{"id":"https://openalex.org/W2978740325","doi":"https://doi.org/10.7196/samj.2019.v109i8b.013888","title":"Haematopoietic stem cell transplantation in South Africa: Current limitations and future perspectives","display_name":"Haematopoietic stem cell transplantation in South Africa: Current limitations and future perspectives","publication_year":2019,"publication_date":"2019-09-10","ids":{"openalex":"https://openalex.org/W2978740325","doi":"https://doi.org/10.7196/samj.2019.v109i8b.013888","mag":"2978740325","pmid":"https://pubmed.ncbi.nlm.nih.gov/31662149"},"language":"en","primary_location":{"id":"doi:10.7196/samj.2019.v109i8b.013888","doi":"https://doi.org/10.7196/samj.2019.v109i8b.013888","is_oa":true,"landing_page_url":"https://doi.org/10.7196/samj.2019.v109i8b.013888","pdf_url":"http://www.samj.org.za/index.php/samj/article/download/12716/8983","source":{"id":"https://openalex.org/S147026946","display_name":"South African Medical Journal","issn_l":"0256-9574","issn":["0256-9574","2078-5135"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["dhet","doaj","dongbi-c","doyens","jpps-2","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo","vabb-shw"],"host_organization":"https://openalex.org/P4310315351","host_organization_name":"Health and Medical Publishing Group","host_organization_lineage":["https://openalex.org/P4310315351"],"host_organization_lineage_names":["Health and Medical Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.samj.org.za/index.php/samj/article/download/12716/8983","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036500677","display_name":"Simone Grobbelaar","orcid":"https://orcid.org/0000-0002-5046-6007","observed_orcids":["https://orcid.org/0000-0002-5046-6007"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"S Grobbelaar","raw_affiliation_strings":["Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa. simonegrow@gmail.com","Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa. simonegrow@gmail.com","institution_ids":["https://openalex.org/I69552723"]},{"raw_affiliation_string":"Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049188201","display_name":"Anne Elisabeth Mercier","orcid":"https://orcid.org/0000-0002-2030-9879","observed_orcids":["https://orcid.org/0000-0002-2030-9879"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"A E Mercier","raw_affiliation_strings":["Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061201808","display_name":"Estelle R. Verburgh","orcid":"https://orcid.org/0000-0003-4657-7318","observed_orcids":["https://orcid.org/0000-0003-4657-7318"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"E Verburgh","raw_affiliation_strings":["Division of Clinical Haematology, Department of Medicine, School of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Haematology, Department of Medicine, School of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056494123","display_name":"David Brittain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Brittain","raw_affiliation_strings":["The Alberts Cellular Therapy Centre, Netcare Pretoria East Hospital, Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Alberts Cellular Therapy Centre, Netcare Pretoria East Hospital, Pretoria, South Africa","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010874845","display_name":"Michael Sean Pepper","orcid":"https://orcid.org/0000-0001-6406-2380","observed_orcids":["https://orcid.org/0000-0001-6406-2380"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"M S Pepper","raw_affiliation_strings":["Institute for Cellular and Molecular Medicine, Department of Immunology, and SAMRC Extramural Unit for Stem Cell Research and Therapy,\r\nSchool of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cellular and Molecular Medicine, Department of Immunology, and SAMRC Extramural Unit for Stem Cell Research and Therapy,\r\nSchool of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I69552723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5732,"currency":"ZAR","value_usd":311},"apc_paid":{"value":5732,"currency":"ZAR","value_usd":311},"fwci":0.7399,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.7314564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"109","issue":"8b","first_page":"46","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":1.0},{"id":"https://openalex.org/keywords/south-africa","display_name":"South Africa","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8109999895095825},{"id":"https://openalex.org/keywords/stem-cell-mobilization","display_name":"stem cell mobilization","score":0.7789999842643738},{"id":"https://openalex.org/keywords/engraftment","display_name":"engraftment","score":0.9549999833106995},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/stem-cell-donors","display_name":"stem cell donors","score":0.6269999742507935},{"id":"https://openalex.org/keywords/transplant-costs","display_name":"transplant costs","score":0.6420000195503235},{"id":"https://openalex.org/keywords/health-professions-education","display_name":"health professions education","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8377165794372559},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7671347856521606},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.728457510471344},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6574351191520691},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5806402564048767},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.569972813129425},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4768708348274231},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4123743772506714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2254321277141571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07195720076560974},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006402","descriptor_name":"Hematologic Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013019","descriptor_name":"South Africa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.7196/samj.2019.v109i8b.013888","doi":"https://doi.org/10.7196/samj.2019.v109i8b.013888","is_oa":true,"landing_page_url":"https://doi.org/10.7196/samj.2019.v109i8b.013888","pdf_url":"http://www.samj.org.za/index.php/samj/article/download/12716/8983","source":{"id":"https://openalex.org/S147026946","display_name":"South African Medical Journal","issn_l":"0256-9574","issn":["0256-9574","2078-5135"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["dhet","doaj","dongbi-c","doyens","jpps-2","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo","vabb-shw"],"host_organization":"https://openalex.org/P4310315351","host_organization_name":"Health and Medical Publishing Group","host_organization_lineage":["https://openalex.org/P4310315351"],"host_organization_lineage_names":["Health and Medical Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African Medical Journal","raw_type":"journal-article"},{"id":"pmid:31662149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31662149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde","raw_type":"Journal Article"},{"id":"pmh:oai:repository.up.ac.za:2263/74773","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2263/74773","pdf_url":null,"source":{"id":"https://openalex.org/S4306401870","display_name":"UpSpace Institutional Repository (University of Pretoria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I69552723","host_organization_name":"University of Pretoria","host_organization_lineage":["https://openalex.org/I69552723"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.7196/samj.2019.v109i8b.013888","doi":"https://doi.org/10.7196/samj.2019.v109i8b.013888","is_oa":true,"landing_page_url":"https://doi.org/10.7196/samj.2019.v109i8b.013888","pdf_url":"http://www.samj.org.za/index.php/samj/article/download/12716/8983","source":{"id":"https://openalex.org/S147026946","display_name":"South African Medical Journal","issn_l":"0256-9574","issn":["0256-9574","2078-5135"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["dhet","doaj","dongbi-c","doyens","jpps-2","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo","vabb-shw"],"host_organization":"https://openalex.org/P4310315351","host_organization_name":"Health and Medical Publishing Group","host_organization_lineage":["https://openalex.org/P4310315351"],"host_organization_lineage_names":["Health and Medical Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South African Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1540679298","display_name":null,"funder_award_id":"RFA\u2010UFSP\u201001\u20102013","funder_id":"https://openalex.org/F4320320672","funder_display_name":"South African Medical Research Council"},{"id":"https://openalex.org/G3969415636","display_name":null,"funder_award_id":"SAMRCRFA-UFSP-01-2013/STEM CELLS","funder_id":"https://openalex.org/F4320320672","funder_display_name":"South African Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320672","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69"},{"id":"https://openalex.org/F4320321099","display_name":"Bundesamt f\u00fcr Gesundheit","ror":"https://ror.org/01qtc5416"},{"id":"https://openalex.org/F4320332873","display_name":"Society for Community Research and Action","ror":"https://ror.org/00rt1d436"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2978740325.pdf","grobid_xml":"https://content.openalex.org/works/W2978740325.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1501039723","https://openalex.org/W1530267129","https://openalex.org/W1532162953","https://openalex.org/W1542075228","https://openalex.org/W1666878942","https://openalex.org/W1880265034","https://openalex.org/W1909964850","https://openalex.org/W1972966329","https://openalex.org/W1975025595","https://openalex.org/W1978683461","https://openalex.org/W1981690705","https://openalex.org/W1996320020","https://openalex.org/W1997025446","https://openalex.org/W2003914332","https://openalex.org/W2011211019","https://openalex.org/W2012302358","https://openalex.org/W2018919532","https://openalex.org/W2025358933","https://openalex.org/W2036736974","https://openalex.org/W2044804132","https://openalex.org/W2054671000","https://openalex.org/W2070842082","https://openalex.org/W2075580305","https://openalex.org/W2077212413","https://openalex.org/W2091541317","https://openalex.org/W2098631716","https://openalex.org/W2111792533","https://openalex.org/W2113754447","https://openalex.org/W2142493118","https://openalex.org/W2160666689","https://openalex.org/W2216209869","https://openalex.org/W2233399393","https://openalex.org/W2259695269","https://openalex.org/W2307974302","https://openalex.org/W2321365245","https://openalex.org/W2346341352","https://openalex.org/W2414804136","https://openalex.org/W2464902886","https://openalex.org/W2501883076","https://openalex.org/W2533952133","https://openalex.org/W2543235356","https://openalex.org/W2588107243","https://openalex.org/W2593566766","https://openalex.org/W2594275567","https://openalex.org/W2601346497","https://openalex.org/W2617908407","https://openalex.org/W2767478860","https://openalex.org/W2772946231","https://openalex.org/W2789917280","https://openalex.org/W2801990729","https://openalex.org/W2900055535","https://openalex.org/W2912839473","https://openalex.org/W4243739353","https://openalex.org/W4255497504"],"related_works":["https://openalex.org/W7219254791","https://openalex.org/W4416063194","https://openalex.org/W6960100918","https://openalex.org/W4387525764","https://openalex.org/W7125149572","https://openalex.org/W7140186532","https://openalex.org/W7214027962","https://openalex.org/W2563893716","https://openalex.org/W4238858259","https://openalex.org/W93125924"],"abstract_inverted_index":{"The":[0,53],"growing":[1],"need":[2],"for":[3,28,97],"haematopoietic":[4,46,62,147],"stem":[5,63,148],"cell":[6,149],"transplantation":[7],"(HSCT)":[8],"is":[9],"reflected":[10],"in":[11,111,119,126,144,168],"the":[12,45,74,89,100,112,120,163,169],"increasing":[13],"number":[14],"of":[15,31,44,56,88,93,108,116,122,136,158,162],"transplants":[16],"performed":[17],"globally":[18],"each":[19],"year.":[20],"HSCT":[21,57,159],"provides":[22],"life-changing":[23],"and":[24,41,50,64,105,114,134,160],"potentially":[25],"curative":[26],"therapy":[27],"a":[29],"range":[30],"pathologies":[32],"including":[33,91],"haematological":[34],"malignancies;":[35],"other":[36],"indications":[37],"include":[38,129],"certain":[39],"congenital":[40],"acquired":[42],"disorders":[43],"system,":[47],"autoimmune":[48],"conditions":[49],"hereditary":[51],"diseases.":[52],"primary":[54],"goals":[55],"are":[58,166],"either":[59],"to":[60,72,154],"replace":[61],"progenitor":[65],"cells":[66,96,110],"(HSPC)":[67],"following":[68],"myeloablative":[69],"chemotherapy":[70],"or":[71,102],"cure":[73],"original":[75],"pathology":[76],"with":[77],"allogeneic":[78,123],"HSPCs.":[79],"Success":[80],"depends":[81],"on":[82],"optimal":[83],"outcomes":[84],"at":[85],"various":[86],"stages":[87],"procedure":[90],"mobilisation":[92],"marrow":[94],"stem/progenitor":[95],"harvesting":[98],"from":[99],"patient":[101],"donor,":[103],"long-term":[104],"sustainable":[106],"engraftment":[107],"these":[109],"recipient,":[113],"prevention":[115],"graft-versus-host":[117],"disease":[118],"case":[121],"HSCT.":[124],"Challenges":[125],"South":[127,170],"Africa":[128],"high":[130],"cost,":[131],"limited":[132],"infrastructure":[133],"lack":[135],"appropriately":[137],"trained":[138],"staff,":[139],"as":[140,142],"well":[141],"limitations":[143],"securing":[145],"suitable":[146],"donors.":[150],"This":[151],"review":[152],"aims":[153],"provide":[155],"an":[156],"overview":[157],"some":[161],"challenges":[164],"that":[165],"faced":[167],"African":[171],"context.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-10-10T00:00:00"}
