{"id":"https://openalex.org/W2978744139","doi":"https://doi.org/10.14309/00000434-201110002-01475","title":"Ursodiol Use for the Chemoprevention of Colorectal Cancer in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis: A Metaanalysis","display_name":"Ursodiol Use for the Chemoprevention of Colorectal Cancer in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis: A Metaanalysis","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2978744139","doi":"https://doi.org/10.14309/00000434-201110002-01475","mag":"2978744139"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-201110002-01475","doi":"https://doi.org/10.14309/00000434-201110002-01475","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201110002-01475","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074629800","display_name":"Imran Ashraf","orcid":"https://orcid.org/0000-0002-8271-6496","observed_orcids":["https://orcid.org/0000-0002-8271-6496"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Imran Ashraf","raw_affiliation_strings":["Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010801984","display_name":"Murtaza Arif","orcid":"https://orcid.org/0000-0002-3562-7968","observed_orcids":["https://orcid.org/0000-0002-3562-7968"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murtaza Arif","raw_affiliation_strings":["Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084841926","display_name":"Abhishek Choudhary","orcid":"https://orcid.org/0000-0001-7951-719X","observed_orcids":["https://orcid.org/0000-0001-7951-719X"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhishek Choudhary","raw_affiliation_strings":["Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031755799","display_name":"Michelle Matteson","orcid":"https://orcid.org/0000-0001-8575-1943","observed_orcids":["https://orcid.org/0000-0001-8575-1943"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Matteson","raw_affiliation_strings":["Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046613718","display_name":"Robert E. Clark","orcid":"https://orcid.org/0000-0003-0235-856X","observed_orcids":["https://orcid.org/0000-0003-0235-856X"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Clark","raw_affiliation_strings":["Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019235446","display_name":"Jonathan D. Godfrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Godfrey","raw_affiliation_strings":["Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074411908","display_name":"Hazem T Hammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hazem Hammad","raw_affiliation_strings":["Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090110630","display_name":"Matthew L. Bechtold","orcid":"https://orcid.org/0000-0002-0205-3400","observed_orcids":["https://orcid.org/0000-0002-0205-3400"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Bechtold","raw_affiliation_strings":["Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Missouri - Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5050709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":null,"first_page":"S564","last_page":"S564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.20029999315738678,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9399999976158142},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":1.0},{"id":"https://openalex.org/keywords/colon-adenoma","display_name":"colonic adenoma","score":0.8320000171661377},{"id":"https://openalex.org/keywords/colonic-neoplasia","display_name":"colonic neoplasia","score":0.7889999747276306},{"id":"https://openalex.org/keywords/bile-acid-therapy","display_name":"bile acid therapy","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9233510494232178},{"id":"https://openalex.org/C2780615123","wikidata":"https://www.wikidata.org/wiki/Q1058608","display_name":"Primary sclerosing cholangitis","level":3,"score":0.8050894737243652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7670853137969971},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7008845806121826},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6802551746368408},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.5786011815071106},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.5699421763420105},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5152300000190735},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5097712874412537},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4886053204536438},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.44364961981773376},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42980608344078064},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34531891345977783},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16434547305107117},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-201110002-01475","doi":"https://doi.org/10.14309/00000434-201110002-01475","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201110002-01475","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2039349018","https://openalex.org/W2979178774","https://openalex.org/W2025779823","https://openalex.org/W2979143029","https://openalex.org/W2008031431","https://openalex.org/W4251269558","https://openalex.org/W2040571623","https://openalex.org/W2977449973","https://openalex.org/W2800320849","https://openalex.org/W2142578122"],"abstract_inverted_index":{"Purpose:":[0],"In":[1],"patients":[2,76,118,231,240,272],"with":[3,77,119,161,232,241,273],"ulcerative":[4],"colitis":[5],"(UC)":[6],"and":[7,55,79,96,121,234,243,275],"primary":[8],"sclerosing":[9],"cholangitis":[10],"(PSC),":[11],"the":[12,26,66,107,138,170,187,251,267],"risk":[13,252],"of":[14,28,68,72,86,91,109,140,151,173,253,269],"colon":[15,29,154,214,256],"cancer":[16,30,155,215],"is":[17],"elevated.":[18],"Many":[19],"modalities":[20],"have":[21,44,53,57],"been":[22,41,58],"utilized":[23,178],"to":[24,37,43,129,225,248,264],"decrease":[25,250],"occurrence":[27,206,216],"in":[31,75,116,204,230,239,271],"these":[32],"patients,":[33],"from":[34,99],"surveillance":[35],"colonoscopy":[36],"chemoprevention.":[38],"Ursodiol":[39,237],"has":[40],"shown":[42],"some":[45],"promise":[46],"as":[47,223],"a":[48,61,191],"chemopreventive":[49],"agent;":[50],"however,":[51],"results":[52],"varied":[54],"trials":[56,261],"small.":[59],"Therefore,":[60],"meta-analysis":[62],"was":[63,145,166,177,193],"performed":[64,146],"comparing":[65],"efficacy":[67],"ursodiol":[69,110,113,141,144,197,227,270],"at":[70],"prevention":[71],"colonic":[73],"neoplasia":[74],"UC":[78,120,233,242,274],"PSC.":[80,235,276],"Methods:":[81],"MEDLINE,":[82],"Cochrane":[83],"Central":[84],"Register":[85],"Controlled":[87],"Trials":[88],"&":[89],"Database":[90],"Systematic":[92],"Reviews,":[93],"CINAHL,":[94],"PubMed,":[95],"recent":[97],"abstracts":[98],"major":[100],"conferences":[101],"were":[102,123,127],"searched":[103],"(4/11).":[104],"Studies":[105],"examining":[106],"use":[108,238,268],"versus":[111],"no":[112,143,199,226],"or":[114,142,153,213,228,255],"placebo":[115,229],"adult":[117],"PSC":[122,244],"included.":[124],"Standard":[125],"forms":[126],"used":[128],"extract":[130],"data":[131],"by":[132,147,157,168],"two":[133],"independent":[134],"reviewers.":[135],"Meta-analysis":[136],"for":[137,179,195],"effect":[139],"calculating":[148,169],"pooled":[149],"estimates":[150],"adenoma":[152,205],"formation":[156],"odds":[158],"ratio":[159],"(OR)":[160],"random":[162],"effects":[163],"model.":[164],"Heterogeneity":[165],"assessed":[167],"I2":[171],"measure":[172],"inconsistency.":[174],"RevMan":[175],"5.1":[176],"statistical":[180],"analysis.":[181],"Results:":[182],"Four":[183],"studies":[184],"(N=281)":[185],"met":[186],"inclusion":[188],"criteria.":[189],"Although":[190],"trend":[192],"noted":[194],"improvement,":[196],"demonstrated":[198],"overall":[200],"statistically":[201],"significant":[202],"improvement":[203],"(OR":[207,217],"0.53;":[208],"95%":[209,219],"CI:":[210,220],"0.19-1.48,":[211],"p=0.23)":[212],"0.50;":[218],"0.18-1.43,":[221],"p=0.20)":[222],"compared":[224],"Conclusion:":[236],"does":[245],"not":[246],"appear":[247],"significantly":[249],"adenomas":[254],"cancer.":[257],"Further":[258],"randomized":[259],"controlled":[260],"are":[262],"required":[263],"fully":[265],"investigate":[266]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-10-10T00:00:00"}