{"id":"https://openalex.org/W29786633","doi":null,"title":"The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases.","display_name":"The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases.","publication_year":1998,"publication_date":"1998-12-16","ids":{"openalex":"https://openalex.org/W29786633","mag":"29786633","pmid":"https://pubmed.ncbi.nlm.nih.gov/9889172"},"language":"en","primary_location":{"id":"pmid:9889172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9889172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medical research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113604493","display_name":"Uwe R. Juergens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U R Juergens","raw_affiliation_strings":["Abteilung Pneumologie, Medizinische Universit\u00e4ts-Poliklinik, Wilhelmstrasse 35-37, D-53111 Bonn, Germany. EurJMedRes@t-online.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung Pneumologie, Medizinische Universit\u00e4ts-Poliklinik, Wilhelmstrasse 35-37, D-53111 Bonn, Germany. EurJMedRes@t-online.de","institution_ids":["https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090822055","display_name":"Meinolf St\u00f6ber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M St\u00f6ber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109318996","display_name":"Hans Vetter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Vetter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.212,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.51886314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"3","issue":"12","first_page":"539","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.2257000058889389,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.2257000058889389,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.21529999375343323,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1860000044107437,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-menthol","display_name":"L-menthol","score":1.0},{"id":"https://openalex.org/keywords/mint-oil","display_name":"mint oil","score":0.9639999866485596},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9340000152587891},{"id":"https://openalex.org/keywords/lipoxygenase-pathway","display_name":"lipoxygenase pathway","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cyclooxygenase-pathway","display_name":"cyclooxygenase pathway","score":0.9950000047683716},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.9070000052452087},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.921999990940094},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/monoterpenes","display_name":"monoterpenes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2780194911","wikidata":"https://www.wikidata.org/wiki/Q407418","display_name":"Menthol","level":2,"score":0.8946421146392822},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6427675485610962},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.5777182579040527},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.5645934343338013},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5509291887283325},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49598655104637146},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4620705246925354},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.4503553807735443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30555200576782227},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21708163619041443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18023952841758728},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007975","descriptor_name":"Leukotriene B4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008610","descriptor_name":"Menthol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010938","descriptor_name":"Plant Oils","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019686","descriptor_name":"Lamiaceae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9889172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9889172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medical research","raw_type":"Comparative Study"},{"id":"mag:29786633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9889172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4308724040","https://openalex.org/W3022935750","https://openalex.org/W3215190330","https://openalex.org/W4410185157","https://openalex.org/W2944264148","https://openalex.org/W1984933366","https://openalex.org/W3176362975","https://openalex.org/W2061228648","https://openalex.org/W2921660782","https://openalex.org/W4402442819"],"abstract_inverted_index":{"The":[0],"anti-inflammatory":[1,22,61,217],"efficacy":[2,241],"of":[3,15,63,78,80,117,136,154,183,219,242,246],"monoterpenes":[4],"is":[5],"still":[6],"unknown.":[7],"In":[8,58,122],"order":[9],"to":[10,139,147,150,222],"evaluate":[11],"the":[12,51,54,60,64,76,81,113,181,238],"potential":[13,239],"role":[14],"L-menthol":[16,73,110,220,243],"and":[17,44,53,102,173,205,255],"mint":[18,124,223],"oil":[19,125,166,224],"as":[20,47,175,196,251],"an":[21],"drug,":[23],"preclinical":[24],"in":[25,87,230],"vitro-investigations":[26],"were":[27,70],"performed":[28],"using":[29],"LPS-stimulated":[30],"monocytes":[31,86,214],"from":[32],"healthy":[33],"volunteers.":[34],"Arachidonic":[35],"acid":[36,203],"metabolism":[37,204],"was":[38,185],"assessed":[39],"by":[40,85,92,98,104,162,186],"measuring":[41],"LTB":[42,89,171],"subset4":[43,90,172],"PGE":[45,96,131,144,159],"subset2":[46,97,132,145,160],"indicators":[48],"for":[49,244],"both":[50],"lipoxygenase":[52],"cyclooxygenase":[55],"pathways":[56],"respectively.":[57],"addition,":[59],"effects":[62,169,218],"two":[65],"terpenes":[66],"on":[67,130,170],"IL-1beta":[68,103,174,206],"production":[69,77,161],"analysed.":[71],"-":[72,208],"significantly":[74],"suppressed":[75,158],"each":[79],"three":[82],"inflammation":[83],"mediators":[84],"vitro.":[88],"decreased":[91],"-64.4":[93],"+/-":[94,100,106],"10%,":[95],"-56.6":[99],"8%,":[101],"-64.2":[105],"7%":[107],"respectively":[108],"at":[109,189,225],"concentrations":[111,135,153,228],"within":[112],"presumed":[114],"therapeutic":[115,240],"range":[116],"about":[118],"10":[119,137,140,155],"superset-7":[120,156],"g/ml.":[121],"contrast,":[123],"had":[126,167],"a":[127,197],"bimodal":[128],"effect":[129],"production:":[133],"lower":[134,190],"superset-10":[138],"superset-8":[141],"g/ml":[142,157],"increased":[143],"up":[146],"6-fold":[148],"compared":[149,221],"baseline":[151],"but":[152],"approximately":[163],"50%.":[164],"Mint":[165],"similar":[168],"its":[176],"main":[177],"constituent,":[178],"L-menthol,":[179],"although":[180],"degree":[182],"suppression":[184],"comparison":[187],"smaller":[188],"concentrations.":[191],"Paraffin":[192],"oil,":[193],"which":[194],"served":[195],"solvent,":[198],"did":[199],"not":[200],"affect":[201],"arachidonic":[202],"production.":[207],"These":[209],"results":[210],"obtained":[211],"with":[212],"human":[213],"suggest":[215],"preferable":[216],"therapeutically":[226],"relevant":[227],"supplied":[229],"enteric":[231],"coated":[232],"capsules.":[233],"Therefore,":[234],"clinical":[235],"trials":[236],"investigating":[237],"treatment":[245],"chronic":[247],"inflammatory":[248],"disorders":[249],"such":[250],"bronchial":[252],"asthma,":[253],"colitis":[254],"allergic":[256],"rhinitis":[257],"seem":[258],"worthwhile.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}