{"id":"https://openalex.org/W2978705437","doi":"https://doi.org/10.14309/00000434-201610001-00002","title":"Detection of Advanced Neoplasia in Pancreatic Cysts by Assay of Novel DNA Methylation Markers in Cyst Fluid: A Multicenter Pilot Study: 2016 ACG Fellows-In-Training Award (Biliary/Pancreas Category)","display_name":"Detection of Advanced Neoplasia in Pancreatic Cysts by Assay of Novel DNA Methylation Markers in Cyst Fluid: A Multicenter Pilot Study: 2016 ACG Fellows-In-Training Award (Biliary/Pancreas Category)","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2978705437","doi":"https://doi.org/10.14309/00000434-201610001-00002","mag":"2978705437"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-201610001-00002","doi":"https://doi.org/10.14309/00000434-201610001-00002","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201610001-00002","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016623207","display_name":"Shounak Majumder","orcid":"https://orcid.org/0000-0001-7687-049X","observed_orcids":["https://orcid.org/0000-0001-7687-049X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shounak Majumder","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101545019","display_name":"William R. Taylor","orcid":"https://orcid.org/0000-0001-9032-847X","observed_orcids":["https://orcid.org/0000-0001-9032-847X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Taylor","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038050880","display_name":"Tracy C. Yab","orcid":"https://orcid.org/0000-0002-9116-8428","observed_orcids":["https://orcid.org/0000-0002-9116-8428"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy C. Yab","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043668707","display_name":"Calise K. Berger","orcid":"https://orcid.org/0009-0006-1407-7895","observed_orcids":["https://orcid.org/0009-0006-1407-7895"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calise K. Berger","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038158795","display_name":"Douglas W. Mahoney","orcid":"https://orcid.org/0000-0001-5144-0645","observed_orcids":["https://orcid.org/0000-0001-5144-0645"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas W. Mahoney","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071877934","display_name":"Harry R. Aslanian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry R. Aslanian","raw_affiliation_strings":["Yale University School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103148810","display_name":"James J. Farrell","orcid":"https://orcid.org/0000-0002-4073-4776","observed_orcids":["https://orcid.org/0000-0002-4073-4776","https://orcid.org/0000-0003-4860-5693"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Farrell","raw_affiliation_strings":["Yale University School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103393690","display_name":"William E. Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Fisher","raw_affiliation_strings":["Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034135495","display_name":"Bonnie Gould Rothberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie Gould Rothberg","raw_affiliation_strings":["Yale Cancer Center, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cancer Center, New Haven, CT","institution_ids":["https://openalex.org/I2802730090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077051180","display_name":"Ronald R. Salem","orcid":"https://orcid.org/0000-0003-2410-7665","observed_orcids":["https://orcid.org/0000-0003-2410-7665"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald R. Salem","raw_affiliation_strings":["Yale University School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030459924","display_name":"Diane M. Simeone","orcid":"https://orcid.org/0000-0001-5142-3087","observed_orcids":["https://orcid.org/0000-0001-5142-3087"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane M. Simeone","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026127519","display_name":"George Van Buren","orcid":"https://orcid.org/0000-0001-7637-3717","observed_orcids":["https://orcid.org/0000-0001-7637-3717"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George J. Van Buren","raw_affiliation_strings":["Baylor College of Medicine, Bradenton, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Bradenton, FL","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012699718","display_name":"Massimo Raimondo","orcid":"https://orcid.org/0000-0002-3750-1541","observed_orcids":["https://orcid.org/0000-0002-3750-1541"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Massimo Raimondo","raw_affiliation_strings":["Mayo Clinic, Jacksonville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048460582","display_name":"Suresh T. Chari","orcid":"https://orcid.org/0000-0002-3924-0971","observed_orcids":["https://orcid.org/0000-0002-3924-0971"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh T. Chari","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017521990","display_name":"John B. Kisiel","orcid":"https://orcid.org/0000-0002-3840-5324","observed_orcids":["https://orcid.org/0000-0002-3840-5324"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B. Kisiel","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046429346","display_name":"Mark D. Topazian","orcid":"https://orcid.org/0000-0003-1090-2844","observed_orcids":["https://orcid.org/0000-0003-1090-2844"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark D. Topazian","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078991711","display_name":"David A. Ahlquist","orcid":"https://orcid.org/0000-0002-0652-0758","observed_orcids":["https://orcid.org/0000-0002-0652-0758"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Ahlquist","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29716672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"111","issue":null,"first_page":"S1","last_page":"S1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cysts","display_name":"pancreatic cysts","score":0.9070000052452087},{"id":"https://openalex.org/keywords/advanced-neoplasia","display_name":"advanced neoplasia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/high-grade-dysplasia","display_name":"high-grade dysplasia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.953000009059906},{"id":"https://openalex.org/keywords/dna-methylation-markers","display_name":"DNA methylation biomarkers","score":0.871999979019165},{"id":"https://openalex.org/keywords/cyst-fluid","display_name":"cyst fluid","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bmp3","display_name":"BMP3","score":0.6970000267028809},{"id":"https://openalex.org/keywords/emx1","display_name":"Emx1","score":1.0},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.5619999766349792},{"id":"https://openalex.org/keywords/low-grade-dysplasia","display_name":"low-grade dysplasia","score":0.7670000195503235},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.4269999861717224},{"id":"https://openalex.org/keywords/clec11a","display_name":"CLEC11A","score":0.6899999976158142},{"id":"https://openalex.org/keywords/methylation-panel","display_name":"methylation panel","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.7507833242416382},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.7261013984680176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7082892060279846},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.6190505623817444},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5329295992851257},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5117018222808838},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.47873565554618835},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.44452592730522156},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.44025492668151855},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41649046540260315},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41006743907928467}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-201610001-00002","doi":"https://doi.org/10.14309/00000434-201610001-00002","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201610001-00002","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/10","score":0.550000011920929,"display_name":"Reduced inequalities"},{"id":"https://metadata.un.org/sdg/16","score":0.4399999976158142,"display_name":"Peace, justice, and strong institutions"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2606586421","https://openalex.org/W2964175665","https://openalex.org/W2606808852","https://openalex.org/W2584686066","https://openalex.org/W7204947421","https://openalex.org/W4376620196","https://openalex.org/W3003833633","https://openalex.org/W4316038590","https://openalex.org/W2041446900","https://openalex.org/W4366992856"],"abstract_inverted_index":{"Introduction:":[0],"An":[1],"important":[2],"subset":[3],"of":[4,38,62,110,165,229,241,255,268,293,305,353],"pancreatic":[5,41,69,143,309,343],"cysts":[6,42,119,127,188,197,273,344],"harbor":[7],"advanced":[8,52,121],"neoplasia":[9,122],"(high-grade":[10],"dysplasia":[11,78,131,207,277],"(HGD)":[12],"or":[13,30,74,133,191,200,317,323],"cancer).":[14],"Yet,":[15],"current":[16],"diagnostic":[17,336],"approaches":[18,337],"for":[19,51,342],"detecting":[20],"this":[21,89,138,260],"high":[22,250],"risk":[23],"group":[24],"are":[25,358],"based":[26],"on":[27],"imaging":[28],"criteria":[29],"cyst":[31,97,114,144,157,310,329],"fluid":[32,115,145,158,238,311,330],"analyses":[33],"which":[34],"lack":[35],"accuracy.":[36],"Management":[37],"patients":[39],"with":[40,118,126,189,198,204,274,315,321],"may":[43],"be":[44,86],"further":[45],"optimized":[46],"by":[47,171],"molecular":[48],"markers":[49,66],"informative":[50],"neoplasia.":[53],"We":[54,301],"have":[55,290,331],"recently":[56],"identified":[57,147],"and":[58,80,107,123,161,183,193,282,351],"validated":[59],"a":[60],"panel":[61,263,288],"novel":[63,306],"methylated":[64],"DNA":[65,153],"(MDMs)":[67],"in":[68,91,113,272],"tissue":[70,92],"that":[71,303],"discriminates":[72],"HGD":[73,192,281,318],"adenocarcinoma":[75,190],"from":[76,116,124,148,154,235,308,319,328],"low-grade":[77,130],"(LGD)":[79,132],"non-dysplastic":[81],"tissue1.":[82],"It":[83],"remains":[84],"to":[85,96,105,178,232,333,338],"determined":[87],"if":[88],"discrimination":[90,251],"holds":[93],"when":[94],"applied":[95],"fluid.":[98],"In":[99,137],"the":[100,226,242,249,285],"present":[101],"study,":[102,141],"we":[103],"aimed":[104],"assess":[106],"compare":[108],"distributions":[109,240],"candidate":[111],"MDMs":[112,167,216,245,307,326],"cases":[117,234,314],"containing":[120,128],"controls":[125,194,320],"either":[129],"no":[134,201,324],"dysplasia.":[135,202,325],"Methods:":[136],"blinded":[139],"multicenter":[140],"archival":[142],"was":[146,159,168],"83":[149],"surgically":[150],"resected":[151],"cysts.":[152],"0.2":[155],"ml":[156],"extracted":[160],"bisulfite":[162],"converted.":[163],"Assay":[164],"selected":[166],"then":[169],"performed":[170],"methylation":[172],"specific":[173],"PCR;":[174],"levels":[175,271],"were":[176,187,196,209],"normalized":[177],"beta":[179],"actin":[180],"(total":[181],"DNA)":[182],"age.":[184],"Cases":[185],"(n=14)":[186],"(n=61)":[195],"LGD":[199,283,322],"Cysts":[203],"intermediate":[205,275],"grade":[206,276],"(n=8)":[208],"analyzed":[210],"separately.":[211],"Results:":[212],"The":[213],"top":[214,244],"5":[215],"(BMP3,":[217,246],"EMX1,":[218],"CLEC11A,":[219],"ST8IA1,":[220],"VWC2)":[221],"individually":[222],"achieved":[223],"areas":[224],"under":[225],"ROC":[227],"curve":[228],"\u2265":[230],"0.90":[231],"distinguish":[233,313],"controls.":[236],"Cyst":[237],"level":[239],"2":[243,261,286],"EMX1)":[247],"illustrate":[248],"(figure).":[252],"At":[253],"specificity":[254],"90%":[256],"(95%":[257],"CI":[258],"80-96%),":[259],"MDM":[262,270,287],"detected":[264],"93%":[265],"(66-100":[266],"%)":[267],"cases.":[269],"generally":[278],"fell":[279],"between":[280],"(figure);":[284],"would":[289],"called":[291],"38%":[292],"these":[294,354],"lesions":[295],"positive":[296],"at":[297,345],"95%":[298],"specificity.":[299],"Conclusion:":[300],"demonstrate":[302],"assay":[304],"accurately":[312],"cancer":[316],"assayed":[327],"potential":[332],"complement":[334],"existing":[335],"improve":[339],"predictive":[340],"accuracy":[341],"highest":[346],"malignant":[347],"risk.":[348],"Further":[349],"investigation":[350],"corroboration":[352],"promising":[355],"early":[356],"results":[357],"needed.1Majumder":[359],"S,":[360],"et":[361],"al.":[362],"Gastroenterology":[363],"2016;":[364],"S120-S121Figure":[365],"1":[366]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-10-10T00:00:00"}
