{"id":"https://openalex.org/W2979075271","doi":"https://doi.org/10.14309/00000434-200809001-00121","title":"The Interrelationship Between Gastric pH and Therapeutic Response to Esomeprazole in Patients with Uninvestigated Dyspepsia","display_name":"The Interrelationship Between Gastric pH and Therapeutic Response to Esomeprazole in Patients with Uninvestigated Dyspepsia","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2979075271","doi":"https://doi.org/10.14309/00000434-200809001-00121","mag":"2979075271"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-200809001-00121","doi":"https://doi.org/10.14309/00000434-200809001-00121","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200809001-00121","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104109527","display_name":"Marek Majewski","orcid":"https://orcid.org/0000-0001-5363-9818","observed_orcids":["https://orcid.org/0000-0001-5363-9818"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["PL","US"],"is_corresponding":true,"raw_author_name":"Marek Majewski","raw_affiliation_strings":["Medicine/GI/Motility Center, KUMC, Kansas City, KS, 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine/GI/Motility Center, KUMC, Kansas City, KS, 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006433297","display_name":"Irene Sarosiek","orcid":"https://orcid.org/0000-0003-1678-7269","observed_orcids":["https://orcid.org/0000-0003-1678-7269"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["PL","US"],"is_corresponding":false,"raw_author_name":"Irene Sarosiek","raw_affiliation_strings":["Medicine/GI/Motility Center, KUMC, Kansas City, KS, 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine/GI/Motility Center, KUMC, Kansas City, KS, 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006072731","display_name":"Grzegorz T. Wallner","orcid":"https://orcid.org/0000-0002-0486-0484","observed_orcids":["https://orcid.org/0000-0002-0486-0484"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["PL","US"],"is_corresponding":false,"raw_author_name":"Grzegorz Wallner","raw_affiliation_strings":["Medicine/GI/Motility Center, KUMC, Kansas City, KS, 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine/GI/Motility Center, KUMC, Kansas City, KS, 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520","https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090303148","display_name":"Jerzy Sarosiek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["PL","US"],"is_corresponding":false,"raw_author_name":"Jerzy Sarosiek","raw_affiliation_strings":["Medicine/GI/Motility Center, KUMC, Kansas City, KS, 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine/GI/Motility Center, KUMC, Kansas City, KS, 2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520","https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5104109527"],"corresponding_institution_ids":["https://openalex.org/I121032520","https://openalex.org/I4210128618"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48986384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"103","issue":null,"first_page":"S48","last_page":"S48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.4097000062465668,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esomeprazole","display_name":"esomeprazole","score":0.8080000281333923},{"id":"https://openalex.org/keywords/uninvestigated-dyspepsia","display_name":"uninvestigated dyspepsia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/gastric-acid-secretion","display_name":"gastric acid secretion","score":0.7900000214576721},{"id":"https://openalex.org/keywords/intragastric-ph","display_name":"gastric pH","score":0.8610000014305115},{"id":"https://openalex.org/keywords/acid-suppression","display_name":"acid suppression","score":0.7239999771118164},{"id":"https://openalex.org/keywords/24-hour-ph-monitoring","display_name":"24-hour pH monitoring","score":0.7350000143051147},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.49900001287460327},{"id":"https://openalex.org/keywords/epigastric-pain","display_name":"epigastric pain","score":0.7760000228881836},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.6119999885559082},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.722000002861023},{"id":"https://openalex.org/keywords/placebo-response","display_name":"placebo response","score":0.39100000262260437},{"id":"https://openalex.org/keywords/symptom-relief","display_name":"symptom relief","score":0.367000013589859},{"id":"https://openalex.org/keywords/rome-ii-criteria","display_name":"Rome II criteria","score":0.515999972820282},{"id":"https://openalex.org/keywords/nonresponders","display_name":"non-responders","score":0.41100001335144043},{"id":"https://openalex.org/keywords/quality-of-life-questionnaires","display_name":"quality of life questionnaires","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9332172870635986},{"id":"https://openalex.org/C2778204628","wikidata":"https://www.wikidata.org/wiki/Q553223","display_name":"Esomeprazole","level":2,"score":0.8853405714035034},{"id":"https://openalex.org/C2776462128","wikidata":"https://www.wikidata.org/wiki/Q537297","display_name":"Heartburn","level":4,"score":0.8407455682754517},{"id":"https://openalex.org/C2991960855","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Epigastric pain","level":3,"score":0.6652317047119141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6542469263076782},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6338939666748047},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5506573915481567},{"id":"https://openalex.org/C2777498785","wikidata":"https://www.wikidata.org/wiki/Q422210","display_name":"Omeprazole","level":2,"score":0.5349994897842407},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5129637122154236},{"id":"https://openalex.org/C2777504413","wikidata":"https://www.wikidata.org/wiki/Q846270","display_name":"Gastric acid","level":3,"score":0.47694793343544006},{"id":"https://openalex.org/C2778715759","wikidata":"https://www.wikidata.org/wiki/Q254296","display_name":"Lansoprazole","level":3,"score":0.4682159423828125},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.25277525186538696},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.16590100526809692},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.09533858299255371},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-200809001-00121","doi":"https://doi.org/10.14309/00000434-200809001-00121","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200809001-00121","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2524925865","https://openalex.org/W2293084969","https://openalex.org/W1574415806","https://openalex.org/W7024064308","https://openalex.org/W1505738485","https://openalex.org/W2139599561","https://openalex.org/W2893160419","https://openalex.org/W94251338","https://openalex.org/W2055435310","https://openalex.org/W2166261298"],"abstract_inverted_index":{"Purpose:":[0],"Management":[1],"of":[2,22,26,29,45,56,67,86,119,143,169,180,203,255,264,301,310,329,374,397,416],"dyspepsia":[3,87,375,411],"remains":[4],"a":[5,172],"challenge":[6],"both":[7,280],"in":[8,20,24,91,238,261,275,317,343,347,353,403,408],"research":[9],"and":[10,42,89,183,197,200,209,219,231,249,283,287,363,377,382],"clinical":[11],"practice.":[12],"Pharmacological":[13],"therapy,":[14,204],"targeting":[15],"gastric":[16,72,92,225,265,302,330,378,398],"acid":[17,46,73,226,266,303,331,379,399],"suppression":[18,47],"results":[19],"relief":[21,41,85,168,373,415],"symptoms":[23,88,118,186,376],"majority":[25],"patients":[27,103],"complaining":[28],"epigastric":[30,120],"pain/discomfort":[31,170],"related":[32],"to":[33,109,149,368,386],"uninvestigated":[34,105],"dyspepsia;":[35],"however,":[36,298],"the":[37,43,54,57,65,82,344],"relationship":[38,83],"between":[39,84,371],"symptom":[40],"degree":[44,300,328],"has":[48],"not":[49],"been":[50],"adequately":[51],"explored.":[52],"Therefore,":[53],"aims":[55],"study":[58],"were":[59,138,147,166],"as":[60,127,401],"follows:":[61],"1.":[62,358],"To":[63,80],"evaluate":[64],"impact":[66],"esomeprazole":[68,155,256],"vs.":[69,349],"placebo":[70,150],"on":[71,101],"during":[74],"24":[75,193],"h":[76,194],"pH":[77,189,210,277,289,312,360,405],"monitoring.":[78],"2.":[79,390],"asses":[81],"changes":[90],"pH.":[93],"Methods:":[94],"This":[95],"randomized,":[96],"double-blind":[97],"trial":[98],"was":[99,190,340],"conducted":[100],"KUMC":[102],"with":[104,113,123,410],"dyspepsia,":[106],"diagnosed":[107],"acc.":[108],"Rome":[110],"II":[111],"criteria,":[112],"at":[114,195,228,285],"least":[115],"moderately":[116],"severe":[117],"pain/discomfort.":[121],"Patients":[122,140],"heartburn":[124],"or":[125,134,154],"regurgitation":[126],"their":[128],"predominant":[129],"symptoms,":[130,171],"H.":[131],"pylori":[132],"(+)":[133],"aspirin-like":[135],"drugs":[136],"users":[137],"excluded.":[139],"(mean":[141],"age":[142],"44.2;":[144],"62.2%":[145],"F)":[146],"randomized":[148],"(N":[151,156],"=":[152,157],"35)":[153],"38)":[158],"40":[159,392],"mg":[160],"QD":[161],"groups.":[162],"Primary":[163],"outcome":[164],"measures":[165],"satisfactory":[167],"7-day":[173],"daily":[174],"diary":[175],"preceding":[176],"each":[177],"visit,":[178],"quality":[179],"life":[181],"questionnaire,":[182],"global":[184],"overall":[185],"assessment.":[187],"Gastric":[188],"monitored":[191],"for":[192,257],"baseline":[196,224,315,338],"after":[198,364],"4":[199,258],"8":[201],"weeks":[202,259],"using":[205],"dual":[206],"probe":[207,290,346],"catheter":[208],"Monitoring":[211],"System":[212],"(Sandhill":[213],"Sci.).":[214],"Results:":[215],"Both":[216],"responders":[217],"(R)":[218],"non-responders":[220],"(NR)":[221],"exhibited":[222],"similar":[223],"secretion":[227,267,380,400],"distal":[229],"(D)":[230],"proximal":[232],"(P)":[233],"probes:":[234],"(pH":[235],">":[236,278,406],"4.0":[237,279,407],"min)":[239],"201":[240],"min":[241,244,247,251],"RD,":[242],"177":[243],"NRD,":[245],"641":[246],"RP,":[248],"628":[250],"NRP,":[252],"respectively.":[253],"Administration":[254],"resulted":[260],"profound":[262,395],"inhibition":[263,381,396],"reflected":[268,402],"by":[269,413],"significant":[270,414],"(P":[271,306,334],"<":[272,307,335],"0.01)":[273],"increase":[274,309,352],"time":[276,311,404],"among":[281],"R":[282,296,348],"NR":[284,321,354],"D":[286,318],"P":[288,345],"locations.":[291],"During":[292],"2nd":[293],"therapy":[294,365],"interval":[295],"exhibited,":[297],"higher":[299],"inhibition,":[304,332],"361%":[305],"0.001)":[308,336],">4.0":[313],"over":[314,337],"value":[316],"probe,":[319],"whereas":[320],"only":[322,350],"157%":[323],"(P=":[324,355],"0.12)":[325],"increase.":[326],"Higher":[327],"162%":[333],"value,":[339],"also":[341],"revealed":[342],"97%":[351],"0.22).":[356],"Conclusion:":[357],"Intragastric":[359],"monitoring":[361],"before":[362],"may":[366],"help":[367,385],"address":[369],"interrelationship":[370],"symptomatic":[372],"could":[383],"potentially":[384],"tailor":[387],"individual":[388],"therapy.":[389],"Esomeprazole,":[391],"QD,":[393],"provides":[394],"patient":[409],"accompanied":[412],"symptoms.":[417]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2019-10-10T00:00:00"}