{"id":"https://openalex.org/W2978357322","doi":"https://doi.org/10.14309/00000434-200509001-00778","title":"Severity of Inflammation Predicts Progression to Colorectal Neoplasia in Ulcerative Colitis","display_name":"Severity of Inflammation Predicts Progression to Colorectal Neoplasia in Ulcerative Colitis","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2978357322","doi":"https://doi.org/10.14309/00000434-200509001-00778","mag":"2978357322"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-200509001-00778","doi":"https://doi.org/10.14309/00000434-200509001-00778","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200509001-00778","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025002618","display_name":"Roopali Bansal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roopali Bansal","raw_affiliation_strings":["Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090463240","display_name":"Steven H. Itzkowitz","orcid":"https://orcid.org/0000-0002-0436-5416","observed_orcids":["https://orcid.org/0000-0002-0436-5416"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Itzkowitz","raw_affiliation_strings":["Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065714981","display_name":"Noam Harpaz","orcid":"https://orcid.org/0000-0003-4923-2200","observed_orcids":["https://orcid.org/0000-0003-4923-2200"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noam Harpaz","raw_affiliation_strings":["Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103387035","display_name":"Sabera Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabera Hossain","raw_affiliation_strings":["Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079837925","display_name":"Sierra R. Matula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sierra Matula","raw_affiliation_strings":["Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065802516","display_name":"Carol Bodian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Bodian","raw_affiliation_strings":["Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038956446","display_name":"Thomas A. Ullman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Ullman","raw_affiliation_strings":["Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, The Mount Sinai School of Medicine, New York, NY and Pathology, The Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.4952,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.7281946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"100","issue":null,"first_page":"S289","last_page":"S289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-neoplasms","display_name":"colorectal neoplasia","score":0.8640000224113464},{"id":"https://openalex.org/keywords/inflammation-severity","display_name":"inflammation severity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6830000281333923},{"id":"https://openalex.org/keywords/high-grade-dysplasia","display_name":"high-grade dysplasia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9190000295639038},{"id":"https://openalex.org/keywords/surveillance-colonoscopy","display_name":"surveillance colonoscopy","score":0.6610000133514404},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5080000162124634},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.4519999921321869},{"id":"https://openalex.org/keywords/colorectal-cancer-risk-stratification","display_name":"colorectal cancer risk stratification","score":0.5979999899864197},{"id":"https://openalex.org/keywords/colorectal-cancer-screening-intervals","display_name":"colorectal cancer screening intervals","score":0.41200000047683716},{"id":"https://openalex.org/keywords/polypectomy","display_name":"polypectomy","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.948375940322876},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.8517414331436157},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7424100637435913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7292769551277161},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.6994523406028748},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6751035451889038},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6621193885803223},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5432078242301941},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.520717442035675},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4523126780986786},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4201706349849701},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34859535098075867},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3273366689682007}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-200509001-00778","doi":"https://doi.org/10.14309/00000434-200509001-00778","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-200509001-00778","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1964102710","https://openalex.org/W1990397098","https://openalex.org/W2050230840","https://openalex.org/W2912693115","https://openalex.org/W3011270434","https://openalex.org/W3142182956","https://openalex.org/W2472723929","https://openalex.org/W2554022371","https://openalex.org/W2036563054","https://openalex.org/W4323350856"],"abstract_inverted_index":{"Purpose:":[0],"Although":[1],"it":[2],"has":[3,26],"long":[4],"been":[5,27],"assumed":[6],"that":[7,68,350],"greater":[8],"severity":[9,137,258,351],"of":[10,23,56,107,193,198,205,222,259,263,335,352,358],"inflammation":[11,354],"(INF)":[12],"predisposes":[13],"to":[14,19,29,134,142,212,233,238,281,310,337],"colorectal":[15,155,369],"neoplasia":[16,150,160,214,265,283,291,313,321],"in":[17,64,339,360],"UC,":[18],"our":[20],"knowledge":[21],"demonstration":[22],"this":[24],"concept":[25],"limited":[28],"one":[30],"case-control":[31],"study.":[32],"Aim:":[33],"To":[34],"determine":[35],"whether":[36],"INF":[37,108,116,136,170,244,260,304,336],"is":[38,344,363],"an":[39,293],"independent":[40],"risk":[41,365],"factor":[42,366],"for":[43,104,224,279,367],"neoplastic":[44],"progression":[45,280,309,338],"among":[46],"patients":[47,362],"(pts)":[48],"with":[49,59,87,302,308],"UC.":[50],"Methods:":[51],"We":[52,90],"studied":[53],"a":[54,60,71,110,139,248,254,364],"cohort":[55,347],"UC":[57,194,361],"pts":[58,182],"colonoscopic":[61],"surveillance":[62,206,359],"exam":[63,86],"1996\u20137,":[65],"who":[66],"at":[67,172,195],"time":[69,197,211,246],"had":[70,76,84,187],"disease":[72],"duration":[73,192],"\u22657":[74],"years,":[75],"no":[77,115],"dysplasia":[78],"detected":[79],"on":[80,146],"initial":[81],"exam,":[82],"and":[83,95,178,219,261,319],"\u22651":[85],"histologic":[88,105,353],"follow-up.":[89],"reviewed":[91],"all":[92],"available":[93],"prior":[94],"subsequent":[96],"pathology":[97],"reports.":[98],"Each":[99],"biopsy":[100],"site":[101,175],"was":[102,132,200,208,215,227,277,305],"scored":[103],"degree":[106],"using":[109],"validated":[111],"scoring":[112],"system:":[113],"0-":[114],"or":[117,154,158,165],"quiescent/inactive":[118],"colitis;":[119],"1-":[120],"mildly":[121],"active;":[122,125],"2-":[123],"moderately":[124],"3-":[126],"severely":[127],"active.":[128],"Proportional":[129],"hazards":[130],"analysis":[131,252],"used":[133],"assess":[135],"as":[138,247,292],"time-changing":[140,249],"covariate":[141],"evaluate":[143],"its":[144],"effect":[145],"the":[147,196,220,225,333,345,356],"endpoints":[148],"advanced":[149,213,234,264,312],"(high-grade":[151],"dysplasia,":[152,162],"HGD":[153],"cancer,":[156],"CRC)":[157],"any":[159,239,282,320],"(low-grade":[161],"LGD,":[163],"HGD,":[164],"CRC)).":[166],"For":[167],"each":[168,173],"colonoscopy,":[169],"scores":[171],"colonic":[174],"were":[176],"summed":[177],"averaged.":[179],"Results:":[180],"418":[181],"met":[183],"inclusion":[184,199],"criteria.":[185],"92%":[186],"extensive":[188],"UC;":[189],"median":[190],"[range]":[191],"16":[201],"[.08,57]":[202],"yrs,":[203,218],"number":[204],"colonoscopies":[207],"5":[209],"[2,17],":[210],"5.8":[216],"[.5,14.9]":[217],"length":[221],"follow-up":[223],"non-progressors":[226],"6.7":[228],"[.3,15]":[229],"yrs.":[230],"18":[231],"progressed":[232,237],"neoplasia;":[235],"74":[236],"neoplasia.":[240,370],"Using":[241],"average":[242],"cumulative":[243],"over":[245,355],"covariate,":[250],"univariate":[251],"demonstrated":[253],"significant":[255,275],"relationship":[256,334],"between":[257],"development":[262],"(HR,":[266,284,314,322],"2.1;":[267],"P":[268,286,316,324],"<":[269],"0.05).":[270],"A":[271],"similar,":[272],"albeit":[273],"not":[274,330],"trend":[276],"observed":[278],"1.3;":[285],"=":[287,317,325],"0.3).":[288],"Excluding":[289],"polypoid":[290],"endpoint":[294],"(because":[295],"these":[296],"lesions":[297],"are":[298],"often":[299],"managed":[300],"conservatively":[301],"polypectomy),":[303],"significantly":[306],"associated":[307],"both":[311],"2.4;":[315],"0.03)":[318],"2.0;":[323],"0.01).":[326],"Other":[327],"variables":[328],"did":[329],"meaningfully":[331],"alter":[332],"multivariable":[340],"modeling.":[341],"Conclusions:":[342],"This":[343],"first":[346],"study":[348],"demonstrating":[349],"course":[357],"developing":[368]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2019-10-10T00:00:00"}
