],"then":[147],"reviewed":[148],"pathology":[151,184],"reports,":[152],"focusing":[153],"specific":[155,421],"indicators":[156],"such":[159],"presence":[161],"diagnosis,":[164],"spicularity,":[165],"core":[167,199,257,288,347,441],"length.":[168],"For":[169],"purposes":[171],"this":[173],"study,":[174],"allowed":[176],"credit":[177],"diagnostic":[180,313,407,432],"reports":[185],"mentioned":[186],"normal":[187],"trilineage":[188],"hematopoiesis":[189],"pathologic":[192],"process":[193],"either":[195],"biopsy.":[200],"Univariate":[201],"associations":[202],"were":[211,236,244,271,279,282,414],"determined":[212],"using":[213],"chi-square":[214],"Fisher's":[216],"exact":[217],"tests;":[218],"multivariable":[219,303,419],"logistic":[220],"regression":[221],"taking":[222],"characteristics":[224],"(age,":[225],"gender":[226],"body":[228],"mass":[229],"index)":[230],"individual":[232],"into":[234],"account":[235],"also":[237],"fit":[238],"that":[243,453],"independently":[245],"predictive":[246],"Finally,":[249,374],"assessed":[251],"association":[253],"spicularity":[255],"length":[258,289,348,442],"diagnosticity.":[260,448],"Results:":[261],"413":[262],"by":[265],"total":[267],"23":[269],"operators":[270],"analyzed.":[272],"91.5%":[273],"evaluations":[278],"diagnostic,":[280],"66.6%":[281],"spicular,":[283],"52.8%":[285],"had":[286,359,380],"greater":[290],"than":[291],"1cm.":[292],"The":[293],"univariate":[294,416],"analysis":[295],"detailed":[300],"below:":[301],"In":[302,394],"models,":[304,420],"no":[305],"technique":[307],"was":[308,319,341,436,443],"significantly":[309,360,445],"obtaining":[312,325,430],"specimens;":[314],"however,":[315],"decubitus":[317],"lower":[322,344],"likelihood":[323,345,428],"spicular":[326],"(odds":[328],"ratio":[329],"(OR)":[330],"0.15":[331],"[95%":[332,352],"confidence":[333],"interval":[334],"(CI)":[335],"0.04,":[336],"0.59],":[337],"p=0.007),":[338],"redirecting":[340,435],">1cm":[349],"(OR":[350],"0.41":[351],"CI":[353],"0.20,":[354],"0.82],":[355],"p=0.01).":[356],"Spicular":[357],"higher":[361,427],"rates":[362],"diagnosticity":[364],"compared":[365],"aspicular":[367],"(96.3%":[369],"vs.":[370],"71%,":[371],"p":[372],"<0.001).":[373],"among":[375],"thirty-five":[377],"patients":[378],"who":[379],"non-diagnostic":[381],"nine":[383],"underwent":[384],"repeat":[385],"within":[387],"thirty":[388],"days":[389],"initial":[391],"procedure.":[392],"Conclusion:":[393],"our":[395,450],"large":[396],"cohort":[397],"observed":[399],"procedures,":[402],"found":[404],"high":[406],"rate":[408],"91.5%.":[410],"Moreover,":[411],"although":[412],"there":[413],"several":[415,454],"associations,":[417],"did":[424],"predict":[426],"specimen.":[433],"shorter":[439],"cores,":[440],"Overall,":[449],"suggest":[452],"different":[455],"ultimately":[458],"result":[459],"similar":[465],"Disclosures:":[467],"No":[468],"relevant":[469],"conflicts":[470],"interest":[472],"declare.":[474]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2019-10-18T00:00:00"}