{"id":"https://openalex.org/W2978751908","doi":"https://doi.org/10.23937/2378-3419/1410122","title":"Expression of P53 and Prognosis in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC)","display_name":"Expression of P53 and Prognosis in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC)","publication_year":2019,"publication_date":"2019-08-09","ids":{"openalex":"https://openalex.org/W2978751908","doi":"https://doi.org/10.23937/2378-3419/1410122","mag":"2978751908"},"language":"en","primary_location":{"id":"doi:10.23937/2378-3419/1410122","doi":"https://doi.org/10.23937/2378-3419/1410122","is_oa":true,"landing_page_url":"https://doi.org/10.23937/2378-3419/1410122","pdf_url":"https://www.clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-6-122.pdf?jid=ijccr","source":{"id":"https://openalex.org/S4210207885","display_name":"International Journal of Cancer and Clinical Research","issn_l":"2378-3419","issn":["2378-3419"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer and Clinical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-6-122.pdf?jid=ijccr","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020154142","display_name":"Lahin M. Amlani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lahin Amlani","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103870316","display_name":"Emily Bellile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Bellile","raw_affiliation_strings":["Department of Biostatistics, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067694439","display_name":"Matthew E. Spector","orcid":"https://orcid.org/0000-0001-7646-6075","observed_orcids":["https://orcid.org/0000-0001-7646-6075"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Spector","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joshua Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Smith","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery , The University of Michigan Schools of Medicine and Public Health , USA","Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery , The University of Michigan Schools of Medicine and Public Health , USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086902130","display_name":"John Chad Brenner","orcid":"https://orcid.org/0000-0003-3238-1111","observed_orcids":["https://orcid.org/0000-0003-3238-1111"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad Brenner","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087457107","display_name":"Laura S. Rozek","orcid":"https://orcid.org/0000-0001-6731-7000","observed_orcids":["https://orcid.org/0000-0001-6731-7000","https://orcid.org/0009-0008-1136-8667"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Rozek","raw_affiliation_strings":["Department of Environmental Health Sciences, The University of Michigan Schools of Medicine and","Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, The University of Michigan Schools of Medicine and","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Public Health, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012872019","display_name":"Ariane Nguyen","orcid":"https://orcid.org/0000-0001-5556-4258","observed_orcids":["https://orcid.org/0000-0001-5556-4258"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariane Nguyen","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery , The University of Michigan Schools of Medicine and Public Health , USA","Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery , The University of Michigan Schools of Medicine and Public Health , USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076944777","display_name":"Katie R. Zarins","orcid":"https://orcid.org/0000-0003-4886-0627","observed_orcids":["https://orcid.org/0000-0003-4886-0627"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Zarins","raw_affiliation_strings":["Department of Environmental Health Sciences, The University of Michigan Schools of Medicine and","Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, The University of Michigan Schools of Medicine and","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Public Health, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102482376","display_name":"Daffyd G. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daffyd Thomas","raw_affiliation_strings":["Department of Pathology, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051202793","display_name":"Jonathan Brad McHugh","orcid":"https://orcid.org/0000-0002-6138-8833","observed_orcids":["https://orcid.org/0000-0002-6138-8833"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan McHugh","raw_affiliation_strings":["Department of Pathology , The University of Michigan Schools of Medicine and Public Health , USA","Department of Pathology, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , The University of Michigan Schools of Medicine and Public Health , USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pathology, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103688436","display_name":"Jeremy M. E. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Taylor","raw_affiliation_strings":["Department of Biostatistics, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083872721","display_name":"Gregory Wolf T","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Wolf T","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, The University of Michigan Schools of Medicine and Public Health, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5552,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66150935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-expression","display_name":"p53 expression","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8769999742507935},{"id":"https://openalex.org/keywords/anti-p53-antibodies","display_name":"anti-p53 antibodies","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.8031424283981323},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.695468544960022},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6708618402481079},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5066969990730286},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4882960319519043},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.48803606629371643},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.46772515773773193},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4380958080291748},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.42590928077697754},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4097597301006317},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3941073715686798},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.3530147075653076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33031678199768066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30799955129623413},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3059976100921631},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23681220412254333},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.19738009572029114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15828928351402283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23937/2378-3419/1410122","doi":"https://doi.org/10.23937/2378-3419/1410122","is_oa":true,"landing_page_url":"https://doi.org/10.23937/2378-3419/1410122","pdf_url":"https://www.clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-6-122.pdf?jid=ijccr","source":{"id":"https://openalex.org/S4210207885","display_name":"International Journal of Cancer and Clinical Research","issn_l":"2378-3419","issn":["2378-3419"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer and Clinical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.23937/2378-3419/1410122","doi":"https://doi.org/10.23937/2378-3419/1410122","is_oa":true,"landing_page_url":"https://doi.org/10.23937/2378-3419/1410122","pdf_url":"https://www.clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-6-122.pdf?jid=ijccr","source":{"id":"https://openalex.org/S4210207885","display_name":"International Journal of Cancer and Clinical Research","issn_l":"2378-3419","issn":["2378-3419"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer and Clinical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","id":"https://metadata.un.org/sdg/1","score":0.6700000166893005}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1404790370","display_name":null,"funder_award_id":"P30CA046592.","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2023598242","display_name":null,"funder_award_id":"T32 DC005356","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2645046766","display_name":null,"funder_award_id":"P50 CA-097248","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2936284972","display_name":null,"funder_award_id":"DC005356","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G461232509","display_name":null,"funder_award_id":"T32 DC005356","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G496050054","display_name":null,"funder_award_id":"P30CA046592","funder_id":"https://openalex.org/F4320309652","funder_display_name":"University of Michigan"},{"id":"https://openalex.org/G5230208091","display_name":null,"funder_award_id":"P50 CA097248","funder_id":"https://openalex.org/F4320309652","funder_display_name":"University of Michigan"},{"id":"https://openalex.org/G6773717512","display_name":null,"funder_award_id":"NIH/NCI P50CA097248","funder_id":"https://openalex.org/F4320309652","funder_display_name":"University of Michigan"},{"id":"https://openalex.org/G9000005129","display_name":null,"funder_award_id":"P30CA046592","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000019055","display_name":null,"funder_award_id":"T32-DC005356","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000034054","display_name":null,"funder_award_id":"P50CA097248","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000249124","display_name":null,"funder_award_id":"DC005356","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2978751908.pdf","grobid_xml":"https://content.openalex.org/works/W2978751908.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1540592014","https://openalex.org/W1827222570","https://openalex.org/W1926293708","https://openalex.org/W1965086052","https://openalex.org/W1978718921","https://openalex.org/W1979319210","https://openalex.org/W2001087320","https://openalex.org/W2045309744","https://openalex.org/W2047766643","https://openalex.org/W2051094704","https://openalex.org/W2054144308","https://openalex.org/W2060763328","https://openalex.org/W2065169702","https://openalex.org/W2073584782","https://openalex.org/W2083379652","https://openalex.org/W2105808730","https://openalex.org/W2108197743","https://openalex.org/W2119532444","https://openalex.org/W2123754647","https://openalex.org/W2133245428","https://openalex.org/W2134524871","https://openalex.org/W2138217871","https://openalex.org/W2141274038","https://openalex.org/W2150097377","https://openalex.org/W2150701531","https://openalex.org/W2159895229","https://openalex.org/W2165314624","https://openalex.org/W2312723781","https://openalex.org/W2438205327","https://openalex.org/W2443877627","https://openalex.org/W2533303333","https://openalex.org/W2553246368","https://openalex.org/W2913665794"],"related_works":["https://openalex.org/W4200022043","https://openalex.org/W3181751144","https://openalex.org/W2112727616","https://openalex.org/W3138359172","https://openalex.org/W2884525857","https://openalex.org/W4322720888","https://openalex.org/W4296613612","https://openalex.org/W3193904228","https://openalex.org/W4389609265","https://openalex.org/W3217171965"],"abstract_inverted_index":{"Mutation":[0],"of":[1,24,41,54,70,89],"TP53":[2,31],"is":[3,61,65],"the":[4,52,68,75],"most":[5],"common":[6],"genetic":[7],"abnormality":[8],"in":[9,19,27,74,97],"head":[10],"and":[11,17,22,51,78,93],"neck":[12],"squamous":[13],"cell":[14],"carcinoma":[15],"(HNSCC)":[16],"results":[18],"an":[20,79],"accumulation":[21,69],"expression":[23,43],"p53":[25,42,55,83,92],"protein":[26],"tumor":[28,76],"cells.":[29],"Disruptive":[30],"mutations":[32],"are":[33],"consistently":[34],"associated":[35,66],"with":[36,44,67,99],"poor":[37],"prognosis":[38,47,64],"but":[39],"correlations":[40],"mutation":[45],"or":[46],"have":[48],"been":[49,85],"variable":[50],"usefulness":[53],"as":[56],"a":[57],"target":[58],"for":[59],"immunotherapy":[60],"unknown.":[62],"Favorable":[63],"T":[71],"lymphocytes":[72],"(TILs)":[73],"microenvironment":[77],"immune":[80],"response":[81],"to":[82,91],"has":[84],"suggested":[86],"by":[87],"demonstration":[88],"antibodies":[90],"p53-restricted":[94],"cytotoxic":[95],"cells":[96],"patients":[98],"HNSCC.":[100]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}