{"id":"https://openalex.org/W2978950438","doi":"https://doi.org/10.14309/00000434-201310001-00896","title":"Polycystic Pancreas Disease Associated with Pancreatic Intraepithelial Neoplasia","display_name":"Polycystic Pancreas Disease Associated with Pancreatic Intraepithelial Neoplasia","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2978950438","doi":"https://doi.org/10.14309/00000434-201310001-00896","mag":"2978950438"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-201310001-00896","doi":"https://doi.org/10.14309/00000434-201310001-00896","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201310001-00896","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076052259","display_name":"Benjamin Lo Bick","orcid":"https://orcid.org/0000-0003-3336-6829","observed_orcids":["https://orcid.org/0000-0003-3336-6829"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Bick","raw_affiliation_strings":["Internal Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100663891","display_name":"Lizhi Zhang","orcid":"https://orcid.org/0000-0001-5829-9234","observed_orcids":["https://orcid.org/0000-0001-5829-9234"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lizhi Zhang","raw_affiliation_strings":["Internal Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048460582","display_name":"Suresh T. Chari","orcid":"https://orcid.org/0000-0002-3924-0971","observed_orcids":["https://orcid.org/0000-0002-3924-0971"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh Chari","raw_affiliation_strings":["Internal Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088169725","display_name":"Aditya P. Devalapalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Devalapalli","raw_affiliation_strings":["Internal Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012239800","display_name":"Patrick S. Kamath","orcid":"https://orcid.org/0000-0002-7888-1165","observed_orcids":["https://orcid.org/0000-0002-7888-1165"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Kamath","raw_affiliation_strings":["Internal Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046429346","display_name":"Mark D. Topazian","orcid":"https://orcid.org/0000-0003-1090-2844","observed_orcids":["https://orcid.org/0000-0003-1090-2844"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Topazian","raw_affiliation_strings":["Internal Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34009086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108","issue":null,"first_page":"S267","last_page":"S267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-intraepithelial-neoplasia","display_name":"pancreatic intraepithelial neoplasia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/polycystic-kidney-disease","display_name":"polycystic kidney disease","score":0.8339999914169312},{"id":"https://openalex.org/keywords/polycystic-liver-disease","display_name":"polycystic liver disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pancreatic-cysts","display_name":"pancreatic cysts","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mucinous-metaplasia","display_name":"mucinous metaplasia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/intraductal-papillary-mucinous-neoplasm","display_name":"intraductal papillary mucinous neoplasm","score":0.9559999704360962},{"id":"https://openalex.org/keywords/total-pancreatectomy","display_name":"total pancreatectomy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/distal-pancreatectomy","display_name":"distal pancreatectomy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pancreatic-cystic-neoplasms","display_name":"pancreatic cystic neoplasms","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8734398484230042},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.7387697696685791},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.71706622838974},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6872974038124084},{"id":"https://openalex.org/C2909925829","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic Intraepithelial Neoplasia","level":5,"score":0.6660707592964172},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.625559389591217},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.5165590047836304},{"id":"https://openalex.org/C2776469228","wikidata":"https://www.wikidata.org/wiki/Q17149811","display_name":"Intraductal papillary mucinous neoplasm","level":3,"score":0.47841840982437134},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.45875999331474304},{"id":"https://openalex.org/C2777798143","wikidata":"https://www.wikidata.org/wiki/Q246070","display_name":"Cystadenoma","level":3,"score":0.45376458764076233},{"id":"https://openalex.org/C2779983558","wikidata":"https://www.wikidata.org/wiki/Q9597","display_name":"Abdomen","level":2,"score":0.4473421573638916},{"id":"https://openalex.org/C2779960720","wikidata":"https://www.wikidata.org/wiki/Q668063","display_name":"Pancreatic duct","level":3,"score":0.42743194103240967},{"id":"https://openalex.org/C2778494859","wikidata":"https://www.wikidata.org/wiki/Q3361964","display_name":"Pancreatectomy","level":3,"score":0.4229119122028351},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3333272933959961},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2843838334083557},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.24214139580726624},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.23440903425216675},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11176228523254395},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-201310001-00896","doi":"https://doi.org/10.14309/00000434-201310001-00896","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201310001-00896","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2023179371","https://openalex.org/W2084365329","https://openalex.org/W2921897977","https://openalex.org/W3142486412","https://openalex.org/W1970322703","https://openalex.org/W2586300415","https://openalex.org/W4327748157","https://openalex.org/W2944747392","https://openalex.org/W2162867801","https://openalex.org/W1963806456"],"abstract_inverted_index":{"Introduction:":[0],"Polycystic":[1],"pancreas":[2,381],"disease":[3,8,14,19],"(PPD)":[4],"is":[5,22,47,57],"a":[6,60,80,386],"rare":[7],"usually":[9,48],"associated":[10,43,86],"with":[11,44,49,68,79,87,131,196,289,340],"polycystic":[12,17],"kidney":[13],"(PKD)":[15],"and":[16,89,97,155,261,342,391,394],"liver":[18],"(PLD).":[20],"It":[21],"even":[23],"rarer":[24],"when":[25],"isolated.":[26],"These":[27],"cysts":[28,143,171,195,240,346],"are":[29,349],"histologically":[30,371],"reported":[31],"as":[32,374,376],"simple":[33,189,303,352],"epithelial":[34,191,305,365],"cysts.":[35,51,308,319],"Although":[36],"pancreatic":[37,113,207,218,295,345],"cystic":[38],"neoplasm":[39,72],"has":[40],"been":[41],"found":[42],"PKD,":[45],"this":[46],"isolated":[50],"The":[52,344],"malignant":[53],"potential":[54],"of":[55,82,99,105,111,140,158,169,199,204,233,281,293,302,311,347,356,367],"PPD":[56,90,332,348,390],"unknown,":[58],"but":[59],"prior":[61,132],"case":[62],"report":[63],"described":[64],"PKD":[65,85,249,341],"in":[66,122,128,213,317,328,335,338,363,379],"association":[67,339,388],"intraductal":[69],"papillary":[70],"mucinous":[71,200,312,361],"(IPMN).":[73],"Case":[74,220],"1:":[75],"An":[76],"18-year-old":[77],"female":[78,224],"history":[81],"autosomal":[83],"recessive":[84],"PLD":[88],"was":[91,144,153,225,254],"seen":[92,226],"for":[93,183,227,256,274,285,291],"chronic":[94],"abdominal":[95],"pain":[96,184],"episodes":[98],"recurrent":[100],"acute":[101],"pancreatitis.":[102],"CT":[103,231],"scan":[104],"the":[106,112,141,148,159,194,234,243,282,294,318,364,368],"abdomen":[107,235],"demonstrated":[108,188,299],"complete":[109],"replacement":[110],"parenchyma":[114],"by":[115,351],"multiple":[116,170,197,238],"cysts,":[117],"up":[118],"to":[119,146,175],"76":[120],"mm":[121],"greatest":[123],"diameter,":[124],"which":[125,370],"appeared":[126],"larger":[127],"size":[129],"compared":[130],"images.":[133],"After":[134],"failed":[135],"medical":[136],"therapy,":[137],"EUS":[138,252],"FNA":[139,253],"largest":[142],"attempted":[145],"reduce":[147],"pain.":[149],"Cyst":[150],"fluid":[151,264],"cytology":[152],"negative,":[154],"Tru-Cut":[156],"biopsies":[157],"cyst":[160,263,369],"walls":[161],"showed":[162,262,360],"bland":[163],"cuboidal":[164,190,353],"epithelium.":[165,354],"Fluid":[166],"CEA":[167,265],"levels":[168,266],"ranged":[172],"from":[173],"30":[174],"4480":[176],"ng/mL.":[177],"She":[178,245,276],"eventually":[179],"underwent":[180,277],"total":[181],"pancreatectomy":[182,279],"control.":[185],"Tissue":[186,297],"histology":[187,298],"cells":[192,306],"lining":[193,307,366],"areas":[198,203,310],"metaplasia.":[201],"Several":[202],"low":[205],"grade":[206],"intraepithelial":[208],"neoplasia":[209],"(PanIN1)":[210],"were":[211,272,314,323],"identified":[212,324],"branch":[214,286,326,382],"ducts":[215,327],"within":[216,325],"adjacent":[217,329,380],"parenchyma.":[219],"2:":[221],"A":[222],"60-year-old":[223],"serial":[228],"findings":[229],"on":[230],"scans":[232],"demonstrating":[236],"progressive":[237],"tiny":[239],"scattered":[241],"throughout":[242],"pancreas.":[244,330],"did":[246],"not":[247],"have":[248],"or":[250,258,337],"PLD.":[251,343],"negative":[255],"mucin":[257],"abnormal":[259],"cytology,":[260],"less":[267],"than":[268],"20.":[269],"Imaging":[270],"characteristics":[271],"indeterminate":[273],"malignancy.":[275],"distal":[278],"because":[280],"clinical":[283],"concern":[284],"duct":[287],"IPMN,":[288],"plan":[290],"surveillance":[292],"head.":[296],"single":[300],"layers":[301],"benign":[304],"Some":[309],"metaplasia":[313,362],"also":[315,359],"present":[316],"Many":[320],"PanIN1":[321,377],"lesions":[322,378],"Discussion:":[331],"may":[333],"occur":[334],"isolation,":[336],"lined":[350],"Both":[355],"these":[357],"cases":[358],"mimics":[372],"PanIN1A,":[373],"well":[375],"ducts.":[383],"This":[384],"suggests":[385],"possible":[387],"between":[389],"both":[392],"IPMN":[393],"PanIN.":[395]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2019-10-10T00:00:00"}