{"id":"https://openalex.org/W2978438841","doi":"https://doi.org/10.21873/anticanres.13746","title":"Expression of Immune Checkpoint Receptors on T-Cells and Their Ligands on Leukemia Blasts in Childhood Acute Leukemia","display_name":"Expression of Immune Checkpoint Receptors on T-Cells and Their Ligands on Leukemia Blasts in Childhood Acute Leukemia","publication_year":2019,"publication_date":"2019-09-30","ids":{"openalex":"https://openalex.org/W2978438841","doi":"https://doi.org/10.21873/anticanres.13746","mag":"2978438841","pmid":"https://pubmed.ncbi.nlm.nih.gov/31570447"},"language":"en","primary_location":{"id":"doi:10.21873/anticanres.13746","doi":"https://doi.org/10.21873/anticanres.13746","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.13746","pdf_url":"https://ar.iiarjournals.org/content/anticanres/39/10/5531.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ar.iiarjournals.org/content/anticanres/39/10/5531.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056354964","display_name":"Sung Han Kang","orcid":"https://orcid.org/0000-0002-1651-4415","observed_orcids":["https://orcid.org/0000-0002-1651-4415"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SUNG HAN KANG","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047162000","display_name":"Hyun Ju Hwang","orcid":"https://orcid.org/0000-0003-0564-0990","observed_orcids":["https://orcid.org/0000-0003-0564-0990"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"HYUN JU HWANG","raw_affiliation_strings":["Asan Institute for Life Sciences and Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Institute for Life Sciences and Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085081441","display_name":"Jae Won Yoo","orcid":"https://orcid.org/0000-0001-7970-1691","observed_orcids":["https://orcid.org/0000-0001-7970-1691","https://orcid.org/0000-0002-0844-4250"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210143602","display_name":"Chungnam National University Hospital","ror":"https://ror.org/04353mq94","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I196345858","https://openalex.org/I4210143602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"JAE WON YOO","raw_affiliation_strings":["Department of Pediatrics, Chungnam National University Hospital, Daejon, Republic of Korea","Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chungnam National University Hospital, Daejon, Republic of Korea","institution_ids":["https://openalex.org/I4210143602"]},{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048011214","display_name":"Hyery Kim","orcid":"https://orcid.org/0000-0003-2852-6832","observed_orcids":["https://orcid.org/0000-0003-2852-6832"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"HYERY KIM","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101759969","display_name":"Eun Seok Choi","orcid":"https://orcid.org/0000-0003-3455-0492","observed_orcids":["https://orcid.org/0000-0003-3455-0492"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"EUN SEOK CHOI","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114376484","display_name":"Sang\u2010Hyun Hwang","orcid":"https://orcid.org/0000-0003-3201-5728","observed_orcids":["https://orcid.org/0000-0003-3201-5728"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SANG-HYUN HWANG","raw_affiliation_strings":["Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060580143","display_name":"Young\u2010Uk Cho","orcid":"https://orcid.org/0000-0002-4403-8989","observed_orcids":["https://orcid.org/0000-0002-4403-8989"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"YOUNG-UK CHO","raw_affiliation_strings":["Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044342301","display_name":"Seongsoo Jang","orcid":"https://orcid.org/0000-0002-0045-1747","observed_orcids":["https://orcid.org/0000-0002-0045-1747"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SEONGSOO JANG","raw_affiliation_strings":["Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073296574","display_name":"Chan\u2010Jeoung Park","orcid":"https://orcid.org/0000-0003-4396-8348","observed_orcids":["https://orcid.org/0000-0003-4396-8348"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"CHAN-JEOUNG PARK","raw_affiliation_strings":["Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064771213","display_name":"Ho Joon Im","orcid":"https://orcid.org/0000-0001-8799-4068","observed_orcids":["https://orcid.org/0000-0001-8799-4068"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"HO JOON IM","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030314619","display_name":"Jong Jin Seo","orcid":"https://orcid.org/0000-0002-0191-7836","observed_orcids":["https://orcid.org/0000-0002-0191-7836"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"JONG JIN SEO","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348060","display_name":"Nayoung Kim","orcid":"https://orcid.org/0000-0001-8598-0068","observed_orcids":["https://orcid.org/0000-0001-8598-0068"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"NAYOUNG KIM","raw_affiliation_strings":["Asan Institute for Life Sciences and Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea pedkkn@amc.seoul.kr naykim@amc.seoul.kr","Asan Institute for Life Sciences and Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Institute for Life Sciences and Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea pedkkn@amc.seoul.kr naykim@amc.seoul.kr","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]},{"raw_affiliation_string":"Asan Institute for Life Sciences and Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000695591","display_name":"Kyung\u2010Nam Koh","orcid":"https://orcid.org/0000-0002-6376-672X","observed_orcids":["https://orcid.org/0000-0002-6376-672X"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"KYUNG-NAM KOH","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea pedkkn@amc.seoul.kr naykim@amc.seoul.kr","Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea pedkkn@amc.seoul.kr naykim@amc.seoul.kr","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]},{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5726,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.84630925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"39","issue":"10","first_page":"5531","last_page":"5539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-receptors","display_name":"immune checkpoint receptors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/childhood-acute-leukemia","display_name":"childhood acute leukemia","score":0.8579999804496765},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/btla","display_name":"BTLA","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hvem","display_name":"HVEM","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.722000002861023},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hla-abc","display_name":"HLA-ABC","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/alpha-beta-t-cells","display_name":"alpha beta T cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/leukemic-blasts","display_name":"leukemic blasts","score":0.6769999861717224},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5690000057220459},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.9819999933242798},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C2780237676","wikidata":"https://www.wikidata.org/wiki/Q18052115","display_name":"BTLA","level":4,"score":0.5923200249671936},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5729220509529114},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.531836986541748},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4700925350189209},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46187829971313477},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44273295998573303},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.43792539834976196},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43645408749580383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4329224228858948},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4213762879371643},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.37527287006378174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3650326132774353},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.354921817779541},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06803417205810547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.21873/anticanres.13746","doi":"https://doi.org/10.21873/anticanres.13746","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.13746","pdf_url":"https://ar.iiarjournals.org/content/anticanres/39/10/5531.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},{"id":"pmid:31570447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31570447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21873/anticanres.13746","doi":"https://doi.org/10.21873/anticanres.13746","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.13746","pdf_url":"https://ar.iiarjournals.org/content/anticanres/39/10/5531.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G854903437","display_name":null,"funder_award_id":"2018R1C1B6008852","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2978438841.pdf","grobid_xml":"https://content.openalex.org/works/W2978438841.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1507573241","https://openalex.org/W1538902372","https://openalex.org/W1652473508","https://openalex.org/W1967889234","https://openalex.org/W1983973479","https://openalex.org/W1993851289","https://openalex.org/W1994993231","https://openalex.org/W2015474424","https://openalex.org/W2015503794","https://openalex.org/W2016370064","https://openalex.org/W2026236493","https://openalex.org/W2046739604","https://openalex.org/W2070873336","https://openalex.org/W2076791524","https://openalex.org/W2094366129","https://openalex.org/W2095826876","https://openalex.org/W2102440640","https://openalex.org/W2117692326","https://openalex.org/W2119685895","https://openalex.org/W2125616358","https://openalex.org/W2129807581","https://openalex.org/W2136859769","https://openalex.org/W2144520999","https://openalex.org/W2156353875","https://openalex.org/W2210668374","https://openalex.org/W2465734185","https://openalex.org/W2581942673","https://openalex.org/W2612422239","https://openalex.org/W2614086758","https://openalex.org/W2772906665","https://openalex.org/W2807729510","https://openalex.org/W2883386987","https://openalex.org/W2887512933","https://openalex.org/W2986834274","https://openalex.org/W4229933927"],"related_works":["https://openalex.org/W4387093634","https://openalex.org/W3014300866","https://openalex.org/W6950617181","https://openalex.org/W7154090167","https://openalex.org/W3181156833","https://openalex.org/W4224317918","https://openalex.org/W3011769954","https://openalex.org/W3048733487","https://openalex.org/W4380576707","https://openalex.org/W3177001459"],"abstract_inverted_index":{"Background:":[0],"Possible":[1],"correlations":[2],"between":[3],"the":[4,152,178,189,240,246],"expression":[5,22,71,95,118,135,145,171,184,217],"of":[6,23,72,146,194,218,239],"immune":[7,219,241],"checkpoint":[8,220,242],"molecules":[9],"and":[10,19,32,34,46,65,83,98,114,124,130,151,165,199,225],"prognosis":[11,232],"in":[12,104,109,127,139,159,177,188,211,222,233,249],"childhood":[13],"acute":[14,54,60],"leukemia":[15,56,62,91],"were":[16,203],"investigated.":[17],"Materials":[18],"Methods:":[20],"The":[21,70,144,215],"programmed-death":[24,73],"1":[25,75],"(PD1),":[26],"cytotoxic":[27],"T-lymphocyte-associated":[28],"protein":[29],"4":[30],"(CTLA-4),":[31],"B-":[33],"T-lymphocyte":[35],"attenuator":[36],"(BTLA)":[37],"was":[38,88,101,119,136,157,175,185],"determined":[39,89],"by":[40],"flow":[41],"cytometry":[42],"on":[43,90,96,122,148,155,172,196,201],"peripheral":[44],"\u03b1\u03b2+":[45,97,123,173],"\u03b3\u03b4+":[47,99,125,149,197],"T-cells":[48,100,126,150,174,198],"from":[49,66],"patients":[50,105,160,250],"with":[51,106,111,161,206,229,251],"newly":[52],"diagnosed":[53],"lymphoblastic":[55],"(ALL)":[57],"(n=9)":[58],"or":[59],"myeloid":[61],"(AML)":[63],"(n=12),":[64],"healthy":[67],"volunteers":[68],"(n=7).":[69],"ligand":[74,154],"(PD-L1),":[76],"B7-1,":[77],"B7-2,":[78],"human":[79],"leukocyte":[80],"antigen-ABC":[81],"(HLA-ABC),":[82],"herpesvirus-entry":[84],"mediator":[85],"(HVEM)":[86],"ligands":[87],"blasts.":[92],"Results:":[93],"PD1":[94,170],"significantly":[102,137,186],"higher":[103,121,138,158,176,187,216],"ALL":[107,128,163,212],"than":[108],"those":[110],"AML":[112,140],"(p=0.0019":[113],"0.0239,":[115],"respectively).":[116,167],"CTLA-4":[117,147,195,224],"moderately":[120],"(p=0.077":[129],"0.077,":[131],"respectively),":[132],"whereas":[133,182],"HLA-ABC":[134],"blast":[141],"cells":[142],"(p=0.0182).":[143],"B7-2":[153],"blasts":[156,202],"high-risk":[162],"(p=0.02":[164],"0.02,":[166],"In":[168],"AML,":[169],"intermediate-risk":[179],"group":[180,191],"(p=0.05),":[181],"HVEM":[183],"low-risk":[190],"(p=0.02).":[192],"Expression":[193],"PD-L1":[200,226],"both":[204],"associated":[205,228],"poor":[207],"relapse-free":[208],"survival":[209],"outcomes":[210,248],"(p=0.049).":[213],"Conclusion:":[214],"molecules,":[221],"particular,":[223],"are":[227],"a":[230],"poorer":[231],"ALL,":[234],"suggesting":[235],"that":[236],"selective":[237],"use":[238],"blockade":[243],"might":[244],"improve":[245],"clinical":[247],"ALL.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-10T00:00:00"}