{"id":"https://openalex.org/W2979029424","doi":"https://doi.org/10.14309/00000434-200410001-00716","title":"ESOMEPRAZOLE REDUCES THE COSTS OF REDUCED WORK PRODUCTIVITY DUE TO GERD-RELATED SLEEP DISTURBANCES","display_name":"ESOMEPRAZOLE REDUCES THE COSTS OF REDUCED WORK PRODUCTIVITY DUE TO GERD-RELATED SLEEP DISTURBANCES","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W2979029424","doi":"https://doi.org/10.14309/00000434-200410001-00716","mag":"2979029424"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-200410001-00716","doi":"https://doi.org/10.14309/00000434-200410001-00716","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200410001-00716","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015649079","display_name":"David Johnson","orcid":"https://orcid.org/0000-0003-0383-1873","observed_orcids":["https://orcid.org/0000-0003-0383-1873"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]},{"id":"https://openalex.org/I4210136621","display_name":"Lynn Health Science Institute","ror":"https://ror.org/02vfnsn98","country_code":"US","type":"other","lineage":["https://openalex.org/I4210136621"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Johnson","raw_affiliation_strings":["AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","Eastern Virginia School of Medicine, Norfolk, Virginia","Lynn Health Science Institute, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754","https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Eastern Virginia School of Medicine, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Lynn Health Science Institute, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I4210136621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109925682","display_name":"William C. Orr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]},{"id":"https://openalex.org/I4210136621","display_name":"Lynn Health Science Institute","ror":"https://ror.org/02vfnsn98","country_code":"US","type":"other","lineage":["https://openalex.org/I4210136621"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Orr","raw_affiliation_strings":["AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","Eastern Virginia School of Medicine, Norfolk, Virginia","Lynn Health Science Institute, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754","https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Eastern Virginia School of Medicine, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Lynn Health Science Institute, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I4210136621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111668723","display_name":"Joseph A. Crawley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]},{"id":"https://openalex.org/I4210136621","display_name":"Lynn Health Science Institute","ror":"https://ror.org/02vfnsn98","country_code":"US","type":"other","lineage":["https://openalex.org/I4210136621"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Crawley","raw_affiliation_strings":["AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","Eastern Virginia School of Medicine, Norfolk, Virginia","Lynn Health Science Institute, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754","https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Eastern Virginia School of Medicine, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Lynn Health Science Institute, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I4210136621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009733952","display_name":"Assunta Cuccia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]},{"id":"https://openalex.org/I4210136621","display_name":"Lynn Health Science Institute","ror":"https://ror.org/02vfnsn98","country_code":"US","type":"other","lineage":["https://openalex.org/I4210136621"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Assunta Cuccia","raw_affiliation_strings":["AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","Eastern Virginia School of Medicine, Norfolk, Virginia","Lynn Health Science Institute, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754","https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Eastern Virginia School of Medicine, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Lynn Health Science Institute, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I4210136621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069327677","display_name":"Barry M. Traxler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]},{"id":"https://openalex.org/I4210136621","display_name":"Lynn Health Science Institute","ror":"https://ror.org/02vfnsn98","country_code":"US","type":"other","lineage":["https://openalex.org/I4210136621"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry Traxler","raw_affiliation_strings":["AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","Eastern Virginia School of Medicine, Norfolk, Virginia","Lynn Health Science Institute, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754","https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Eastern Virginia School of Medicine, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Lynn Health Science Institute, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I4210136621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110640025","display_name":"Kurt A. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]},{"id":"https://openalex.org/I4210136621","display_name":"Lynn Health Science Institute","ror":"https://ror.org/02vfnsn98","country_code":"US","type":"other","lineage":["https://openalex.org/I4210136621"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt Brown","raw_affiliation_strings":["AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","Eastern Virginia School of Medicine, Norfolk, Virginia","Lynn Health Science Institute, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754","https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Eastern Virginia School of Medicine, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Lynn Health Science Institute, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I4210136621"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011832419","display_name":"Thomas G. Roth","orcid":"https://orcid.org/0000-0001-8309-4134","observed_orcids":["https://orcid.org/0000-0001-8309-4134"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]},{"id":"https://openalex.org/I4210136621","display_name":"Lynn Health Science Institute","ror":"https://ror.org/02vfnsn98","country_code":"US","type":"other","lineage":["https://openalex.org/I4210136621"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Roth","raw_affiliation_strings":["AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","Eastern Virginia School of Medicine, Norfolk, Virginia","Lynn Health Science Institute, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca LP, Wilmington, Delaware and Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754","https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Eastern Virginia School of Medicine, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Lynn Health Science Institute, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I4210136621"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47345414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"99","issue":null,"first_page":"S233","last_page":"S233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esomeprazole","display_name":"esomeprazole","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.9380000233650208},{"id":"https://openalex.org/keywords/labor-productivity","display_name":"labor productivity","score":0.9729999899864197},{"id":"https://openalex.org/keywords/absenteeism","display_name":"absenteeism","score":0.9440000057220459},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/economic-burden-of-disease","display_name":"economic burden of disease","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.9659290909767151},{"id":"https://openalex.org/C2778204628","wikidata":"https://www.wikidata.org/wiki/Q553223","display_name":"Esomeprazole","level":2,"score":0.8725707530975342},{"id":"https://openalex.org/C2776462128","wikidata":"https://www.wikidata.org/wiki/Q537297","display_name":"Heartburn","level":4,"score":0.854631245136261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8534600138664246},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.7111729979515076},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6444259881973267},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.6072793006896973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4746200144290924},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.46997517347335815},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.4469456374645233},{"id":"https://openalex.org/C27400517","wikidata":"https://www.wikidata.org/wiki/Q332278","display_name":"Absenteeism","level":2,"score":0.41871339082717896},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3997686505317688},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.23330405354499817},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2248798906803131},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11300486326217651},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-200410001-00716","doi":"https://doi.org/10.14309/00000434-200410001-00716","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200410001-00716","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.6452000141143799,"id":"https://metadata.un.org/sdg/8","display_name":"Decent work and economic growth"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966723422","https://openalex.org/W1512932705","https://openalex.org/W2041135235","https://openalex.org/W2035405838","https://openalex.org/W1965269448","https://openalex.org/W2119799418","https://openalex.org/W2141847141","https://openalex.org/W2161277471","https://openalex.org/W2978771800","https://openalex.org/W2128220046"],"abstract_inverted_index":{"Purpose:":[0],"Patients":[1,60,105,139],"with":[2,49,87,106,144,284,309],"symptomatic":[3,69],"gastroesophageal":[4],"reflux":[5],"disease":[6],"(GERD)":[7],"experience":[8],"nighttime":[9,57],"heartburn":[10],"(NHB),":[11],"a":[12,71,97],"frequently":[13],"reported":[14],"cause":[15],"of":[16,28,73,91,100,136,159,210,217,224,229,257,280,291,305],"sleep":[17,51,74,84,114,175,297],"disturbance,":[18,176],"which":[19,170],"can":[20],"impair":[21],"work":[22,40,182,191,292,320],"productivity.":[23,321],"We":[24],"evaluated":[25],"the":[26,92,122,134,137,163,184,193,214,237,242,255,289],"effect":[27],"once":[29],"daily":[30],"esomeprazole":[31,145,148,266,286],"40":[32,146],"mg":[33,36],"or":[34,151],"20":[35,149],"versus":[37,252,276],"placebo":[38,268],"on":[39,89],"hours":[41,179,243,281],"lost":[42],"and":[43,53,83,132,155,166,183,220,234,249,254,267,278,299],"its":[44,300],"associated":[45,86,301],"costs":[46,304],"in":[47,236,263,319],"patients":[48,161,231],"GERD-related":[50,174],"disturbance":[52,75,85],"moderate":[54,79],"to":[55,80,102,112,142,177,246,295],"severe":[56,81],"heartburn.":[58],"Methods:":[59],"eligible":[61],"for":[62,76,126,133,173],"this":[63],"trial":[64],"(D961AC0000":[65],"1/Study":[66],"319)":[67],"had":[68],"GERD,":[70],"history":[72],">1":[77],"month,":[78],"NHB,":[82],"GERD":[88,110,307],"\u22653":[90,127],"last":[93],"7":[94],"days":[95],"during":[96,192],"run-in":[98],"period":[99],"up":[101],"14":[103],"days.":[104],"conditions":[107],"other":[108],"than":[109,314],"known":[111],"disturb":[113],"were":[115,140,200,232],"excluded.":[116],"Sleep":[117],"medication":[118],"was":[119,124,171,188,269],"allowed":[120],"if":[121],"dose":[123],"stable":[125],"months":[128],"before":[129],"study":[130],"entry":[131],"duration":[135],"study.":[138],"randomized":[141],"treatment":[143,287],"mg,":[147,150],"placebo.":[152],"At":[153],"baseline":[154,199,253,277],"after":[156],"4":[157],"weeks":[158],"treatment,":[160],"completed":[162],"Work":[164],"Productivity":[165],"Activity":[167],"Impairment":[168],"Questionnaire,":[169],"modified":[172],"assess":[178],"absent":[180],"from":[181,198,213],"amount":[185],"that":[186],"productivity":[187,251,293],"reduced":[189,247],"at":[190],"previous":[194],"week.":[195],"The":[196,239,260],"changes":[197],"converted":[201],"into":[202],"monetary":[203],"values":[204],"using":[205,222],"an":[206],"average":[207,261],"hourly":[208],"wage":[209],"$24.59":[211],"obtained":[212],"US":[215],"Bureau":[216],"Labor":[218],"Statistics":[219],"analyzed":[221],"analysis":[223],"variance.":[225],"Results:":[226],"A":[227],"total":[228],"350":[230],"employed":[233],"included":[235],"analysis.":[238],"table":[240],"shows":[241],"saved":[244,273],"due":[245,294],"absenteeism":[248],"increased":[250],"cost":[256,279],"those":[258],"hours.":[259],"difference":[262],"savings":[264],"between":[265],"$141.Table":[270],"1:":[271],"Hours":[272],"per":[274],"patient":[275],"savedConclusions:":[282],"Compared":[283],"placebo,":[285],"reduces":[288],"loss":[290],"GERD-associated":[296],"disturbances":[298],"costs.":[302],"Medication":[303],"effective":[306],"therapy":[308],"PPIs":[310],"may":[311],"be":[312],"more":[313],"offset":[315],"by":[316],"commensurate":[317],"increases":[318]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2019-10-10T00:00:00"}