{"id":"https://openalex.org/W2978970147","doi":"https://doi.org/10.21873/anticanres.13750","title":"Impact of Extravasated Platelet Activation and Podoplanin-positive Cancer-associated Fibroblasts in Pancreatic Cancer Stroma","display_name":"Impact of Extravasated Platelet Activation and Podoplanin-positive Cancer-associated Fibroblasts in Pancreatic Cancer Stroma","publication_year":2019,"publication_date":"2019-09-30","ids":{"openalex":"https://openalex.org/W2978970147","doi":"https://doi.org/10.21873/anticanres.13750","mag":"2978970147","pmid":"https://pubmed.ncbi.nlm.nih.gov/31570451"},"language":"en","primary_location":{"id":"doi:10.21873/anticanres.13750","doi":"https://doi.org/10.21873/anticanres.13750","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.13750","pdf_url":"https://ar.iiarjournals.org/content/anticanres/39/10/5565.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ar.iiarjournals.org/content/anticanres/39/10/5565.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075738891","display_name":"Tomoharu Miyashita","orcid":"https://orcid.org/0000-0002-3771-0773","observed_orcids":["https://orcid.org/0000-0002-3771-0773"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TOMOHARU MIYASHITA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan tomoharumiya@gmail.com","Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan tomoharumiya@gmail.com","institution_ids":["https://openalex.org/I4210104330"]},{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056226936","display_name":"Hidehiro Tajima","orcid":"https://orcid.org/0000-0003-1605-9747","observed_orcids":["https://orcid.org/0000-0003-1605-9747","https://orcid.org/0009-0000-7961-8724"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIDEHIRO TAJIMA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020121709","display_name":"Ryosuke Gabata","orcid":"https://orcid.org/0000-0003-2060-5499","observed_orcids":["https://orcid.org/0000-0003-2060-5499"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"RYOSUKE GABATA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021109178","display_name":"Mitsuyoshi Okazaki","orcid":"https://orcid.org/0000-0002-0552-0297","observed_orcids":["https://orcid.org/0000-0002-0552-0297"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MITSUYOSHI OKAZAKI","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039199277","display_name":"Shimbashi Hiroyuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROYUKI SHIMBASHI","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076857911","display_name":"Yoshinao Ohbatake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOSHINAO OHBATAKE","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087613838","display_name":"Koichi Okamoto","orcid":"https://orcid.org/0000-0002-9438-9445","observed_orcids":["https://orcid.org/0000-0002-9438-9445"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KOICHI OKAMOTO","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024909467","display_name":"Shinichi Nakanuma","orcid":"https://orcid.org/0000-0002-5118-2225","observed_orcids":["https://orcid.org/0000-0002-5118-2225"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SINICHI NAKANUMA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043812307","display_name":"Seisho Sakai","orcid":"https://orcid.org/0000-0003-4998-1439","observed_orcids":["https://orcid.org/0000-0003-4998-1439"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SEISHO SAKAI","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015560023","display_name":"Isamu Makino","orcid":"https://orcid.org/0000-0001-6023-7163","observed_orcids":["https://orcid.org/0000-0001-6023-7163"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"ISAMU MAKINO","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081758735","display_name":"Jun Kinoshita","orcid":"https://orcid.org/0000-0002-2871-9549","observed_orcids":["https://orcid.org/0000-0002-2871-9549"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"JUN KINOSHITA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103007509","display_name":"Hironori Hayashi","orcid":"https://orcid.org/0000-0002-8441-095X","observed_orcids":["https://orcid.org/0000-0002-8441-095X"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIRONORI HAYASHI","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109377004","display_name":"Keishi Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KEISHI NAKAMURA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101827582","display_name":"Hiroyuki Takamura","orcid":"https://orcid.org/0000-0002-8824-6763","observed_orcids":["https://orcid.org/0000-0002-8824-6763"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROYUKI TAKAMURA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048730959","display_name":"Itasu Ninomiya","orcid":"https://orcid.org/0000-0002-3356-5505","observed_orcids":["https://orcid.org/0000-0002-3356-5505"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"ITASU NINOMIYA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024644803","display_name":"Sachio Fushida","orcid":"https://orcid.org/0000-0001-5567-7383","observed_orcids":["https://orcid.org/0000-0001-5567-7383"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SACHIO FUSHIDA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062512150","display_name":"John W. Harmon","orcid":"https://orcid.org/0000-0002-2857-3850","observed_orcids":["https://orcid.org/0000-0002-2857-3850"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN W. HARMON","raw_affiliation_strings":["Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109830939","display_name":"Tetsuo Ohta","orcid":"https://orcid.org/0000-0002-1965-2864","observed_orcids":["https://orcid.org/0000-0002-1965-2864"]},"institutions":[{"id":"https://openalex.org/I4210104330","display_name":"Kanazawa University Hospital","ror":"https://ror.org/00xsdn005","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104330"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TETSUO OHTA","raw_affiliation_strings":["Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Japan","institution_ids":["https://openalex.org/I4210104330"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5211,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.67350213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"39","issue":"10","first_page":"5565","last_page":"5572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.8759999871253967},{"id":"https://openalex.org/keywords/podoplanin","display_name":"podoplanin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cd42b","display_name":"CD42b","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9359999895095825},{"id":"https://openalex.org/keywords/s-1","display_name":"S-1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.9919999837875366},{"id":"https://openalex.org/keywords/collagen-disorganization","display_name":"collagen disorganization","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2909316934","wikidata":"https://www.wikidata.org/wiki/Q2100344","display_name":"Podoplanin","level":3,"score":0.9561772346496582},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.7652847766876221},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.7250174283981323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5728945136070251},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5718072056770325},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5343016982078552},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5142781138420105},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.4642162322998047},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4552108943462372},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4178520143032074},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.345746785402298},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3329753875732422},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.32742568850517273},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.230476975440979}],"mesh":[{"descriptor_ui":"D000072645","descriptor_name":"Cancer-Associated Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000072645","descriptor_name":"Cancer-Associated Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098853","descriptor_name":"Podoplanin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019038","descriptor_name":"Platelet Glycoprotein GPIb-IX Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.21873/anticanres.13750","doi":"https://doi.org/10.21873/anticanres.13750","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.13750","pdf_url":"https://ar.iiarjournals.org/content/anticanres/39/10/5565.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},{"id":"pmid:31570451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31570451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21873/anticanres.13750","doi":"https://doi.org/10.21873/anticanres.13750","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.13750","pdf_url":"https://ar.iiarjournals.org/content/anticanres/39/10/5565.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4151304164","display_name":"THE INFLUENCE OF SENESCENT STROMA ON PDAC","funder_award_id":"17K10693","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2978970147.pdf","grobid_xml":"https://content.openalex.org/works/W2978970147.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W107368788","https://openalex.org/W1522760404","https://openalex.org/W1552571254","https://openalex.org/W1605655296","https://openalex.org/W1757407923","https://openalex.org/W1940673072","https://openalex.org/W1942341004","https://openalex.org/W1962115721","https://openalex.org/W1968812902","https://openalex.org/W1978489538","https://openalex.org/W1990313926","https://openalex.org/W2003762242","https://openalex.org/W2009230738","https://openalex.org/W2072525040","https://openalex.org/W2075465677","https://openalex.org/W2075730871","https://openalex.org/W2078323166","https://openalex.org/W2081923494","https://openalex.org/W2100766964","https://openalex.org/W2101490383","https://openalex.org/W2111895881","https://openalex.org/W2121020822","https://openalex.org/W2143132394","https://openalex.org/W2146560284","https://openalex.org/W2160321750","https://openalex.org/W2160816795","https://openalex.org/W2326081342","https://openalex.org/W2401629601","https://openalex.org/W2467285438","https://openalex.org/W2512899508","https://openalex.org/W2558817730","https://openalex.org/W2564815138","https://openalex.org/W2590002384","https://openalex.org/W2734243012","https://openalex.org/W2740930554","https://openalex.org/W2754554082","https://openalex.org/W2770304338","https://openalex.org/W2775876340","https://openalex.org/W2807211990"],"related_works":["https://openalex.org/W2801116864","https://openalex.org/W2775876340","https://openalex.org/W2159829336","https://openalex.org/W2146560284","https://openalex.org/W6886168313","https://openalex.org/W3005615664","https://openalex.org/W4307138125","https://openalex.org/W2981427310","https://openalex.org/W1998149120","https://openalex.org/W2630984254"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"The":[1],"aim":[2],"of":[3,11,34,51,126],"the":[4,9,49,90,97,113,141,159,182],"study":[5],"was":[6,71,78,110,130,154],"to":[7],"evaluate":[8],"status":[10],"extravasated":[12],"platelet":[13],"activation":[14],"(EPA)":[15],"surrounding":[16,69],"podoplanin":[17],"(PDPN)-positive":[18],"cancer-associated":[19],"fibroblasts":[20,139],"(CAFs)":[21],"in":[22,39,48,68,73,89,96,112,140,145,174],"pancreatic":[23,175],"cancer":[24,176],"stroma":[25],"by":[26,118],"neoadjuvant":[27],"chemotherapy.":[28],"PATIENTS":[29],"AND":[30],"METHODS:":[31],"A":[32],"total":[33],"74":[35],"patients":[36],"were":[37,86],"enrolled":[38],"this":[40],"study.":[41],"We":[42],"investigated":[43],"CD42b":[44,66,76,134],"and":[45,60,100,122,136,149,171],"PDPN":[46,82,108],"expression":[47,67,77,109,135],"groups":[50,101],"untreated,":[52,146],"gemcitabine":[53],"(GEM)":[54],"alone,":[55,148],"GEM":[56,61,104,147],"plus":[57,62],"S-1":[58],"(GS)":[59],"nab-paclitaxel":[63],"(GnP).":[64],"RESULTS:":[65],"CAFs":[70,173],"observed":[72],"58%":[74],"patients.":[75],"significantly":[79,87,132],"correlated":[80],"with":[81,93,103],"expression.":[83],"CD42b-positive":[84],"cases":[85],"lower":[88,133],"group":[91,99,143],"treated":[92,102],"GnP":[94,114,142,183],"than":[95,144],"untreated":[98],"alone":[105],"or":[106],"GS.":[107],"reduced":[111],"group,":[115],"as":[116],"revealed":[117],"markedly":[119],"disorganized":[120],"collagen":[121],"a":[123,131,166],"low":[124],"density":[125],"PDPN-positive":[127,138,172,188],"fibroblasts.":[128],"There":[129,164],"fewer":[137],"GS":[150],"groups,":[151],"but":[152],"there":[153],"no":[155],"significant":[156,167],"difference":[157],"between":[158,169],"latter":[160],"three":[161],"groups.":[162],"CONCLUSION:":[163],"is":[165],"association":[168],"EPA":[170,186],"stroma.":[177],"Our":[178],"data":[179],"suggest":[180],"that":[181],"regimen":[184],"decreases":[185],"through":[187],"CAF":[189],"depletion.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-10-10T00:00:00"}
