{"id":"https://openalex.org/W2979358556","doi":null,"title":"Immunoglobulin E induces colon cancer cell apoptosis via enhancing cyp27b1 expression.","display_name":"Immunoglobulin E induces colon cancer cell apoptosis via enhancing cyp27b1 expression.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2979358556","mag":"2979358556","pmid":"https://pubmed.ncbi.nlm.nih.gov/28078042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5209522"},"language":"en","primary_location":{"id":"pmid:28078042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28078042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5209522/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080122127","display_name":"Zhen\u2010Shi Ye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhen-Shi Ye","raw_affiliation_strings":["Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li-Na Fan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Na Fan","raw_affiliation_strings":["Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403241","display_name":"Lin Wang","orcid":"https://orcid.org/0000-0003-2276-4987","observed_orcids":["https://orcid.org/0000-0003-2276-4987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Wang","raw_affiliation_strings":["Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079720679","display_name":"Bin Yang","orcid":"https://orcid.org/0000-0002-1499-5569","observed_orcids":["https://orcid.org/0000-0002-1499-5569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Yang","raw_affiliation_strings":["Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100399603","display_name":"Lifeng Wang","orcid":"https://orcid.org/0000-0001-5095-6842","observed_orcids":["https://orcid.org/0000-0001-5095-6842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Feng Wang","raw_affiliation_strings":["Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018620403","display_name":"Yuansheng Liu","orcid":"https://orcid.org/0000-0002-7680-3155","observed_orcids":["https://orcid.org/0000-0002-7680-3155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan-Sheng Liu","raw_affiliation_strings":["Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082650053","display_name":"Su-Na Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Su-Na Ji","raw_affiliation_strings":["Department of Pharmacology, Medical College of Xiamen University 168 University Road, Xiamen 361005, Fujian Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Medical College of Xiamen University 168 University Road, Xiamen 361005, Fujian Province, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100756351","display_name":"Hongzhi Xu","orcid":"https://orcid.org/0000-0001-6238-3965","observed_orcids":["https://orcid.org/0000-0001-6238-3965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-Zhi Xu","raw_affiliation_strings":["Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongshan Hospital 201 Hubin South Road, Xiamen 361004, Fujian Province, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067489617","display_name":"Chuanxing Xiao","orcid":"https://orcid.org/0000-0002-6948-2664","observed_orcids":["https://orcid.org/0000-0002-6948-2664"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210124907","display_name":"Zhongshan Hospital of Xiamen University","ror":"https://ror.org/02z125451","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124907"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuan-Xing Xiao","raw_affiliation_strings":["Department of Gastroenterology, Zhongshan Hospital201 Hubin South Road, Xiamen 361004, Fujian Province, China; Department of Clinical Medicine, Medical College of Xiamen University168 University Road, Xiamen 361005, Fujian Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongshan Hospital201 Hubin South Road, Xiamen 361004, Fujian Province, China; Department of Clinical Medicine, Medical College of Xiamen University168 University Road, Xiamen 361005, Fujian Province, China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210124907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5114,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67831092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"8","issue":"12","first_page":"5715","last_page":"5722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoglobulin-e","display_name":"immunoglobulin E","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd23","display_name":"CD23","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cyp27b1","display_name":"CYP27B1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.6240000128746033},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.8550000190734863},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.699999988079071},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C34814297","wikidata":"https://www.wikidata.org/wiki/Q4845302","display_name":"CD23","level":4,"score":0.9251077175140381},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.801906943321228},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.7626587152481079},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.584305465221405},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4251779317855835},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39867642521858215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38689735531806946},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3501531481742859},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3258435130119324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3234475255012512},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10388463735580444}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:28078042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28078042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5209522","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5209522/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2979358556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28078042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5209522","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5209522/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1539341331","https://openalex.org/W1969087061","https://openalex.org/W1976776496","https://openalex.org/W1990507184","https://openalex.org/W1995315750","https://openalex.org/W1997222174","https://openalex.org/W2010052516","https://openalex.org/W2060941966","https://openalex.org/W2068650409","https://openalex.org/W2077973373","https://openalex.org/W2092974774","https://openalex.org/W2094397671","https://openalex.org/W2123865871","https://openalex.org/W2131116969","https://openalex.org/W2152852802","https://openalex.org/W2161702636","https://openalex.org/W2175626822","https://openalex.org/W2178157469","https://openalex.org/W2221715624","https://openalex.org/W2254563264","https://openalex.org/W2291030743","https://openalex.org/W2297082581","https://openalex.org/W2302280624","https://openalex.org/W2326964905","https://openalex.org/W2403783822","https://openalex.org/W2405678952","https://openalex.org/W2408550845","https://openalex.org/W2417645219","https://openalex.org/W2918113740","https://openalex.org/W3146592426"],"related_works":["https://openalex.org/W2178722564","https://openalex.org/W2172080383","https://openalex.org/W2461165402","https://openalex.org/W2045187623","https://openalex.org/W2147149256","https://openalex.org/W7099608475","https://openalex.org/W7100406526","https://openalex.org/W7096135429","https://openalex.org/W1994660225","https://openalex.org/W2341222160"],"abstract_inverted_index":{"The":[0,66,147],"pathogenesis":[1],"of":[2,50,52,59,68,70,90,100,108,117,125,133,159],"colon":[3],"cancer":[4,17,136],"(Cca)":[5],"is":[6,14,22,131],"to":[7,39,110,145],"be":[8],"further":[9],"investigated.":[10],"Vitamin":[11],"D":[12],"deficiency":[13],"associated":[15],"with":[16,63,92],"growth;":[18],"the":[19,48,57,98,106,112,115,135,157],"underlying":[20],"mechanism":[21],"unclear.":[23],"Published":[24],"data":[25],"indicate":[26],"that":[27,37,84,150],"Cca":[28,42,64,71,85,95,120,126],"cells":[29,72,86,96],"express":[30,87],"CD23.":[31],"This":[32],"study":[33],"tests":[34],"a":[35,78],"hypothesis":[36],"exposure":[38],"IgE":[40,55,74,93,130,151],"induces":[41],"cell":[43,79,137],"apoptosis.":[44],"In":[45,128],"this":[46],"study,":[47],"effect":[49],"ligation":[51,89],"CD23":[53,91,141],"by":[54,73,119],"on":[56,94],"expression":[58,99,116],"cyp27b1":[60,101],"was":[61,75],"performed":[62],"cells.":[65,127],"induction":[67],"apoptosis":[69,124,138],"assessed":[76],"in":[77,102,156],"culture":[80],"model.":[81],"We":[82],"observed":[83],"CD23;":[88],"increased":[97,114],"Cca,":[103],"which":[104],"promoted":[105],"conversion":[107],"VD3":[109,144],"calcitriol,":[111],"latter":[113],"FasL":[118],"cells,":[121],"and":[122,142],"induced":[123],"conclusion,":[129],"capable":[132],"inducing":[134],"via":[139],"ligating":[140],"converting":[143],"calcitriol.":[146],"results":[148],"suggest":[149],"may":[152],"have":[153],"therapeutic":[154],"potential":[155],"treatment":[158],"Cca.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-10-18T00:00:00"}